"STUDYID","USUBJID","SUBJID","PARAMCD","PARAM","PARAMN","AVISIT","AVISITN","AVAL","BASE","CHG" "PHB-CH1","PHB-CH1-001",1,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,76,76,0 "PHB-CH1","PHB-CH1-001",1,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,64,76,-12 "PHB-CH1","PHB-CH1-001",1,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,54,76,-22 "PHB-CH1","PHB-CH1-001",1,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,64,, "PHB-CH1","PHB-CH1-001",1,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,62,, "PHB-CH1","PHB-CH1-001",1,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,43,, "PHB-CH1","PHB-CH1-001",1,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-001",1,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-001",1,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-001",1,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-001",1,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,6,, "PHB-CH1","PHB-CH1-001",1,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,448,, "PHB-CH1","PHB-CH1-001",1,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-001",1,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-001",1,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-001",1,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-001",1,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,33.4,33.4,0 "PHB-CH1","PHB-CH1-001",1,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,46,33.4,12.6 "PHB-CH1","PHB-CH1-001",1,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,30.9,33.4,-2.5 "PHB-CH1","PHB-CH1-001",1,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,21.4,33.4,-12 "PHB-CH1","PHB-CH1-001",1,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,34.3,34.3,0 "PHB-CH1","PHB-CH1-001",1,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,45.7,34.3,11.4 "PHB-CH1","PHB-CH1-001",1,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,64.7,34.3,30.4 "PHB-CH1","PHB-CH1-001",1,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,45.4,34.3,11.1 "PHB-CH1","PHB-CH1-001",1,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.2,5.2,0 "PHB-CH1","PHB-CH1-001",1,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.4,5.2,0.2 "PHB-CH1","PHB-CH1-001",1,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.7,5.2,-0.5 "PHB-CH1","PHB-CH1-001",1,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.5,5.2,-0.7 "PHB-CH1","PHB-CH1-001",1,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.6,5.2,-1.6 "PHB-CH1","PHB-CH1-001",1,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2.6,5.2,-2.6 "PHB-CH1","PHB-CH1-001",1,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2.7,5.2,-2.5 "PHB-CH1","PHB-CH1-001",1,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3,5.2,-2.2 "PHB-CH1","PHB-CH1-001",1,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.6,5.2,-0.6 "PHB-CH1","PHB-CH1-001",1,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.2,5.2,-1 "PHB-CH1","PHB-CH1-001",1,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.8,5.2,-0.4 "PHB-CH1","PHB-CH1-001",1,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.5,5.2,-0.7 "PHB-CH1","PHB-CH1-001",1,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4,5.2,-1.2 "PHB-CH1","PHB-CH1-001",1,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.8,5.2,-0.4 "PHB-CH1","PHB-CH1-001",1,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.9,3.9,0 "PHB-CH1","PHB-CH1-001",1,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.6,3.9,-0.3 "PHB-CH1","PHB-CH1-001",1,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.4,3.9,-0.5 "PHB-CH1","PHB-CH1-001",1,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.1,3.9,-0.8 "PHB-CH1","PHB-CH1-001",1,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,1.6,3.9,-2.3 "PHB-CH1","PHB-CH1-001",1,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,2.3,3.9,-1.6 "PHB-CH1","PHB-CH1-001",1,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,2,3.9,-1.9 "PHB-CH1","PHB-CH1-001",1,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.1,3.9,-0.8 "PHB-CH1","PHB-CH1-001",1,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.9,3.9,1 "PHB-CH1","PHB-CH1-001",1,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.5,3.9,0.6 "PHB-CH1","PHB-CH1-001",1,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.8,3.9,0.9 "PHB-CH1","PHB-CH1-001",1,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.1,3.9,-0.8 "PHB-CH1","PHB-CH1-001",1,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2.7,3.9,-1.2 "PHB-CH1","PHB-CH1-001",1,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.3,3.9,-0.6 "PHB-CH1","PHB-CH1-002",2,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,39,39,0 "PHB-CH1","PHB-CH1-002",2,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,34,39,-5 "PHB-CH1","PHB-CH1-002",2,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,48,39,9 "PHB-CH1","PHB-CH1-002",2,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,52,, "PHB-CH1","PHB-CH1-002",2,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,39,, "PHB-CH1","PHB-CH1-002",2,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,40,, "PHB-CH1","PHB-CH1-002",2,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-002",2,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-002",2,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-002",2,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-002",2,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,10,, "PHB-CH1","PHB-CH1-002",2,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,402,, "PHB-CH1","PHB-CH1-002",2,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-002",2,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-002",2,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-002",2,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-002",2,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,48,48,0 "PHB-CH1","PHB-CH1-002",2,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,48.2,48,0.200000000000003 "PHB-CH1","PHB-CH1-002",2,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,45.3,48,-2.7 "PHB-CH1","PHB-CH1-002",2,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,36.2,48,-11.8 "PHB-CH1","PHB-CH1-002",2,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,58.9,58.9,0 "PHB-CH1","PHB-CH1-002",2,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,62.8,58.9,3.9 "PHB-CH1","PHB-CH1-002",2,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,57.3,58.9,-1.6 "PHB-CH1","PHB-CH1-002",2,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,68.7,58.9,9.8 "PHB-CH1","PHB-CH1-002",2,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.6,5.6,0 "PHB-CH1","PHB-CH1-002",2,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.6,5.6,-1 "PHB-CH1","PHB-CH1-002",2,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.2,5.6,-1.4 "PHB-CH1","PHB-CH1-002",2,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.2,5.6,-0.399999999999999 "PHB-CH1","PHB-CH1-002",2,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.3,5.6,0.7 "PHB-CH1","PHB-CH1-002",2,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.4,5.6,-1.2 "PHB-CH1","PHB-CH1-002",2,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5,5.6,-0.6 "PHB-CH1","PHB-CH1-002",2,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.7,5.6,-0.9 "PHB-CH1","PHB-CH1-002",2,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.7,5.6,0.100000000000001 "PHB-CH1","PHB-CH1-002",2,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.2,5.6,0.6 "PHB-CH1","PHB-CH1-002",2,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5,5.6,-0.6 "PHB-CH1","PHB-CH1-002",2,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.7,5.6,0.100000000000001 "PHB-CH1","PHB-CH1-002",2,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.1,5.6,-0.5 "PHB-CH1","PHB-CH1-002",2,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6,5.6,0.4 "PHB-CH1","PHB-CH1-002",2,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.4,6.4,0 "PHB-CH1","PHB-CH1-002",2,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.5,6.4,-0.9 "PHB-CH1","PHB-CH1-002",2,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.6,6.4,-0.800000000000001 "PHB-CH1","PHB-CH1-002",2,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,7.1,6.4,0.699999999999999 "PHB-CH1","PHB-CH1-002",2,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.2,6.4,-0.2 "PHB-CH1","PHB-CH1-002",2,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.8,6.4,-0.6 "PHB-CH1","PHB-CH1-002",2,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7.3,6.4,0.9 "PHB-CH1","PHB-CH1-002",2,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,7.1,6.4,0.699999999999999 "PHB-CH1","PHB-CH1-002",2,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,8.6,6.4,2.2 "PHB-CH1","PHB-CH1-002",2,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,8,6.4,1.6 "PHB-CH1","PHB-CH1-002",2,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.9,6.4,0.5 "PHB-CH1","PHB-CH1-002",2,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.7,6.4,1.3 "PHB-CH1","PHB-CH1-002",2,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6,6.4,-0.4 "PHB-CH1","PHB-CH1-002",2,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.6,6.4,-0.800000000000001 "PHB-CH1","PHB-CH1-003",3,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,43,43,0 "PHB-CH1","PHB-CH1-003",3,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,34,43,-9 "PHB-CH1","PHB-CH1-003",3,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,43,43,0 "PHB-CH1","PHB-CH1-003",3,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,39,, "PHB-CH1","PHB-CH1-003",3,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,60,, "PHB-CH1","PHB-CH1-003",3,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,56,, "PHB-CH1","PHB-CH1-003",3,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-003",3,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-003",3,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-003",3,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-003",3,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,9,, "PHB-CH1","PHB-CH1-003",3,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,420,, "PHB-CH1","PHB-CH1-003",3,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-003",3,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-003",3,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-003",3,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-003",3,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,49,49,0 "PHB-CH1","PHB-CH1-003",3,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,53.7,49,4.7 "PHB-CH1","PHB-CH1-003",3,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,47.4,49,-1.6 "PHB-CH1","PHB-CH1-003",3,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,42.1,49,-6.9 "PHB-CH1","PHB-CH1-003",3,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,35.2,35.2,0 "PHB-CH1","PHB-CH1-003",3,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,45.6,35.2,10.4 "PHB-CH1","PHB-CH1-003",3,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,53.1,35.2,17.9 "PHB-CH1","PHB-CH1-003",3,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,57.1,35.2,21.9 "PHB-CH1","PHB-CH1-003",3,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.9,3.9,0 "PHB-CH1","PHB-CH1-003",3,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,1.7,3.9,-2.2 "PHB-CH1","PHB-CH1-003",3,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.3,3.9,-1.6 "PHB-CH1","PHB-CH1-003",3,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.5,3.9,-1.4 "PHB-CH1","PHB-CH1-003",3,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.7,3.9,-0.2 "PHB-CH1","PHB-CH1-003",3,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.1,3.9,0.2 "PHB-CH1","PHB-CH1-003",3,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.4,3.9,0.5 "PHB-CH1","PHB-CH1-003",3,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.6,3.9,0.7 "PHB-CH1","PHB-CH1-003",3,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.1,3.9,0.2 "PHB-CH1","PHB-CH1-003",3,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,2.9,3.9,-1 "PHB-CH1","PHB-CH1-003",3,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.7,3.9,-1.2 "PHB-CH1","PHB-CH1-003",3,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,2.5,3.9,-1.4 "PHB-CH1","PHB-CH1-003",3,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.4,3.9,-1.5 "PHB-CH1","PHB-CH1-003",3,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.1,3.9,-0.8 "PHB-CH1","PHB-CH1-003",3,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,8.3,8.3,0 "PHB-CH1","PHB-CH1-003",3,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.4,8.3,-1.9 "PHB-CH1","PHB-CH1-003",3,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.9,8.3,-1.4 "PHB-CH1","PHB-CH1-003",3,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.7,8.3,-1.6 "PHB-CH1","PHB-CH1-003",3,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,7.2,8.3,-1.1 "PHB-CH1","PHB-CH1-003",3,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,9.3,8.3,1 "PHB-CH1","PHB-CH1-003",3,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,10,8.3,1.7 "PHB-CH1","PHB-CH1-003",3,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,9.3,8.3,1 "PHB-CH1","PHB-CH1-003",3,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,9,8.3,0.699999999999999 "PHB-CH1","PHB-CH1-003",3,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.9,8.3,-0.4 "PHB-CH1","PHB-CH1-003",3,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,8.7,8.3,0.399999999999999 "PHB-CH1","PHB-CH1-003",3,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.6,8.3,-0.700000000000001 "PHB-CH1","PHB-CH1-003",3,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.2,8.3,-1.1 "PHB-CH1","PHB-CH1-003",3,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,8.5,8.3,0.199999999999999 "PHB-CH1","PHB-CH1-004",4,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,31,31,0 "PHB-CH1","PHB-CH1-004",4,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,37,31,6 "PHB-CH1","PHB-CH1-004",4,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,31,31,0 "PHB-CH1","PHB-CH1-004",4,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,44,, "PHB-CH1","PHB-CH1-004",4,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,24,, "PHB-CH1","PHB-CH1-004",4,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,42,, "PHB-CH1","PHB-CH1-004",4,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-004",4,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-004",4,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-004",4,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-004",4,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,12,, "PHB-CH1","PHB-CH1-004",4,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,401,, "PHB-CH1","PHB-CH1-004",4,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-004",4,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-004",4,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-004",4,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-004",4,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,43.2,43.2,0 "PHB-CH1","PHB-CH1-004",4,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,46.4,43.2,3.2 "PHB-CH1","PHB-CH1-004",4,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,40.5,43.2,-2.7 "PHB-CH1","PHB-CH1-004",4,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,40.5,43.2,-2.7 "PHB-CH1","PHB-CH1-004",4,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,37.1,37.1,0 "PHB-CH1","PHB-CH1-004",4,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,47.9,37.1,10.8 "PHB-CH1","PHB-CH1-004",4,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,43.5,37.1,6.4 "PHB-CH1","PHB-CH1-004",4,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,58.6,37.1,21.5 "PHB-CH1","PHB-CH1-004",4,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.7,6.7,0 "PHB-CH1","PHB-CH1-004",4,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,7.5,6.7,0.8 "PHB-CH1","PHB-CH1-004",4,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.7,6.7,0 "PHB-CH1","PHB-CH1-004",4,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.9,6.7,0.2 "PHB-CH1","PHB-CH1-004",4,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.6,6.7,-1.1 "PHB-CH1","PHB-CH1-004",4,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.8,6.7,-0.9 "PHB-CH1","PHB-CH1-004",4,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.9,6.7,-1.8 "PHB-CH1","PHB-CH1-004",4,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.5,6.7,-2.2 "PHB-CH1","PHB-CH1-004",4,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.8,6.7,-0.9 "PHB-CH1","PHB-CH1-004",4,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.7,6.7,-1 "PHB-CH1","PHB-CH1-004",4,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.2,6.7,-2.5 "PHB-CH1","PHB-CH1-004",4,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.1,6.7,-0.6 "PHB-CH1","PHB-CH1-004",4,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.1,6.7,-1.6 "PHB-CH1","PHB-CH1-004",4,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.2,6.7,-3.5 "PHB-CH1","PHB-CH1-004",4,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.6,5.6,0 "PHB-CH1","PHB-CH1-004",4,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.1,5.6,-0.5 "PHB-CH1","PHB-CH1-004",4,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.7,5.6,0.100000000000001 "PHB-CH1","PHB-CH1-004",4,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.2,5.6,-0.399999999999999 "PHB-CH1","PHB-CH1-004",4,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5,5.6,-0.6 "PHB-CH1","PHB-CH1-004",4,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5,5.6,-0.6 "PHB-CH1","PHB-CH1-004",4,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.2,5.6,-0.399999999999999 "PHB-CH1","PHB-CH1-004",4,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.3,5.6,-2.3 "PHB-CH1","PHB-CH1-004",4,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.7,5.6,-0.9 "PHB-CH1","PHB-CH1-004",4,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4,5.6,-1.6 "PHB-CH1","PHB-CH1-004",4,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.5,5.6,-1.1 "PHB-CH1","PHB-CH1-004",4,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.4,5.6,-1.2 "PHB-CH1","PHB-CH1-004",4,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.8,5.6,-0.8 "PHB-CH1","PHB-CH1-004",4,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.3,5.6,-2.3 "PHB-CH1","PHB-CH1-005",5,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,60,60,0 "PHB-CH1","PHB-CH1-005",5,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,55,60,-5 "PHB-CH1","PHB-CH1-005",5,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,51,60,-9 "PHB-CH1","PHB-CH1-005",5,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,65,, "PHB-CH1","PHB-CH1-005",5,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,70,, "PHB-CH1","PHB-CH1-005",5,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,31,, "PHB-CH1","PHB-CH1-005",5,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-005",5,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,1,, "PHB-CH1","PHB-CH1-005",5,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-005",5,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-005",5,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,4,, "PHB-CH1","PHB-CH1-005",5,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,415,, "PHB-CH1","PHB-CH1-005",5,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-005",5,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-005",5,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-005",5,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-005",5,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,57.8,57.8,0 "PHB-CH1","PHB-CH1-005",5,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,39.1,57.8,-18.7 "PHB-CH1","PHB-CH1-005",5,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,48.6,57.8,-9.2 "PHB-CH1","PHB-CH1-005",5,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,45,57.8,-12.8 "PHB-CH1","PHB-CH1-005",5,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,41.7,41.7,0 "PHB-CH1","PHB-CH1-005",5,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,35.3,41.7,-6.40000000000001 "PHB-CH1","PHB-CH1-005",5,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,32.4,41.7,-9.3 "PHB-CH1","PHB-CH1-005",5,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,57.4,41.7,15.7 "PHB-CH1","PHB-CH1-005",5,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.7,3.7,0 "PHB-CH1","PHB-CH1-005",5,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.7,3.7,0 "PHB-CH1","PHB-CH1-005",5,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.6,3.7,0.9 "PHB-CH1","PHB-CH1-005",5,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.7,3.7,1 "PHB-CH1","PHB-CH1-005",5,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.8,3.7,1.1 "PHB-CH1","PHB-CH1-005",5,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.1,3.7,1.4 "PHB-CH1","PHB-CH1-005",5,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.5,3.7,-0.2 "PHB-CH1","PHB-CH1-005",5,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.4,3.7,-0.3 "PHB-CH1","PHB-CH1-005",5,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.7,3.7,0 "PHB-CH1","PHB-CH1-005",5,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.5,3.7,0.8 "PHB-CH1","PHB-CH1-005",5,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.8,3.7,1.1 "PHB-CH1","PHB-CH1-005",5,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.8,3.7,1.1 "PHB-CH1","PHB-CH1-005",5,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.9,3.7,1.2 "PHB-CH1","PHB-CH1-005",5,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.3,3.7,1.6 "PHB-CH1","PHB-CH1-005",5,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.5,4.5,0 "PHB-CH1","PHB-CH1-005",5,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.5,4.5,0 "PHB-CH1","PHB-CH1-005",5,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.4,4.5,0.9 "PHB-CH1","PHB-CH1-005",5,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.2,4.5,0.7 "PHB-CH1","PHB-CH1-005",5,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.7,4.5,0.2 "PHB-CH1","PHB-CH1-005",5,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4,4.5,-0.5 "PHB-CH1","PHB-CH1-005",5,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,2.6,4.5,-1.9 "PHB-CH1","PHB-CH1-005",5,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4,4.5,-0.5 "PHB-CH1","PHB-CH1-005",5,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.5,4.5,-1 "PHB-CH1","PHB-CH1-005",5,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.7,4.5,-0.8 "PHB-CH1","PHB-CH1-005",5,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.1,4.5,-0.4 "PHB-CH1","PHB-CH1-005",5,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.5,4.5,-1 "PHB-CH1","PHB-CH1-005",5,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.2,4.5,-0.3 "PHB-CH1","PHB-CH1-005",5,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.5,4.5,0 "PHB-CH1","PHB-CH1-006",6,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,54,54,0 "PHB-CH1","PHB-CH1-006",6,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,62,54,8 "PHB-CH1","PHB-CH1-006",6,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,42,54,-12 "PHB-CH1","PHB-CH1-006",6,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,33,, "PHB-CH1","PHB-CH1-006",6,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,35,, "PHB-CH1","PHB-CH1-006",6,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,30,, "PHB-CH1","PHB-CH1-006",6,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-006",6,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-006",6,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-006",6,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-006",6,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,13,, "PHB-CH1","PHB-CH1-006",6,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,340,, "PHB-CH1","PHB-CH1-006",6,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-006",6,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-006",6,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-006",6,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-006",6,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,41.6,41.6,0 "PHB-CH1","PHB-CH1-006",6,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,29.5,41.6,-12.1 "PHB-CH1","PHB-CH1-006",6,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,40.8,41.6,-0.800000000000004 "PHB-CH1","PHB-CH1-006",6,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,33.9,41.6,-7.7 "PHB-CH1","PHB-CH1-006",6,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,53.8,53.8,0 "PHB-CH1","PHB-CH1-006",6,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,61.7,53.8,7.90000000000001 "PHB-CH1","PHB-CH1-006",6,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,42.2,53.8,-11.6 "PHB-CH1","PHB-CH1-006",6,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,62,53.8,8.2 "PHB-CH1","PHB-CH1-006",6,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,8.4,8.4,0 "PHB-CH1","PHB-CH1-006",6,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.7,8.4,-1.7 "PHB-CH1","PHB-CH1-006",6,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7.7,8.4,-0.7 "PHB-CH1","PHB-CH1-006",6,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,8.7,8.4,0.299999999999999 "PHB-CH1","PHB-CH1-006",6,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,8.1,8.4,-0.300000000000001 "PHB-CH1","PHB-CH1-006",6,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,9.2,8.4,0.799999999999999 "PHB-CH1","PHB-CH1-006",6,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,9.5,8.4,1.1 "PHB-CH1","PHB-CH1-006",6,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,8.6,8.4,0.199999999999999 "PHB-CH1","PHB-CH1-006",6,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,8.4,8.4,0 "PHB-CH1","PHB-CH1-006",6,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,8.3,8.4,-0.0999999999999996 "PHB-CH1","PHB-CH1-006",6,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,8.4,8.4,0 "PHB-CH1","PHB-CH1-006",6,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,8.2,8.4,-0.200000000000001 "PHB-CH1","PHB-CH1-006",6,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,8.9,8.4,0.5 "PHB-CH1","PHB-CH1-006",6,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,9.5,8.4,1.1 "PHB-CH1","PHB-CH1-006",6,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.6,5.6,0 "PHB-CH1","PHB-CH1-006",6,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.4,5.6,-1.2 "PHB-CH1","PHB-CH1-006",6,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6,5.6,0.4 "PHB-CH1","PHB-CH1-006",6,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.6,5.6,1 "PHB-CH1","PHB-CH1-006",6,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6,5.6,0.4 "PHB-CH1","PHB-CH1-006",6,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.8,5.6,0.2 "PHB-CH1","PHB-CH1-006",6,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.1,5.6,0.5 "PHB-CH1","PHB-CH1-006",6,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.2,5.6,0.6 "PHB-CH1","PHB-CH1-006",6,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.4,5.6,0.800000000000001 "PHB-CH1","PHB-CH1-006",6,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.4,5.6,-0.199999999999999 "PHB-CH1","PHB-CH1-006",6,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6,5.6,0.4 "PHB-CH1","PHB-CH1-006",6,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.8,5.6,-0.8 "PHB-CH1","PHB-CH1-006",6,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.7,5.6,1.1 "PHB-CH1","PHB-CH1-006",6,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.2,5.6,0.6 "PHB-CH1","PHB-CH1-007",7,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,25,25,0 "PHB-CH1","PHB-CH1-007",7,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,25,25,0 "PHB-CH1","PHB-CH1-007",7,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,29,25,4 "PHB-CH1","PHB-CH1-007",7,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,42,, "PHB-CH1","PHB-CH1-007",7,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,42,, "PHB-CH1","PHB-CH1-007",7,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,69,, "PHB-CH1","PHB-CH1-007",7,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-007",7,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-007",7,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-007",7,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-007",7,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,14,, "PHB-CH1","PHB-CH1-007",7,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,355,, "PHB-CH1","PHB-CH1-007",7,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-007",7,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-007",7,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-007",7,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-007",7,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,35.8,35.8,0 "PHB-CH1","PHB-CH1-007",7,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,48.8,35.8,13 "PHB-CH1","PHB-CH1-007",7,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,50,35.8,14.2 "PHB-CH1","PHB-CH1-007",7,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,42.4,35.8,6.6 "PHB-CH1","PHB-CH1-007",7,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,70.7,70.7,0 "PHB-CH1","PHB-CH1-007",7,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,61.9,70.7,-8.8 "PHB-CH1","PHB-CH1-007",7,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,67.2,70.7,-3.5 "PHB-CH1","PHB-CH1-007",7,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,61.2,70.7,-9.5 "PHB-CH1","PHB-CH1-007",7,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,7,7,0 "PHB-CH1","PHB-CH1-007",7,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,7.4,7,0.4 "PHB-CH1","PHB-CH1-007",7,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7.5,7,0.5 "PHB-CH1","PHB-CH1-007",7,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.6,7,-2.4 "PHB-CH1","PHB-CH1-007",7,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.6,7,-2.4 "PHB-CH1","PHB-CH1-007",7,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,7.1,7,0.0999999999999996 "PHB-CH1","PHB-CH1-007",7,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.1,7,-0.9 "PHB-CH1","PHB-CH1-007",7,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.4,7,-2.6 "PHB-CH1","PHB-CH1-007",7,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.6,7,-2.4 "PHB-CH1","PHB-CH1-007",7,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.8,7,-2.2 "PHB-CH1","PHB-CH1-007",7,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.8,7,-1.2 "PHB-CH1","PHB-CH1-007",7,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.1,7,-0.9 "PHB-CH1","PHB-CH1-007",7,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.5,7,-2.5 "PHB-CH1","PHB-CH1-007",7,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.8,7,-1.2 "PHB-CH1","PHB-CH1-007",7,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.2,4.2,0 "PHB-CH1","PHB-CH1-007",7,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-007",7,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.3,4.2,0.0999999999999996 "PHB-CH1","PHB-CH1-007",7,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,2.4,4.2,-1.8 "PHB-CH1","PHB-CH1-007",7,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,2.7,4.2,-1.5 "PHB-CH1","PHB-CH1-007",7,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.2,4.2,0 "PHB-CH1","PHB-CH1-007",7,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.5,4.2,-0.7 "PHB-CH1","PHB-CH1-007",7,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,1.4,4.2,-2.8 "PHB-CH1","PHB-CH1-007",7,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.2,4.2,-2 "PHB-CH1","PHB-CH1-007",7,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,2.6,4.2,-1.6 "PHB-CH1","PHB-CH1-007",7,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,2.8,4.2,-1.4 "PHB-CH1","PHB-CH1-007",7,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.8,4.2,-0.4 "PHB-CH1","PHB-CH1-007",7,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2.1,4.2,-2.1 "PHB-CH1","PHB-CH1-007",7,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.1,4.2,-1.1 "PHB-CH1","PHB-CH1-008",8,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,80,80,0 "PHB-CH1","PHB-CH1-008",8,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,76,80,-4 "PHB-CH1","PHB-CH1-008",8,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,63,80,-17 "PHB-CH1","PHB-CH1-008",8,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,69,, "PHB-CH1","PHB-CH1-008",8,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,63,, "PHB-CH1","PHB-CH1-008",8,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,73,, "PHB-CH1","PHB-CH1-008",8,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-008",8,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-008",8,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-008",8,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-008",8,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,7,, "PHB-CH1","PHB-CH1-008",8,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,420,, "PHB-CH1","PHB-CH1-008",8,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-008",8,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-008",8,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-008",8,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-008",8,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,53.6,53.6,0 "PHB-CH1","PHB-CH1-008",8,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,56.8,53.6,3.2 "PHB-CH1","PHB-CH1-008",8,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,45.3,53.6,-8.3 "PHB-CH1","PHB-CH1-008",8,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,54.8,53.6,1.2 "PHB-CH1","PHB-CH1-008",8,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,53.5,53.5,0 "PHB-CH1","PHB-CH1-008",8,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,41.7,53.5,-11.8 "PHB-CH1","PHB-CH1-008",8,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,67.1,53.5,13.6 "PHB-CH1","PHB-CH1-008",8,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,49.4,53.5,-4.1 "PHB-CH1","PHB-CH1-008",8,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.9,4.9,0 "PHB-CH1","PHB-CH1-008",8,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.6,4.9,-1.3 "PHB-CH1","PHB-CH1-008",8,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.1,4.9,-0.800000000000001 "PHB-CH1","PHB-CH1-008",8,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.1,4.9,-0.800000000000001 "PHB-CH1","PHB-CH1-008",8,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.2,4.9,1.3 "PHB-CH1","PHB-CH1-008",8,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.4,4.9,0.5 "PHB-CH1","PHB-CH1-008",8,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.9,4.9,0 "PHB-CH1","PHB-CH1-008",8,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.5,4.9,-0.4 "PHB-CH1","PHB-CH1-008",8,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.5,4.9,-1.4 "PHB-CH1","PHB-CH1-008",8,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.4,4.9,-0.5 "PHB-CH1","PHB-CH1-008",8,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.5,4.9,-1.4 "PHB-CH1","PHB-CH1-008",8,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.8,4.9,-1.1 "PHB-CH1","PHB-CH1-008",8,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.7,4.9,-0.2 "PHB-CH1","PHB-CH1-008",8,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.7,4.9,-1.2 "PHB-CH1","PHB-CH1-008",8,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4,4,0 "PHB-CH1","PHB-CH1-008",8,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4,4,0 "PHB-CH1","PHB-CH1-008",8,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.6,4,-0.4 "PHB-CH1","PHB-CH1-008",8,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.4,4,-0.6 "PHB-CH1","PHB-CH1-008",8,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.5,4,0.5 "PHB-CH1","PHB-CH1-008",8,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.7,4,0.7 "PHB-CH1","PHB-CH1-008",8,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.9,4,0.9 "PHB-CH1","PHB-CH1-008",8,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.6,4,0.6 "PHB-CH1","PHB-CH1-008",8,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.5,4,-0.5 "PHB-CH1","PHB-CH1-008",8,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.6,4,0.6 "PHB-CH1","PHB-CH1-008",8,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.6,4,-0.4 "PHB-CH1","PHB-CH1-008",8,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,2.9,4,-1.1 "PHB-CH1","PHB-CH1-008",8,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2.7,4,-1.3 "PHB-CH1","PHB-CH1-008",8,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,2.8,4,-1.2 "PHB-CH1","PHB-CH1-009",9,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,30,30,0 "PHB-CH1","PHB-CH1-009",9,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,27,30,-3 "PHB-CH1","PHB-CH1-009",9,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,35,30,5 "PHB-CH1","PHB-CH1-009",9,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,45,, "PHB-CH1","PHB-CH1-009",9,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,47,, "PHB-CH1","PHB-CH1-009",9,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,62,, "PHB-CH1","PHB-CH1-009",9,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-009",9,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-009",9,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-009",9,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-009",9,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,6,, "PHB-CH1","PHB-CH1-009",9,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,435,, "PHB-CH1","PHB-CH1-009",9,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-009",9,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-009",9,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-009",9,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-009",9,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,47.4,47.4,0 "PHB-CH1","PHB-CH1-009",9,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,56.1,47.4,8.7 "PHB-CH1","PHB-CH1-009",9,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,67.1,47.4,19.7 "PHB-CH1","PHB-CH1-009",9,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,44.7,47.4,-2.7 "PHB-CH1","PHB-CH1-009",9,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,58.5,58.5,0 "PHB-CH1","PHB-CH1-009",9,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,50,58.5,-8.5 "PHB-CH1","PHB-CH1-009",9,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,62.9,58.5,4.4 "PHB-CH1","PHB-CH1-009",9,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,54.6,58.5,-3.9 "PHB-CH1","PHB-CH1-009",9,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,8.2,8.2,0 "PHB-CH1","PHB-CH1-009",9,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,8.1,8.2,-0.0999999999999996 "PHB-CH1","PHB-CH1-009",9,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.8,8.2,-1.4 "PHB-CH1","PHB-CH1-009",9,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.4,8.2,-2.8 "PHB-CH1","PHB-CH1-009",9,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6,8.2,-2.2 "PHB-CH1","PHB-CH1-009",9,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.8,8.2,-2.4 "PHB-CH1","PHB-CH1-009",9,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,7.2,8.2,-0.999999999999999 "PHB-CH1","PHB-CH1-009",9,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.5,8.2,-0.699999999999999 "PHB-CH1","PHB-CH1-009",9,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,7.6,8.2,-0.6 "PHB-CH1","PHB-CH1-009",9,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6,8.2,-2.2 "PHB-CH1","PHB-CH1-009",9,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6,8.2,-2.2 "PHB-CH1","PHB-CH1-009",9,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.8,8.2,-2.4 "PHB-CH1","PHB-CH1-009",9,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.4,8.2,-1.8 "PHB-CH1","PHB-CH1-009",9,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.3,8.2,-1.9 "PHB-CH1","PHB-CH1-009",9,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,8.6,8.6,0 "PHB-CH1","PHB-CH1-009",9,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,8,8.6,-0.6 "PHB-CH1","PHB-CH1-009",9,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7.7,8.6,-0.9 "PHB-CH1","PHB-CH1-009",9,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.4,8.6,-2.2 "PHB-CH1","PHB-CH1-009",9,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.5,8.6,-3.1 "PHB-CH1","PHB-CH1-009",9,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.7,8.6,-1.9 "PHB-CH1","PHB-CH1-009",9,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7,8.6,-1.6 "PHB-CH1","PHB-CH1-009",9,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.4,8.6,-2.2 "PHB-CH1","PHB-CH1-009",9,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.1,8.6,-2.5 "PHB-CH1","PHB-CH1-009",9,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.4,8.6,-1.2 "PHB-CH1","PHB-CH1-009",9,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.4,8.6,-2.2 "PHB-CH1","PHB-CH1-009",9,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.3,8.6,-1.3 "PHB-CH1","PHB-CH1-009",9,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.4,8.6,-1.2 "PHB-CH1","PHB-CH1-009",9,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.5,8.6,-1.1 "PHB-CH1","PHB-CH1-010",10,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,32,32,0 "PHB-CH1","PHB-CH1-010",10,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,38,32,6 "PHB-CH1","PHB-CH1-010",10,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,11,32,-21 "PHB-CH1","PHB-CH1-010",10,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,38,, "PHB-CH1","PHB-CH1-010",10,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,43,, "PHB-CH1","PHB-CH1-010",10,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,60,, "PHB-CH1","PHB-CH1-010",10,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-010",10,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-010",10,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-010",10,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-010",10,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,42,, "PHB-CH1","PHB-CH1-010",10,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,126,, "PHB-CH1","PHB-CH1-010",10,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-010",10,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-010",10,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-010",10,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-010",10,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,43.8,43.8,0 "PHB-CH1","PHB-CH1-010",10,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,31.2,43.8,-12.6 "PHB-CH1","PHB-CH1-010",10,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,37.4,43.8,-6.4 "PHB-CH1","PHB-CH1-010",10,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,33.1,43.8,-10.7 "PHB-CH1","PHB-CH1-010",10,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,69.6,69.6,0 "PHB-CH1","PHB-CH1-010",10,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,65.4,69.6,-4.19999999999999 "PHB-CH1","PHB-CH1-010",10,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,64.7,69.6,-4.89999999999999 "PHB-CH1","PHB-CH1-010",10,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,64.2,69.6,-5.39999999999999 "PHB-CH1","PHB-CH1-010",10,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6,6,0 "PHB-CH1","PHB-CH1-010",10,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4,6,-2 "PHB-CH1","PHB-CH1-010",10,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.1,6,-1.9 "PHB-CH1","PHB-CH1-010",10,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.7,6,-0.3 "PHB-CH1","PHB-CH1-010",10,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6,6,0 "PHB-CH1","PHB-CH1-010",10,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.9,6,-1.1 "PHB-CH1","PHB-CH1-010",10,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.6,6,-0.4 "PHB-CH1","PHB-CH1-010",10,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.7,6,-1.3 "PHB-CH1","PHB-CH1-010",10,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.8,6,0.8 "PHB-CH1","PHB-CH1-010",10,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,7.4,6,1.4 "PHB-CH1","PHB-CH1-010",10,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.6,6,0.6 "PHB-CH1","PHB-CH1-010",10,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.5,6,-0.5 "PHB-CH1","PHB-CH1-010",10,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.1,6,0.0999999999999996 "PHB-CH1","PHB-CH1-010",10,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.9,6,-0.0999999999999996 "PHB-CH1","PHB-CH1-010",10,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.2,4.2,0 "PHB-CH1","PHB-CH1-010",10,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.3,4.2,-0.9 "PHB-CH1","PHB-CH1-010",10,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,2.1,4.2,-2.1 "PHB-CH1","PHB-CH1-010",10,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.9,4.2,-0.3 "PHB-CH1","PHB-CH1-010",10,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,2.8,4.2,-1.4 "PHB-CH1","PHB-CH1-010",10,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,2.1,4.2,-2.1 "PHB-CH1","PHB-CH1-010",10,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.7,4.2,-0.5 "PHB-CH1","PHB-CH1-010",10,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.7,4.2,-0.5 "PHB-CH1","PHB-CH1-010",10,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.2,4.2,1 "PHB-CH1","PHB-CH1-010",10,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.5,4.2,1.3 "PHB-CH1","PHB-CH1-010",10,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-010",10,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.8,4.2,-0.4 "PHB-CH1","PHB-CH1-010",10,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.6,4.2,0.399999999999999 "PHB-CH1","PHB-CH1-010",10,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.6,4.2,0.399999999999999 "PHB-CH1","PHB-CH1-011",11,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,26,26,0 "PHB-CH1","PHB-CH1-011",11,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,42,26,16 "PHB-CH1","PHB-CH1-011",11,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,25,26,-1 "PHB-CH1","PHB-CH1-011",11,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,20,, "PHB-CH1","PHB-CH1-011",11,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,34,, "PHB-CH1","PHB-CH1-011",11,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,33,, "PHB-CH1","PHB-CH1-011",11,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-011",11,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-011",11,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,5,, "PHB-CH1","PHB-CH1-011",11,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,5,, "PHB-CH1","PHB-CH1-011",11,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,2,, "PHB-CH1","PHB-CH1-011",11,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,533,, "PHB-CH1","PHB-CH1-011",11,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-011",11,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-011",11,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-011",11,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-011",11,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,41.4,41.4,0 "PHB-CH1","PHB-CH1-011",11,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,45.5,41.4,4.1 "PHB-CH1","PHB-CH1-011",11,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,46.5,41.4,5.1 "PHB-CH1","PHB-CH1-011",11,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,43.7,41.4,2.3 "PHB-CH1","PHB-CH1-011",11,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,32.3,32.3,0 "PHB-CH1","PHB-CH1-011",11,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,48.1,32.3,15.8 "PHB-CH1","PHB-CH1-011",11,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,54.5,32.3,22.2 "PHB-CH1","PHB-CH1-011",11,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,50.2,32.3,17.9 "PHB-CH1","PHB-CH1-011",11,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.3,5.3,0 "PHB-CH1","PHB-CH1-011",11,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.7,5.3,-0.6 "PHB-CH1","PHB-CH1-011",11,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7.1,5.3,1.8 "PHB-CH1","PHB-CH1-011",11,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.3,5.3,0 "PHB-CH1","PHB-CH1-011",11,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5,5.3,-0.3 "PHB-CH1","PHB-CH1-011",11,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.4,5.3,1.1 "PHB-CH1","PHB-CH1-011",11,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5,5.3,-0.3 "PHB-CH1","PHB-CH1-011",11,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.6,5.3,0.3 "PHB-CH1","PHB-CH1-011",11,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.1,5.3,0.8 "PHB-CH1","PHB-CH1-011",11,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.9,5.3,-0.399999999999999 "PHB-CH1","PHB-CH1-011",11,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.1,5.3,-0.2 "PHB-CH1","PHB-CH1-011",11,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.5,5.3,0.2 "PHB-CH1","PHB-CH1-011",11,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.4,5.3,-0.9 "PHB-CH1","PHB-CH1-011",11,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.6,5.3,-1.7 "PHB-CH1","PHB-CH1-011",11,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.4,3.4,0 "PHB-CH1","PHB-CH1-011",11,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.2,3.4,0.8 "PHB-CH1","PHB-CH1-011",11,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.8,3.4,1.4 "PHB-CH1","PHB-CH1-011",11,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.1,3.4,0.7 "PHB-CH1","PHB-CH1-011",11,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4,3.4,0.6 "PHB-CH1","PHB-CH1-011",11,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5,3.4,1.6 "PHB-CH1","PHB-CH1-011",11,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.9,3.4,0.5 "PHB-CH1","PHB-CH1-011",11,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.5,3.4,1.1 "PHB-CH1","PHB-CH1-011",11,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.4,3.4,2 "PHB-CH1","PHB-CH1-011",11,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.4,3.4,1 "PHB-CH1","PHB-CH1-011",11,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.2,3.4,1.8 "PHB-CH1","PHB-CH1-011",11,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.8,3.4,1.4 "PHB-CH1","PHB-CH1-011",11,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.3,3.4,0.9 "PHB-CH1","PHB-CH1-011",11,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.3,3.4,0.9 "PHB-CH1","PHB-CH1-012",12,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,43,43,0 "PHB-CH1","PHB-CH1-012",12,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,46,43,3 "PHB-CH1","PHB-CH1-012",12,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,29,43,-14 "PHB-CH1","PHB-CH1-012",12,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,39,, "PHB-CH1","PHB-CH1-012",12,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,38,, "PHB-CH1","PHB-CH1-012",12,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,51,, "PHB-CH1","PHB-CH1-012",12,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-012",12,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-012",12,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-012",12,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-012",12,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,7,, "PHB-CH1","PHB-CH1-012",12,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,466,, "PHB-CH1","PHB-CH1-012",12,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-012",12,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-012",12,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-012",12,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-012",12,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,52.2,52.2,0 "PHB-CH1","PHB-CH1-012",12,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,41.5,52.2,-10.7 "PHB-CH1","PHB-CH1-012",12,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,46.7,52.2,-5.5 "PHB-CH1","PHB-CH1-012",12,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,48,52.2,-4.2 "PHB-CH1","PHB-CH1-012",12,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,52.2,52.2,0 "PHB-CH1","PHB-CH1-012",12,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,51.5,52.2,-0.700000000000003 "PHB-CH1","PHB-CH1-012",12,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,46.8,52.2,-5.40000000000001 "PHB-CH1","PHB-CH1-012",12,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,52.8,52.2,0.599999999999994 "PHB-CH1","PHB-CH1-012",12,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.2,6.2,0 "PHB-CH1","PHB-CH1-012",12,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5,6.2,-1.2 "PHB-CH1","PHB-CH1-012",12,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.9,6.2,-0.3 "PHB-CH1","PHB-CH1-012",12,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.1,6.2,-2.1 "PHB-CH1","PHB-CH1-012",12,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.9,6.2,-2.3 "PHB-CH1","PHB-CH1-012",12,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.7,6.2,-2.5 "PHB-CH1","PHB-CH1-012",12,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4,6.2,-2.2 "PHB-CH1","PHB-CH1-012",12,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4,6.2,-2.2 "PHB-CH1","PHB-CH1-012",12,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6,6.2,-0.2 "PHB-CH1","PHB-CH1-012",12,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.2,6.2,-1 "PHB-CH1","PHB-CH1-012",12,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.7,6.2,-2.5 "PHB-CH1","PHB-CH1-012",12,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.1,6.2,-2.1 "PHB-CH1","PHB-CH1-012",12,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.2,6.2,-2 "PHB-CH1","PHB-CH1-012",12,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.9,6.2,-0.3 "PHB-CH1","PHB-CH1-012",12,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.7,3.7,0 "PHB-CH1","PHB-CH1-012",12,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,2.1,3.7,-1.6 "PHB-CH1","PHB-CH1-012",12,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.2,3.7,-0.5 "PHB-CH1","PHB-CH1-012",12,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,2.8,3.7,-0.9 "PHB-CH1","PHB-CH1-012",12,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,2.2,3.7,-1.5 "PHB-CH1","PHB-CH1-012",12,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,2,3.7,-1.7 "PHB-CH1","PHB-CH1-012",12,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,1.8,3.7,-1.9 "PHB-CH1","PHB-CH1-012",12,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2,3.7,-1.7 "PHB-CH1","PHB-CH1-012",12,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.8,3.7,1.1 "PHB-CH1","PHB-CH1-012",12,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.2,3.7,-0.5 "PHB-CH1","PHB-CH1-012",12,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,1.2,3.7,-2.5 "PHB-CH1","PHB-CH1-012",12,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,1.6,3.7,-2.1 "PHB-CH1","PHB-CH1-012",12,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,1.7,3.7,-2 "PHB-CH1","PHB-CH1-012",12,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.8,3.7,0.0999999999999996 "PHB-CH1","PHB-CH1-013",13,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,41,41,0 "PHB-CH1","PHB-CH1-013",13,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,49,41,8 "PHB-CH1","PHB-CH1-013",13,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,29,41,-12 "PHB-CH1","PHB-CH1-013",13,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,45,, "PHB-CH1","PHB-CH1-013",13,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,36,, "PHB-CH1","PHB-CH1-013",13,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,54,, "PHB-CH1","PHB-CH1-013",13,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-013",13,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-013",13,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-013",13,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-013",13,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,17,, "PHB-CH1","PHB-CH1-013",13,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,336,, "PHB-CH1","PHB-CH1-013",13,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-013",13,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-013",13,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-013",13,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-013",13,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,56.6,56.6,0 "PHB-CH1","PHB-CH1-013",13,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,67.5,56.6,10.9 "PHB-CH1","PHB-CH1-013",13,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,59.1,56.6,2.5 "PHB-CH1","PHB-CH1-013",13,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,62,56.6,5.4 "PHB-CH1","PHB-CH1-013",13,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,51,51,0 "PHB-CH1","PHB-CH1-013",13,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,60.8,51,9.8 "PHB-CH1","PHB-CH1-013",13,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,64.5,51,13.5 "PHB-CH1","PHB-CH1-013",13,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,72.5,51,21.5 "PHB-CH1","PHB-CH1-013",13,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.4,6.4,0 "PHB-CH1","PHB-CH1-013",13,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.8,6.4,0.399999999999999 "PHB-CH1","PHB-CH1-013",13,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6,6.4,-0.4 "PHB-CH1","PHB-CH1-013",13,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5,6.4,-1.4 "PHB-CH1","PHB-CH1-013",13,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.8,6.4,0.399999999999999 "PHB-CH1","PHB-CH1-013",13,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.8,6.4,-0.6 "PHB-CH1","PHB-CH1-013",13,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.8,6.4,0.399999999999999 "PHB-CH1","PHB-CH1-013",13,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,8.2,6.4,1.8 "PHB-CH1","PHB-CH1-013",13,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,8.3,6.4,1.9 "PHB-CH1","PHB-CH1-013",13,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.6,6.4,0.199999999999999 "PHB-CH1","PHB-CH1-013",13,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.7,6.4,0.3 "PHB-CH1","PHB-CH1-013",13,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.9,6.4,-0.5 "PHB-CH1","PHB-CH1-013",13,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.1,6.4,-1.3 "PHB-CH1","PHB-CH1-013",13,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.6,6.4,-1.8 "PHB-CH1","PHB-CH1-013",13,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.7,5.7,0 "PHB-CH1","PHB-CH1-013",13,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.9,5.7,0.2 "PHB-CH1","PHB-CH1-013",13,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.6,5.7,-1.1 "PHB-CH1","PHB-CH1-013",13,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.8,5.7,-0.9 "PHB-CH1","PHB-CH1-013",13,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.5,5.7,0.8 "PHB-CH1","PHB-CH1-013",13,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.8,5.7,1.1 "PHB-CH1","PHB-CH1-013",13,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.6,5.7,0.9 "PHB-CH1","PHB-CH1-013",13,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,7.7,5.7,2 "PHB-CH1","PHB-CH1-013",13,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.7,5.7,2 "PHB-CH1","PHB-CH1-013",13,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.7,5.7,2 "PHB-CH1","PHB-CH1-013",13,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.4,5.7,1.7 "PHB-CH1","PHB-CH1-013",13,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.3,5.7,0.6 "PHB-CH1","PHB-CH1-013",13,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.8,5.7,0.0999999999999996 "PHB-CH1","PHB-CH1-013",13,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.1,5.7,0.399999999999999 "PHB-CH1","PHB-CH1-014",14,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,67,67,0 "PHB-CH1","PHB-CH1-014",14,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,64,67,-3 "PHB-CH1","PHB-CH1-014",14,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,55,67,-12 "PHB-CH1","PHB-CH1-014",14,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,64,, "PHB-CH1","PHB-CH1-014",14,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,64,, "PHB-CH1","PHB-CH1-014",14,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,58,, "PHB-CH1","PHB-CH1-014",14,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-014",14,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-014",14,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-014",14,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-014",14,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,11,, "PHB-CH1","PHB-CH1-014",14,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,364,, "PHB-CH1","PHB-CH1-014",14,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-014",14,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-014",14,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-014",14,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-014",14,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,67.8,67.8,0 "PHB-CH1","PHB-CH1-014",14,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,73,67.8,5.2 "PHB-CH1","PHB-CH1-014",14,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,69,67.8,1.2 "PHB-CH1","PHB-CH1-014",14,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,63.2,67.8,-4.59999999999999 "PHB-CH1","PHB-CH1-014",14,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,69.6,69.6,0 "PHB-CH1","PHB-CH1-014",14,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,60.3,69.6,-9.3 "PHB-CH1","PHB-CH1-014",14,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,58.4,69.6,-11.2 "PHB-CH1","PHB-CH1-014",14,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,60,69.6,-9.59999999999999 "PHB-CH1","PHB-CH1-014",14,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.5,6.5,0 "PHB-CH1","PHB-CH1-014",14,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,7.9,6.5,1.4 "PHB-CH1","PHB-CH1-014",14,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,8.3,6.5,1.8 "PHB-CH1","PHB-CH1-014",14,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,7.6,6.5,1.1 "PHB-CH1","PHB-CH1-014",14,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.7,6.5,0.2 "PHB-CH1","PHB-CH1-014",14,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.9,6.5,0.4 "PHB-CH1","PHB-CH1-014",14,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.9,6.5,0.4 "PHB-CH1","PHB-CH1-014",14,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7,6.5,0.5 "PHB-CH1","PHB-CH1-014",14,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.4,6.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-014",14,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.1,6.5,-0.4 "PHB-CH1","PHB-CH1-014",14,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6,6.5,-0.5 "PHB-CH1","PHB-CH1-014",14,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.5,6.5,-2 "PHB-CH1","PHB-CH1-014",14,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.9,6.5,-1.6 "PHB-CH1","PHB-CH1-014",14,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.3,6.5,-1.2 "PHB-CH1","PHB-CH1-014",14,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.8,3.8,0 "PHB-CH1","PHB-CH1-014",14,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.5,3.8,0.7 "PHB-CH1","PHB-CH1-014",14,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.7,3.8,0.9 "PHB-CH1","PHB-CH1-014",14,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.9,3.8,0.1 "PHB-CH1","PHB-CH1-014",14,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.2,3.8,0.4 "PHB-CH1","PHB-CH1-014",14,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5,3.8,1.2 "PHB-CH1","PHB-CH1-014",14,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.7,3.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-014",14,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.6,3.8,0.8 "PHB-CH1","PHB-CH1-014",14,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.4,3.8,0.6 "PHB-CH1","PHB-CH1-014",14,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.1,3.8,0.3 "PHB-CH1","PHB-CH1-014",14,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.3,3.8,0.5 "PHB-CH1","PHB-CH1-014",14,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.6,3.8,-0.2 "PHB-CH1","PHB-CH1-014",14,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.6,3.8,0.8 "PHB-CH1","PHB-CH1-014",14,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.7,3.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-015",15,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,36,36,0 "PHB-CH1","PHB-CH1-015",15,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,39,36,3 "PHB-CH1","PHB-CH1-015",15,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,33,36,-3 "PHB-CH1","PHB-CH1-015",15,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,52,, "PHB-CH1","PHB-CH1-015",15,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,39,, "PHB-CH1","PHB-CH1-015",15,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,42,, "PHB-CH1","PHB-CH1-015",15,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-015",15,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-015",15,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-015",15,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-015",15,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,28,, "PHB-CH1","PHB-CH1-015",15,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,259,, "PHB-CH1","PHB-CH1-015",15,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-015",15,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-015",15,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-015",15,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-015",15,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,44.9,44.9,0 "PHB-CH1","PHB-CH1-015",15,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,26.7,44.9,-18.2 "PHB-CH1","PHB-CH1-015",15,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,40.4,44.9,-4.5 "PHB-CH1","PHB-CH1-015",15,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,22.1,44.9,-22.8 "PHB-CH1","PHB-CH1-015",15,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,38.3,38.3,0 "PHB-CH1","PHB-CH1-015",15,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,53.2,38.3,14.9 "PHB-CH1","PHB-CH1-015",15,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,46.8,38.3,8.5 "PHB-CH1","PHB-CH1-015",15,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,43.4,38.3,5.1 "PHB-CH1","PHB-CH1-015",15,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.5,4.5,0 "PHB-CH1","PHB-CH1-015",15,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.6,4.5,1.1 "PHB-CH1","PHB-CH1-015",15,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.4,4.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-015",15,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.7,4.5,-1.8 "PHB-CH1","PHB-CH1-015",15,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,2.8,4.5,-1.7 "PHB-CH1","PHB-CH1-015",15,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.2,4.5,-1.3 "PHB-CH1","PHB-CH1-015",15,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.1,4.5,-0.4 "PHB-CH1","PHB-CH1-015",15,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.5,4.5,-1 "PHB-CH1","PHB-CH1-015",15,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.5,4.5,-1 "PHB-CH1","PHB-CH1-015",15,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,2.3,4.5,-2.2 "PHB-CH1","PHB-CH1-015",15,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3,4.5,-1.5 "PHB-CH1","PHB-CH1-015",15,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.2,4.5,-1.3 "PHB-CH1","PHB-CH1-015",15,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.3,4.5,-1.2 "PHB-CH1","PHB-CH1-015",15,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.2,4.5,0.7 "PHB-CH1","PHB-CH1-015",15,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7,7,0 "PHB-CH1","PHB-CH1-015",15,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.7,7,-0.3 "PHB-CH1","PHB-CH1-015",15,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.6,7,-1.4 "PHB-CH1","PHB-CH1-015",15,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5,7,-2 "PHB-CH1","PHB-CH1-015",15,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.4,7,-1.6 "PHB-CH1","PHB-CH1-015",15,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.9,7,-2.1 "PHB-CH1","PHB-CH1-015",15,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5,7,-2 "PHB-CH1","PHB-CH1-015",15,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.7,7,-2.3 "PHB-CH1","PHB-CH1-015",15,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.3,7,-2.7 "PHB-CH1","PHB-CH1-015",15,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.6,7,-2.4 "PHB-CH1","PHB-CH1-015",15,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.2,7,-2.8 "PHB-CH1","PHB-CH1-015",15,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.3,7,-2.7 "PHB-CH1","PHB-CH1-015",15,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.8,7,-2.2 "PHB-CH1","PHB-CH1-015",15,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.1,7,-0.9 "PHB-CH1","PHB-CH1-016",16,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,44,44,0 "PHB-CH1","PHB-CH1-016",16,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,38,44,-6 "PHB-CH1","PHB-CH1-016",16,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,49,44,5 "PHB-CH1","PHB-CH1-016",16,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,52,, "PHB-CH1","PHB-CH1-016",16,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,53,, "PHB-CH1","PHB-CH1-016",16,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,64,, "PHB-CH1","PHB-CH1-016",16,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-016",16,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-016",16,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-016",16,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-016",16,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,15,, "PHB-CH1","PHB-CH1-016",16,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,367,, "PHB-CH1","PHB-CH1-016",16,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-016",16,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-016",16,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-016",16,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-016",16,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,42.7,42.7,0 "PHB-CH1","PHB-CH1-016",16,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,46.3,42.7,3.59999999999999 "PHB-CH1","PHB-CH1-016",16,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,63.8,42.7,21.1 "PHB-CH1","PHB-CH1-016",16,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,47.3,42.7,4.59999999999999 "PHB-CH1","PHB-CH1-016",16,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,68,68,0 "PHB-CH1","PHB-CH1-016",16,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,63.6,68,-4.4 "PHB-CH1","PHB-CH1-016",16,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,74.5,68,6.5 "PHB-CH1","PHB-CH1-016",16,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,73.5,68,5.5 "PHB-CH1","PHB-CH1-016",16,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.7,6.7,0 "PHB-CH1","PHB-CH1-016",16,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.4,6.7,-1.3 "PHB-CH1","PHB-CH1-016",16,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.4,6.7,-1.3 "PHB-CH1","PHB-CH1-016",16,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.4,6.7,-1.3 "PHB-CH1","PHB-CH1-016",16,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.2,6.7,-1.5 "PHB-CH1","PHB-CH1-016",16,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.9,6.7,-2.8 "PHB-CH1","PHB-CH1-016",16,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.7,6.7,-2 "PHB-CH1","PHB-CH1-016",16,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.1,6.7,-2.6 "PHB-CH1","PHB-CH1-016",16,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.7,6.7,-2 "PHB-CH1","PHB-CH1-016",16,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.8,6.7,-1.9 "PHB-CH1","PHB-CH1-016",16,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.5,6.7,-1.2 "PHB-CH1","PHB-CH1-016",16,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.3,6.7,-0.4 "PHB-CH1","PHB-CH1-016",16,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.8,6.7,0.0999999999999996 "PHB-CH1","PHB-CH1-016",16,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.7,6.7,0 "PHB-CH1","PHB-CH1-016",16,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7.4,7.4,0 "PHB-CH1","PHB-CH1-016",16,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.1,7.4,-1.3 "PHB-CH1","PHB-CH1-016",16,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.2,7.4,-2.2 "PHB-CH1","PHB-CH1-016",16,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.7,7.4,-0.7 "PHB-CH1","PHB-CH1-016",16,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.8,7.4,-0.6 "PHB-CH1","PHB-CH1-016",16,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.3,7.4,-1.1 "PHB-CH1","PHB-CH1-016",16,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.1,7.4,-2.3 "PHB-CH1","PHB-CH1-016",16,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.8,7.4,-1.6 "PHB-CH1","PHB-CH1-016",16,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6,7.4,-1.4 "PHB-CH1","PHB-CH1-016",16,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.9,7.4,-0.5 "PHB-CH1","PHB-CH1-016",16,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.3,7.4,-0.100000000000001 "PHB-CH1","PHB-CH1-016",16,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.6,7.4,-0.800000000000001 "PHB-CH1","PHB-CH1-016",16,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.1,7.4,-0.300000000000001 "PHB-CH1","PHB-CH1-016",16,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.6,7.4,-0.800000000000001 "PHB-CH1","PHB-CH1-017",17,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,42,42,0 "PHB-CH1","PHB-CH1-017",17,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,36,42,-6 "PHB-CH1","PHB-CH1-017",17,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,39,42,-3 "PHB-CH1","PHB-CH1-017",17,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,46,, "PHB-CH1","PHB-CH1-017",17,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,51,, "PHB-CH1","PHB-CH1-017",17,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,63,, "PHB-CH1","PHB-CH1-017",17,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-017",17,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-017",17,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-017",17,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-017",17,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,19,, "PHB-CH1","PHB-CH1-017",17,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,295,, "PHB-CH1","PHB-CH1-017",17,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-017",17,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-017",17,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-017",17,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-017",17,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,46.7,46.7,0 "PHB-CH1","PHB-CH1-017",17,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,39.1,46.7,-7.6 "PHB-CH1","PHB-CH1-017",17,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,29.1,46.7,-17.6 "PHB-CH1","PHB-CH1-017",17,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,31.7,46.7,-15 "PHB-CH1","PHB-CH1-017",17,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,40.8,40.8,0 "PHB-CH1","PHB-CH1-017",17,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,38.1,40.8,-2.7 "PHB-CH1","PHB-CH1-017",17,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,40.2,40.8,-0.599999999999994 "PHB-CH1","PHB-CH1-017",17,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,47.8,40.8,7 "PHB-CH1","PHB-CH1-017",17,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,1.3,1.3,0 "PHB-CH1","PHB-CH1-017",17,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,0.3,1.3,-1 "PHB-CH1","PHB-CH1-017",17,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,0.1,1.3,-1.2 "PHB-CH1","PHB-CH1-017",17,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,0.6,1.3,-0.7 "PHB-CH1","PHB-CH1-017",17,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,0.4,1.3,-0.9 "PHB-CH1","PHB-CH1-017",17,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,0.9,1.3,-0.4 "PHB-CH1","PHB-CH1-017",17,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2.9,1.3,1.6 "PHB-CH1","PHB-CH1-017",17,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,2.4,1.3,1.1 "PHB-CH1","PHB-CH1-017",17,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,0.7,1.3,-0.6 "PHB-CH1","PHB-CH1-017",17,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.2,1.3,1.9 "PHB-CH1","PHB-CH1-017",17,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,0.9,1.3,-0.4 "PHB-CH1","PHB-CH1-017",17,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,0.3,1.3,-1 "PHB-CH1","PHB-CH1-017",17,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,1.9,1.3,0.6 "PHB-CH1","PHB-CH1-017",17,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2.4,1.3,1.1 "PHB-CH1","PHB-CH1-017",17,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7.5,7.5,0 "PHB-CH1","PHB-CH1-017",17,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.6,7.5,-0.9 "PHB-CH1","PHB-CH1-017",17,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7,7.5,-0.5 "PHB-CH1","PHB-CH1-017",17,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,7.4,7.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-017",17,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,7.2,7.5,-0.3 "PHB-CH1","PHB-CH1-017",17,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,8.2,7.5,0.699999999999999 "PHB-CH1","PHB-CH1-017",17,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,9.7,7.5,2.2 "PHB-CH1","PHB-CH1-017",17,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,9.4,7.5,1.9 "PHB-CH1","PHB-CH1-017",17,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.5,7.5,0 "PHB-CH1","PHB-CH1-017",17,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,8.2,7.5,0.699999999999999 "PHB-CH1","PHB-CH1-017",17,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.1,7.5,-0.4 "PHB-CH1","PHB-CH1-017",17,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.6,7.5,-0.9 "PHB-CH1","PHB-CH1-017",17,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.5,7.5,0 "PHB-CH1","PHB-CH1-017",17,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,8.6,7.5,1.1 "PHB-CH1","PHB-CH1-018",18,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,62,62,0 "PHB-CH1","PHB-CH1-018",18,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,48,62,-14 "PHB-CH1","PHB-CH1-018",18,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,67,62,5 "PHB-CH1","PHB-CH1-018",18,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,51,, "PHB-CH1","PHB-CH1-018",18,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,71,, "PHB-CH1","PHB-CH1-018",18,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,44,, "PHB-CH1","PHB-CH1-018",18,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-018",18,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-018",18,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-018",18,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-018",18,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,22,, "PHB-CH1","PHB-CH1-018",18,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,250,, "PHB-CH1","PHB-CH1-018",18,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-018",18,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-018",18,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-018",18,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-018",18,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,42.3,42.3,0 "PHB-CH1","PHB-CH1-018",18,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,37,42.3,-5.3 "PHB-CH1","PHB-CH1-018",18,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,45.6,42.3,3.3 "PHB-CH1","PHB-CH1-018",18,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,47.6,42.3,5.3 "PHB-CH1","PHB-CH1-018",18,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,39.2,39.2,0 "PHB-CH1","PHB-CH1-018",18,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,44.4,39.2,5.2 "PHB-CH1","PHB-CH1-018",18,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,29.1,39.2,-10.1 "PHB-CH1","PHB-CH1-018",18,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,35.7,39.2,-3.5 "PHB-CH1","PHB-CH1-018",18,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.6,5.6,0 "PHB-CH1","PHB-CH1-018",18,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.5,5.6,0.9 "PHB-CH1","PHB-CH1-018",18,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7.5,5.6,1.9 "PHB-CH1","PHB-CH1-018",18,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.7,5.6,1.1 "PHB-CH1","PHB-CH1-018",18,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.4,5.6,-0.199999999999999 "PHB-CH1","PHB-CH1-018",18,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.7,5.6,1.1 "PHB-CH1","PHB-CH1-018",18,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,7.5,5.6,1.9 "PHB-CH1","PHB-CH1-018",18,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.6,5.6,2 "PHB-CH1","PHB-CH1-018",18,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,7.3,5.6,1.7 "PHB-CH1","PHB-CH1-018",18,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,7.2,5.6,1.6 "PHB-CH1","PHB-CH1-018",18,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.5,5.6,0.9 "PHB-CH1","PHB-CH1-018",18,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.3,5.6,-0.3 "PHB-CH1","PHB-CH1-018",18,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.2,5.6,0.6 "PHB-CH1","PHB-CH1-018",18,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.6,5.6,-1 "PHB-CH1","PHB-CH1-018",18,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.6,6.6,0 "PHB-CH1","PHB-CH1-018",18,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.8,6.6,-0.8 "PHB-CH1","PHB-CH1-018",18,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.2,6.6,-1.4 "PHB-CH1","PHB-CH1-018",18,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.6,6.6,0 "PHB-CH1","PHB-CH1-018",18,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.9,6.6,-1.7 "PHB-CH1","PHB-CH1-018",18,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,7.1,6.6,0.5 "PHB-CH1","PHB-CH1-018",18,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.9,6.6,0.300000000000001 "PHB-CH1","PHB-CH1-018",18,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.8,6.6,0.2 "PHB-CH1","PHB-CH1-018",18,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.4,6.6,-0.199999999999999 "PHB-CH1","PHB-CH1-018",18,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7,6.6,0.4 "PHB-CH1","PHB-CH1-018",18,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.9,6.6,0.300000000000001 "PHB-CH1","PHB-CH1-018",18,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,8.1,6.6,1.5 "PHB-CH1","PHB-CH1-018",18,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.7,6.6,1.1 "PHB-CH1","PHB-CH1-018",18,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.3,6.6,-0.3 "PHB-CH1","PHB-CH1-019",19,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,78,78,0 "PHB-CH1","PHB-CH1-019",19,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,66,78,-12 "PHB-CH1","PHB-CH1-019",19,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,77,78,-1 "PHB-CH1","PHB-CH1-019",19,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,52,, "PHB-CH1","PHB-CH1-019",19,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,60,, "PHB-CH1","PHB-CH1-019",19,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,54,, "PHB-CH1","PHB-CH1-019",19,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-019",19,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-019",19,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-019",19,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-019",19,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,1,, "PHB-CH1","PHB-CH1-019",19,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,556,, "PHB-CH1","PHB-CH1-019",19,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-019",19,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-019",19,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-019",19,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-019",19,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,42.1,42.1,0 "PHB-CH1","PHB-CH1-019",19,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,52.7,42.1,10.6 "PHB-CH1","PHB-CH1-019",19,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,48.6,42.1,6.5 "PHB-CH1","PHB-CH1-019",19,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,54,42.1,11.9 "PHB-CH1","PHB-CH1-019",19,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,50.5,50.5,0 "PHB-CH1","PHB-CH1-019",19,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,45.8,50.5,-4.7 "PHB-CH1","PHB-CH1-019",19,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,65.5,50.5,15 "PHB-CH1","PHB-CH1-019",19,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,69.6,50.5,19.1 "PHB-CH1","PHB-CH1-019",19,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.8,5.8,0 "PHB-CH1","PHB-CH1-019",19,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.8,5.8,0 "PHB-CH1","PHB-CH1-019",19,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5,5.8,-0.8 "PHB-CH1","PHB-CH1-019",19,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.9,5.8,0.100000000000001 "PHB-CH1","PHB-CH1-019",19,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.9,5.8,-0.9 "PHB-CH1","PHB-CH1-019",19,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.8,5.8,0 "PHB-CH1","PHB-CH1-019",19,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.8,5.8,0 "PHB-CH1","PHB-CH1-019",19,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.7,5.8,-2.1 "PHB-CH1","PHB-CH1-019",19,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.4,5.8,-2.4 "PHB-CH1","PHB-CH1-019",19,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.3,5.8,-1.5 "PHB-CH1","PHB-CH1-019",19,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.8,5.8,-3 "PHB-CH1","PHB-CH1-019",19,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.8,5.8,-2 "PHB-CH1","PHB-CH1-019",19,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.3,5.8,-1.5 "PHB-CH1","PHB-CH1-019",19,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.4,5.8,-1.4 "PHB-CH1","PHB-CH1-019",19,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7.9,7.9,0 "PHB-CH1","PHB-CH1-019",19,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,7.2,7.9,-0.7 "PHB-CH1","PHB-CH1-019",19,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.9,7.9,-1 "PHB-CH1","PHB-CH1-019",19,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.5,7.9,-2.4 "PHB-CH1","PHB-CH1-019",19,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.3,7.9,-2.6 "PHB-CH1","PHB-CH1-019",19,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.6,7.9,-1.3 "PHB-CH1","PHB-CH1-019",19,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7,7.9,-0.9 "PHB-CH1","PHB-CH1-019",19,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.6,7.9,-3.3 "PHB-CH1","PHB-CH1-019",19,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.6,7.9,-3.3 "PHB-CH1","PHB-CH1-019",19,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.7,7.9,-3.2 "PHB-CH1","PHB-CH1-019",19,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.1,7.9,-3.8 "PHB-CH1","PHB-CH1-019",19,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.3,7.9,-3.6 "PHB-CH1","PHB-CH1-019",19,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.3,7.9,-1.6 "PHB-CH1","PHB-CH1-019",19,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.7,7.9,-2.2 "PHB-CH1","PHB-CH1-020",20,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,32,32,0 "PHB-CH1","PHB-CH1-020",20,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,39,32,7 "PHB-CH1","PHB-CH1-020",20,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,6,32,-26 "PHB-CH1","PHB-CH1-020",20,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,34,, "PHB-CH1","PHB-CH1-020",20,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,30,, "PHB-CH1","PHB-CH1-020",20,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,37,, "PHB-CH1","PHB-CH1-020",20,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-020",20,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-020",20,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,5,, "PHB-CH1","PHB-CH1-020",20,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-020",20,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,9,, "PHB-CH1","PHB-CH1-020",20,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,347,, "PHB-CH1","PHB-CH1-020",20,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-020",20,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-020",20,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-020",20,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-020",20,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,42.3,42.3,0 "PHB-CH1","PHB-CH1-020",20,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,46.3,42.3,4 "PHB-CH1","PHB-CH1-020",20,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,60.5,42.3,18.2 "PHB-CH1","PHB-CH1-020",20,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,58.8,42.3,16.5 "PHB-CH1","PHB-CH1-020",20,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,41.8,41.8,0 "PHB-CH1","PHB-CH1-020",20,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,32.9,41.8,-8.9 "PHB-CH1","PHB-CH1-020",20,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,55.6,41.8,13.8 "PHB-CH1","PHB-CH1-020",20,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,43,41.8,1.2 "PHB-CH1","PHB-CH1-020",20,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.6,3.6,0 "PHB-CH1","PHB-CH1-020",20,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.8,3.6,0.2 "PHB-CH1","PHB-CH1-020",20,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.8,3.6,0.2 "PHB-CH1","PHB-CH1-020",20,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.8,3.6,-0.8 "PHB-CH1","PHB-CH1-020",20,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.1,3.6,0.5 "PHB-CH1","PHB-CH1-020",20,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.5,3.6,2.9 "PHB-CH1","PHB-CH1-020",20,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.8,3.6,1.2 "PHB-CH1","PHB-CH1-020",20,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.2,3.6,0.6 "PHB-CH1","PHB-CH1-020",20,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4,3.6,0.4 "PHB-CH1","PHB-CH1-020",20,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.5,3.6,-0.1 "PHB-CH1","PHB-CH1-020",20,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.1,3.6,-0.5 "PHB-CH1","PHB-CH1-020",20,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.1,3.6,0.5 "PHB-CH1","PHB-CH1-020",20,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.2,3.6,0.6 "PHB-CH1","PHB-CH1-020",20,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5,3.6,1.4 "PHB-CH1","PHB-CH1-020",20,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.7,5.7,0 "PHB-CH1","PHB-CH1-020",20,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.9,5.7,0.2 "PHB-CH1","PHB-CH1-020",20,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.3,5.7,0.6 "PHB-CH1","PHB-CH1-020",20,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5,5.7,-0.7 "PHB-CH1","PHB-CH1-020",20,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.6,5.7,-0.100000000000001 "PHB-CH1","PHB-CH1-020",20,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.7,5.7,1 "PHB-CH1","PHB-CH1-020",20,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.5,5.7,-0.2 "PHB-CH1","PHB-CH1-020",20,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.8,5.7,1.1 "PHB-CH1","PHB-CH1-020",20,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7,5.7,1.3 "PHB-CH1","PHB-CH1-020",20,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.6,5.7,-1.1 "PHB-CH1","PHB-CH1-020",20,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.2,5.7,-0.5 "PHB-CH1","PHB-CH1-020",20,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.6,5.7,-0.100000000000001 "PHB-CH1","PHB-CH1-020",20,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6,5.7,0.3 "PHB-CH1","PHB-CH1-020",20,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.3,5.7,0.6 "PHB-CH1","PHB-CH1-021",21,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,72,72,0 "PHB-CH1","PHB-CH1-021",21,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,73,72,1 "PHB-CH1","PHB-CH1-021",21,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,69,72,-3 "PHB-CH1","PHB-CH1-021",21,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,72,, "PHB-CH1","PHB-CH1-021",21,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,45,, "PHB-CH1","PHB-CH1-021",21,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,29,, "PHB-CH1","PHB-CH1-021",21,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-021",21,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-021",21,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-021",21,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-021",21,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,17,, "PHB-CH1","PHB-CH1-021",21,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,379,, "PHB-CH1","PHB-CH1-021",21,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-021",21,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-021",21,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-021",21,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-021",21,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,59.4,59.4,0 "PHB-CH1","PHB-CH1-021",21,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,48.2,59.4,-11.2 "PHB-CH1","PHB-CH1-021",21,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,66.2,59.4,6.8 "PHB-CH1","PHB-CH1-021",21,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,65.6,59.4,6.2 "PHB-CH1","PHB-CH1-021",21,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,58.9,58.9,0 "PHB-CH1","PHB-CH1-021",21,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,53.2,58.9,-5.7 "PHB-CH1","PHB-CH1-021",21,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,62,58.9,3.1 "PHB-CH1","PHB-CH1-021",21,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,51.2,58.9,-7.7 "PHB-CH1","PHB-CH1-021",21,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,2.7,2.7,0 "PHB-CH1","PHB-CH1-021",21,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4,2.7,1.3 "PHB-CH1","PHB-CH1-021",21,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.9,2.7,1.2 "PHB-CH1","PHB-CH1-021",21,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.1,2.7,1.4 "PHB-CH1","PHB-CH1-021",21,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.1,2.7,1.4 "PHB-CH1","PHB-CH1-021",21,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.8,2.7,1.1 "PHB-CH1","PHB-CH1-021",21,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.2,2.7,0.5 "PHB-CH1","PHB-CH1-021",21,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.3,2.7,2.6 "PHB-CH1","PHB-CH1-021",21,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.6,2.7,1.9 "PHB-CH1","PHB-CH1-021",21,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.2,2.7,0.5 "PHB-CH1","PHB-CH1-021",21,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.3,2.7,0.6 "PHB-CH1","PHB-CH1-021",21,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.5,2.7,0.8 "PHB-CH1","PHB-CH1-021",21,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.2,2.7,1.5 "PHB-CH1","PHB-CH1-021",21,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2.9,2.7,0.2 "PHB-CH1","PHB-CH1-021",21,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.1,3.1,0 "PHB-CH1","PHB-CH1-021",21,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.9,3.1,0.8 "PHB-CH1","PHB-CH1-021",21,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.3,3.1,0.2 "PHB-CH1","PHB-CH1-021",21,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.4,3.1,1.3 "PHB-CH1","PHB-CH1-021",21,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.2,3.1,1.1 "PHB-CH1","PHB-CH1-021",21,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.7,3.1,2.6 "PHB-CH1","PHB-CH1-021",21,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.3,3.1,0.2 "PHB-CH1","PHB-CH1-021",21,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.1,3.1,2 "PHB-CH1","PHB-CH1-021",21,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.4,3.1,1.3 "PHB-CH1","PHB-CH1-021",21,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,2.9,3.1,-0.2 "PHB-CH1","PHB-CH1-021",21,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.6,3.1,0.5 "PHB-CH1","PHB-CH1-021",21,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.2,3.1,1.1 "PHB-CH1","PHB-CH1-021",21,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.9,3.1,0.8 "PHB-CH1","PHB-CH1-021",21,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.1,3.1,0 "PHB-CH1","PHB-CH1-022",22,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,76,76,0 "PHB-CH1","PHB-CH1-022",22,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,73,76,-3 "PHB-CH1","PHB-CH1-022",22,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,65,76,-11 "PHB-CH1","PHB-CH1-022",22,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,54,, "PHB-CH1","PHB-CH1-022",22,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,70,, "PHB-CH1","PHB-CH1-022",22,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,63,, "PHB-CH1","PHB-CH1-022",22,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-022",22,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-022",22,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-022",22,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-022",22,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,34,, "PHB-CH1","PHB-CH1-022",22,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,259,, "PHB-CH1","PHB-CH1-022",22,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-022",22,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-022",22,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-022",22,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-022",22,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,28.5,28.5,0 "PHB-CH1","PHB-CH1-022",22,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,31.8,28.5,3.3 "PHB-CH1","PHB-CH1-022",22,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,30.8,28.5,2.3 "PHB-CH1","PHB-CH1-022",22,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,39.7,28.5,11.2 "PHB-CH1","PHB-CH1-022",22,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,50.8,50.8,0 "PHB-CH1","PHB-CH1-022",22,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,64.5,50.8,13.7 "PHB-CH1","PHB-CH1-022",22,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,60.2,50.8,9.40000000000001 "PHB-CH1","PHB-CH1-022",22,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,45.8,50.8,-5 "PHB-CH1","PHB-CH1-022",22,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-022",22,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.3,5.1,-0.8 "PHB-CH1","PHB-CH1-022",22,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.7,5.1,-0.399999999999999 "PHB-CH1","PHB-CH1-022",22,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.6,5.1,0.5 "PHB-CH1","PHB-CH1-022",22,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5,5.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-022",22,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.4,5.1,0.300000000000001 "PHB-CH1","PHB-CH1-022",22,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.7,5.1,-1.4 "PHB-CH1","PHB-CH1-022",22,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.4,5.1,-1.7 "PHB-CH1","PHB-CH1-022",22,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.1,5.1,-1 "PHB-CH1","PHB-CH1-022",22,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.1,5.1,0 "PHB-CH1","PHB-CH1-022",22,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.6,5.1,0.5 "PHB-CH1","PHB-CH1-022",22,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6,5.1,0.9 "PHB-CH1","PHB-CH1-022",22,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.8,5.1,0.7 "PHB-CH1","PHB-CH1-022",22,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.9,5.1,-0.199999999999999 "PHB-CH1","PHB-CH1-022",22,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.7,2.7,0 "PHB-CH1","PHB-CH1-022",22,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.4,2.7,0.7 "PHB-CH1","PHB-CH1-022",22,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,1.6,2.7,-1.1 "PHB-CH1","PHB-CH1-022",22,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,2.7,2.7,0 "PHB-CH1","PHB-CH1-022",22,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,1.8,2.7,-0.9 "PHB-CH1","PHB-CH1-022",22,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.3,2.7,0.6 "PHB-CH1","PHB-CH1-022",22,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,1.7,2.7,-1 "PHB-CH1","PHB-CH1-022",22,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,1.4,2.7,-1.3 "PHB-CH1","PHB-CH1-022",22,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.7,2.7,0 "PHB-CH1","PHB-CH1-022",22,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.1,2.7,0.4 "PHB-CH1","PHB-CH1-022",22,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3,2.7,0.3 "PHB-CH1","PHB-CH1-022",22,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.1,2.7,0.4 "PHB-CH1","PHB-CH1-022",22,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3,2.7,0.3 "PHB-CH1","PHB-CH1-022",22,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,2,2.7,-0.7 "PHB-CH1","PHB-CH1-023",23,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,49,49,0 "PHB-CH1","PHB-CH1-023",23,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,51,49,2 "PHB-CH1","PHB-CH1-023",23,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,53,49,4 "PHB-CH1","PHB-CH1-023",23,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,43,, "PHB-CH1","PHB-CH1-023",23,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,48,, "PHB-CH1","PHB-CH1-023",23,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,56,, "PHB-CH1","PHB-CH1-023",23,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-023",23,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-023",23,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-023",23,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-023",23,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,0,, "PHB-CH1","PHB-CH1-023",23,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,569,, "PHB-CH1","PHB-CH1-023",23,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-023",23,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-023",23,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-023",23,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-023",23,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,41.5,41.5,0 "PHB-CH1","PHB-CH1-023",23,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,53.1,41.5,11.6 "PHB-CH1","PHB-CH1-023",23,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,55.1,41.5,13.6 "PHB-CH1","PHB-CH1-023",23,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,30.2,41.5,-11.3 "PHB-CH1","PHB-CH1-023",23,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,58.6,58.6,0 "PHB-CH1","PHB-CH1-023",23,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,59.6,58.6,1 "PHB-CH1","PHB-CH1-023",23,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,57.3,58.6,-1.3 "PHB-CH1","PHB-CH1-023",23,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,55.1,58.6,-3.5 "PHB-CH1","PHB-CH1-023",23,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3,3,0 "PHB-CH1","PHB-CH1-023",23,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.8,3,0.8 "PHB-CH1","PHB-CH1-023",23,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.8,3,-0.2 "PHB-CH1","PHB-CH1-023",23,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.8,3,-0.2 "PHB-CH1","PHB-CH1-023",23,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4,3,1 "PHB-CH1","PHB-CH1-023",23,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.9,3,0.9 "PHB-CH1","PHB-CH1-023",23,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2.4,3,-0.6 "PHB-CH1","PHB-CH1-023",23,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.1,3,1.1 "PHB-CH1","PHB-CH1-023",23,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.1,3,0.1 "PHB-CH1","PHB-CH1-023",23,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,2.9,3,-0.1 "PHB-CH1","PHB-CH1-023",23,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.7,3,1.7 "PHB-CH1","PHB-CH1-023",23,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.1,3,0.1 "PHB-CH1","PHB-CH1-023",23,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.3,3,0.3 "PHB-CH1","PHB-CH1-023",23,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.6,3,0.6 "PHB-CH1","PHB-CH1-023",23,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.2,4.2,0 "PHB-CH1","PHB-CH1-023",23,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-023",23,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4,4.2,-0.2 "PHB-CH1","PHB-CH1-023",23,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.1,4.2,-1.1 "PHB-CH1","PHB-CH1-023",23,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.9,4.2,-0.3 "PHB-CH1","PHB-CH1-023",23,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4,4.2,-0.2 "PHB-CH1","PHB-CH1-023",23,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,2.5,4.2,-1.7 "PHB-CH1","PHB-CH1-023",23,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.4,4.2,1.2 "PHB-CH1","PHB-CH1-023",23,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.8,4.2,-0.4 "PHB-CH1","PHB-CH1-023",23,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.8,4.2,-0.4 "PHB-CH1","PHB-CH1-023",23,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.8,4.2,0.6 "PHB-CH1","PHB-CH1-023",23,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.3,4.2,-0.9 "PHB-CH1","PHB-CH1-023",23,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.5,4.2,0.3 "PHB-CH1","PHB-CH1-023",23,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.6,4.2,-0.6 "PHB-CH1","PHB-CH1-024",24,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,59,59,0 "PHB-CH1","PHB-CH1-024",24,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,58,59,-1 "PHB-CH1","PHB-CH1-024",24,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,43,59,-16 "PHB-CH1","PHB-CH1-024",24,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,59,, "PHB-CH1","PHB-CH1-024",24,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,60,, "PHB-CH1","PHB-CH1-024",24,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,55,, "PHB-CH1","PHB-CH1-024",24,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-024",24,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-024",24,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,5,, "PHB-CH1","PHB-CH1-024",24,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-024",24,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,2,, "PHB-CH1","PHB-CH1-024",24,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,523,, "PHB-CH1","PHB-CH1-024",24,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-024",24,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-024",24,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-024",24,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-024",24,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,34.6,34.6,0 "PHB-CH1","PHB-CH1-024",24,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,25.4,34.6,-9.2 "PHB-CH1","PHB-CH1-024",24,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,18.5,34.6,-16.1 "PHB-CH1","PHB-CH1-024",24,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,29.4,34.6,-5.2 "PHB-CH1","PHB-CH1-024",24,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,26.1,26.1,0 "PHB-CH1","PHB-CH1-024",24,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,12.7,26.1,-13.4 "PHB-CH1","PHB-CH1-024",24,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,21.3,26.1,-4.8 "PHB-CH1","PHB-CH1-024",24,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,5.4,26.1,-20.7 "PHB-CH1","PHB-CH1-024",24,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.3,3.3,0 "PHB-CH1","PHB-CH1-024",24,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.9,3.3,1.6 "PHB-CH1","PHB-CH1-024",24,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.7,3.3,0.4 "PHB-CH1","PHB-CH1-024",24,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.5,3.3,0.2 "PHB-CH1","PHB-CH1-024",24,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.5,3.3,1.2 "PHB-CH1","PHB-CH1-024",24,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.9,3.3,0.6 "PHB-CH1","PHB-CH1-024",24,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2.2,3.3,-1.1 "PHB-CH1","PHB-CH1-024",24,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.4,3.3,0.1 "PHB-CH1","PHB-CH1-024",24,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.1,3.3,-0.2 "PHB-CH1","PHB-CH1-024",24,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.6,3.3,1.3 "PHB-CH1","PHB-CH1-024",24,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.2,3.3,0.9 "PHB-CH1","PHB-CH1-024",24,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.5,3.3,1.2 "PHB-CH1","PHB-CH1-024",24,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.3,3.3,0 "PHB-CH1","PHB-CH1-024",24,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.6,3.3,1.3 "PHB-CH1","PHB-CH1-024",24,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.3,4.3,0 "PHB-CH1","PHB-CH1-024",24,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.8,4.3,0.5 "PHB-CH1","PHB-CH1-024",24,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.4,4.3,-0.9 "PHB-CH1","PHB-CH1-024",24,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.1,4.3,-0.2 "PHB-CH1","PHB-CH1-024",24,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.6,4.3,0.3 "PHB-CH1","PHB-CH1-024",24,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.9,4.3,-0.4 "PHB-CH1","PHB-CH1-024",24,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.5,4.3,-0.8 "PHB-CH1","PHB-CH1-024",24,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.3,4.3,-1 "PHB-CH1","PHB-CH1-024",24,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.3,4.3,0 "PHB-CH1","PHB-CH1-024",24,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.8,4.3,0.5 "PHB-CH1","PHB-CH1-024",24,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.2,4.3,0.9 "PHB-CH1","PHB-CH1-024",24,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.1,4.3,0.8 "PHB-CH1","PHB-CH1-024",24,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.1,4.3,-0.2 "PHB-CH1","PHB-CH1-024",24,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.9,4.3,0.6 "PHB-CH1","PHB-CH1-025",25,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,22,22,0 "PHB-CH1","PHB-CH1-025",25,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,20,22,-2 "PHB-CH1","PHB-CH1-025",25,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,11,22,-11 "PHB-CH1","PHB-CH1-025",25,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,37,, "PHB-CH1","PHB-CH1-025",25,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,23,, "PHB-CH1","PHB-CH1-025",25,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,70,, "PHB-CH1","PHB-CH1-025",25,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-025",25,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-025",25,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-025",25,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-025",25,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,23,, "PHB-CH1","PHB-CH1-025",25,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,258,, "PHB-CH1","PHB-CH1-025",25,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-025",25,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-025",25,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-025",25,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-025",25,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,38,38,0 "PHB-CH1","PHB-CH1-025",25,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,42.7,38,4.7 "PHB-CH1","PHB-CH1-025",25,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,59.5,38,21.5 "PHB-CH1","PHB-CH1-025",25,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,46.1,38,8.1 "PHB-CH1","PHB-CH1-025",25,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,57.9,57.9,0 "PHB-CH1","PHB-CH1-025",25,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,47.9,57.9,-10 "PHB-CH1","PHB-CH1-025",25,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,62.8,57.9,4.9 "PHB-CH1","PHB-CH1-025",25,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,46.5,57.9,-11.4 "PHB-CH1","PHB-CH1-025",25,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-025",25,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.7,5.1,0.6 "PHB-CH1","PHB-CH1-025",25,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5,5.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-025",25,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.1,5.1,0 "PHB-CH1","PHB-CH1-025",25,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.3,5.1,0.2 "PHB-CH1","PHB-CH1-025",25,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.8,5.1,0.7 "PHB-CH1","PHB-CH1-025",25,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.6,5.1,-0.5 "PHB-CH1","PHB-CH1-025",25,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.2,5.1,1.1 "PHB-CH1","PHB-CH1-025",25,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6,5.1,0.9 "PHB-CH1","PHB-CH1-025",25,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.7,5.1,1.6 "PHB-CH1","PHB-CH1-025",25,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,8.2,5.1,3.1 "PHB-CH1","PHB-CH1-025",25,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.8,5.1,1.7 "PHB-CH1","PHB-CH1-025",25,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.7,5.1,1.6 "PHB-CH1","PHB-CH1-025",25,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6,5.1,0.9 "PHB-CH1","PHB-CH1-025",25,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5,5,0 "PHB-CH1","PHB-CH1-025",25,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.8,5,0.8 "PHB-CH1","PHB-CH1-025",25,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.3,5,0.3 "PHB-CH1","PHB-CH1-025",25,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.6,5,-0.4 "PHB-CH1","PHB-CH1-025",25,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.3,5,-0.7 "PHB-CH1","PHB-CH1-025",25,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.1,5,0.0999999999999996 "PHB-CH1","PHB-CH1-025",25,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.3,5,-1.7 "PHB-CH1","PHB-CH1-025",25,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.8,5,-0.2 "PHB-CH1","PHB-CH1-025",25,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.6,5,-1.4 "PHB-CH1","PHB-CH1-025",25,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4,5,-1 "PHB-CH1","PHB-CH1-025",25,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.2,5,1.2 "PHB-CH1","PHB-CH1-025",25,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.2,5,0.2 "PHB-CH1","PHB-CH1-025",25,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.8,5,-0.2 "PHB-CH1","PHB-CH1-025",25,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.1,5,-0.9 "PHB-CH1","PHB-CH1-026",26,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,53,53,0 "PHB-CH1","PHB-CH1-026",26,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,47,53,-6 "PHB-CH1","PHB-CH1-026",26,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,46,53,-7 "PHB-CH1","PHB-CH1-026",26,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,50,, "PHB-CH1","PHB-CH1-026",26,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,55,, "PHB-CH1","PHB-CH1-026",26,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,35,, "PHB-CH1","PHB-CH1-026",26,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-026",26,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-026",26,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-026",26,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-026",26,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,23,, "PHB-CH1","PHB-CH1-026",26,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,318,, "PHB-CH1","PHB-CH1-026",26,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-026",26,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-026",26,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-026",26,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-026",26,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,61.5,61.5,0 "PHB-CH1","PHB-CH1-026",26,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,55.4,61.5,-6.1 "PHB-CH1","PHB-CH1-026",26,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,52.1,61.5,-9.4 "PHB-CH1","PHB-CH1-026",26,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,52.3,61.5,-9.2 "PHB-CH1","PHB-CH1-026",26,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,44,44,0 "PHB-CH1","PHB-CH1-026",26,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,60.9,44,16.9 "PHB-CH1","PHB-CH1-026",26,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,38.5,44,-5.5 "PHB-CH1","PHB-CH1-026",26,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,43.3,44,-0.700000000000003 "PHB-CH1","PHB-CH1-026",26,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-026",26,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.9,4.7,-0.8 "PHB-CH1","PHB-CH1-026",26,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.3,4.7,0.6 "PHB-CH1","PHB-CH1-026",26,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5,4.7,0.3 "PHB-CH1","PHB-CH1-026",26,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.5,4.7,-1.2 "PHB-CH1","PHB-CH1-026",26,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.4,4.7,-1.3 "PHB-CH1","PHB-CH1-026",26,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.2,4.7,-1.5 "PHB-CH1","PHB-CH1-026",26,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.3,4.7,-0.4 "PHB-CH1","PHB-CH1-026",26,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.1,4.7,-0.6 "PHB-CH1","PHB-CH1-026",26,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,2.1,4.7,-2.6 "PHB-CH1","PHB-CH1-026",26,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.6,4.7,-2.1 "PHB-CH1","PHB-CH1-026",26,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.3,4.7,-0.4 "PHB-CH1","PHB-CH1-026",26,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3,4.7,-1.7 "PHB-CH1","PHB-CH1-026",26,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.7,4.7,-1 "PHB-CH1","PHB-CH1-026",26,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.9,3.9,0 "PHB-CH1","PHB-CH1-026",26,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.6,3.9,0.7 "PHB-CH1","PHB-CH1-026",26,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.2,3.9,2.3 "PHB-CH1","PHB-CH1-026",26,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.1,3.9,1.2 "PHB-CH1","PHB-CH1-026",26,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.4,3.9,1.5 "PHB-CH1","PHB-CH1-026",26,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.4,3.9,1.5 "PHB-CH1","PHB-CH1-026",26,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.3,3.9,0.4 "PHB-CH1","PHB-CH1-026",26,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.8,3.9,0.9 "PHB-CH1","PHB-CH1-026",26,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.1,3.9,-0.8 "PHB-CH1","PHB-CH1-026",26,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,2.2,3.9,-1.7 "PHB-CH1","PHB-CH1-026",26,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.4,3.9,-0.5 "PHB-CH1","PHB-CH1-026",26,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.6,3.9,0.7 "PHB-CH1","PHB-CH1-026",26,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.7,3.9,-0.2 "PHB-CH1","PHB-CH1-026",26,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.8,3.9,0.9 "PHB-CH1","PHB-CH1-027",27,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,39,39,0 "PHB-CH1","PHB-CH1-027",27,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,45,39,6 "PHB-CH1","PHB-CH1-027",27,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,42,39,3 "PHB-CH1","PHB-CH1-027",27,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,40,, "PHB-CH1","PHB-CH1-027",27,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,50,, "PHB-CH1","PHB-CH1-027",27,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,50,, "PHB-CH1","PHB-CH1-027",27,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-027",27,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-027",27,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-027",27,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-027",27,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,5,, "PHB-CH1","PHB-CH1-027",27,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,415,, "PHB-CH1","PHB-CH1-027",27,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-027",27,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-027",27,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-027",27,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-027",27,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,65.1,65.1,0 "PHB-CH1","PHB-CH1-027",27,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,66.4,65.1,1.30000000000001 "PHB-CH1","PHB-CH1-027",27,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,58.1,65.1,-6.99999999999999 "PHB-CH1","PHB-CH1-027",27,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,65,65.1,-0.0999999999999943 "PHB-CH1","PHB-CH1-027",27,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,74.7,74.7,0 "PHB-CH1","PHB-CH1-027",27,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,66.1,74.7,-8.60000000000001 "PHB-CH1","PHB-CH1-027",27,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,68.5,74.7,-6.2 "PHB-CH1","PHB-CH1-027",27,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,63.3,74.7,-11.4 "PHB-CH1","PHB-CH1-027",27,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.2,5.2,0 "PHB-CH1","PHB-CH1-027",27,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.5,5.2,1.3 "PHB-CH1","PHB-CH1-027",27,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.3,5.2,0.0999999999999996 "PHB-CH1","PHB-CH1-027",27,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.3,5.2,-1.9 "PHB-CH1","PHB-CH1-027",27,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.4,5.2,0.2 "PHB-CH1","PHB-CH1-027",27,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.4,5.2,-0.8 "PHB-CH1","PHB-CH1-027",27,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.8,5.2,-1.4 "PHB-CH1","PHB-CH1-027",27,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.3,5.2,-0.9 "PHB-CH1","PHB-CH1-027",27,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.1,5.2,-1.1 "PHB-CH1","PHB-CH1-027",27,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.5,5.2,0.3 "PHB-CH1","PHB-CH1-027",27,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.4,5.2,-1.8 "PHB-CH1","PHB-CH1-027",27,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4,5.2,-1.2 "PHB-CH1","PHB-CH1-027",27,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.2,5.2,-1 "PHB-CH1","PHB-CH1-027",27,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.9,5.2,-1.3 "PHB-CH1","PHB-CH1-027",27,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.3,6.3,0 "PHB-CH1","PHB-CH1-027",27,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,7.4,6.3,1.1 "PHB-CH1","PHB-CH1-027",27,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7,6.3,0.7 "PHB-CH1","PHB-CH1-027",27,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.4,6.3,0.100000000000001 "PHB-CH1","PHB-CH1-027",27,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.9,6.3,0.6 "PHB-CH1","PHB-CH1-027",27,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.1,6.3,-0.2 "PHB-CH1","PHB-CH1-027",27,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.3,6.3,0 "PHB-CH1","PHB-CH1-027",27,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.4,6.3,-0.9 "PHB-CH1","PHB-CH1-027",27,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.6,6.3,-0.7 "PHB-CH1","PHB-CH1-027",27,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.3,6.3,1 "PHB-CH1","PHB-CH1-027",27,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.4,6.3,1.1 "PHB-CH1","PHB-CH1-027",27,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.4,6.3,0.100000000000001 "PHB-CH1","PHB-CH1-027",27,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.8,6.3,0.5 "PHB-CH1","PHB-CH1-027",27,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.1,6.3,-0.2 "PHB-CH1","PHB-CH1-028",28,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,44,44,0 "PHB-CH1","PHB-CH1-028",28,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,42,44,-2 "PHB-CH1","PHB-CH1-028",28,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,37,44,-7 "PHB-CH1","PHB-CH1-028",28,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,49,, "PHB-CH1","PHB-CH1-028",28,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,36,, "PHB-CH1","PHB-CH1-028",28,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,54,, "PHB-CH1","PHB-CH1-028",28,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-028",28,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-028",28,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-028",28,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-028",28,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,1,, "PHB-CH1","PHB-CH1-028",28,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,583,, "PHB-CH1","PHB-CH1-028",28,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-028",28,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-028",28,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-028",28,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-028",28,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,88.2,88.2,0 "PHB-CH1","PHB-CH1-028",28,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,82.7,88.2,-5.5 "PHB-CH1","PHB-CH1-028",28,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,69,88.2,-19.2 "PHB-CH1","PHB-CH1-028",28,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,67.5,88.2,-20.7 "PHB-CH1","PHB-CH1-028",28,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,85.1,85.1,0 "PHB-CH1","PHB-CH1-028",28,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,89.5,85.1,4.40000000000001 "PHB-CH1","PHB-CH1-028",28,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,85.9,85.1,0.800000000000011 "PHB-CH1","PHB-CH1-028",28,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,83.9,85.1,-1.19999999999999 "PHB-CH1","PHB-CH1-028",28,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.8,6.8,0 "PHB-CH1","PHB-CH1-028",28,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,8.2,6.8,1.4 "PHB-CH1","PHB-CH1-028",28,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,9.4,6.8,2.6 "PHB-CH1","PHB-CH1-028",28,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,9.4,6.8,2.6 "PHB-CH1","PHB-CH1-028",28,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,7.1,6.8,0.3 "PHB-CH1","PHB-CH1-028",28,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,8.2,6.8,1.4 "PHB-CH1","PHB-CH1-028",28,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.7,6.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-028",28,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,8.1,6.8,1.3 "PHB-CH1","PHB-CH1-028",28,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,7.6,6.8,0.8 "PHB-CH1","PHB-CH1-028",28,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,8.5,6.8,1.7 "PHB-CH1","PHB-CH1-028",28,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,8.2,6.8,1.4 "PHB-CH1","PHB-CH1-028",28,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,8.2,6.8,1.4 "PHB-CH1","PHB-CH1-028",28,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,8.4,6.8,1.6 "PHB-CH1","PHB-CH1-028",28,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,7.6,6.8,0.8 "PHB-CH1","PHB-CH1-028",28,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5,5,0 "PHB-CH1","PHB-CH1-028",28,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.9,5,0.9 "PHB-CH1","PHB-CH1-028",28,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7.2,5,2.2 "PHB-CH1","PHB-CH1-028",28,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,7.4,5,2.4 "PHB-CH1","PHB-CH1-028",28,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.2,5,0.2 "PHB-CH1","PHB-CH1-028",28,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.7,5,0.7 "PHB-CH1","PHB-CH1-028",28,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.5,5,-0.5 "PHB-CH1","PHB-CH1-028",28,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.5,5,-0.5 "PHB-CH1","PHB-CH1-028",28,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.9,5,-0.0999999999999996 "PHB-CH1","PHB-CH1-028",28,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.4,5,0.4 "PHB-CH1","PHB-CH1-028",28,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.7,5,0.7 "PHB-CH1","PHB-CH1-028",28,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.6,5,-0.4 "PHB-CH1","PHB-CH1-028",28,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.2,5,1.2 "PHB-CH1","PHB-CH1-028",28,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.5,5,1.5 "PHB-CH1","PHB-CH1-029",29,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,54,54,0 "PHB-CH1","PHB-CH1-029",29,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,55,54,1 "PHB-CH1","PHB-CH1-029",29,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,57,54,3 "PHB-CH1","PHB-CH1-029",29,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,48,, "PHB-CH1","PHB-CH1-029",29,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,36,, "PHB-CH1","PHB-CH1-029",29,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,55,, "PHB-CH1","PHB-CH1-029",29,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-029",29,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-029",29,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-029",29,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-029",29,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,3,, "PHB-CH1","PHB-CH1-029",29,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,504,, "PHB-CH1","PHB-CH1-029",29,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-029",29,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-029",29,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-029",29,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-029",29,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,32.9,32.9,0 "PHB-CH1","PHB-CH1-029",29,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,54.7,32.9,21.8 "PHB-CH1","PHB-CH1-029",29,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,54.3,32.9,21.4 "PHB-CH1","PHB-CH1-029",29,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,57.7,32.9,24.8 "PHB-CH1","PHB-CH1-029",29,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,35.8,35.8,0 "PHB-CH1","PHB-CH1-029",29,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,50.2,35.8,14.4 "PHB-CH1","PHB-CH1-029",29,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,51.4,35.8,15.6 "PHB-CH1","PHB-CH1-029",29,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,50.2,35.8,14.4 "PHB-CH1","PHB-CH1-029",29,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.6,5.6,0 "PHB-CH1","PHB-CH1-029",29,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.4,5.6,-0.199999999999999 "PHB-CH1","PHB-CH1-029",29,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.6,5.6,0 "PHB-CH1","PHB-CH1-029",29,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.1,5.6,-0.5 "PHB-CH1","PHB-CH1-029",29,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.1,5.6,-0.5 "PHB-CH1","PHB-CH1-029",29,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.3,5.6,-0.3 "PHB-CH1","PHB-CH1-029",29,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.9,5.6,-0.699999999999999 "PHB-CH1","PHB-CH1-029",29,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.2,5.6,-0.399999999999999 "PHB-CH1","PHB-CH1-029",29,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.4,5.6,0.800000000000001 "PHB-CH1","PHB-CH1-029",29,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.7,5.6,1.1 "PHB-CH1","PHB-CH1-029",29,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.7,5.6,0.100000000000001 "PHB-CH1","PHB-CH1-029",29,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.8,5.6,0.2 "PHB-CH1","PHB-CH1-029",29,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.1,5.6,-0.5 "PHB-CH1","PHB-CH1-029",29,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.4,5.6,-1.2 "PHB-CH1","PHB-CH1-029",29,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.1,6.1,0 "PHB-CH1","PHB-CH1-029",29,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.4,6.1,-0.699999999999999 "PHB-CH1","PHB-CH1-029",29,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.7,6.1,-1.4 "PHB-CH1","PHB-CH1-029",29,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.5,6.1,-0.6 "PHB-CH1","PHB-CH1-029",29,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.4,6.1,-0.699999999999999 "PHB-CH1","PHB-CH1-029",29,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.8,6.1,-1.3 "PHB-CH1","PHB-CH1-029",29,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.9,6.1,-1.2 "PHB-CH1","PHB-CH1-029",29,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.2,6.1,-1.9 "PHB-CH1","PHB-CH1-029",29,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.8,6.1,0.7 "PHB-CH1","PHB-CH1-029",29,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.4,6.1,1.3 "PHB-CH1","PHB-CH1-029",29,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.7,6.1,0.6 "PHB-CH1","PHB-CH1-029",29,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6,6.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-029",29,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5,6.1,-1.1 "PHB-CH1","PHB-CH1-029",29,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.9,6.1,-2.2 "PHB-CH1","PHB-CH1-030",30,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,60,60,0 "PHB-CH1","PHB-CH1-030",30,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,55,60,-5 "PHB-CH1","PHB-CH1-030",30,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,62,60,2 "PHB-CH1","PHB-CH1-030",30,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,56,, "PHB-CH1","PHB-CH1-030",30,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,49,, "PHB-CH1","PHB-CH1-030",30,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,54,, "PHB-CH1","PHB-CH1-030",30,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-030",30,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-030",30,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-030",30,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-030",30,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,31,, "PHB-CH1","PHB-CH1-030",30,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,235,, "PHB-CH1","PHB-CH1-030",30,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-030",30,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-030",30,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-030",30,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-030",30,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,48.5,48.5,0 "PHB-CH1","PHB-CH1-030",30,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,45.6,48.5,-2.9 "PHB-CH1","PHB-CH1-030",30,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,47.3,48.5,-1.2 "PHB-CH1","PHB-CH1-030",30,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,40.4,48.5,-8.1 "PHB-CH1","PHB-CH1-030",30,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,42.3,42.3,0 "PHB-CH1","PHB-CH1-030",30,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,42.9,42.3,0.600000000000001 "PHB-CH1","PHB-CH1-030",30,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,52.8,42.3,10.5 "PHB-CH1","PHB-CH1-030",30,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,41.8,42.3,-0.5 "PHB-CH1","PHB-CH1-030",30,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.1,6.1,0 "PHB-CH1","PHB-CH1-030",30,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,8.1,6.1,2 "PHB-CH1","PHB-CH1-030",30,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.2,6.1,0.100000000000001 "PHB-CH1","PHB-CH1-030",30,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.2,6.1,0.100000000000001 "PHB-CH1","PHB-CH1-030",30,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.9,6.1,-2.2 "PHB-CH1","PHB-CH1-030",30,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4,6.1,-2.1 "PHB-CH1","PHB-CH1-030",30,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.1,6.1,-2 "PHB-CH1","PHB-CH1-030",30,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.7,6.1,-2.4 "PHB-CH1","PHB-CH1-030",30,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.3,6.1,-1.8 "PHB-CH1","PHB-CH1-030",30,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5,6.1,-1.1 "PHB-CH1","PHB-CH1-030",30,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.3,6.1,-0.8 "PHB-CH1","PHB-CH1-030",30,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.5,6.1,-0.6 "PHB-CH1","PHB-CH1-030",30,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.7,6.1,-0.399999999999999 "PHB-CH1","PHB-CH1-030",30,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.5,6.1,-0.6 "PHB-CH1","PHB-CH1-030",30,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.3,5.3,0 "PHB-CH1","PHB-CH1-030",30,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,8.4,5.3,3.1 "PHB-CH1","PHB-CH1-030",30,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.9,5.3,0.6 "PHB-CH1","PHB-CH1-030",30,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,7.3,5.3,2 "PHB-CH1","PHB-CH1-030",30,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5,5.3,-0.3 "PHB-CH1","PHB-CH1-030",30,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.6,5.3,0.3 "PHB-CH1","PHB-CH1-030",30,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7.1,5.3,1.8 "PHB-CH1","PHB-CH1-030",30,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.6,5.3,1.3 "PHB-CH1","PHB-CH1-030",30,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,8.1,5.3,2.8 "PHB-CH1","PHB-CH1-030",30,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7,5.3,1.7 "PHB-CH1","PHB-CH1-030",30,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.3,5.3,2 "PHB-CH1","PHB-CH1-030",30,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.1,5.3,1.8 "PHB-CH1","PHB-CH1-030",30,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.3,5.3,2 "PHB-CH1","PHB-CH1-030",30,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.1,5.3,0.8 "PHB-CH1","PHB-CH1-031",31,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,59,59,0 "PHB-CH1","PHB-CH1-031",31,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,46,59,-13 "PHB-CH1","PHB-CH1-031",31,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,59,59,0 "PHB-CH1","PHB-CH1-031",31,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,40,, "PHB-CH1","PHB-CH1-031",31,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,70,, "PHB-CH1","PHB-CH1-031",31,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,23,, "PHB-CH1","PHB-CH1-031",31,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-031",31,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-031",31,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,5,, "PHB-CH1","PHB-CH1-031",31,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-031",31,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,0,, "PHB-CH1","PHB-CH1-031",31,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,677,, "PHB-CH1","PHB-CH1-031",31,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-031",31,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-031",31,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-031",31,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-031",31,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,41.6,41.6,0 "PHB-CH1","PHB-CH1-031",31,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,49.6,41.6,8 "PHB-CH1","PHB-CH1-031",31,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,42.1,41.6,0.5 "PHB-CH1","PHB-CH1-031",31,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,53.2,41.6,11.6 "PHB-CH1","PHB-CH1-031",31,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,49.5,49.5,0 "PHB-CH1","PHB-CH1-031",31,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,64.3,49.5,14.8 "PHB-CH1","PHB-CH1-031",31,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,55.5,49.5,6 "PHB-CH1","PHB-CH1-031",31,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,56,49.5,6.5 "PHB-CH1","PHB-CH1-031",31,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.2,5.2,0 "PHB-CH1","PHB-CH1-031",31,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.6,5.2,-0.6 "PHB-CH1","PHB-CH1-031",31,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.9,5.2,-1.3 "PHB-CH1","PHB-CH1-031",31,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.9,5.2,-1.3 "PHB-CH1","PHB-CH1-031",31,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4,5.2,-1.2 "PHB-CH1","PHB-CH1-031",31,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.3,5.2,0.0999999999999996 "PHB-CH1","PHB-CH1-031",31,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.4,5.2,0.2 "PHB-CH1","PHB-CH1-031",31,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6,5.2,0.8 "PHB-CH1","PHB-CH1-031",31,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.3,5.2,0.0999999999999996 "PHB-CH1","PHB-CH1-031",31,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.4,5.2,-0.8 "PHB-CH1","PHB-CH1-031",31,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.7,5.2,-2.5 "PHB-CH1","PHB-CH1-031",31,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.3,5.2,-1.9 "PHB-CH1","PHB-CH1-031",31,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.1,5.2,-0.100000000000001 "PHB-CH1","PHB-CH1-031",31,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.5,5.2,0.3 "PHB-CH1","PHB-CH1-031",31,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.3,6.3,0 "PHB-CH1","PHB-CH1-031",31,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.7,6.3,0.4 "PHB-CH1","PHB-CH1-031",31,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.8,6.3,-0.5 "PHB-CH1","PHB-CH1-031",31,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.4,6.3,-0.9 "PHB-CH1","PHB-CH1-031",31,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.5,6.3,-0.8 "PHB-CH1","PHB-CH1-031",31,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.9,6.3,-0.399999999999999 "PHB-CH1","PHB-CH1-031",31,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6,6.3,-0.3 "PHB-CH1","PHB-CH1-031",31,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.3,6.3,0 "PHB-CH1","PHB-CH1-031",31,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.7,6.3,-0.6 "PHB-CH1","PHB-CH1-031",31,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.9,6.3,-0.399999999999999 "PHB-CH1","PHB-CH1-031",31,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.7,6.3,-1.6 "PHB-CH1","PHB-CH1-031",31,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.9,6.3,-0.399999999999999 "PHB-CH1","PHB-CH1-031",31,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.6,6.3,1.3 "PHB-CH1","PHB-CH1-031",31,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.1,6.3,0.8 "PHB-CH1","PHB-CH1-032",32,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,83,83,0 "PHB-CH1","PHB-CH1-032",32,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,86,83,3 "PHB-CH1","PHB-CH1-032",32,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,57,83,-26 "PHB-CH1","PHB-CH1-032",32,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,71,, "PHB-CH1","PHB-CH1-032",32,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,66,, "PHB-CH1","PHB-CH1-032",32,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,41,, "PHB-CH1","PHB-CH1-032",32,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-032",32,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-032",32,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-032",32,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-032",32,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,6,, "PHB-CH1","PHB-CH1-032",32,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,435,, "PHB-CH1","PHB-CH1-032",32,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-032",32,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-032",32,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-032",32,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-032",32,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,38.4,38.4,0 "PHB-CH1","PHB-CH1-032",32,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,43.6,38.4,5.2 "PHB-CH1","PHB-CH1-032",32,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,43.8,38.4,5.4 "PHB-CH1","PHB-CH1-032",32,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,30.9,38.4,-7.5 "PHB-CH1","PHB-CH1-032",32,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,32.3,32.3,0 "PHB-CH1","PHB-CH1-032",32,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,38.1,32.3,5.8 "PHB-CH1","PHB-CH1-032",32,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,30.9,32.3,-1.4 "PHB-CH1","PHB-CH1-032",32,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,34,32.3,1.7 "PHB-CH1","PHB-CH1-032",32,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,2.1,2.1,0 "PHB-CH1","PHB-CH1-032",32,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2.9,2.1,0.8 "PHB-CH1","PHB-CH1-032",32,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.2,2.1,2.1 "PHB-CH1","PHB-CH1-032",32,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4,2.1,1.9 "PHB-CH1","PHB-CH1-032",32,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.3,2.1,1.2 "PHB-CH1","PHB-CH1-032",32,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.2,2.1,1.1 "PHB-CH1","PHB-CH1-032",32,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.2,2.1,1.1 "PHB-CH1","PHB-CH1-032",32,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,2.3,2.1,0.2 "PHB-CH1","PHB-CH1-032",32,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.9,2.1,1.8 "PHB-CH1","PHB-CH1-032",32,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.2,2.1,2.1 "PHB-CH1","PHB-CH1-032",32,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.7,2.1,1.6 "PHB-CH1","PHB-CH1-032",32,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.8,2.1,1.7 "PHB-CH1","PHB-CH1-032",32,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.7,2.1,0.6 "PHB-CH1","PHB-CH1-032",32,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2.7,2.1,0.6 "PHB-CH1","PHB-CH1-032",32,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7.2,7.2,0 "PHB-CH1","PHB-CH1-032",32,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,8,7.2,0.8 "PHB-CH1","PHB-CH1-032",32,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7,7.2,-0.2 "PHB-CH1","PHB-CH1-032",32,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.2,7.2,-1 "PHB-CH1","PHB-CH1-032",32,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6,7.2,-1.2 "PHB-CH1","PHB-CH1-032",32,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.3,7.2,-0.9 "PHB-CH1","PHB-CH1-032",32,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.2,7.2,-1 "PHB-CH1","PHB-CH1-032",32,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,7,7.2,-0.2 "PHB-CH1","PHB-CH1-032",32,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.2,7.2,0 "PHB-CH1","PHB-CH1-032",32,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.5,7.2,-0.7 "PHB-CH1","PHB-CH1-032",32,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.4,7.2,-0.8 "PHB-CH1","PHB-CH1-032",32,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.1,7.2,-1.1 "PHB-CH1","PHB-CH1-032",32,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7,7.2,-0.2 "PHB-CH1","PHB-CH1-032",32,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.1,7.2,-0.100000000000001 "PHB-CH1","PHB-CH1-033",33,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,68,68,0 "PHB-CH1","PHB-CH1-033",33,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,64,68,-4 "PHB-CH1","PHB-CH1-033",33,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,61,68,-7 "PHB-CH1","PHB-CH1-033",33,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,63,, "PHB-CH1","PHB-CH1-033",33,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,56,, "PHB-CH1","PHB-CH1-033",33,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,70,, "PHB-CH1","PHB-CH1-033",33,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-033",33,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-033",33,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-033",33,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-033",33,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,16,, "PHB-CH1","PHB-CH1-033",33,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,340,, "PHB-CH1","PHB-CH1-033",33,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-033",33,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-033",33,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-033",33,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-033",33,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,32.7,32.7,0 "PHB-CH1","PHB-CH1-033",33,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,41.1,32.7,8.4 "PHB-CH1","PHB-CH1-033",33,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,42.3,32.7,9.59999999999999 "PHB-CH1","PHB-CH1-033",33,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,31.6,32.7,-1.1 "PHB-CH1","PHB-CH1-033",33,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,43.4,43.4,0 "PHB-CH1","PHB-CH1-033",33,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,47.2,43.4,3.8 "PHB-CH1","PHB-CH1-033",33,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,68.8,43.4,25.4 "PHB-CH1","PHB-CH1-033",33,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,46.8,43.4,3.4 "PHB-CH1","PHB-CH1-033",33,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,8,8,0 "PHB-CH1","PHB-CH1-033",33,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,8.6,8,0.6 "PHB-CH1","PHB-CH1-033",33,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,8.5,8,0.5 "PHB-CH1","PHB-CH1-033",33,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.4,8,-2.6 "PHB-CH1","PHB-CH1-033",33,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.2,8,-1.8 "PHB-CH1","PHB-CH1-033",33,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.8,8,-2.2 "PHB-CH1","PHB-CH1-033",33,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,8.4,8,0.4 "PHB-CH1","PHB-CH1-033",33,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,8.7,8,0.699999999999999 "PHB-CH1","PHB-CH1-033",33,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,7.9,8,-0.0999999999999996 "PHB-CH1","PHB-CH1-033",33,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,9.4,8,1.4 "PHB-CH1","PHB-CH1-033",33,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,9.5,8,1.5 "PHB-CH1","PHB-CH1-033",33,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,9.2,8,1.2 "PHB-CH1","PHB-CH1-033",33,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.4,8,-1.6 "PHB-CH1","PHB-CH1-033",33,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.8,8,-2.2 "PHB-CH1","PHB-CH1-033",33,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7.9,7.9,0 "PHB-CH1","PHB-CH1-033",33,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,8.3,7.9,0.4 "PHB-CH1","PHB-CH1-033",33,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.9,7.9,-1 "PHB-CH1","PHB-CH1-033",33,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,7,7.9,-0.9 "PHB-CH1","PHB-CH1-033",33,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.8,7.9,-1.1 "PHB-CH1","PHB-CH1-033",33,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.4,7.9,-2.5 "PHB-CH1","PHB-CH1-033",33,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7.9,7.9,0 "PHB-CH1","PHB-CH1-033",33,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,8.6,7.9,0.699999999999999 "PHB-CH1","PHB-CH1-033",33,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,8.6,7.9,0.699999999999999 "PHB-CH1","PHB-CH1-033",33,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,8.8,7.9,0.9 "PHB-CH1","PHB-CH1-033",33,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,8.1,7.9,0.199999999999999 "PHB-CH1","PHB-CH1-033",33,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,10,7.9,2.1 "PHB-CH1","PHB-CH1-033",33,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,8.7,7.9,0.799999999999999 "PHB-CH1","PHB-CH1-033",33,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.1,7.9,-0.800000000000001 "PHB-CH1","PHB-CH1-034",34,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,43,43,0 "PHB-CH1","PHB-CH1-034",34,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,42,43,-1 "PHB-CH1","PHB-CH1-034",34,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,39,43,-4 "PHB-CH1","PHB-CH1-034",34,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,37,, "PHB-CH1","PHB-CH1-034",34,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,56,, "PHB-CH1","PHB-CH1-034",34,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,55,, "PHB-CH1","PHB-CH1-034",34,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-034",34,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-034",34,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-034",34,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-034",34,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,8,, "PHB-CH1","PHB-CH1-034",34,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,373,, "PHB-CH1","PHB-CH1-034",34,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-034",34,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-034",34,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-034",34,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-034",34,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,39.6,39.6,0 "PHB-CH1","PHB-CH1-034",34,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,42.3,39.6,2.7 "PHB-CH1","PHB-CH1-034",34,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,41.1,39.6,1.5 "PHB-CH1","PHB-CH1-034",34,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,44.7,39.6,5.1 "PHB-CH1","PHB-CH1-034",34,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,46.9,46.9,0 "PHB-CH1","PHB-CH1-034",34,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,67.6,46.9,20.7 "PHB-CH1","PHB-CH1-034",34,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,42.9,46.9,-4 "PHB-CH1","PHB-CH1-034",34,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,60.2,46.9,13.3 "PHB-CH1","PHB-CH1-034",34,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.5,5.5,0 "PHB-CH1","PHB-CH1-034",34,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.8,5.5,0.3 "PHB-CH1","PHB-CH1-034",34,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.3,5.5,-0.2 "PHB-CH1","PHB-CH1-034",34,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6,5.5,0.5 "PHB-CH1","PHB-CH1-034",34,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.2,5.5,0.7 "PHB-CH1","PHB-CH1-034",34,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.6,5.5,1.1 "PHB-CH1","PHB-CH1-034",34,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.9,5.5,1.4 "PHB-CH1","PHB-CH1-034",34,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5,5.5,-0.5 "PHB-CH1","PHB-CH1-034",34,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.7,5.5,-0.8 "PHB-CH1","PHB-CH1-034",34,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6,5.5,0.5 "PHB-CH1","PHB-CH1-034",34,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.7,5.5,-0.8 "PHB-CH1","PHB-CH1-034",34,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.5,5.5,-1 "PHB-CH1","PHB-CH1-034",34,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.1,5.5,-0.4 "PHB-CH1","PHB-CH1-034",34,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.8,5.5,-0.7 "PHB-CH1","PHB-CH1-034",34,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.5,4.5,0 "PHB-CH1","PHB-CH1-034",34,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.8,4.5,-0.7 "PHB-CH1","PHB-CH1-034",34,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.5,4.5,-1 "PHB-CH1","PHB-CH1-034",34,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.3,4.5,-0.2 "PHB-CH1","PHB-CH1-034",34,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4,4.5,-0.5 "PHB-CH1","PHB-CH1-034",34,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.8,4.5,0.3 "PHB-CH1","PHB-CH1-034",34,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.4,4.5,-1.1 "PHB-CH1","PHB-CH1-034",34,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.3,4.5,-1.2 "PHB-CH1","PHB-CH1-034",34,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.1,4.5,-1.4 "PHB-CH1","PHB-CH1-034",34,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.7,4.5,-0.8 "PHB-CH1","PHB-CH1-034",34,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.9,4.5,-0.6 "PHB-CH1","PHB-CH1-034",34,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.2,4.5,-1.3 "PHB-CH1","PHB-CH1-034",34,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4,4.5,-0.5 "PHB-CH1","PHB-CH1-034",34,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.6,4.5,0.0999999999999996 "PHB-CH1","PHB-CH1-035",35,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,52,52,0 "PHB-CH1","PHB-CH1-035",35,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,55,52,3 "PHB-CH1","PHB-CH1-035",35,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,57,52,5 "PHB-CH1","PHB-CH1-035",35,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,43,, "PHB-CH1","PHB-CH1-035",35,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,47,, "PHB-CH1","PHB-CH1-035",35,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,38,, "PHB-CH1","PHB-CH1-035",35,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-035",35,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-035",35,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-035",35,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-035",35,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,9,, "PHB-CH1","PHB-CH1-035",35,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,438,, "PHB-CH1","PHB-CH1-035",35,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-035",35,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-035",35,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-035",35,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-035",35,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,67.1,67.1,0 "PHB-CH1","PHB-CH1-035",35,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,54.2,67.1,-12.9 "PHB-CH1","PHB-CH1-035",35,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,48.5,67.1,-18.6 "PHB-CH1","PHB-CH1-035",35,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,51.4,67.1,-15.7 "PHB-CH1","PHB-CH1-035",35,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,59.6,59.6,0 "PHB-CH1","PHB-CH1-035",35,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,55.5,59.6,-4.1 "PHB-CH1","PHB-CH1-035",35,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,47.7,59.6,-11.9 "PHB-CH1","PHB-CH1-035",35,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,38.2,59.6,-21.4 "PHB-CH1","PHB-CH1-035",35,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,10,10,0 "PHB-CH1","PHB-CH1-035",35,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,8.9,10,-1.1 "PHB-CH1","PHB-CH1-035",35,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,9.8,10,-0.199999999999999 "PHB-CH1","PHB-CH1-035",35,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,10,10,0 "PHB-CH1","PHB-CH1-035",35,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,9.2,10,-0.800000000000001 "PHB-CH1","PHB-CH1-035",35,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,10,10,0 "PHB-CH1","PHB-CH1-035",35,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,8.4,10,-1.6 "PHB-CH1","PHB-CH1-035",35,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,8.1,10,-1.9 "PHB-CH1","PHB-CH1-035",35,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,7.1,10,-2.9 "PHB-CH1","PHB-CH1-035",35,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,9.3,10,-0.699999999999999 "PHB-CH1","PHB-CH1-035",35,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,8,10,-2 "PHB-CH1","PHB-CH1-035",35,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,8.4,10,-1.6 "PHB-CH1","PHB-CH1-035",35,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,8.2,10,-1.8 "PHB-CH1","PHB-CH1-035",35,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,9.6,10,-0.4 "PHB-CH1","PHB-CH1-035",35,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.4,6.4,0 "PHB-CH1","PHB-CH1-035",35,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.8,6.4,-1.6 "PHB-CH1","PHB-CH1-035",35,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.5,6.4,-1.9 "PHB-CH1","PHB-CH1-035",35,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.9,6.4,-0.5 "PHB-CH1","PHB-CH1-035",35,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.1,6.4,-0.300000000000001 "PHB-CH1","PHB-CH1-035",35,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,8,6.4,1.6 "PHB-CH1","PHB-CH1-035",35,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.6,6.4,-0.800000000000001 "PHB-CH1","PHB-CH1-035",35,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6,6.4,-0.4 "PHB-CH1","PHB-CH1-035",35,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.5,6.4,-1.9 "PHB-CH1","PHB-CH1-035",35,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.7,6.4,1.3 "PHB-CH1","PHB-CH1-035",35,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.8,6.4,-0.6 "PHB-CH1","PHB-CH1-035",35,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.3,6.4,-0.100000000000001 "PHB-CH1","PHB-CH1-035",35,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.1,6.4,-0.300000000000001 "PHB-CH1","PHB-CH1-035",35,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.7,6.4,-0.7 "PHB-CH1","PHB-CH1-036",36,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,45,45,0 "PHB-CH1","PHB-CH1-036",36,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,62,45,17 "PHB-CH1","PHB-CH1-036",36,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,41,45,-4 "PHB-CH1","PHB-CH1-036",36,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,30,, "PHB-CH1","PHB-CH1-036",36,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,60,, "PHB-CH1","PHB-CH1-036",36,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,66,, "PHB-CH1","PHB-CH1-036",36,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-036",36,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-036",36,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-036",36,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-036",36,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,34,, "PHB-CH1","PHB-CH1-036",36,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,188,, "PHB-CH1","PHB-CH1-036",36,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-036",36,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-036",36,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-036",36,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-036",36,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,55.6,55.6,0 "PHB-CH1","PHB-CH1-036",36,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,56.9,55.6,1.3 "PHB-CH1","PHB-CH1-036",36,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,43,55.6,-12.6 "PHB-CH1","PHB-CH1-036",36,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,45.7,55.6,-9.9 "PHB-CH1","PHB-CH1-036",36,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,46.2,46.2,0 "PHB-CH1","PHB-CH1-036",36,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,49.8,46.2,3.59999999999999 "PHB-CH1","PHB-CH1-036",36,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,33.7,46.2,-12.5 "PHB-CH1","PHB-CH1-036",36,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,59.4,46.2,13.2 "PHB-CH1","PHB-CH1-036",36,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.5,4.5,0 "PHB-CH1","PHB-CH1-036",36,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.8,4.5,1.3 "PHB-CH1","PHB-CH1-036",36,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6,4.5,1.5 "PHB-CH1","PHB-CH1-036",36,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6,4.5,1.5 "PHB-CH1","PHB-CH1-036",36,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.4,4.5,1.9 "PHB-CH1","PHB-CH1-036",36,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.2,4.5,1.7 "PHB-CH1","PHB-CH1-036",36,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,7,4.5,2.5 "PHB-CH1","PHB-CH1-036",36,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,8.2,4.5,3.7 "PHB-CH1","PHB-CH1-036",36,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,7.3,4.5,2.8 "PHB-CH1","PHB-CH1-036",36,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.1,4.5,0.6 "PHB-CH1","PHB-CH1-036",36,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.1,4.5,1.6 "PHB-CH1","PHB-CH1-036",36,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,7.2,4.5,2.7 "PHB-CH1","PHB-CH1-036",36,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.4,4.5,1.9 "PHB-CH1","PHB-CH1-036",36,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,7,4.5,2.5 "PHB-CH1","PHB-CH1-036",36,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.6,4.6,0 "PHB-CH1","PHB-CH1-036",36,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5,4.6,0.4 "PHB-CH1","PHB-CH1-036",36,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.3,4.6,0.7 "PHB-CH1","PHB-CH1-036",36,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.8,4.6,1.2 "PHB-CH1","PHB-CH1-036",36,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.9,4.6,0.300000000000001 "PHB-CH1","PHB-CH1-036",36,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.7,4.6,-0.9 "PHB-CH1","PHB-CH1-036",36,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.2,4.6,0.6 "PHB-CH1","PHB-CH1-036",36,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.7,4.6,2.1 "PHB-CH1","PHB-CH1-036",36,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.8,4.6,1.2 "PHB-CH1","PHB-CH1-036",36,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.3,4.6,-0.3 "PHB-CH1","PHB-CH1-036",36,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.5,4.6,0.9 "PHB-CH1","PHB-CH1-036",36,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.1,4.6,1.5 "PHB-CH1","PHB-CH1-036",36,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.9,4.6,1.3 "PHB-CH1","PHB-CH1-036",36,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.4,4.6,1.8 "PHB-CH1","PHB-CH1-037",37,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,31,31,0 "PHB-CH1","PHB-CH1-037",37,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,34,31,3 "PHB-CH1","PHB-CH1-037",37,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,29,31,-2 "PHB-CH1","PHB-CH1-037",37,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,40,, "PHB-CH1","PHB-CH1-037",37,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,28,, "PHB-CH1","PHB-CH1-037",37,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,52,, "PHB-CH1","PHB-CH1-037",37,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-037",37,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-037",37,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-037",37,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-037",37,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,6,, "PHB-CH1","PHB-CH1-037",37,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,443,, "PHB-CH1","PHB-CH1-037",37,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-037",37,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-037",37,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-037",37,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-037",37,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,51.9,51.9,0 "PHB-CH1","PHB-CH1-037",37,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,54.5,51.9,2.6 "PHB-CH1","PHB-CH1-037",37,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,50.5,51.9,-1.4 "PHB-CH1","PHB-CH1-037",37,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,43.8,51.9,-8.1 "PHB-CH1","PHB-CH1-037",37,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,40.2,40.2,0 "PHB-CH1","PHB-CH1-037",37,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,57.7,40.2,17.5 "PHB-CH1","PHB-CH1-037",37,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,61.3,40.2,21.1 "PHB-CH1","PHB-CH1-037",37,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,56.5,40.2,16.3 "PHB-CH1","PHB-CH1-037",37,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-037",37,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.8,4.7,0.0999999999999996 "PHB-CH1","PHB-CH1-037",37,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.4,4.7,0.7 "PHB-CH1","PHB-CH1-037",37,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.4,4.7,-0.3 "PHB-CH1","PHB-CH1-037",37,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.6,4.7,-1.1 "PHB-CH1","PHB-CH1-037",37,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.7,4.7,0 "PHB-CH1","PHB-CH1-037",37,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.5,4.7,-0.2 "PHB-CH1","PHB-CH1-037",37,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5,4.7,0.3 "PHB-CH1","PHB-CH1-037",37,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.6,4.7,-0.100000000000001 "PHB-CH1","PHB-CH1-037",37,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.4,4.7,0.7 "PHB-CH1","PHB-CH1-037",37,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.4,4.7,0.7 "PHB-CH1","PHB-CH1-037",37,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.1,4.7,1.4 "PHB-CH1","PHB-CH1-037",37,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.7,4.7,2 "PHB-CH1","PHB-CH1-037",37,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.5,4.7,0.8 "PHB-CH1","PHB-CH1-037",37,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.5,5.5,0 "PHB-CH1","PHB-CH1-037",37,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,7,5.5,1.5 "PHB-CH1","PHB-CH1-037",37,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,8.1,5.5,2.6 "PHB-CH1","PHB-CH1-037",37,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6,5.5,0.5 "PHB-CH1","PHB-CH1-037",37,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.1,5.5,-0.4 "PHB-CH1","PHB-CH1-037",37,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.4,5.5,0.9 "PHB-CH1","PHB-CH1-037",37,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.4,5.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-037",37,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.4,5.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-037",37,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.7,5.5,0.2 "PHB-CH1","PHB-CH1-037",37,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.9,5.5,1.4 "PHB-CH1","PHB-CH1-037",37,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.3,5.5,-1.2 "PHB-CH1","PHB-CH1-037",37,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.1,5.5,0.6 "PHB-CH1","PHB-CH1-037",37,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7,5.5,1.5 "PHB-CH1","PHB-CH1-037",37,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.4,5.5,0.9 "PHB-CH1","PHB-CH1-038",38,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,53,53,0 "PHB-CH1","PHB-CH1-038",38,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,64,53,11 "PHB-CH1","PHB-CH1-038",38,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,55,53,2 "PHB-CH1","PHB-CH1-038",38,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,44,, "PHB-CH1","PHB-CH1-038",38,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,55,, "PHB-CH1","PHB-CH1-038",38,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,60,, "PHB-CH1","PHB-CH1-038",38,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-038",38,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-038",38,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-038",38,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-038",38,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,12,, "PHB-CH1","PHB-CH1-038",38,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,386,, "PHB-CH1","PHB-CH1-038",38,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-038",38,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-038",38,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-038",38,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-038",38,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,49.2,49.2,0 "PHB-CH1","PHB-CH1-038",38,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,62.4,49.2,13.2 "PHB-CH1","PHB-CH1-038",38,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,59.1,49.2,9.9 "PHB-CH1","PHB-CH1-038",38,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,69.8,49.2,20.6 "PHB-CH1","PHB-CH1-038",38,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,82.7,82.7,0 "PHB-CH1","PHB-CH1-038",38,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,64.4,82.7,-18.3 "PHB-CH1","PHB-CH1-038",38,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,64.4,82.7,-18.3 "PHB-CH1","PHB-CH1-038",38,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,74.7,82.7,-8 "PHB-CH1","PHB-CH1-038",38,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.8,4.8,0 "PHB-CH1","PHB-CH1-038",38,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.1,4.8,-0.7 "PHB-CH1","PHB-CH1-038",38,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5,4.8,0.2 "PHB-CH1","PHB-CH1-038",38,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.6,4.8,-0.2 "PHB-CH1","PHB-CH1-038",38,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.2,4.8,0.4 "PHB-CH1","PHB-CH1-038",38,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.4,4.8,-0.399999999999999 "PHB-CH1","PHB-CH1-038",38,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4,4.8,-0.8 "PHB-CH1","PHB-CH1-038",38,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.9,4.8,-0.9 "PHB-CH1","PHB-CH1-038",38,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.4,4.8,-0.399999999999999 "PHB-CH1","PHB-CH1-038",38,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.3,4.8,-0.5 "PHB-CH1","PHB-CH1-038",38,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.6,4.8,-0.2 "PHB-CH1","PHB-CH1-038",38,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.6,4.8,0.8 "PHB-CH1","PHB-CH1-038",38,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.8,4.8,0 "PHB-CH1","PHB-CH1-038",38,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.7,4.8,0.9 "PHB-CH1","PHB-CH1-038",38,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.2,4.2,0 "PHB-CH1","PHB-CH1-038",38,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.3,4.2,0.0999999999999996 "PHB-CH1","PHB-CH1-038",38,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.2,4.2,0 "PHB-CH1","PHB-CH1-038",38,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-038",38,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.9,4.2,0.7 "PHB-CH1","PHB-CH1-038",38,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.2,4.2,1 "PHB-CH1","PHB-CH1-038",38,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.5,4.2,0.3 "PHB-CH1","PHB-CH1-038",38,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.7,4.2,-0.5 "PHB-CH1","PHB-CH1-038",38,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.8,4.2,0.6 "PHB-CH1","PHB-CH1-038",38,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.3,4.2,1.1 "PHB-CH1","PHB-CH1-038",38,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.5,4.2,1.3 "PHB-CH1","PHB-CH1-038",38,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.2,4.2,2 "PHB-CH1","PHB-CH1-038",38,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-038",38,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.2,4.2,1 "PHB-CH1","PHB-CH1-039",39,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,73,73,0 "PHB-CH1","PHB-CH1-039",39,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,76,73,3 "PHB-CH1","PHB-CH1-039",39,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,71,73,-2 "PHB-CH1","PHB-CH1-039",39,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,65,, "PHB-CH1","PHB-CH1-039",39,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,62,, "PHB-CH1","PHB-CH1-039",39,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,66,, "PHB-CH1","PHB-CH1-039",39,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-039",39,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-039",39,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-039",39,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-039",39,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,5,, "PHB-CH1","PHB-CH1-039",39,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,418,, "PHB-CH1","PHB-CH1-039",39,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-039",39,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-039",39,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-039",39,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-039",39,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,38.9,38.9,0 "PHB-CH1","PHB-CH1-039",39,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,30.3,38.9,-8.6 "PHB-CH1","PHB-CH1-039",39,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,33.8,38.9,-5.1 "PHB-CH1","PHB-CH1-039",39,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,43.3,38.9,4.4 "PHB-CH1","PHB-CH1-039",39,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,49.1,49.1,0 "PHB-CH1","PHB-CH1-039",39,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,66.6,49.1,17.5 "PHB-CH1","PHB-CH1-039",39,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,53.8,49.1,4.7 "PHB-CH1","PHB-CH1-039",39,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,56.6,49.1,7.5 "PHB-CH1","PHB-CH1-039",39,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.1,3.1,0 "PHB-CH1","PHB-CH1-039",39,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.8,3.1,0.7 "PHB-CH1","PHB-CH1-039",39,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.3,3.1,1.2 "PHB-CH1","PHB-CH1-039",39,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5,3.1,1.9 "PHB-CH1","PHB-CH1-039",39,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.6,3.1,1.5 "PHB-CH1","PHB-CH1-039",39,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.1,3.1,2 "PHB-CH1","PHB-CH1-039",39,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.3,3.1,2.2 "PHB-CH1","PHB-CH1-039",39,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.9,3.1,2.8 "PHB-CH1","PHB-CH1-039",39,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.9,3.1,1.8 "PHB-CH1","PHB-CH1-039",39,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.6,3.1,2.5 "PHB-CH1","PHB-CH1-039",39,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.9,3.1,1.8 "PHB-CH1","PHB-CH1-039",39,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.1,3.1,2 "PHB-CH1","PHB-CH1-039",39,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4,3.1,0.9 "PHB-CH1","PHB-CH1-039",39,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.6,3.1,0.5 "PHB-CH1","PHB-CH1-039",39,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.5,2.5,0 "PHB-CH1","PHB-CH1-039",39,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,2.8,2.5,0.3 "PHB-CH1","PHB-CH1-039",39,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.3,2.5,1.8 "PHB-CH1","PHB-CH1-039",39,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,2.7,2.5,0.2 "PHB-CH1","PHB-CH1-039",39,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,1.9,2.5,-0.6 "PHB-CH1","PHB-CH1-039",39,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.5,2.5,1 "PHB-CH1","PHB-CH1-039",39,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.4,2.5,0.9 "PHB-CH1","PHB-CH1-039",39,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.9,2.5,0.4 "PHB-CH1","PHB-CH1-039",39,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3,2.5,0.5 "PHB-CH1","PHB-CH1-039",39,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.4,2.5,1.9 "PHB-CH1","PHB-CH1-039",39,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,2.9,2.5,0.4 "PHB-CH1","PHB-CH1-039",39,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.2,2.5,1.7 "PHB-CH1","PHB-CH1-039",39,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.3,2.5,0.8 "PHB-CH1","PHB-CH1-039",39,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.3,2.5,1.8 "PHB-CH1","PHB-CH1-040",40,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,52,52,0 "PHB-CH1","PHB-CH1-040",40,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,47,52,-5 "PHB-CH1","PHB-CH1-040",40,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,39,52,-13 "PHB-CH1","PHB-CH1-040",40,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,60,, "PHB-CH1","PHB-CH1-040",40,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,57,, "PHB-CH1","PHB-CH1-040",40,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,51,, "PHB-CH1","PHB-CH1-040",40,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-040",40,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-040",40,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-040",40,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-040",40,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,16,, "PHB-CH1","PHB-CH1-040",40,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,337,, "PHB-CH1","PHB-CH1-040",40,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-040",40,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-040",40,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-040",40,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-040",40,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,20.5,20.5,0 "PHB-CH1","PHB-CH1-040",40,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,33.6,20.5,13.1 "PHB-CH1","PHB-CH1-040",40,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,25.5,20.5,5 "PHB-CH1","PHB-CH1-040",40,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,24,20.5,3.5 "PHB-CH1","PHB-CH1-040",40,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,47.9,47.9,0 "PHB-CH1","PHB-CH1-040",40,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,52.5,47.9,4.6 "PHB-CH1","PHB-CH1-040",40,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,54.1,47.9,6.2 "PHB-CH1","PHB-CH1-040",40,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,52.2,47.9,4.3 "PHB-CH1","PHB-CH1-040",40,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.4,3.4,0 "PHB-CH1","PHB-CH1-040",40,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2.7,3.4,-0.7 "PHB-CH1","PHB-CH1-040",40,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.6,3.4,-0.8 "PHB-CH1","PHB-CH1-040",40,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.6,3.4,-0.8 "PHB-CH1","PHB-CH1-040",40,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.4,3.4,1 "PHB-CH1","PHB-CH1-040",40,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.7,3.4,0.3 "PHB-CH1","PHB-CH1-040",40,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2.8,3.4,-0.6 "PHB-CH1","PHB-CH1-040",40,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.6,3.4,0.2 "PHB-CH1","PHB-CH1-040",40,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.7,3.4,0.3 "PHB-CH1","PHB-CH1-040",40,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.3,3.4,-0.1 "PHB-CH1","PHB-CH1-040",40,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.4,3.4,0 "PHB-CH1","PHB-CH1-040",40,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.1,3.4,0.7 "PHB-CH1","PHB-CH1-040",40,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.4,3.4,0 "PHB-CH1","PHB-CH1-040",40,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.2,3.4,-0.2 "PHB-CH1","PHB-CH1-040",40,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.3,4.3,0 "PHB-CH1","PHB-CH1-040",40,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.8,4.3,0.5 "PHB-CH1","PHB-CH1-040",40,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.3,4.3,0 "PHB-CH1","PHB-CH1-040",40,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.7,4.3,0.4 "PHB-CH1","PHB-CH1-040",40,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.7,4.3,0.4 "PHB-CH1","PHB-CH1-040",40,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.3,4.3,0 "PHB-CH1","PHB-CH1-040",40,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.2,4.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-040",40,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.2,4.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-040",40,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.3,4.3,0 "PHB-CH1","PHB-CH1-040",40,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.3,4.3,0 "PHB-CH1","PHB-CH1-040",40,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3,4.3,-1.3 "PHB-CH1","PHB-CH1-040",40,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,2.8,4.3,-1.5 "PHB-CH1","PHB-CH1-040",40,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.2,4.3,-1.1 "PHB-CH1","PHB-CH1-040",40,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,2.4,4.3,-1.9 "PHB-CH1","PHB-CH1-041",41,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,51,51,0 "PHB-CH1","PHB-CH1-041",41,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,56,51,5 "PHB-CH1","PHB-CH1-041",41,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,33,51,-18 "PHB-CH1","PHB-CH1-041",41,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,59,, "PHB-CH1","PHB-CH1-041",41,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,54,, "PHB-CH1","PHB-CH1-041",41,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,69,, "PHB-CH1","PHB-CH1-041",41,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-041",41,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-041",41,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-041",41,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-041",41,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,6,, "PHB-CH1","PHB-CH1-041",41,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,413,, "PHB-CH1","PHB-CH1-041",41,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-041",41,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-041",41,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-041",41,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-041",41,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,53.6,53.6,0 "PHB-CH1","PHB-CH1-041",41,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,64.7,53.6,11.1 "PHB-CH1","PHB-CH1-041",41,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,47.1,53.6,-6.5 "PHB-CH1","PHB-CH1-041",41,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,57.2,53.6,3.6 "PHB-CH1","PHB-CH1-041",41,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,52,52,0 "PHB-CH1","PHB-CH1-041",41,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,63.9,52,11.9 "PHB-CH1","PHB-CH1-041",41,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,74.3,52,22.3 "PHB-CH1","PHB-CH1-041",41,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,56.6,52,4.6 "PHB-CH1","PHB-CH1-041",41,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.6,4.6,0 "PHB-CH1","PHB-CH1-041",41,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.6,4.6,1 "PHB-CH1","PHB-CH1-041",41,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.7,4.6,1.1 "PHB-CH1","PHB-CH1-041",41,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.7,4.6,1.1 "PHB-CH1","PHB-CH1-041",41,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.4,4.6,0.800000000000001 "PHB-CH1","PHB-CH1-041",41,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.4,4.6,-0.199999999999999 "PHB-CH1","PHB-CH1-041",41,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4,4.6,-0.6 "PHB-CH1","PHB-CH1-041",41,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.7,4.6,0.100000000000001 "PHB-CH1","PHB-CH1-041",41,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.6,4.6,1 "PHB-CH1","PHB-CH1-041",41,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.9,4.6,1.3 "PHB-CH1","PHB-CH1-041",41,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.5,4.6,-0.0999999999999996 "PHB-CH1","PHB-CH1-041",41,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.6,4.6,2 "PHB-CH1","PHB-CH1-041",41,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,7.1,4.6,2.5 "PHB-CH1","PHB-CH1-041",41,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.1,4.6,0.5 "PHB-CH1","PHB-CH1-041",41,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.1,3.1,0 "PHB-CH1","PHB-CH1-041",41,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.3,3.1,1.2 "PHB-CH1","PHB-CH1-041",41,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.2,3.1,1.1 "PHB-CH1","PHB-CH1-041",41,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.8,3.1,0.7 "PHB-CH1","PHB-CH1-041",41,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.1,3.1,2 "PHB-CH1","PHB-CH1-041",41,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.9,3.1,0.8 "PHB-CH1","PHB-CH1-041",41,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.5,3.1,0.4 "PHB-CH1","PHB-CH1-041",41,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.8,3.1,-0.3 "PHB-CH1","PHB-CH1-041",41,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.1,3.1,0 "PHB-CH1","PHB-CH1-041",41,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.4,3.1,1.3 "PHB-CH1","PHB-CH1-041",41,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.9,3.1,0.8 "PHB-CH1","PHB-CH1-041",41,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.5,3.1,3.4 "PHB-CH1","PHB-CH1-041",41,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.1,3.1,3 "PHB-CH1","PHB-CH1-041",41,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.1,3.1,1 "PHB-CH1","PHB-CH1-042",42,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,62,62,0 "PHB-CH1","PHB-CH1-042",42,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,61,62,-1 "PHB-CH1","PHB-CH1-042",42,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,50,62,-12 "PHB-CH1","PHB-CH1-042",42,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,46,, "PHB-CH1","PHB-CH1-042",42,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,53,, "PHB-CH1","PHB-CH1-042",42,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,62,, "PHB-CH1","PHB-CH1-042",42,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-042",42,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-042",42,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-042",42,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-042",42,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,13,, "PHB-CH1","PHB-CH1-042",42,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,311,, "PHB-CH1","PHB-CH1-042",42,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-042",42,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-042",42,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-042",42,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-042",42,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,49.1,49.1,0 "PHB-CH1","PHB-CH1-042",42,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,33.5,49.1,-15.6 "PHB-CH1","PHB-CH1-042",42,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,35.4,49.1,-13.7 "PHB-CH1","PHB-CH1-042",42,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,34.9,49.1,-14.2 "PHB-CH1","PHB-CH1-042",42,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,26.8,26.8,0 "PHB-CH1","PHB-CH1-042",42,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,18.9,26.8,-7.9 "PHB-CH1","PHB-CH1-042",42,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,21.7,26.8,-5.1 "PHB-CH1","PHB-CH1-042",42,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,14,26.8,-12.8 "PHB-CH1","PHB-CH1-042",42,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.1,4.1,0 "PHB-CH1","PHB-CH1-042",42,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.5,4.1,-0.6 "PHB-CH1","PHB-CH1-042",42,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.8,4.1,-0.3 "PHB-CH1","PHB-CH1-042",42,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.7,4.1,0.6 "PHB-CH1","PHB-CH1-042",42,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5,4.1,0.9 "PHB-CH1","PHB-CH1-042",42,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,7.1,4.1,3 "PHB-CH1","PHB-CH1-042",42,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,7.4,4.1,3.3 "PHB-CH1","PHB-CH1-042",42,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.2,4.1,3.1 "PHB-CH1","PHB-CH1-042",42,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.3,4.1,2.2 "PHB-CH1","PHB-CH1-042",42,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.3,4.1,0.2 "PHB-CH1","PHB-CH1-042",42,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.9,4.1,1.8 "PHB-CH1","PHB-CH1-042",42,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.2,4.1,1.1 "PHB-CH1","PHB-CH1-042",42,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.5,4.1,1.4 "PHB-CH1","PHB-CH1-042",42,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.7,4.1,-0.399999999999999 "PHB-CH1","PHB-CH1-042",42,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.8,2.8,0 "PHB-CH1","PHB-CH1-042",42,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,2.7,2.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-042",42,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,2.4,2.8,-0.4 "PHB-CH1","PHB-CH1-042",42,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3,2.8,0.2 "PHB-CH1","PHB-CH1-042",42,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5,2.8,2.2 "PHB-CH1","PHB-CH1-042",42,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.2,2.8,1.4 "PHB-CH1","PHB-CH1-042",42,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3,2.8,0.2 "PHB-CH1","PHB-CH1-042",42,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.3,2.8,1.5 "PHB-CH1","PHB-CH1-042",42,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.8,2.8,1 "PHB-CH1","PHB-CH1-042",42,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,1.9,2.8,-0.9 "PHB-CH1","PHB-CH1-042",42,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.9,2.8,1.1 "PHB-CH1","PHB-CH1-042",42,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.6,2.8,0.8 "PHB-CH1","PHB-CH1-042",42,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2.7,2.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-042",42,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,2.6,2.8,-0.2 "PHB-CH1","PHB-CH1-043",43,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,58,58,0 "PHB-CH1","PHB-CH1-043",43,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,63,58,5 "PHB-CH1","PHB-CH1-043",43,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,38,58,-20 "PHB-CH1","PHB-CH1-043",43,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,49,, "PHB-CH1","PHB-CH1-043",43,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,37,, "PHB-CH1","PHB-CH1-043",43,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,55,, "PHB-CH1","PHB-CH1-043",43,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-043",43,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,1,, "PHB-CH1","PHB-CH1-043",43,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-043",43,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-043",43,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,8,, "PHB-CH1","PHB-CH1-043",43,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,414,, "PHB-CH1","PHB-CH1-043",43,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-043",43,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-043",43,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-043",43,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-043",43,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,30.5,30.5,0 "PHB-CH1","PHB-CH1-043",43,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,48.8,30.5,18.3 "PHB-CH1","PHB-CH1-043",43,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,31.9,30.5,1.4 "PHB-CH1","PHB-CH1-043",43,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,32.3,30.5,1.8 "PHB-CH1","PHB-CH1-043",43,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,58.9,58.9,0 "PHB-CH1","PHB-CH1-043",43,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,55.5,58.9,-3.4 "PHB-CH1","PHB-CH1-043",43,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,54.7,58.9,-4.2 "PHB-CH1","PHB-CH1-043",43,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,32.9,58.9,-26 "PHB-CH1","PHB-CH1-043",43,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.3,6.3,0 "PHB-CH1","PHB-CH1-043",43,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5,6.3,-1.3 "PHB-CH1","PHB-CH1-043",43,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.8,6.3,-1.5 "PHB-CH1","PHB-CH1-043",43,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5,6.3,-1.3 "PHB-CH1","PHB-CH1-043",43,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.1,6.3,-2.2 "PHB-CH1","PHB-CH1-043",43,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.8,6.3,-1.5 "PHB-CH1","PHB-CH1-043",43,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.1,6.3,-2.2 "PHB-CH1","PHB-CH1-043",43,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.1,6.3,-1.2 "PHB-CH1","PHB-CH1-043",43,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.3,6.3,-1 "PHB-CH1","PHB-CH1-043",43,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.4,6.3,-0.9 "PHB-CH1","PHB-CH1-043",43,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.7,6.3,-2.6 "PHB-CH1","PHB-CH1-043",43,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.4,6.3,-0.9 "PHB-CH1","PHB-CH1-043",43,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.8,6.3,-1.5 "PHB-CH1","PHB-CH1-043",43,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.6,6.3,-1.7 "PHB-CH1","PHB-CH1-043",43,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.5,2.5,0 "PHB-CH1","PHB-CH1-043",43,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,1.3,2.5,-1.2 "PHB-CH1","PHB-CH1-043",43,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,0,2.5,-2.5 "PHB-CH1","PHB-CH1-043",43,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,1.4,2.5,-1.1 "PHB-CH1","PHB-CH1-043",43,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,1.9,2.5,-0.6 "PHB-CH1","PHB-CH1-043",43,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,1,2.5,-1.5 "PHB-CH1","PHB-CH1-043",43,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,0.7,2.5,-1.8 "PHB-CH1","PHB-CH1-043",43,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.3,2.5,-0.2 "PHB-CH1","PHB-CH1-043",43,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,1.4,2.5,-1.1 "PHB-CH1","PHB-CH1-043",43,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,1.5,2.5,-1 "PHB-CH1","PHB-CH1-043",43,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,1.6,2.5,-0.9 "PHB-CH1","PHB-CH1-043",43,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,2.1,2.5,-0.4 "PHB-CH1","PHB-CH1-043",43,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2,2.5,-0.5 "PHB-CH1","PHB-CH1-043",43,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,1.8,2.5,-0.7 "PHB-CH1","PHB-CH1-044",44,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,29,29,0 "PHB-CH1","PHB-CH1-044",44,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,37,29,8 "PHB-CH1","PHB-CH1-044",44,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,11,29,-18 "PHB-CH1","PHB-CH1-044",44,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,33,, "PHB-CH1","PHB-CH1-044",44,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,33,, "PHB-CH1","PHB-CH1-044",44,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,54,, "PHB-CH1","PHB-CH1-044",44,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-044",44,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-044",44,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-044",44,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-044",44,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,49,, "PHB-CH1","PHB-CH1-044",44,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,207,, "PHB-CH1","PHB-CH1-044",44,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-044",44,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-044",44,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-044",44,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-044",44,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,15.1,15.1,0 "PHB-CH1","PHB-CH1-044",44,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,6.2,15.1,-8.9 "PHB-CH1","PHB-CH1-044",44,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,32,15.1,16.9 "PHB-CH1","PHB-CH1-044",44,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,25.5,15.1,10.4 "PHB-CH1","PHB-CH1-044",44,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,27.4,27.4,0 "PHB-CH1","PHB-CH1-044",44,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,22.8,27.4,-4.6 "PHB-CH1","PHB-CH1-044",44,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,40.5,27.4,13.1 "PHB-CH1","PHB-CH1-044",44,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,45.3,27.4,17.9 "PHB-CH1","PHB-CH1-044",44,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.3,5.3,0 "PHB-CH1","PHB-CH1-044",44,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.2,5.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-044",44,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6,5.3,0.7 "PHB-CH1","PHB-CH1-044",44,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.7,5.3,1.4 "PHB-CH1","PHB-CH1-044",44,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.5,5.3,0.2 "PHB-CH1","PHB-CH1-044",44,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.6,5.3,0.3 "PHB-CH1","PHB-CH1-044",44,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.2,5.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-044",44,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.7,5.3,0.4 "PHB-CH1","PHB-CH1-044",44,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.4,5.3,-0.9 "PHB-CH1","PHB-CH1-044",44,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.3,5.3,0 "PHB-CH1","PHB-CH1-044",44,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.3,5.3,0 "PHB-CH1","PHB-CH1-044",44,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.1,5.3,-0.2 "PHB-CH1","PHB-CH1-044",44,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.4,5.3,0.100000000000001 "PHB-CH1","PHB-CH1-044",44,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.1,5.3,-1.2 "PHB-CH1","PHB-CH1-044",44,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.9,3.9,0 "PHB-CH1","PHB-CH1-044",44,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.3,3.9,1.4 "PHB-CH1","PHB-CH1-044",44,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6,3.9,2.1 "PHB-CH1","PHB-CH1-044",44,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.3,3.9,1.4 "PHB-CH1","PHB-CH1-044",44,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.3,3.9,0.4 "PHB-CH1","PHB-CH1-044",44,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4,3.9,0.1 "PHB-CH1","PHB-CH1-044",44,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.3,3.9,-0.6 "PHB-CH1","PHB-CH1-044",44,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.7,3.9,-0.2 "PHB-CH1","PHB-CH1-044",44,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.5,3.9,0.6 "PHB-CH1","PHB-CH1-044",44,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.3,3.9,1.4 "PHB-CH1","PHB-CH1-044",44,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4,3.9,0.1 "PHB-CH1","PHB-CH1-044",44,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5,3.9,1.1 "PHB-CH1","PHB-CH1-044",44,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.6,3.9,0.7 "PHB-CH1","PHB-CH1-044",44,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.8,3.9,0.9 "PHB-CH1","PHB-CH1-045",45,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,62,62,0 "PHB-CH1","PHB-CH1-045",45,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,57,62,-5 "PHB-CH1","PHB-CH1-045",45,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,58,62,-4 "PHB-CH1","PHB-CH1-045",45,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,75,, "PHB-CH1","PHB-CH1-045",45,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,61,, "PHB-CH1","PHB-CH1-045",45,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,66,, "PHB-CH1","PHB-CH1-045",45,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-045",45,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-045",45,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-045",45,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-045",45,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,36,, "PHB-CH1","PHB-CH1-045",45,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,238,, "PHB-CH1","PHB-CH1-045",45,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-045",45,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-045",45,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-045",45,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-045",45,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,44.4,44.4,0 "PHB-CH1","PHB-CH1-045",45,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,37,44.4,-7.4 "PHB-CH1","PHB-CH1-045",45,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,37,44.4,-7.4 "PHB-CH1","PHB-CH1-045",45,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,35.4,44.4,-9 "PHB-CH1","PHB-CH1-045",45,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,46.5,46.5,0 "PHB-CH1","PHB-CH1-045",45,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,36,46.5,-10.5 "PHB-CH1","PHB-CH1-045",45,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,47.7,46.5,1.2 "PHB-CH1","PHB-CH1-045",45,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,45.8,46.5,-0.700000000000003 "PHB-CH1","PHB-CH1-045",45,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-045",45,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.2,5.1,0.100000000000001 "PHB-CH1","PHB-CH1-045",45,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.6,5.1,-0.5 "PHB-CH1","PHB-CH1-045",45,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.7,5.1,-1.4 "PHB-CH1","PHB-CH1-045",45,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.5,5.1,-0.6 "PHB-CH1","PHB-CH1-045",45,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.9,5.1,0.800000000000001 "PHB-CH1","PHB-CH1-045",45,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.9,5.1,-1.2 "PHB-CH1","PHB-CH1-045",45,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.6,5.1,-1.5 "PHB-CH1","PHB-CH1-045",45,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.2,5.1,-1.9 "PHB-CH1","PHB-CH1-045",45,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.7,5.1,-1.4 "PHB-CH1","PHB-CH1-045",45,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.3,5.1,0.2 "PHB-CH1","PHB-CH1-045",45,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.4,5.1,0.300000000000001 "PHB-CH1","PHB-CH1-045",45,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.9,5.1,-0.199999999999999 "PHB-CH1","PHB-CH1-045",45,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.8,5.1,-0.3 "PHB-CH1","PHB-CH1-045",45,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.2,3.2,0 "PHB-CH1","PHB-CH1-045",45,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.4,3.2,1.2 "PHB-CH1","PHB-CH1-045",45,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.2,3.2,1 "PHB-CH1","PHB-CH1-045",45,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4,3.2,0.8 "PHB-CH1","PHB-CH1-045",45,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,2.8,3.2,-0.4 "PHB-CH1","PHB-CH1-045",45,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.3,3.2,0.0999999999999996 "PHB-CH1","PHB-CH1-045",45,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,2.1,3.2,-1.1 "PHB-CH1","PHB-CH1-045",45,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,1.9,3.2,-1.3 "PHB-CH1","PHB-CH1-045",45,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.2,3.2,-1 "PHB-CH1","PHB-CH1-045",45,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,2.6,3.2,-0.6 "PHB-CH1","PHB-CH1-045",45,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.4,3.2,0.2 "PHB-CH1","PHB-CH1-045",45,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.7,3.2,1.5 "PHB-CH1","PHB-CH1-045",45,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.1,3.2,-0.1 "PHB-CH1","PHB-CH1-045",45,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.5,3.2,0.3 "PHB-CH1","PHB-CH1-046",46,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,34,34,0 "PHB-CH1","PHB-CH1-046",46,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,24,34,-10 "PHB-CH1","PHB-CH1-046",46,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,29,34,-5 "PHB-CH1","PHB-CH1-046",46,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,23,, "PHB-CH1","PHB-CH1-046",46,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,38,, "PHB-CH1","PHB-CH1-046",46,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,24,, "PHB-CH1","PHB-CH1-046",46,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-046",46,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-046",46,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-046",46,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-046",46,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,4,, "PHB-CH1","PHB-CH1-046",46,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,473,, "PHB-CH1","PHB-CH1-046",46,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-046",46,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-046",46,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-046",46,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-046",46,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,57.2,57.2,0 "PHB-CH1","PHB-CH1-046",46,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,61.3,57.2,4.09999999999999 "PHB-CH1","PHB-CH1-046",46,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,68.7,57.2,11.5 "PHB-CH1","PHB-CH1-046",46,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,71.2,57.2,14 "PHB-CH1","PHB-CH1-046",46,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,85,85,0 "PHB-CH1","PHB-CH1-046",46,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,78.4,85,-6.59999999999999 "PHB-CH1","PHB-CH1-046",46,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,73,85,-12 "PHB-CH1","PHB-CH1-046",46,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,74.4,85,-10.6 "PHB-CH1","PHB-CH1-046",46,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.6,5.6,0 "PHB-CH1","PHB-CH1-046",46,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.6,5.6,-1 "PHB-CH1","PHB-CH1-046",46,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.1,5.6,-0.5 "PHB-CH1","PHB-CH1-046",46,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.1,5.6,0.5 "PHB-CH1","PHB-CH1-046",46,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.1,5.6,0.5 "PHB-CH1","PHB-CH1-046",46,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6,5.6,0.4 "PHB-CH1","PHB-CH1-046",46,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.5,5.6,-1.1 "PHB-CH1","PHB-CH1-046",46,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.5,5.6,0.9 "PHB-CH1","PHB-CH1-046",46,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.1,5.6,0.5 "PHB-CH1","PHB-CH1-046",46,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,2.9,5.6,-2.7 "PHB-CH1","PHB-CH1-046",46,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.3,5.6,-1.3 "PHB-CH1","PHB-CH1-046",46,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.4,5.6,-0.199999999999999 "PHB-CH1","PHB-CH1-046",46,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.9,5.6,0.300000000000001 "PHB-CH1","PHB-CH1-046",46,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.7,5.6,0.100000000000001 "PHB-CH1","PHB-CH1-046",46,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-046",46,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.7,5.1,-0.399999999999999 "PHB-CH1","PHB-CH1-046",46,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.1,5.1,-1 "PHB-CH1","PHB-CH1-046",46,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.6,5.1,-0.5 "PHB-CH1","PHB-CH1-046",46,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.8,5.1,0.7 "PHB-CH1","PHB-CH1-046",46,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.9,5.1,0.800000000000001 "PHB-CH1","PHB-CH1-046",46,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.8,5.1,-1.3 "PHB-CH1","PHB-CH1-046",46,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.2,5.1,-0.9 "PHB-CH1","PHB-CH1-046",46,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.9,5.1,-0.199999999999999 "PHB-CH1","PHB-CH1-046",46,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.4,5.1,-1.7 "PHB-CH1","PHB-CH1-046",46,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.1,5.1,-1 "PHB-CH1","PHB-CH1-046",46,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.8,5.1,-0.3 "PHB-CH1","PHB-CH1-046",46,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.6,5.1,0.5 "PHB-CH1","PHB-CH1-046",46,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5,5.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-047",47,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,64,64,0 "PHB-CH1","PHB-CH1-047",47,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,66,64,2 "PHB-CH1","PHB-CH1-047",47,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,51,64,-13 "PHB-CH1","PHB-CH1-047",47,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,44,, "PHB-CH1","PHB-CH1-047",47,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,67,, "PHB-CH1","PHB-CH1-047",47,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,59,, "PHB-CH1","PHB-CH1-047",47,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-047",47,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-047",47,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-047",47,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-047",47,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,5,, "PHB-CH1","PHB-CH1-047",47,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,455,, "PHB-CH1","PHB-CH1-047",47,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-047",47,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-047",47,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-047",47,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-047",47,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,56.6,56.6,0 "PHB-CH1","PHB-CH1-047",47,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,56.5,56.6,-0.100000000000001 "PHB-CH1","PHB-CH1-047",47,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,56.6,56.6,0 "PHB-CH1","PHB-CH1-047",47,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,48.8,56.6,-7.8 "PHB-CH1","PHB-CH1-047",47,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,63.3,63.3,0 "PHB-CH1","PHB-CH1-047",47,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,57.4,63.3,-5.9 "PHB-CH1","PHB-CH1-047",47,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,65.3,63.3,2 "PHB-CH1","PHB-CH1-047",47,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,61.5,63.3,-1.8 "PHB-CH1","PHB-CH1-047",47,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3,3,0 "PHB-CH1","PHB-CH1-047",47,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.8,3,0.8 "PHB-CH1","PHB-CH1-047",47,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.7,3,-0.3 "PHB-CH1","PHB-CH1-047",47,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.2,3,-0.8 "PHB-CH1","PHB-CH1-047",47,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3,3,0 "PHB-CH1","PHB-CH1-047",47,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.3,3,0.3 "PHB-CH1","PHB-CH1-047",47,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.9,3,0.9 "PHB-CH1","PHB-CH1-047",47,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.3,3,0.3 "PHB-CH1","PHB-CH1-047",47,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.3,3,0.3 "PHB-CH1","PHB-CH1-047",47,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,2.5,3,-0.5 "PHB-CH1","PHB-CH1-047",47,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.4,3,0.4 "PHB-CH1","PHB-CH1-047",47,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.5,3,0.5 "PHB-CH1","PHB-CH1-047",47,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4,3,1 "PHB-CH1","PHB-CH1-047",47,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2.8,3,-0.2 "PHB-CH1","PHB-CH1-047",47,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-047",47,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.9,5.4,-0.5 "PHB-CH1","PHB-CH1-047",47,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.3,5.4,-1.1 "PHB-CH1","PHB-CH1-047",47,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.2,5.4,-0.2 "PHB-CH1","PHB-CH1-047",47,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.5,5.4,0.0999999999999996 "PHB-CH1","PHB-CH1-047",47,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.9,5.4,0.5 "PHB-CH1","PHB-CH1-047",47,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.8,5.4,1.4 "PHB-CH1","PHB-CH1-047",47,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,7.6,5.4,2.2 "PHB-CH1","PHB-CH1-047",47,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.6,5.4,0.199999999999999 "PHB-CH1","PHB-CH1-047",47,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.1,5.4,-1.3 "PHB-CH1","PHB-CH1-047",47,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.4,5.4,-1 "PHB-CH1","PHB-CH1-047",47,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.1,5.4,0.699999999999999 "PHB-CH1","PHB-CH1-047",47,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.3,5.4,0.9 "PHB-CH1","PHB-CH1-047",47,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.4,5.4,-1 "PHB-CH1","PHB-CH1-048",48,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,57,57,0 "PHB-CH1","PHB-CH1-048",48,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,58,57,1 "PHB-CH1","PHB-CH1-048",48,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,54,57,-3 "PHB-CH1","PHB-CH1-048",48,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,59,, "PHB-CH1","PHB-CH1-048",48,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,50,, "PHB-CH1","PHB-CH1-048",48,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,36,, "PHB-CH1","PHB-CH1-048",48,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-048",48,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-048",48,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-048",48,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-048",48,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,1,, "PHB-CH1","PHB-CH1-048",48,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,600,, "PHB-CH1","PHB-CH1-048",48,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-048",48,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-048",48,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-048",48,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-048",48,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,59.8,59.8,0 "PHB-CH1","PHB-CH1-048",48,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,74.2,59.8,14.4 "PHB-CH1","PHB-CH1-048",48,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,73.6,59.8,13.8 "PHB-CH1","PHB-CH1-048",48,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,71.1,59.8,11.3 "PHB-CH1","PHB-CH1-048",48,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,69.3,69.3,0 "PHB-CH1","PHB-CH1-048",48,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,69.4,69.3,0.100000000000009 "PHB-CH1","PHB-CH1-048",48,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,86.4,69.3,17.1 "PHB-CH1","PHB-CH1-048",48,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,61,69.3,-8.3 "PHB-CH1","PHB-CH1-048",48,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.2,6.2,0 "PHB-CH1","PHB-CH1-048",48,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,7,6.2,0.8 "PHB-CH1","PHB-CH1-048",48,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7.4,6.2,1.2 "PHB-CH1","PHB-CH1-048",48,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,7,6.2,0.8 "PHB-CH1","PHB-CH1-048",48,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.9,6.2,-0.3 "PHB-CH1","PHB-CH1-048",48,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.5,6.2,0.3 "PHB-CH1","PHB-CH1-048",48,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.6,6.2,-0.6 "PHB-CH1","PHB-CH1-048",48,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.8,6.2,0.6 "PHB-CH1","PHB-CH1-048",48,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.8,6.2,-0.4 "PHB-CH1","PHB-CH1-048",48,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.8,6.2,0.6 "PHB-CH1","PHB-CH1-048",48,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,7.7,6.2,1.5 "PHB-CH1","PHB-CH1-048",48,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.3,6.2,0.0999999999999996 "PHB-CH1","PHB-CH1-048",48,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.8,6.2,-0.4 "PHB-CH1","PHB-CH1-048",48,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.4,6.2,0.2 "PHB-CH1","PHB-CH1-048",48,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6,6,0 "PHB-CH1","PHB-CH1-048",48,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.4,6,-0.6 "PHB-CH1","PHB-CH1-048",48,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.2,6,-0.8 "PHB-CH1","PHB-CH1-048",48,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5,6,-1 "PHB-CH1","PHB-CH1-048",48,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.1,6,-1.9 "PHB-CH1","PHB-CH1-048",48,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.8,6,-2.2 "PHB-CH1","PHB-CH1-048",48,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.8,6,-2.2 "PHB-CH1","PHB-CH1-048",48,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.2,6,-1.8 "PHB-CH1","PHB-CH1-048",48,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.7,6,-2.3 "PHB-CH1","PHB-CH1-048",48,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.5,6,-1.5 "PHB-CH1","PHB-CH1-048",48,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.4,6,0.4 "PHB-CH1","PHB-CH1-048",48,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.1,6,-1.9 "PHB-CH1","PHB-CH1-048",48,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.5,6,-2.5 "PHB-CH1","PHB-CH1-048",48,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.6,6,-1.4 "PHB-CH1","PHB-CH1-049",49,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,50,50,0 "PHB-CH1","PHB-CH1-049",49,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,45,50,-5 "PHB-CH1","PHB-CH1-049",49,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,38,50,-12 "PHB-CH1","PHB-CH1-049",49,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,53,, "PHB-CH1","PHB-CH1-049",49,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,41,, "PHB-CH1","PHB-CH1-049",49,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,78,, "PHB-CH1","PHB-CH1-049",49,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-049",49,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-049",49,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-049",49,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-049",49,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,2,, "PHB-CH1","PHB-CH1-049",49,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,536,, "PHB-CH1","PHB-CH1-049",49,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-049",49,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-049",49,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-049",49,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-049",49,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,42.3,42.3,0 "PHB-CH1","PHB-CH1-049",49,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,46.6,42.3,4.3 "PHB-CH1","PHB-CH1-049",49,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,51.7,42.3,9.40000000000001 "PHB-CH1","PHB-CH1-049",49,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,56.5,42.3,14.2 "PHB-CH1","PHB-CH1-049",49,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,47.5,47.5,0 "PHB-CH1","PHB-CH1-049",49,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,70.4,47.5,22.9 "PHB-CH1","PHB-CH1-049",49,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,71.9,47.5,24.4 "PHB-CH1","PHB-CH1-049",49,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,58.9,47.5,11.4 "PHB-CH1","PHB-CH1-049",49,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-049",49,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.1,5.4,0.699999999999999 "PHB-CH1","PHB-CH1-049",49,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.8,5.4,0.399999999999999 "PHB-CH1","PHB-CH1-049",49,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.2,5.4,-0.2 "PHB-CH1","PHB-CH1-049",49,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5,5.4,-0.4 "PHB-CH1","PHB-CH1-049",49,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.4,5.4,0 "PHB-CH1","PHB-CH1-049",49,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5,5.4,-0.4 "PHB-CH1","PHB-CH1-049",49,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.8,5.4,-0.6 "PHB-CH1","PHB-CH1-049",49,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.5,5.4,-1.9 "PHB-CH1","PHB-CH1-049",49,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.3,5.4,-1.1 "PHB-CH1","PHB-CH1-049",49,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6,5.4,0.6 "PHB-CH1","PHB-CH1-049",49,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.1,5.4,-0.300000000000001 "PHB-CH1","PHB-CH1-049",49,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.3,5.4,-0.100000000000001 "PHB-CH1","PHB-CH1-049",49,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.4,5.4,1 "PHB-CH1","PHB-CH1-049",49,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.5,4.5,0 "PHB-CH1","PHB-CH1-049",49,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.1,4.5,0.6 "PHB-CH1","PHB-CH1-049",49,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.2,4.5,0.7 "PHB-CH1","PHB-CH1-049",49,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5,4.5,0.5 "PHB-CH1","PHB-CH1-049",49,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.2,4.5,-0.3 "PHB-CH1","PHB-CH1-049",49,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.4,4.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-049",49,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.5,4.5,-1 "PHB-CH1","PHB-CH1-049",49,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.2,4.5,-1.3 "PHB-CH1","PHB-CH1-049",49,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4,4.5,-0.5 "PHB-CH1","PHB-CH1-049",49,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.2,4.5,-0.3 "PHB-CH1","PHB-CH1-049",49,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.4,4.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-049",49,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.8,4.5,-0.7 "PHB-CH1","PHB-CH1-049",49,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.2,4.5,-0.3 "PHB-CH1","PHB-CH1-049",49,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.5,4.5,1 "PHB-CH1","PHB-CH1-050",50,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,25,25,0 "PHB-CH1","PHB-CH1-050",50,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,33,25,8 "PHB-CH1","PHB-CH1-050",50,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,27,25,2 "PHB-CH1","PHB-CH1-050",50,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,36,, "PHB-CH1","PHB-CH1-050",50,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,40,, "PHB-CH1","PHB-CH1-050",50,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,28,, "PHB-CH1","PHB-CH1-050",50,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-050",50,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-050",50,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-050",50,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-050",50,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,0,, "PHB-CH1","PHB-CH1-050",50,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,622,, "PHB-CH1","PHB-CH1-050",50,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-050",50,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-050",50,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-050",50,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-050",50,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,55.7,55.7,0 "PHB-CH1","PHB-CH1-050",50,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,35.4,55.7,-20.3 "PHB-CH1","PHB-CH1-050",50,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,56.3,55.7,0.599999999999994 "PHB-CH1","PHB-CH1-050",50,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,49.7,55.7,-6 "PHB-CH1","PHB-CH1-050",50,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,67.8,67.8,0 "PHB-CH1","PHB-CH1-050",50,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,58.9,67.8,-8.9 "PHB-CH1","PHB-CH1-050",50,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,67.8,67.8,0 "PHB-CH1","PHB-CH1-050",50,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,64.2,67.8,-3.59999999999999 "PHB-CH1","PHB-CH1-050",50,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,7.7,7.7,0 "PHB-CH1","PHB-CH1-050",50,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.7,7.7,-1 "PHB-CH1","PHB-CH1-050",50,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.1,7.7,-1.6 "PHB-CH1","PHB-CH1-050",50,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.4,7.7,-4.3 "PHB-CH1","PHB-CH1-050",50,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.9,7.7,-2.8 "PHB-CH1","PHB-CH1-050",50,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.2,7.7,-1.5 "PHB-CH1","PHB-CH1-050",50,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.7,7.7,-3 "PHB-CH1","PHB-CH1-050",50,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.2,7.7,-0.5 "PHB-CH1","PHB-CH1-050",50,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.8,7.7,-0.9 "PHB-CH1","PHB-CH1-050",50,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.9,7.7,-3.8 "PHB-CH1","PHB-CH1-050",50,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.2,7.7,-3.5 "PHB-CH1","PHB-CH1-050",50,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.8,7.7,-3.9 "PHB-CH1","PHB-CH1-050",50,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.4,7.7,-3.3 "PHB-CH1","PHB-CH1-050",50,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.9,7.7,-1.8 "PHB-CH1","PHB-CH1-050",50,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.8,6.8,0 "PHB-CH1","PHB-CH1-050",50,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.3,6.8,-1.5 "PHB-CH1","PHB-CH1-050",50,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.1,6.8,-0.7 "PHB-CH1","PHB-CH1-050",50,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.4,6.8,-2.4 "PHB-CH1","PHB-CH1-050",50,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.1,6.8,-1.7 "PHB-CH1","PHB-CH1-050",50,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.1,6.8,-1.7 "PHB-CH1","PHB-CH1-050",50,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.6,6.8,-2.2 "PHB-CH1","PHB-CH1-050",50,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.5,6.8,-0.3 "PHB-CH1","PHB-CH1-050",50,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.1,6.8,-0.7 "PHB-CH1","PHB-CH1-050",50,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.4,6.8,-0.399999999999999 "PHB-CH1","PHB-CH1-050",50,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.8,6.8,-1 "PHB-CH1","PHB-CH1-050",50,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.3,6.8,-1.5 "PHB-CH1","PHB-CH1-050",50,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.7,6.8,-3.1 "PHB-CH1","PHB-CH1-050",50,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.6,6.8,-2.2 "PHB-CH1","PHB-CH1-051",51,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,60,60,0 "PHB-CH1","PHB-CH1-051",51,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,57,60,-3 "PHB-CH1","PHB-CH1-051",51,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,46,60,-14 "PHB-CH1","PHB-CH1-051",51,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,60,, "PHB-CH1","PHB-CH1-051",51,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,66,, "PHB-CH1","PHB-CH1-051",51,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,57,, "PHB-CH1","PHB-CH1-051",51,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-051",51,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-051",51,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-051",51,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-051",51,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,18,, "PHB-CH1","PHB-CH1-051",51,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,339,, "PHB-CH1","PHB-CH1-051",51,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-051",51,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-051",51,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-051",51,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-051",51,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,22.6,22.6,0 "PHB-CH1","PHB-CH1-051",51,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,21.5,22.6,-1.1 "PHB-CH1","PHB-CH1-051",51,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,27.6,22.6,5 "PHB-CH1","PHB-CH1-051",51,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,18.9,22.6,-3.7 "PHB-CH1","PHB-CH1-051",51,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,31.9,31.9,0 "PHB-CH1","PHB-CH1-051",51,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,35.4,31.9,3.5 "PHB-CH1","PHB-CH1-051",51,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,37.4,31.9,5.5 "PHB-CH1","PHB-CH1-051",51,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,32.4,31.9,0.5 "PHB-CH1","PHB-CH1-051",51,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.7,6.7,0 "PHB-CH1","PHB-CH1-051",51,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.8,6.7,0.0999999999999996 "PHB-CH1","PHB-CH1-051",51,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.6,6.7,-0.100000000000001 "PHB-CH1","PHB-CH1-051",51,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.3,6.7,-1.4 "PHB-CH1","PHB-CH1-051",51,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.8,6.7,-2.9 "PHB-CH1","PHB-CH1-051",51,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5,6.7,-1.7 "PHB-CH1","PHB-CH1-051",51,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.2,6.7,-2.5 "PHB-CH1","PHB-CH1-051",51,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,2.9,6.7,-3.8 "PHB-CH1","PHB-CH1-051",51,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,2.1,6.7,-4.6 "PHB-CH1","PHB-CH1-051",51,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.1,6.7,-3.6 "PHB-CH1","PHB-CH1-051",51,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.6,6.7,-4.1 "PHB-CH1","PHB-CH1-051",51,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.6,6.7,-3.1 "PHB-CH1","PHB-CH1-051",51,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.6,6.7,-1.1 "PHB-CH1","PHB-CH1-051",51,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.8,6.7,-1.9 "PHB-CH1","PHB-CH1-051",51,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.2,4.2,0 "PHB-CH1","PHB-CH1-051",51,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.1,4.2,0.9 "PHB-CH1","PHB-CH1-051",51,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.5,4.2,0.3 "PHB-CH1","PHB-CH1-051",51,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.8,4.2,0.6 "PHB-CH1","PHB-CH1-051",51,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.5,4.2,0.3 "PHB-CH1","PHB-CH1-051",51,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4,4.2,-0.2 "PHB-CH1","PHB-CH1-051",51,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4,4.2,-0.2 "PHB-CH1","PHB-CH1-051",51,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.1,4.2,-0.100000000000001 "PHB-CH1","PHB-CH1-051",51,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.1,4.2,-1.1 "PHB-CH1","PHB-CH1-051",51,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,2.8,4.2,-1.4 "PHB-CH1","PHB-CH1-051",51,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,2.9,4.2,-1.3 "PHB-CH1","PHB-CH1-051",51,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.6,4.2,-0.6 "PHB-CH1","PHB-CH1-051",51,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.1,4.2,0.9 "PHB-CH1","PHB-CH1-051",51,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4,4.2,-0.2 "PHB-CH1","PHB-CH1-052",52,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,51,51,0 "PHB-CH1","PHB-CH1-052",52,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,63,51,12 "PHB-CH1","PHB-CH1-052",52,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,50,51,-1 "PHB-CH1","PHB-CH1-052",52,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,51,, "PHB-CH1","PHB-CH1-052",52,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,65,, "PHB-CH1","PHB-CH1-052",52,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,60,, "PHB-CH1","PHB-CH1-052",52,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-052",52,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-052",52,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-052",52,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-052",52,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,3,, "PHB-CH1","PHB-CH1-052",52,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,522,, "PHB-CH1","PHB-CH1-052",52,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-052",52,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-052",52,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-052",52,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-052",52,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,62.3,62.3,0 "PHB-CH1","PHB-CH1-052",52,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,59.6,62.3,-2.7 "PHB-CH1","PHB-CH1-052",52,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,53,62.3,-9.3 "PHB-CH1","PHB-CH1-052",52,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,63.6,62.3,1.3 "PHB-CH1","PHB-CH1-052",52,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,68.6,68.6,0 "PHB-CH1","PHB-CH1-052",52,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,74.4,68.6,5.80000000000001 "PHB-CH1","PHB-CH1-052",52,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,58.2,68.6,-10.4 "PHB-CH1","PHB-CH1-052",52,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,61.5,68.6,-7.09999999999999 "PHB-CH1","PHB-CH1-052",52,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.7,5.7,0 "PHB-CH1","PHB-CH1-052",52,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.8,5.7,-0.9 "PHB-CH1","PHB-CH1-052",52,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.7,5.7,0 "PHB-CH1","PHB-CH1-052",52,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.3,5.7,-0.4 "PHB-CH1","PHB-CH1-052",52,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.6,5.7,-0.100000000000001 "PHB-CH1","PHB-CH1-052",52,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.9,5.7,0.2 "PHB-CH1","PHB-CH1-052",52,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.9,5.7,-1.8 "PHB-CH1","PHB-CH1-052",52,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.7,5.7,-2 "PHB-CH1","PHB-CH1-052",52,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,2.9,5.7,-2.8 "PHB-CH1","PHB-CH1-052",52,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.1,5.7,-2.6 "PHB-CH1","PHB-CH1-052",52,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.3,5.7,-0.4 "PHB-CH1","PHB-CH1-052",52,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.1,5.7,-0.6 "PHB-CH1","PHB-CH1-052",52,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.5,5.7,-0.2 "PHB-CH1","PHB-CH1-052",52,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6,5.7,0.3 "PHB-CH1","PHB-CH1-052",52,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.9,5.9,0 "PHB-CH1","PHB-CH1-052",52,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.1,5.9,-0.800000000000001 "PHB-CH1","PHB-CH1-052",52,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.4,5.9,-0.5 "PHB-CH1","PHB-CH1-052",52,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.5,5.9,-0.4 "PHB-CH1","PHB-CH1-052",52,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.8,5.9,-0.100000000000001 "PHB-CH1","PHB-CH1-052",52,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.1,5.9,0.199999999999999 "PHB-CH1","PHB-CH1-052",52,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.1,5.9,-0.800000000000001 "PHB-CH1","PHB-CH1-052",52,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.7,5.9,-0.2 "PHB-CH1","PHB-CH1-052",52,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.3,5.9,-0.6 "PHB-CH1","PHB-CH1-052",52,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.9,5.9,0 "PHB-CH1","PHB-CH1-052",52,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.7,5.9,0.8 "PHB-CH1","PHB-CH1-052",52,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.8,5.9,0.9 "PHB-CH1","PHB-CH1-052",52,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5,5.9,-0.9 "PHB-CH1","PHB-CH1-052",52,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.2,5.9,-0.7 "PHB-CH1","PHB-CH1-053",53,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,73,73,0 "PHB-CH1","PHB-CH1-053",53,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,71,73,-2 "PHB-CH1","PHB-CH1-053",53,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,60,73,-13 "PHB-CH1","PHB-CH1-053",53,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,69,, "PHB-CH1","PHB-CH1-053",53,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,73,, "PHB-CH1","PHB-CH1-053",53,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,59,, "PHB-CH1","PHB-CH1-053",53,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-053",53,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-053",53,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-053",53,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-053",53,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,8,, "PHB-CH1","PHB-CH1-053",53,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,430,, "PHB-CH1","PHB-CH1-053",53,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-053",53,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-053",53,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-053",53,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-053",53,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,56.2,56.2,0 "PHB-CH1","PHB-CH1-053",53,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,36.6,56.2,-19.6 "PHB-CH1","PHB-CH1-053",53,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,51.7,56.2,-4.5 "PHB-CH1","PHB-CH1-053",53,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,51.1,56.2,-5.1 "PHB-CH1","PHB-CH1-053",53,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,65.5,65.5,0 "PHB-CH1","PHB-CH1-053",53,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,42.8,65.5,-22.7 "PHB-CH1","PHB-CH1-053",53,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,39.2,65.5,-26.3 "PHB-CH1","PHB-CH1-053",53,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,49.5,65.5,-16 "PHB-CH1","PHB-CH1-053",53,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.5,5.5,0 "PHB-CH1","PHB-CH1-053",53,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6,5.5,0.5 "PHB-CH1","PHB-CH1-053",53,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.2,5.5,-0.3 "PHB-CH1","PHB-CH1-053",53,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.3,5.5,-0.2 "PHB-CH1","PHB-CH1-053",53,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.6,5.5,-0.9 "PHB-CH1","PHB-CH1-053",53,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.2,5.5,-1.3 "PHB-CH1","PHB-CH1-053",53,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.5,5.5,-2 "PHB-CH1","PHB-CH1-053",53,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.1,5.5,-0.4 "PHB-CH1","PHB-CH1-053",53,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.1,5.5,-0.4 "PHB-CH1","PHB-CH1-053",53,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.7,5.5,-1.8 "PHB-CH1","PHB-CH1-053",53,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4,5.5,-1.5 "PHB-CH1","PHB-CH1-053",53,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.7,5.5,-1.8 "PHB-CH1","PHB-CH1-053",53,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.7,5.5,-0.8 "PHB-CH1","PHB-CH1-053",53,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.5,5.5,-1 "PHB-CH1","PHB-CH1-053",53,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.3,4.3,0 "PHB-CH1","PHB-CH1-053",53,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.9,4.3,1.6 "PHB-CH1","PHB-CH1-053",53,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.1,4.3,-0.2 "PHB-CH1","PHB-CH1-053",53,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.6,4.3,-0.7 "PHB-CH1","PHB-CH1-053",53,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.2,4.3,-1.1 "PHB-CH1","PHB-CH1-053",53,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.8,4.3,-0.5 "PHB-CH1","PHB-CH1-053",53,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.7,4.3,-0.6 "PHB-CH1","PHB-CH1-053",53,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.5,4.3,-0.8 "PHB-CH1","PHB-CH1-053",53,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.1,4.3,-1.2 "PHB-CH1","PHB-CH1-053",53,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,0.2,4.3,-4.1 "PHB-CH1","PHB-CH1-053",53,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3,4.3,-1.3 "PHB-CH1","PHB-CH1-053",53,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,2,4.3,-2.3 "PHB-CH1","PHB-CH1-053",53,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.5,4.3,-0.8 "PHB-CH1","PHB-CH1-053",53,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.2,4.3,-1.1 "PHB-CH1","PHB-CH1-054",54,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,66,66,0 "PHB-CH1","PHB-CH1-054",54,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,61,66,-5 "PHB-CH1","PHB-CH1-054",54,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,59,66,-7 "PHB-CH1","PHB-CH1-054",54,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,86,, "PHB-CH1","PHB-CH1-054",54,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,68,, "PHB-CH1","PHB-CH1-054",54,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,70,, "PHB-CH1","PHB-CH1-054",54,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-054",54,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-054",54,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-054",54,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-054",54,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,37,, "PHB-CH1","PHB-CH1-054",54,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,156,, "PHB-CH1","PHB-CH1-054",54,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-054",54,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-054",54,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-054",54,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-054",54,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,31.1,31.1,0 "PHB-CH1","PHB-CH1-054",54,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,22,31.1,-9.1 "PHB-CH1","PHB-CH1-054",54,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,39.8,31.1,8.7 "PHB-CH1","PHB-CH1-054",54,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,30.2,31.1,-0.900000000000002 "PHB-CH1","PHB-CH1-054",54,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,50.1,50.1,0 "PHB-CH1","PHB-CH1-054",54,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,45,50.1,-5.1 "PHB-CH1","PHB-CH1-054",54,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,49.4,50.1,-0.700000000000003 "PHB-CH1","PHB-CH1-054",54,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,44.8,50.1,-5.3 "PHB-CH1","PHB-CH1-054",54,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.5,5.5,0 "PHB-CH1","PHB-CH1-054",54,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.4,5.5,-2.1 "PHB-CH1","PHB-CH1-054",54,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.6,5.5,-1.9 "PHB-CH1","PHB-CH1-054",54,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.9,5.5,-1.6 "PHB-CH1","PHB-CH1-054",54,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.6,5.5,-0.9 "PHB-CH1","PHB-CH1-054",54,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3,5.5,-2.5 "PHB-CH1","PHB-CH1-054",54,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.8,5.5,-1.7 "PHB-CH1","PHB-CH1-054",54,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4,5.5,-1.5 "PHB-CH1","PHB-CH1-054",54,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.8,5.5,-0.7 "PHB-CH1","PHB-CH1-054",54,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4,5.5,-1.5 "PHB-CH1","PHB-CH1-054",54,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.7,5.5,-0.8 "PHB-CH1","PHB-CH1-054",54,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.7,5.5,-1.8 "PHB-CH1","PHB-CH1-054",54,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.2,5.5,-1.3 "PHB-CH1","PHB-CH1-054",54,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.4,5.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-054",54,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.8,6.8,0 "PHB-CH1","PHB-CH1-054",54,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.7,6.8,-1.1 "PHB-CH1","PHB-CH1-054",54,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.9,6.8,0.100000000000001 "PHB-CH1","PHB-CH1-054",54,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.4,6.8,-0.399999999999999 "PHB-CH1","PHB-CH1-054",54,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.8,6.8,-1 "PHB-CH1","PHB-CH1-054",54,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.4,6.8,-0.399999999999999 "PHB-CH1","PHB-CH1-054",54,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7.5,6.8,0.7 "PHB-CH1","PHB-CH1-054",54,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,7.2,6.8,0.4 "PHB-CH1","PHB-CH1-054",54,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.1,6.8,0.3 "PHB-CH1","PHB-CH1-054",54,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.6,6.8,-0.2 "PHB-CH1","PHB-CH1-054",54,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,8,6.8,1.2 "PHB-CH1","PHB-CH1-054",54,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.9,6.8,0.100000000000001 "PHB-CH1","PHB-CH1-054",54,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.3,6.8,-0.5 "PHB-CH1","PHB-CH1-054",54,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.3,6.8,-0.5 "PHB-CH1","PHB-CH1-055",55,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,54,54,0 "PHB-CH1","PHB-CH1-055",55,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,64,54,10 "PHB-CH1","PHB-CH1-055",55,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,36,54,-18 "PHB-CH1","PHB-CH1-055",55,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,60,, "PHB-CH1","PHB-CH1-055",55,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,60,, "PHB-CH1","PHB-CH1-055",55,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,65,, "PHB-CH1","PHB-CH1-055",55,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-055",55,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-055",55,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-055",55,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-055",55,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,18,, "PHB-CH1","PHB-CH1-055",55,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,337,, "PHB-CH1","PHB-CH1-055",55,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-055",55,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-055",55,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-055",55,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-055",55,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,71.4,71.4,0 "PHB-CH1","PHB-CH1-055",55,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,65.9,71.4,-5.5 "PHB-CH1","PHB-CH1-055",55,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,70.6,71.4,-0.800000000000011 "PHB-CH1","PHB-CH1-055",55,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,88,71.4,16.6 "PHB-CH1","PHB-CH1-055",55,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,50.1,50.1,0 "PHB-CH1","PHB-CH1-055",55,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,62.7,50.1,12.6 "PHB-CH1","PHB-CH1-055",55,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,46.6,50.1,-3.5 "PHB-CH1","PHB-CH1-055",55,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,67.6,50.1,17.5 "PHB-CH1","PHB-CH1-055",55,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.5,4.5,0 "PHB-CH1","PHB-CH1-055",55,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.4,4.5,0.9 "PHB-CH1","PHB-CH1-055",55,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.8,4.5,1.3 "PHB-CH1","PHB-CH1-055",55,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.7,4.5,2.2 "PHB-CH1","PHB-CH1-055",55,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.4,4.5,1.9 "PHB-CH1","PHB-CH1-055",55,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5,4.5,0.5 "PHB-CH1","PHB-CH1-055",55,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.5,4.5,0 "PHB-CH1","PHB-CH1-055",55,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.3,4.5,-1.2 "PHB-CH1","PHB-CH1-055",55,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4,4.5,-0.5 "PHB-CH1","PHB-CH1-055",55,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.2,4.5,0.7 "PHB-CH1","PHB-CH1-055",55,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.3,4.5,-0.2 "PHB-CH1","PHB-CH1-055",55,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.1,4.5,0.6 "PHB-CH1","PHB-CH1-055",55,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.3,4.5,-0.2 "PHB-CH1","PHB-CH1-055",55,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.9,4.5,0.4 "PHB-CH1","PHB-CH1-055",55,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.9,3.9,0 "PHB-CH1","PHB-CH1-055",55,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.9,3.9,1 "PHB-CH1","PHB-CH1-055",55,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.5,3.9,0.6 "PHB-CH1","PHB-CH1-055",55,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5,3.9,1.1 "PHB-CH1","PHB-CH1-055",55,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.1,3.9,0.2 "PHB-CH1","PHB-CH1-055",55,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.4,3.9,-0.5 "PHB-CH1","PHB-CH1-055",55,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,2.8,3.9,-1.1 "PHB-CH1","PHB-CH1-055",55,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,1.7,3.9,-2.2 "PHB-CH1","PHB-CH1-055",55,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.2,3.9,-0.7 "PHB-CH1","PHB-CH1-055",55,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.4,3.9,-0.5 "PHB-CH1","PHB-CH1-055",55,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.7,3.9,-0.2 "PHB-CH1","PHB-CH1-055",55,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.4,3.9,-0.5 "PHB-CH1","PHB-CH1-055",55,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2.1,3.9,-1.8 "PHB-CH1","PHB-CH1-055",55,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.9,3.9,0 "PHB-CH1","PHB-CH1-056",56,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,75,75,0 "PHB-CH1","PHB-CH1-056",56,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,54,75,-21 "PHB-CH1","PHB-CH1-056",56,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,63,75,-12 "PHB-CH1","PHB-CH1-056",56,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,67,, "PHB-CH1","PHB-CH1-056",56,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,47,, "PHB-CH1","PHB-CH1-056",56,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,43,, "PHB-CH1","PHB-CH1-056",56,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-056",56,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-056",56,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,5,, "PHB-CH1","PHB-CH1-056",56,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-056",56,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,1,, "PHB-CH1","PHB-CH1-056",56,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,579,, "PHB-CH1","PHB-CH1-056",56,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-056",56,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-056",56,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-056",56,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-056",56,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,38.7,38.7,0 "PHB-CH1","PHB-CH1-056",56,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,40.2,38.7,1.5 "PHB-CH1","PHB-CH1-056",56,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,38.5,38.7,-0.200000000000003 "PHB-CH1","PHB-CH1-056",56,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,60.4,38.7,21.7 "PHB-CH1","PHB-CH1-056",56,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,46.7,46.7,0 "PHB-CH1","PHB-CH1-056",56,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,46.4,46.7,-0.300000000000004 "PHB-CH1","PHB-CH1-056",56,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,47.4,46.7,0.699999999999996 "PHB-CH1","PHB-CH1-056",56,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,44.1,46.7,-2.6 "PHB-CH1","PHB-CH1-056",56,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,8.7,8.7,0 "PHB-CH1","PHB-CH1-056",56,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,9.2,8.7,0.5 "PHB-CH1","PHB-CH1-056",56,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7.1,8.7,-1.6 "PHB-CH1","PHB-CH1-056",56,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,9.3,8.7,0.600000000000001 "PHB-CH1","PHB-CH1-056",56,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,7.5,8.7,-1.2 "PHB-CH1","PHB-CH1-056",56,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,7.6,8.7,-1.1 "PHB-CH1","PHB-CH1-056",56,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,7.8,8.7,-0.9 "PHB-CH1","PHB-CH1-056",56,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,8.1,8.7,-0.6 "PHB-CH1","PHB-CH1-056",56,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,8.9,8.7,0.200000000000001 "PHB-CH1","PHB-CH1-056",56,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,8,8.7,-0.699999999999999 "PHB-CH1","PHB-CH1-056",56,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,7.9,8.7,-0.799999999999999 "PHB-CH1","PHB-CH1-056",56,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,7.5,8.7,-1.2 "PHB-CH1","PHB-CH1-056",56,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,7.3,8.7,-1.4 "PHB-CH1","PHB-CH1-056",56,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,8.1,8.7,-0.6 "PHB-CH1","PHB-CH1-056",56,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.4,4.4,0 "PHB-CH1","PHB-CH1-056",56,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.9,4.4,0.5 "PHB-CH1","PHB-CH1-056",56,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.6,4.4,0.199999999999999 "PHB-CH1","PHB-CH1-056",56,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.9,4.4,1.5 "PHB-CH1","PHB-CH1-056",56,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.7,4.4,-0.7 "PHB-CH1","PHB-CH1-056",56,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,2.9,4.4,-1.5 "PHB-CH1","PHB-CH1-056",56,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.1,4.4,-0.300000000000001 "PHB-CH1","PHB-CH1-056",56,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.3,4.4,-0.100000000000001 "PHB-CH1","PHB-CH1-056",56,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.4,4.4,0 "PHB-CH1","PHB-CH1-056",56,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.8,4.4,0.399999999999999 "PHB-CH1","PHB-CH1-056",56,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.4,4.4,0 "PHB-CH1","PHB-CH1-056",56,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.7,4.4,0.3 "PHB-CH1","PHB-CH1-056",56,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.8,4.4,-0.6 "PHB-CH1","PHB-CH1-056",56,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5,4.4,0.6 "PHB-CH1","PHB-CH1-057",57,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,50,50,0 "PHB-CH1","PHB-CH1-057",57,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,49,50,-1 "PHB-CH1","PHB-CH1-057",57,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,58,50,8 "PHB-CH1","PHB-CH1-057",57,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,69,, "PHB-CH1","PHB-CH1-057",57,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,72,, "PHB-CH1","PHB-CH1-057",57,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,54,, "PHB-CH1","PHB-CH1-057",57,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-057",57,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-057",57,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-057",57,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-057",57,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,3,, "PHB-CH1","PHB-CH1-057",57,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,523,, "PHB-CH1","PHB-CH1-057",57,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-057",57,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-057",57,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-057",57,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-057",57,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,30.3,30.3,0 "PHB-CH1","PHB-CH1-057",57,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,42.4,30.3,12.1 "PHB-CH1","PHB-CH1-057",57,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,48.2,30.3,17.9 "PHB-CH1","PHB-CH1-057",57,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,38.1,30.3,7.8 "PHB-CH1","PHB-CH1-057",57,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,48.9,48.9,0 "PHB-CH1","PHB-CH1-057",57,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,58.7,48.9,9.8 "PHB-CH1","PHB-CH1-057",57,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,50.1,48.9,1.2 "PHB-CH1","PHB-CH1-057",57,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,52.8,48.9,3.9 "PHB-CH1","PHB-CH1-057",57,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.9,3.9,0 "PHB-CH1","PHB-CH1-057",57,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.1,3.9,2.2 "PHB-CH1","PHB-CH1-057",57,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.1,3.9,2.2 "PHB-CH1","PHB-CH1-057",57,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.3,3.9,1.4 "PHB-CH1","PHB-CH1-057",57,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.6,3.9,1.7 "PHB-CH1","PHB-CH1-057",57,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.6,3.9,2.7 "PHB-CH1","PHB-CH1-057",57,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.6,3.9,1.7 "PHB-CH1","PHB-CH1-057",57,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.2,3.9,1.3 "PHB-CH1","PHB-CH1-057",57,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.5,3.9,1.6 "PHB-CH1","PHB-CH1-057",57,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.8,3.9,0.9 "PHB-CH1","PHB-CH1-057",57,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.7,3.9,1.8 "PHB-CH1","PHB-CH1-057",57,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.8,3.9,1.9 "PHB-CH1","PHB-CH1-057",57,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.7,3.9,0.8 "PHB-CH1","PHB-CH1-057",57,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.6,3.9,0.7 "PHB-CH1","PHB-CH1-057",57,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.4,4.4,0 "PHB-CH1","PHB-CH1-057",57,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.6,4.4,2.2 "PHB-CH1","PHB-CH1-057",57,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.1,4.4,0.699999999999999 "PHB-CH1","PHB-CH1-057",57,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.5,4.4,0.0999999999999996 "PHB-CH1","PHB-CH1-057",57,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.3,4.4,-0.100000000000001 "PHB-CH1","PHB-CH1-057",57,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.4,4.4,1 "PHB-CH1","PHB-CH1-057",57,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.1,4.4,0.699999999999999 "PHB-CH1","PHB-CH1-057",57,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.5,4.4,1.1 "PHB-CH1","PHB-CH1-057",57,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6,4.4,1.6 "PHB-CH1","PHB-CH1-057",57,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.3,4.4,0.9 "PHB-CH1","PHB-CH1-057",57,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.8,4.4,1.4 "PHB-CH1","PHB-CH1-057",57,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.4,4.4,1 "PHB-CH1","PHB-CH1-057",57,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.1,4.4,0.699999999999999 "PHB-CH1","PHB-CH1-057",57,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.6,4.4,1.2 "PHB-CH1","PHB-CH1-058",58,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,38,38,0 "PHB-CH1","PHB-CH1-058",58,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,46,38,8 "PHB-CH1","PHB-CH1-058",58,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,28,38,-10 "PHB-CH1","PHB-CH1-058",58,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,22,, "PHB-CH1","PHB-CH1-058",58,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,32,, "PHB-CH1","PHB-CH1-058",58,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,26,, "PHB-CH1","PHB-CH1-058",58,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-058",58,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-058",58,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-058",58,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-058",58,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,0,, "PHB-CH1","PHB-CH1-058",58,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,594,, "PHB-CH1","PHB-CH1-058",58,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-058",58,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-058",58,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-058",58,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-058",58,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,67.8,67.8,0 "PHB-CH1","PHB-CH1-058",58,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,55.9,67.8,-11.9 "PHB-CH1","PHB-CH1-058",58,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,65.5,67.8,-2.3 "PHB-CH1","PHB-CH1-058",58,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,61,67.8,-6.8 "PHB-CH1","PHB-CH1-058",58,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,50.9,50.9,0 "PHB-CH1","PHB-CH1-058",58,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,67.7,50.9,16.8 "PHB-CH1","PHB-CH1-058",58,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,57.1,50.9,6.2 "PHB-CH1","PHB-CH1-058",58,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,59.1,50.9,8.2 "PHB-CH1","PHB-CH1-058",58,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.8,3.8,0 "PHB-CH1","PHB-CH1-058",58,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.7,3.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-058",58,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.5,3.8,0.7 "PHB-CH1","PHB-CH1-058",58,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.3,3.8,-0.5 "PHB-CH1","PHB-CH1-058",58,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.5,3.8,0.7 "PHB-CH1","PHB-CH1-058",58,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.5,3.8,0.7 "PHB-CH1","PHB-CH1-058",58,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.2,3.8,0.4 "PHB-CH1","PHB-CH1-058",58,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.4,3.8,2.6 "PHB-CH1","PHB-CH1-058",58,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.9,3.8,1.1 "PHB-CH1","PHB-CH1-058",58,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.1,3.8,0.3 "PHB-CH1","PHB-CH1-058",58,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.1,3.8,0.3 "PHB-CH1","PHB-CH1-058",58,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.2,3.8,0.4 "PHB-CH1","PHB-CH1-058",58,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3,3.8,-0.8 "PHB-CH1","PHB-CH1-058",58,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.2,3.8,0.4 "PHB-CH1","PHB-CH1-058",58,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.8,2.8,0 "PHB-CH1","PHB-CH1-058",58,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,2.7,2.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-058",58,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,2.8,2.8,0 "PHB-CH1","PHB-CH1-058",58,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.5,2.8,0.7 "PHB-CH1","PHB-CH1-058",58,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,2.6,2.8,-0.2 "PHB-CH1","PHB-CH1-058",58,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.6,2.8,0.8 "PHB-CH1","PHB-CH1-058",58,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.2,2.8,1.4 "PHB-CH1","PHB-CH1-058",58,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.3,2.8,1.5 "PHB-CH1","PHB-CH1-058",58,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.8,2.8,0 "PHB-CH1","PHB-CH1-058",58,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.1,2.8,0.3 "PHB-CH1","PHB-CH1-058",58,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.7,2.8,0.9 "PHB-CH1","PHB-CH1-058",58,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.3,2.8,0.5 "PHB-CH1","PHB-CH1-058",58,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2.1,2.8,-0.7 "PHB-CH1","PHB-CH1-058",58,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.4,2.8,0.6 "PHB-CH1","PHB-CH1-059",59,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,59,59,0 "PHB-CH1","PHB-CH1-059",59,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,58,59,-1 "PHB-CH1","PHB-CH1-059",59,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,46,59,-13 "PHB-CH1","PHB-CH1-059",59,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,41,, "PHB-CH1","PHB-CH1-059",59,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,60,, "PHB-CH1","PHB-CH1-059",59,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,51,, "PHB-CH1","PHB-CH1-059",59,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-059",59,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-059",59,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-059",59,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-059",59,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,2,, "PHB-CH1","PHB-CH1-059",59,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,467,, "PHB-CH1","PHB-CH1-059",59,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-059",59,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-059",59,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-059",59,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-059",59,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,48.9,48.9,0 "PHB-CH1","PHB-CH1-059",59,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,62,48.9,13.1 "PHB-CH1","PHB-CH1-059",59,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,47.5,48.9,-1.4 "PHB-CH1","PHB-CH1-059",59,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,37.4,48.9,-11.5 "PHB-CH1","PHB-CH1-059",59,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,43.7,43.7,0 "PHB-CH1","PHB-CH1-059",59,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,48.7,43.7,5 "PHB-CH1","PHB-CH1-059",59,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,47.7,43.7,4 "PHB-CH1","PHB-CH1-059",59,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,50.7,43.7,7 "PHB-CH1","PHB-CH1-059",59,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.2,4.2,0 "PHB-CH1","PHB-CH1-059",59,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.9,4.2,-0.3 "PHB-CH1","PHB-CH1-059",59,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.5,4.2,-1.7 "PHB-CH1","PHB-CH1-059",59,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.5,4.2,-1.7 "PHB-CH1","PHB-CH1-059",59,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.5,4.2,-0.7 "PHB-CH1","PHB-CH1-059",59,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-059",59,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.1,4.2,-0.100000000000001 "PHB-CH1","PHB-CH1-059",59,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.4,4.2,-0.8 "PHB-CH1","PHB-CH1-059",59,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-059",59,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.3,4.2,1.1 "PHB-CH1","PHB-CH1-059",59,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.8,4.2,-0.4 "PHB-CH1","PHB-CH1-059",59,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.9,4.2,-0.3 "PHB-CH1","PHB-CH1-059",59,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.8,4.2,1.6 "PHB-CH1","PHB-CH1-059",59,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-059",59,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.6,4.6,0 "PHB-CH1","PHB-CH1-059",59,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.6,4.6,0 "PHB-CH1","PHB-CH1-059",59,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.1,4.6,0.5 "PHB-CH1","PHB-CH1-059",59,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4,4.6,-0.6 "PHB-CH1","PHB-CH1-059",59,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.6,4.6,0 "PHB-CH1","PHB-CH1-059",59,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.2,4.6,-0.399999999999999 "PHB-CH1","PHB-CH1-059",59,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.2,4.6,0.6 "PHB-CH1","PHB-CH1-059",59,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.3,4.6,-0.3 "PHB-CH1","PHB-CH1-059",59,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5,4.6,0.4 "PHB-CH1","PHB-CH1-059",59,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.9,4.6,0.300000000000001 "PHB-CH1","PHB-CH1-059",59,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5,4.6,0.4 "PHB-CH1","PHB-CH1-059",59,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.8,4.6,0.2 "PHB-CH1","PHB-CH1-059",59,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.9,4.6,1.3 "PHB-CH1","PHB-CH1-059",59,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4,4.6,-0.6 "PHB-CH1","PHB-CH1-060",60,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,51,51,0 "PHB-CH1","PHB-CH1-060",60,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,51,51,0 "PHB-CH1","PHB-CH1-060",60,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,43,51,-8 "PHB-CH1","PHB-CH1-060",60,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,63,, "PHB-CH1","PHB-CH1-060",60,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,41,, "PHB-CH1","PHB-CH1-060",60,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,39,, "PHB-CH1","PHB-CH1-060",60,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-060",60,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-060",60,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-060",60,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-060",60,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,32,, "PHB-CH1","PHB-CH1-060",60,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,224,, "PHB-CH1","PHB-CH1-060",60,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-060",60,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-060",60,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-060",60,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-060",60,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,16.5,16.5,0 "PHB-CH1","PHB-CH1-060",60,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,24,16.5,7.5 "PHB-CH1","PHB-CH1-060",60,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,21,16.5,4.5 "PHB-CH1","PHB-CH1-060",60,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,26.3,16.5,9.8 "PHB-CH1","PHB-CH1-060",60,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,39.2,39.2,0 "PHB-CH1","PHB-CH1-060",60,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,52.8,39.2,13.6 "PHB-CH1","PHB-CH1-060",60,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,56.3,39.2,17.1 "PHB-CH1","PHB-CH1-060",60,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,35.2,39.2,-4 "PHB-CH1","PHB-CH1-060",60,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,8.9,8.9,0 "PHB-CH1","PHB-CH1-060",60,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,9.5,8.9,0.6 "PHB-CH1","PHB-CH1-060",60,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,8.8,8.9,-0.0999999999999996 "PHB-CH1","PHB-CH1-060",60,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,9.3,8.9,0.4 "PHB-CH1","PHB-CH1-060",60,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,8.5,8.9,-0.4 "PHB-CH1","PHB-CH1-060",60,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,7.9,8.9,-1 "PHB-CH1","PHB-CH1-060",60,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.6,8.9,-2.3 "PHB-CH1","PHB-CH1-060",60,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.4,8.9,-1.5 "PHB-CH1","PHB-CH1-060",60,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,7.8,8.9,-1.1 "PHB-CH1","PHB-CH1-060",60,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,8.6,8.9,-0.300000000000001 "PHB-CH1","PHB-CH1-060",60,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,7.2,8.9,-1.7 "PHB-CH1","PHB-CH1-060",60,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,8.3,8.9,-0.6 "PHB-CH1","PHB-CH1-060",60,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,9.4,8.9,0.5 "PHB-CH1","PHB-CH1-060",60,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,7.6,8.9,-1.3 "PHB-CH1","PHB-CH1-060",60,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.1,6.1,0 "PHB-CH1","PHB-CH1-060",60,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.8,6.1,0.7 "PHB-CH1","PHB-CH1-060",60,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.3,6.1,0.2 "PHB-CH1","PHB-CH1-060",60,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.7,6.1,0.6 "PHB-CH1","PHB-CH1-060",60,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,7.1,6.1,1 "PHB-CH1","PHB-CH1-060",60,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,7.6,6.1,1.5 "PHB-CH1","PHB-CH1-060",60,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.7,6.1,0.6 "PHB-CH1","PHB-CH1-060",60,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.6,6.1,0.5 "PHB-CH1","PHB-CH1-060",60,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.3,6.1,1.2 "PHB-CH1","PHB-CH1-060",60,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.8,6.1,1.7 "PHB-CH1","PHB-CH1-060",60,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.6,6.1,0.5 "PHB-CH1","PHB-CH1-060",60,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.6,6.1,1.5 "PHB-CH1","PHB-CH1-060",60,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.6,6.1,1.5 "PHB-CH1","PHB-CH1-060",60,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.5,6.1,-0.6 "PHB-CH1","PHB-CH1-061",61,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,66,66,0 "PHB-CH1","PHB-CH1-061",61,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,68,66,2 "PHB-CH1","PHB-CH1-061",61,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,71,66,5 "PHB-CH1","PHB-CH1-061",61,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,64,, "PHB-CH1","PHB-CH1-061",61,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,70,, "PHB-CH1","PHB-CH1-061",61,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,52,, "PHB-CH1","PHB-CH1-061",61,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-061",61,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-061",61,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-061",61,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-061",61,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,15,, "PHB-CH1","PHB-CH1-061",61,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,394,, "PHB-CH1","PHB-CH1-061",61,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-061",61,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-061",61,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-061",61,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-061",61,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,30.5,30.5,0 "PHB-CH1","PHB-CH1-061",61,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,39.6,30.5,9.1 "PHB-CH1","PHB-CH1-061",61,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,58.5,30.5,28 "PHB-CH1","PHB-CH1-061",61,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,25.7,30.5,-4.8 "PHB-CH1","PHB-CH1-061",61,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,49.9,49.9,0 "PHB-CH1","PHB-CH1-061",61,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,50.9,49.9,1 "PHB-CH1","PHB-CH1-061",61,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,56.7,49.9,6.8 "PHB-CH1","PHB-CH1-061",61,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,59.7,49.9,9.8 "PHB-CH1","PHB-CH1-061",61,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,7.6,7.6,0 "PHB-CH1","PHB-CH1-061",61,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.7,7.6,-2.9 "PHB-CH1","PHB-CH1-061",61,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.9,7.6,-2.7 "PHB-CH1","PHB-CH1-061",61,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.2,7.6,-2.4 "PHB-CH1","PHB-CH1-061",61,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.9,7.6,-1.7 "PHB-CH1","PHB-CH1-061",61,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.5,7.6,-2.1 "PHB-CH1","PHB-CH1-061",61,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.4,7.6,-2.2 "PHB-CH1","PHB-CH1-061",61,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.4,7.6,-3.2 "PHB-CH1","PHB-CH1-061",61,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.1,7.6,-1.5 "PHB-CH1","PHB-CH1-061",61,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.5,7.6,-3.1 "PHB-CH1","PHB-CH1-061",61,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.5,7.6,-2.1 "PHB-CH1","PHB-CH1-061",61,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.7,7.6,-2.9 "PHB-CH1","PHB-CH1-061",61,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.6,7.6,-2 "PHB-CH1","PHB-CH1-061",61,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5,7.6,-2.6 "PHB-CH1","PHB-CH1-061",61,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.7,6.7,0 "PHB-CH1","PHB-CH1-061",61,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.5,6.7,-2.2 "PHB-CH1","PHB-CH1-061",61,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.5,6.7,-1.2 "PHB-CH1","PHB-CH1-061",61,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.4,6.7,-1.3 "PHB-CH1","PHB-CH1-061",61,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.5,6.7,-1.2 "PHB-CH1","PHB-CH1-061",61,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.9,6.7,-1.8 "PHB-CH1","PHB-CH1-061",61,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.1,6.7,-2.6 "PHB-CH1","PHB-CH1-061",61,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.4,6.7,-3.3 "PHB-CH1","PHB-CH1-061",61,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.7,6.7,-1 "PHB-CH1","PHB-CH1-061",61,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.7,6.7,-2 "PHB-CH1","PHB-CH1-061",61,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.2,6.7,-2.5 "PHB-CH1","PHB-CH1-061",61,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4,6.7,-2.7 "PHB-CH1","PHB-CH1-061",61,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.6,6.7,-2.1 "PHB-CH1","PHB-CH1-061",61,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.5,6.7,-2.2 "PHB-CH1","PHB-CH1-062",62,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,48,48,0 "PHB-CH1","PHB-CH1-062",62,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,38,48,-10 "PHB-CH1","PHB-CH1-062",62,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,47,48,-1 "PHB-CH1","PHB-CH1-062",62,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,41,, "PHB-CH1","PHB-CH1-062",62,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,63,, "PHB-CH1","PHB-CH1-062",62,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,70,, "PHB-CH1","PHB-CH1-062",62,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-062",62,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-062",62,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-062",62,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-062",62,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,1,, "PHB-CH1","PHB-CH1-062",62,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,547,, "PHB-CH1","PHB-CH1-062",62,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-062",62,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-062",62,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-062",62,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-062",62,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,53.3,53.3,0 "PHB-CH1","PHB-CH1-062",62,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,33.9,53.3,-19.4 "PHB-CH1","PHB-CH1-062",62,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,40.8,53.3,-12.5 "PHB-CH1","PHB-CH1-062",62,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,40.7,53.3,-12.6 "PHB-CH1","PHB-CH1-062",62,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,40.4,40.4,0 "PHB-CH1","PHB-CH1-062",62,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,35.4,40.4,-5 "PHB-CH1","PHB-CH1-062",62,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,43.3,40.4,2.9 "PHB-CH1","PHB-CH1-062",62,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,31.6,40.4,-8.8 "PHB-CH1","PHB-CH1-062",62,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.2,4.2,0 "PHB-CH1","PHB-CH1-062",62,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.7,4.2,-0.5 "PHB-CH1","PHB-CH1-062",62,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.7,4.2,0.5 "PHB-CH1","PHB-CH1-062",62,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.3,4.2,-1.9 "PHB-CH1","PHB-CH1-062",62,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.6,4.2,0.399999999999999 "PHB-CH1","PHB-CH1-062",62,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.6,4.2,-0.6 "PHB-CH1","PHB-CH1-062",62,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.7,4.2,-0.5 "PHB-CH1","PHB-CH1-062",62,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.6,4.2,-0.6 "PHB-CH1","PHB-CH1-062",62,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,2.3,4.2,-1.9 "PHB-CH1","PHB-CH1-062",62,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.5,4.2,0.3 "PHB-CH1","PHB-CH1-062",62,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.4,4.2,-0.8 "PHB-CH1","PHB-CH1-062",62,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,2.7,4.2,-1.5 "PHB-CH1","PHB-CH1-062",62,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.3,4.2,-0.9 "PHB-CH1","PHB-CH1-062",62,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.3,4.2,0.0999999999999996 "PHB-CH1","PHB-CH1-062",62,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.1,6.1,0 "PHB-CH1","PHB-CH1-062",62,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.5,6.1,-0.6 "PHB-CH1","PHB-CH1-062",62,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.8,6.1,0.7 "PHB-CH1","PHB-CH1-062",62,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.4,6.1,-1.7 "PHB-CH1","PHB-CH1-062",62,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.5,6.1,-0.6 "PHB-CH1","PHB-CH1-062",62,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.5,6.1,-1.6 "PHB-CH1","PHB-CH1-062",62,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.1,6.1,-1 "PHB-CH1","PHB-CH1-062",62,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.1,6.1,-2 "PHB-CH1","PHB-CH1-062",62,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4,6.1,-2.1 "PHB-CH1","PHB-CH1-062",62,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.7,6.1,0.6 "PHB-CH1","PHB-CH1-062",62,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.4,6.1,0.300000000000001 "PHB-CH1","PHB-CH1-062",62,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.3,6.1,-0.8 "PHB-CH1","PHB-CH1-062",62,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.7,6.1,-0.399999999999999 "PHB-CH1","PHB-CH1-062",62,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.1,6.1,0 "PHB-CH1","PHB-CH1-063",63,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,34,34,0 "PHB-CH1","PHB-CH1-063",63,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,33,34,-1 "PHB-CH1","PHB-CH1-063",63,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,28,34,-6 "PHB-CH1","PHB-CH1-063",63,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,50,, "PHB-CH1","PHB-CH1-063",63,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,51,, "PHB-CH1","PHB-CH1-063",63,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,36,, "PHB-CH1","PHB-CH1-063",63,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-063",63,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-063",63,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-063",63,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-063",63,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,17,, "PHB-CH1","PHB-CH1-063",63,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,362,, "PHB-CH1","PHB-CH1-063",63,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-063",63,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-063",63,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-063",63,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-063",63,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,59.5,59.5,0 "PHB-CH1","PHB-CH1-063",63,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,57.5,59.5,-2 "PHB-CH1","PHB-CH1-063",63,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,70.1,59.5,10.6 "PHB-CH1","PHB-CH1-063",63,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,63.8,59.5,4.3 "PHB-CH1","PHB-CH1-063",63,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,61.9,61.9,0 "PHB-CH1","PHB-CH1-063",63,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,61.9,61.9,0 "PHB-CH1","PHB-CH1-063",63,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,70.9,61.9,9.00000000000001 "PHB-CH1","PHB-CH1-063",63,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,76.2,61.9,14.3 "PHB-CH1","PHB-CH1-063",63,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.3,5.3,0 "PHB-CH1","PHB-CH1-063",63,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.9,5.3,-1.4 "PHB-CH1","PHB-CH1-063",63,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.7,5.3,-0.6 "PHB-CH1","PHB-CH1-063",63,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4,5.3,-1.3 "PHB-CH1","PHB-CH1-063",63,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4,5.3,-1.3 "PHB-CH1","PHB-CH1-063",63,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.2,5.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-063",63,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.5,5.3,1.2 "PHB-CH1","PHB-CH1-063",63,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.5,5.3,0.2 "PHB-CH1","PHB-CH1-063",63,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.7,5.3,1.4 "PHB-CH1","PHB-CH1-063",63,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6,5.3,0.7 "PHB-CH1","PHB-CH1-063",63,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.8,5.3,0.5 "PHB-CH1","PHB-CH1-063",63,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.1,5.3,0.8 "PHB-CH1","PHB-CH1-063",63,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.1,5.3,0.8 "PHB-CH1","PHB-CH1-063",63,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.1,5.3,-0.2 "PHB-CH1","PHB-CH1-063",63,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,8.3,8.3,0 "PHB-CH1","PHB-CH1-063",63,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,8.3,8.3,0 "PHB-CH1","PHB-CH1-063",63,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7.7,8.3,-0.6 "PHB-CH1","PHB-CH1-063",63,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.3,8.3,-2 "PHB-CH1","PHB-CH1-063",63,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.4,8.3,-2.9 "PHB-CH1","PHB-CH1-063",63,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6,8.3,-2.3 "PHB-CH1","PHB-CH1-063",63,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.6,8.3,-1.7 "PHB-CH1","PHB-CH1-063",63,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.7,8.3,-2.6 "PHB-CH1","PHB-CH1-063",63,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.5,8.3,-2.8 "PHB-CH1","PHB-CH1-063",63,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.1,8.3,-2.2 "PHB-CH1","PHB-CH1-063",63,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.2,8.3,-2.1 "PHB-CH1","PHB-CH1-063",63,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.1,8.3,-2.2 "PHB-CH1","PHB-CH1-063",63,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.1,8.3,-2.2 "PHB-CH1","PHB-CH1-063",63,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.3,8.3,-1 "PHB-CH1","PHB-CH1-064",64,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,57,57,0 "PHB-CH1","PHB-CH1-064",64,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,53,57,-4 "PHB-CH1","PHB-CH1-064",64,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,70,57,13 "PHB-CH1","PHB-CH1-064",64,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,37,, "PHB-CH1","PHB-CH1-064",64,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,69,, "PHB-CH1","PHB-CH1-064",64,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,53,, "PHB-CH1","PHB-CH1-064",64,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-064",64,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-064",64,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-064",64,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-064",64,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,19,, "PHB-CH1","PHB-CH1-064",64,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,360,, "PHB-CH1","PHB-CH1-064",64,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-064",64,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-064",64,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-064",64,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-064",64,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,74.6,74.6,0 "PHB-CH1","PHB-CH1-064",64,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,70.7,74.6,-3.89999999999999 "PHB-CH1","PHB-CH1-064",64,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,59.6,74.6,-15 "PHB-CH1","PHB-CH1-064",64,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,66.3,74.6,-8.3 "PHB-CH1","PHB-CH1-064",64,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,63.7,63.7,0 "PHB-CH1","PHB-CH1-064",64,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,81.4,63.7,17.7 "PHB-CH1","PHB-CH1-064",64,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,61.3,63.7,-2.40000000000001 "PHB-CH1","PHB-CH1-064",64,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,67.2,63.7,3.5 "PHB-CH1","PHB-CH1-064",64,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.3,4.3,0 "PHB-CH1","PHB-CH1-064",64,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2.8,4.3,-1.5 "PHB-CH1","PHB-CH1-064",64,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.7,4.3,-0.6 "PHB-CH1","PHB-CH1-064",64,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.7,4.3,-0.6 "PHB-CH1","PHB-CH1-064",64,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.2,4.3,-1.1 "PHB-CH1","PHB-CH1-064",64,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.1,4.3,-1.2 "PHB-CH1","PHB-CH1-064",64,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.6,4.3,-0.7 "PHB-CH1","PHB-CH1-064",64,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.6,4.3,-0.7 "PHB-CH1","PHB-CH1-064",64,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.1,4.3,-0.2 "PHB-CH1","PHB-CH1-064",64,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.2,4.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-064",64,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.9,4.3,0.6 "PHB-CH1","PHB-CH1-064",64,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5,4.3,0.7 "PHB-CH1","PHB-CH1-064",64,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.6,4.3,0.3 "PHB-CH1","PHB-CH1-064",64,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.6,4.3,-0.7 "PHB-CH1","PHB-CH1-064",64,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-064",64,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.7,5.1,-1.4 "PHB-CH1","PHB-CH1-064",64,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.4,5.1,0.300000000000001 "PHB-CH1","PHB-CH1-064",64,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6,5.1,0.9 "PHB-CH1","PHB-CH1-064",64,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.8,5.1,-0.3 "PHB-CH1","PHB-CH1-064",64,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.7,5.1,0.6 "PHB-CH1","PHB-CH1-064",64,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.5,5.1,0.4 "PHB-CH1","PHB-CH1-064",64,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.1,5.1,0 "PHB-CH1","PHB-CH1-064",64,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.7,5.1,0.6 "PHB-CH1","PHB-CH1-064",64,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.3,5.1,1.2 "PHB-CH1","PHB-CH1-064",64,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.2,5.1,1.1 "PHB-CH1","PHB-CH1-064",64,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.9,5.1,1.8 "PHB-CH1","PHB-CH1-064",64,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.9,5.1,0.800000000000001 "PHB-CH1","PHB-CH1-064",64,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.2,5.1,1.1 "PHB-CH1","PHB-CH1-065",65,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,41,41,0 "PHB-CH1","PHB-CH1-065",65,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,39,41,-2 "PHB-CH1","PHB-CH1-065",65,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,36,41,-5 "PHB-CH1","PHB-CH1-065",65,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,38,, "PHB-CH1","PHB-CH1-065",65,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,57,, "PHB-CH1","PHB-CH1-065",65,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,42,, "PHB-CH1","PHB-CH1-065",65,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-065",65,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-065",65,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-065",65,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-065",65,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,2,, "PHB-CH1","PHB-CH1-065",65,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,512,, "PHB-CH1","PHB-CH1-065",65,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-065",65,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-065",65,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-065",65,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-065",65,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,27.2,27.2,0 "PHB-CH1","PHB-CH1-065",65,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,26.8,27.2,-0.399999999999999 "PHB-CH1","PHB-CH1-065",65,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,34.3,27.2,7.1 "PHB-CH1","PHB-CH1-065",65,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,30,27.2,2.8 "PHB-CH1","PHB-CH1-065",65,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,45.9,45.9,0 "PHB-CH1","PHB-CH1-065",65,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,35.7,45.9,-10.2 "PHB-CH1","PHB-CH1-065",65,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,36.5,45.9,-9.4 "PHB-CH1","PHB-CH1-065",65,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,45.3,45.9,-0.600000000000001 "PHB-CH1","PHB-CH1-065",65,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.1,6.1,0 "PHB-CH1","PHB-CH1-065",65,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.2,6.1,-0.9 "PHB-CH1","PHB-CH1-065",65,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.4,6.1,-0.699999999999999 "PHB-CH1","PHB-CH1-065",65,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.4,6.1,-1.7 "PHB-CH1","PHB-CH1-065",65,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.7,6.1,-0.399999999999999 "PHB-CH1","PHB-CH1-065",65,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.4,6.1,0.300000000000001 "PHB-CH1","PHB-CH1-065",65,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.5,6.1,0.4 "PHB-CH1","PHB-CH1-065",65,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.1,6.1,-1 "PHB-CH1","PHB-CH1-065",65,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.6,6.1,-1.5 "PHB-CH1","PHB-CH1-065",65,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.6,6.1,-1.5 "PHB-CH1","PHB-CH1-065",65,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.7,6.1,-1.4 "PHB-CH1","PHB-CH1-065",65,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5,6.1,-1.1 "PHB-CH1","PHB-CH1-065",65,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.1,6.1,0 "PHB-CH1","PHB-CH1-065",65,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.3,6.1,0.2 "PHB-CH1","PHB-CH1-065",65,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7.5,7.5,0 "PHB-CH1","PHB-CH1-065",65,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.6,7.5,-1.9 "PHB-CH1","PHB-CH1-065",65,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.8,7.5,-1.7 "PHB-CH1","PHB-CH1-065",65,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.8,7.5,-3.7 "PHB-CH1","PHB-CH1-065",65,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.8,7.5,-2.7 "PHB-CH1","PHB-CH1-065",65,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.7,7.5,-0.8 "PHB-CH1","PHB-CH1-065",65,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.3,7.5,-1.2 "PHB-CH1","PHB-CH1-065",65,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.5,7.5,-2 "PHB-CH1","PHB-CH1-065",65,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.4,7.5,-3.1 "PHB-CH1","PHB-CH1-065",65,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.9,7.5,-3.6 "PHB-CH1","PHB-CH1-065",65,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.2,7.5,-3.3 "PHB-CH1","PHB-CH1-065",65,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.8,7.5,-1.7 "PHB-CH1","PHB-CH1-065",65,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.4,7.5,-2.1 "PHB-CH1","PHB-CH1-065",65,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.7,7.5,-1.8 "PHB-CH1","PHB-CH1-066",66,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,43,43,0 "PHB-CH1","PHB-CH1-066",66,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,52,43,9 "PHB-CH1","PHB-CH1-066",66,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,44,43,1 "PHB-CH1","PHB-CH1-066",66,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,42,, "PHB-CH1","PHB-CH1-066",66,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,50,, "PHB-CH1","PHB-CH1-066",66,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,32,, "PHB-CH1","PHB-CH1-066",66,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-066",66,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-066",66,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-066",66,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-066",66,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,8,, "PHB-CH1","PHB-CH1-066",66,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,336,, "PHB-CH1","PHB-CH1-066",66,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-066",66,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-066",66,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-066",66,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-066",66,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,51.8,51.8,0 "PHB-CH1","PHB-CH1-066",66,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,53.6,51.8,1.8 "PHB-CH1","PHB-CH1-066",66,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,64.7,51.8,12.9 "PHB-CH1","PHB-CH1-066",66,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,49.9,51.8,-1.9 "PHB-CH1","PHB-CH1-066",66,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,45.6,45.6,0 "PHB-CH1","PHB-CH1-066",66,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,51.6,45.6,6 "PHB-CH1","PHB-CH1-066",66,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,56.6,45.6,11 "PHB-CH1","PHB-CH1-066",66,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,47.9,45.6,2.3 "PHB-CH1","PHB-CH1-066",66,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.9,3.9,0 "PHB-CH1","PHB-CH1-066",66,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5,3.9,1.1 "PHB-CH1","PHB-CH1-066",66,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4,3.9,0.1 "PHB-CH1","PHB-CH1-066",66,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.8,3.9,-0.1 "PHB-CH1","PHB-CH1-066",66,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.5,3.9,-0.4 "PHB-CH1","PHB-CH1-066",66,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2.8,3.9,-1.1 "PHB-CH1","PHB-CH1-066",66,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2,3.9,-1.9 "PHB-CH1","PHB-CH1-066",66,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.3,3.9,-0.6 "PHB-CH1","PHB-CH1-066",66,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.2,3.9,-0.7 "PHB-CH1","PHB-CH1-066",66,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.4,3.9,-0.5 "PHB-CH1","PHB-CH1-066",66,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.9,3.9,-1 "PHB-CH1","PHB-CH1-066",66,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.2,3.9,-0.7 "PHB-CH1","PHB-CH1-066",66,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.7,3.9,-1.2 "PHB-CH1","PHB-CH1-066",66,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.5,3.9,-0.4 "PHB-CH1","PHB-CH1-066",66,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.8,4.8,0 "PHB-CH1","PHB-CH1-066",66,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.3,4.8,1.5 "PHB-CH1","PHB-CH1-066",66,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.1,4.8,1.3 "PHB-CH1","PHB-CH1-066",66,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5,4.8,0.2 "PHB-CH1","PHB-CH1-066",66,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.7,4.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-066",66,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.9,4.8,0.100000000000001 "PHB-CH1","PHB-CH1-066",66,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.2,4.8,0.4 "PHB-CH1","PHB-CH1-066",66,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6,4.8,1.2 "PHB-CH1","PHB-CH1-066",66,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.5,4.8,1.7 "PHB-CH1","PHB-CH1-066",66,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.1,4.8,0.3 "PHB-CH1","PHB-CH1-066",66,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.5,4.8,0.7 "PHB-CH1","PHB-CH1-066",66,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.7,4.8,0.9 "PHB-CH1","PHB-CH1-066",66,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.1,4.8,0.3 "PHB-CH1","PHB-CH1-066",66,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.8,4.8,1 "PHB-CH1","PHB-CH1-067",67,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,55,55,0 "PHB-CH1","PHB-CH1-067",67,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,50,55,-5 "PHB-CH1","PHB-CH1-067",67,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,40,55,-15 "PHB-CH1","PHB-CH1-067",67,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,48,, "PHB-CH1","PHB-CH1-067",67,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,42,, "PHB-CH1","PHB-CH1-067",67,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,63,, "PHB-CH1","PHB-CH1-067",67,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-067",67,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-067",67,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-067",67,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-067",67,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,11,, "PHB-CH1","PHB-CH1-067",67,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,342,, "PHB-CH1","PHB-CH1-067",67,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-067",67,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-067",67,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-067",67,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-067",67,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,37.6,37.6,0 "PHB-CH1","PHB-CH1-067",67,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,42.6,37.6,5 "PHB-CH1","PHB-CH1-067",67,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,33.7,37.6,-3.9 "PHB-CH1","PHB-CH1-067",67,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,59.4,37.6,21.8 "PHB-CH1","PHB-CH1-067",67,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,41.1,41.1,0 "PHB-CH1","PHB-CH1-067",67,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,52.5,41.1,11.4 "PHB-CH1","PHB-CH1-067",67,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,43.7,41.1,2.6 "PHB-CH1","PHB-CH1-067",67,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,59.2,41.1,18.1 "PHB-CH1","PHB-CH1-067",67,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,7.3,7.3,0 "PHB-CH1","PHB-CH1-067",67,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,7.1,7.3,-0.2 "PHB-CH1","PHB-CH1-067",67,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7.4,7.3,0.100000000000001 "PHB-CH1","PHB-CH1-067",67,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.8,7.3,-0.5 "PHB-CH1","PHB-CH1-067",67,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,7.2,7.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-067",67,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.3,7.3,-1 "PHB-CH1","PHB-CH1-067",67,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,8.5,7.3,1.2 "PHB-CH1","PHB-CH1-067",67,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.6,7.3,-1.7 "PHB-CH1","PHB-CH1-067",67,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.1,7.3,-2.2 "PHB-CH1","PHB-CH1-067",67,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.5,7.3,-0.8 "PHB-CH1","PHB-CH1-067",67,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,7.5,7.3,0.2 "PHB-CH1","PHB-CH1-067",67,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,8,7.3,0.7 "PHB-CH1","PHB-CH1-067",67,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,8.7,7.3,1.4 "PHB-CH1","PHB-CH1-067",67,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,7.8,7.3,0.5 "PHB-CH1","PHB-CH1-067",67,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.4,6.4,0 "PHB-CH1","PHB-CH1-067",67,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.5,6.4,0.0999999999999996 "PHB-CH1","PHB-CH1-067",67,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.5,6.4,0.0999999999999996 "PHB-CH1","PHB-CH1-067",67,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.9,6.4,-1.5 "PHB-CH1","PHB-CH1-067",67,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.8,6.4,-1.6 "PHB-CH1","PHB-CH1-067",67,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.7,6.4,-0.7 "PHB-CH1","PHB-CH1-067",67,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.2,6.4,-0.2 "PHB-CH1","PHB-CH1-067",67,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.3,6.4,-2.1 "PHB-CH1","PHB-CH1-067",67,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.1,6.4,-2.3 "PHB-CH1","PHB-CH1-067",67,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.6,6.4,-1.8 "PHB-CH1","PHB-CH1-067",67,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.5,6.4,0.0999999999999996 "PHB-CH1","PHB-CH1-067",67,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.6,6.4,0.199999999999999 "PHB-CH1","PHB-CH1-067",67,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.8,6.4,0.399999999999999 "PHB-CH1","PHB-CH1-067",67,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.9,6.4,-0.5 "PHB-CH1","PHB-CH1-068",68,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,38,38,0 "PHB-CH1","PHB-CH1-068",68,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,38,38,0 "PHB-CH1","PHB-CH1-068",68,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,40,38,2 "PHB-CH1","PHB-CH1-068",68,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,46,, "PHB-CH1","PHB-CH1-068",68,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,42,, "PHB-CH1","PHB-CH1-068",68,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,64,, "PHB-CH1","PHB-CH1-068",68,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-068",68,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-068",68,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-068",68,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-068",68,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,13,, "PHB-CH1","PHB-CH1-068",68,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,410,, "PHB-CH1","PHB-CH1-068",68,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-068",68,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-068",68,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-068",68,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-068",68,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,55,55,0 "PHB-CH1","PHB-CH1-068",68,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,42.8,55,-12.2 "PHB-CH1","PHB-CH1-068",68,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,48.8,55,-6.2 "PHB-CH1","PHB-CH1-068",68,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,59.8,55,4.8 "PHB-CH1","PHB-CH1-068",68,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,64.9,64.9,0 "PHB-CH1","PHB-CH1-068",68,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,76.4,64.9,11.5 "PHB-CH1","PHB-CH1-068",68,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,71.5,64.9,6.59999999999999 "PHB-CH1","PHB-CH1-068",68,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,74,64.9,9.09999999999999 "PHB-CH1","PHB-CH1-068",68,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,7.3,7.3,0 "PHB-CH1","PHB-CH1-068",68,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,7.4,7.3,0.100000000000001 "PHB-CH1","PHB-CH1-068",68,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7,7.3,-0.3 "PHB-CH1","PHB-CH1-068",68,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.1,7.3,-1.2 "PHB-CH1","PHB-CH1-068",68,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.2,7.3,-1.1 "PHB-CH1","PHB-CH1-068",68,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6,7.3,-1.3 "PHB-CH1","PHB-CH1-068",68,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.3,7.3,-1 "PHB-CH1","PHB-CH1-068",68,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.7,7.3,-0.6 "PHB-CH1","PHB-CH1-068",68,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.4,7.3,-0.9 "PHB-CH1","PHB-CH1-068",68,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.5,7.3,-0.8 "PHB-CH1","PHB-CH1-068",68,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.6,7.3,-0.7 "PHB-CH1","PHB-CH1-068",68,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.1,7.3,-1.2 "PHB-CH1","PHB-CH1-068",68,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.7,7.3,-0.6 "PHB-CH1","PHB-CH1-068",68,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.8,7.3,-0.5 "PHB-CH1","PHB-CH1-068",68,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.1,6.1,0 "PHB-CH1","PHB-CH1-068",68,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.8,6.1,0.7 "PHB-CH1","PHB-CH1-068",68,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.5,6.1,0.4 "PHB-CH1","PHB-CH1-068",68,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6,6.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-068",68,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.4,6.1,-0.699999999999999 "PHB-CH1","PHB-CH1-068",68,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.5,6.1,-0.6 "PHB-CH1","PHB-CH1-068",68,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.8,6.1,-0.3 "PHB-CH1","PHB-CH1-068",68,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.7,6.1,-1.4 "PHB-CH1","PHB-CH1-068",68,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6,6.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-068",68,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.8,6.1,-0.3 "PHB-CH1","PHB-CH1-068",68,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6,6.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-068",68,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.4,6.1,-1.7 "PHB-CH1","PHB-CH1-068",68,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.2,6.1,0.100000000000001 "PHB-CH1","PHB-CH1-068",68,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.8,6.1,-0.3 "PHB-CH1","PHB-CH1-069",69,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,36,36,0 "PHB-CH1","PHB-CH1-069",69,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,32,36,-4 "PHB-CH1","PHB-CH1-069",69,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,31,36,-5 "PHB-CH1","PHB-CH1-069",69,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,42,, "PHB-CH1","PHB-CH1-069",69,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,41,, "PHB-CH1","PHB-CH1-069",69,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,49,, "PHB-CH1","PHB-CH1-069",69,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-069",69,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-069",69,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-069",69,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-069",69,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,20,, "PHB-CH1","PHB-CH1-069",69,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,303,, "PHB-CH1","PHB-CH1-069",69,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-069",69,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-069",69,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-069",69,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-069",69,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,45.4,45.4,0 "PHB-CH1","PHB-CH1-069",69,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,56.2,45.4,10.8 "PHB-CH1","PHB-CH1-069",69,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,36,45.4,-9.4 "PHB-CH1","PHB-CH1-069",69,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,48.4,45.4,3 "PHB-CH1","PHB-CH1-069",69,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,55.2,55.2,0 "PHB-CH1","PHB-CH1-069",69,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,63.8,55.2,8.59999999999999 "PHB-CH1","PHB-CH1-069",69,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,45,55.2,-10.2 "PHB-CH1","PHB-CH1-069",69,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,48.8,55.2,-6.40000000000001 "PHB-CH1","PHB-CH1-069",69,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.8,5.8,0 "PHB-CH1","PHB-CH1-069",69,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.5,5.8,-0.3 "PHB-CH1","PHB-CH1-069",69,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.6,5.8,0.8 "PHB-CH1","PHB-CH1-069",69,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.9,5.8,-1.9 "PHB-CH1","PHB-CH1-069",69,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.1,5.8,-0.7 "PHB-CH1","PHB-CH1-069",69,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6,5.8,0.2 "PHB-CH1","PHB-CH1-069",69,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,8,5.8,2.2 "PHB-CH1","PHB-CH1-069",69,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.8,5.8,-1 "PHB-CH1","PHB-CH1-069",69,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,2.8,5.8,-3 "PHB-CH1","PHB-CH1-069",69,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.8,5.8,0 "PHB-CH1","PHB-CH1-069",69,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.9,5.8,-0.9 "PHB-CH1","PHB-CH1-069",69,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.3,5.8,-2.5 "PHB-CH1","PHB-CH1-069",69,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.7,5.8,-2.1 "PHB-CH1","PHB-CH1-069",69,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.7,5.8,-1.1 "PHB-CH1","PHB-CH1-069",69,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.7,5.7,0 "PHB-CH1","PHB-CH1-069",69,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.8,5.7,0.0999999999999996 "PHB-CH1","PHB-CH1-069",69,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.4,5.7,-0.3 "PHB-CH1","PHB-CH1-069",69,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5,5.7,-0.7 "PHB-CH1","PHB-CH1-069",69,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.1,5.7,-0.6 "PHB-CH1","PHB-CH1-069",69,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.9,5.7,-0.8 "PHB-CH1","PHB-CH1-069",69,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.4,5.7,0.7 "PHB-CH1","PHB-CH1-069",69,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.2,5.7,-1.5 "PHB-CH1","PHB-CH1-069",69,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.1,5.7,-2.6 "PHB-CH1","PHB-CH1-069",69,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.8,5.7,-1.9 "PHB-CH1","PHB-CH1-069",69,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.5,5.7,-2.2 "PHB-CH1","PHB-CH1-069",69,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,2.8,5.7,-2.9 "PHB-CH1","PHB-CH1-069",69,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2.6,5.7,-3.1 "PHB-CH1","PHB-CH1-069",69,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.8,5.7,-1.9 "PHB-CH1","PHB-CH1-070",70,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,56,56,0 "PHB-CH1","PHB-CH1-070",70,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,42,56,-14 "PHB-CH1","PHB-CH1-070",70,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,51,56,-5 "PHB-CH1","PHB-CH1-070",70,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,48,, "PHB-CH1","PHB-CH1-070",70,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,52,, "PHB-CH1","PHB-CH1-070",70,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,61,, "PHB-CH1","PHB-CH1-070",70,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-070",70,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-070",70,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-070",70,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-070",70,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,16,, "PHB-CH1","PHB-CH1-070",70,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,324,, "PHB-CH1","PHB-CH1-070",70,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-070",70,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-070",70,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-070",70,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-070",70,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,35.7,35.7,0 "PHB-CH1","PHB-CH1-070",70,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,39.4,35.7,3.7 "PHB-CH1","PHB-CH1-070",70,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,54.7,35.7,19 "PHB-CH1","PHB-CH1-070",70,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,35.7,35.7,0 "PHB-CH1","PHB-CH1-070",70,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,55,55,0 "PHB-CH1","PHB-CH1-070",70,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,67.9,55,12.9 "PHB-CH1","PHB-CH1-070",70,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,53.6,55,-1.4 "PHB-CH1","PHB-CH1-070",70,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,51.1,55,-3.9 "PHB-CH1","PHB-CH1-070",70,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.1,4.1,0 "PHB-CH1","PHB-CH1-070",70,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.8,4.1,0.7 "PHB-CH1","PHB-CH1-070",70,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.9,4.1,-0.2 "PHB-CH1","PHB-CH1-070",70,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.6,4.1,0.5 "PHB-CH1","PHB-CH1-070",70,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.9,4.1,1.8 "PHB-CH1","PHB-CH1-070",70,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.9,4.1,0.800000000000001 "PHB-CH1","PHB-CH1-070",70,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.2,4.1,0.100000000000001 "PHB-CH1","PHB-CH1-070",70,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.5,4.1,0.4 "PHB-CH1","PHB-CH1-070",70,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.6,4.1,1.5 "PHB-CH1","PHB-CH1-070",70,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.2,4.1,0.100000000000001 "PHB-CH1","PHB-CH1-070",70,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.6,4.1,-0.5 "PHB-CH1","PHB-CH1-070",70,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.6,4.1,0.5 "PHB-CH1","PHB-CH1-070",70,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.7,4.1,1.6 "PHB-CH1","PHB-CH1-070",70,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.1,4.1,2 "PHB-CH1","PHB-CH1-070",70,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.8,4.8,0 "PHB-CH1","PHB-CH1-070",70,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.5,4.8,0.7 "PHB-CH1","PHB-CH1-070",70,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.3,4.8,-1.5 "PHB-CH1","PHB-CH1-070",70,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4,4.8,-0.8 "PHB-CH1","PHB-CH1-070",70,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.6,4.8,-0.2 "PHB-CH1","PHB-CH1-070",70,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.6,4.8,-0.2 "PHB-CH1","PHB-CH1-070",70,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.4,4.8,-0.399999999999999 "PHB-CH1","PHB-CH1-070",70,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.3,4.8,0.5 "PHB-CH1","PHB-CH1-070",70,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.8,4.8,1 "PHB-CH1","PHB-CH1-070",70,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4,4.8,-0.8 "PHB-CH1","PHB-CH1-070",70,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4,4.8,-0.8 "PHB-CH1","PHB-CH1-070",70,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.8,4.8,0 "PHB-CH1","PHB-CH1-070",70,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.4,4.8,0.6 "PHB-CH1","PHB-CH1-070",70,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4,4.8,-0.8 "PHB-CH1","PHB-CH1-071",71,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,54,54,0 "PHB-CH1","PHB-CH1-071",71,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,68,54,14 "PHB-CH1","PHB-CH1-071",71,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,61,54,7 "PHB-CH1","PHB-CH1-071",71,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,54,, "PHB-CH1","PHB-CH1-071",71,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,67,, "PHB-CH1","PHB-CH1-071",71,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,46,, "PHB-CH1","PHB-CH1-071",71,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-071",71,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-071",71,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-071",71,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-071",71,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,10,, "PHB-CH1","PHB-CH1-071",71,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,366,, "PHB-CH1","PHB-CH1-071",71,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-071",71,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-071",71,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-071",71,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-071",71,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,68.8,68.8,0 "PHB-CH1","PHB-CH1-071",71,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,48.6,68.8,-20.2 "PHB-CH1","PHB-CH1-071",71,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,53,68.8,-15.8 "PHB-CH1","PHB-CH1-071",71,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,66.5,68.8,-2.3 "PHB-CH1","PHB-CH1-071",71,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,63.1,63.1,0 "PHB-CH1","PHB-CH1-071",71,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,44.3,63.1,-18.8 "PHB-CH1","PHB-CH1-071",71,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,63.9,63.1,0.799999999999997 "PHB-CH1","PHB-CH1-071",71,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,55.9,63.1,-7.2 "PHB-CH1","PHB-CH1-071",71,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,8.1,8.1,0 "PHB-CH1","PHB-CH1-071",71,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,7.1,8.1,-1 "PHB-CH1","PHB-CH1-071",71,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6,8.1,-2.1 "PHB-CH1","PHB-CH1-071",71,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,7,8.1,-1.1 "PHB-CH1","PHB-CH1-071",71,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.9,8.1,-2.2 "PHB-CH1","PHB-CH1-071",71,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.5,8.1,-1.6 "PHB-CH1","PHB-CH1-071",71,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,9.1,8.1,1 "PHB-CH1","PHB-CH1-071",71,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,8.6,8.1,0.5 "PHB-CH1","PHB-CH1-071",71,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.9,8.1,-1.2 "PHB-CH1","PHB-CH1-071",71,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,7.1,8.1,-1 "PHB-CH1","PHB-CH1-071",71,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.8,8.1,-2.3 "PHB-CH1","PHB-CH1-071",71,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,7.7,8.1,-0.399999999999999 "PHB-CH1","PHB-CH1-071",71,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,7.5,8.1,-0.6 "PHB-CH1","PHB-CH1-071",71,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,7.1,8.1,-1 "PHB-CH1","PHB-CH1-071",71,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,8.6,8.6,0 "PHB-CH1","PHB-CH1-071",71,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.4,8.6,-2.2 "PHB-CH1","PHB-CH1-071",71,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7.4,8.6,-1.2 "PHB-CH1","PHB-CH1-071",71,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.1,8.6,-2.5 "PHB-CH1","PHB-CH1-071",71,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.8,8.6,-3.8 "PHB-CH1","PHB-CH1-071",71,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.7,8.6,-1.9 "PHB-CH1","PHB-CH1-071",71,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,8.6,8.6,0 "PHB-CH1","PHB-CH1-071",71,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,8.1,8.6,-0.5 "PHB-CH1","PHB-CH1-071",71,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.7,8.6,-0.9 "PHB-CH1","PHB-CH1-071",71,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,8.1,8.6,-0.5 "PHB-CH1","PHB-CH1-071",71,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.8,8.6,-1.8 "PHB-CH1","PHB-CH1-071",71,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.6,8.6,-2 "PHB-CH1","PHB-CH1-071",71,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.6,8.6,-2 "PHB-CH1","PHB-CH1-071",71,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.2,8.6,-2.4 "PHB-CH1","PHB-CH1-072",72,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,37,37,0 "PHB-CH1","PHB-CH1-072",72,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,44,37,7 "PHB-CH1","PHB-CH1-072",72,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,35,37,-2 "PHB-CH1","PHB-CH1-072",72,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,40,, "PHB-CH1","PHB-CH1-072",72,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,54,, "PHB-CH1","PHB-CH1-072",72,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,35,, "PHB-CH1","PHB-CH1-072",72,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-072",72,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-072",72,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,5,, "PHB-CH1","PHB-CH1-072",72,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-072",72,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,54,, "PHB-CH1","PHB-CH1-072",72,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,108,, "PHB-CH1","PHB-CH1-072",72,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-072",72,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-072",72,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-072",72,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-072",72,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,29,29,0 "PHB-CH1","PHB-CH1-072",72,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,22.4,29,-6.6 "PHB-CH1","PHB-CH1-072",72,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,23.5,29,-5.5 "PHB-CH1","PHB-CH1-072",72,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,35.3,29,6.3 "PHB-CH1","PHB-CH1-072",72,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,28.6,28.6,0 "PHB-CH1","PHB-CH1-072",72,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,16.3,28.6,-12.3 "PHB-CH1","PHB-CH1-072",72,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,30.3,28.6,1.7 "PHB-CH1","PHB-CH1-072",72,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,38.4,28.6,9.8 "PHB-CH1","PHB-CH1-072",72,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,2.1,2.1,0 "PHB-CH1","PHB-CH1-072",72,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2.9,2.1,0.8 "PHB-CH1","PHB-CH1-072",72,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.1,2.1,2 "PHB-CH1","PHB-CH1-072",72,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.1,2.1,2 "PHB-CH1","PHB-CH1-072",72,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.2,2.1,1.1 "PHB-CH1","PHB-CH1-072",72,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2.9,2.1,0.8 "PHB-CH1","PHB-CH1-072",72,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.6,2.1,1.5 "PHB-CH1","PHB-CH1-072",72,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.3,2.1,2.2 "PHB-CH1","PHB-CH1-072",72,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.8,2.1,2.7 "PHB-CH1","PHB-CH1-072",72,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.6,2.1,2.5 "PHB-CH1","PHB-CH1-072",72,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3,2.1,0.9 "PHB-CH1","PHB-CH1-072",72,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.9,2.1,1.8 "PHB-CH1","PHB-CH1-072",72,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.5,2.1,2.4 "PHB-CH1","PHB-CH1-072",72,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.2,2.1,4.1 "PHB-CH1","PHB-CH1-072",72,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7.9,7.9,0 "PHB-CH1","PHB-CH1-072",72,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,7.8,7.9,-0.100000000000001 "PHB-CH1","PHB-CH1-072",72,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,9.4,7.9,1.5 "PHB-CH1","PHB-CH1-072",72,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,8.7,7.9,0.799999999999999 "PHB-CH1","PHB-CH1-072",72,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,7.7,7.9,-0.2 "PHB-CH1","PHB-CH1-072",72,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,7.9,7.9,0 "PHB-CH1","PHB-CH1-072",72,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,8.6,7.9,0.699999999999999 "PHB-CH1","PHB-CH1-072",72,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,9.5,7.9,1.6 "PHB-CH1","PHB-CH1-072",72,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,9.5,7.9,1.6 "PHB-CH1","PHB-CH1-072",72,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,9.9,7.9,2 "PHB-CH1","PHB-CH1-072",72,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,8.1,7.9,0.199999999999999 "PHB-CH1","PHB-CH1-072",72,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,9,7.9,1.1 "PHB-CH1","PHB-CH1-072",72,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,10,7.9,2.1 "PHB-CH1","PHB-CH1-072",72,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,10,7.9,2.1 "PHB-CH1","PHB-CH1-073",73,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,72,72,0 "PHB-CH1","PHB-CH1-073",73,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,66,72,-6 "PHB-CH1","PHB-CH1-073",73,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,75,72,3 "PHB-CH1","PHB-CH1-073",73,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,51,, "PHB-CH1","PHB-CH1-073",73,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,64,, "PHB-CH1","PHB-CH1-073",73,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,47,, "PHB-CH1","PHB-CH1-073",73,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-073",73,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-073",73,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,5,, "PHB-CH1","PHB-CH1-073",73,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,5,, "PHB-CH1","PHB-CH1-073",73,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,9,, "PHB-CH1","PHB-CH1-073",73,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,358,, "PHB-CH1","PHB-CH1-073",73,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-073",73,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-073",73,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-073",73,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-073",73,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,35.1,35.1,0 "PHB-CH1","PHB-CH1-073",73,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,29.5,35.1,-5.6 "PHB-CH1","PHB-CH1-073",73,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,49.5,35.1,14.4 "PHB-CH1","PHB-CH1-073",73,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,38.5,35.1,3.4 "PHB-CH1","PHB-CH1-073",73,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,43,43,0 "PHB-CH1","PHB-CH1-073",73,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,51.3,43,8.3 "PHB-CH1","PHB-CH1-073",73,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,38.8,43,-4.2 "PHB-CH1","PHB-CH1-073",73,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,43.2,43,0.200000000000003 "PHB-CH1","PHB-CH1-073",73,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.1,6.1,0 "PHB-CH1","PHB-CH1-073",73,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.9,6.1,0.800000000000001 "PHB-CH1","PHB-CH1-073",73,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.6,6.1,0.5 "PHB-CH1","PHB-CH1-073",73,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,7.9,6.1,1.8 "PHB-CH1","PHB-CH1-073",73,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,7.8,6.1,1.7 "PHB-CH1","PHB-CH1-073",73,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.9,6.1,0.800000000000001 "PHB-CH1","PHB-CH1-073",73,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.9,6.1,-0.199999999999999 "PHB-CH1","PHB-CH1-073",73,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.6,6.1,1.5 "PHB-CH1","PHB-CH1-073",73,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.7,6.1,0.6 "PHB-CH1","PHB-CH1-073",73,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.9,6.1,0.800000000000001 "PHB-CH1","PHB-CH1-073",73,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.8,6.1,-0.3 "PHB-CH1","PHB-CH1-073",73,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.4,6.1,0.300000000000001 "PHB-CH1","PHB-CH1-073",73,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,7.5,6.1,1.4 "PHB-CH1","PHB-CH1-073",73,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,7,6.1,0.9 "PHB-CH1","PHB-CH1-073",73,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-073",73,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.5,5.1,0.4 "PHB-CH1","PHB-CH1-073",73,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.6,5.1,0.5 "PHB-CH1","PHB-CH1-073",73,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.1,5.1,0 "PHB-CH1","PHB-CH1-073",73,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.2,5.1,0.100000000000001 "PHB-CH1","PHB-CH1-073",73,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.1,5.1,-1 "PHB-CH1","PHB-CH1-073",73,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.4,5.1,-1.7 "PHB-CH1","PHB-CH1-073",73,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.8,5.1,0.7 "PHB-CH1","PHB-CH1-073",73,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5,5.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-073",73,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.2,5.1,1.1 "PHB-CH1","PHB-CH1-073",73,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.3,5.1,0.2 "PHB-CH1","PHB-CH1-073",73,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.1,5.1,0 "PHB-CH1","PHB-CH1-073",73,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.8,5.1,1.7 "PHB-CH1","PHB-CH1-073",73,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.3,5.1,0.2 "PHB-CH1","PHB-CH1-074",74,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,53,53,0 "PHB-CH1","PHB-CH1-074",74,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,56,53,3 "PHB-CH1","PHB-CH1-074",74,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,51,53,-2 "PHB-CH1","PHB-CH1-074",74,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,44,, "PHB-CH1","PHB-CH1-074",74,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,41,, "PHB-CH1","PHB-CH1-074",74,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,57,, "PHB-CH1","PHB-CH1-074",74,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-074",74,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-074",74,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-074",74,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-074",74,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,1,, "PHB-CH1","PHB-CH1-074",74,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,623,, "PHB-CH1","PHB-CH1-074",74,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-074",74,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-074",74,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-074",74,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-074",74,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,47.4,47.4,0 "PHB-CH1","PHB-CH1-074",74,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,53.4,47.4,6 "PHB-CH1","PHB-CH1-074",74,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,41.4,47.4,-6 "PHB-CH1","PHB-CH1-074",74,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,40.3,47.4,-7.1 "PHB-CH1","PHB-CH1-074",74,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,22.4,22.4,0 "PHB-CH1","PHB-CH1-074",74,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,52.6,22.4,30.2 "PHB-CH1","PHB-CH1-074",74,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,19.5,22.4,-2.9 "PHB-CH1","PHB-CH1-074",74,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,36.2,22.4,13.8 "PHB-CH1","PHB-CH1-074",74,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-074",74,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.2,5.1,-1.9 "PHB-CH1","PHB-CH1-074",74,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.3,5.1,-0.8 "PHB-CH1","PHB-CH1-074",74,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.2,5.1,-0.9 "PHB-CH1","PHB-CH1-074",74,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.3,5.1,-0.8 "PHB-CH1","PHB-CH1-074",74,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4,5.1,-1.1 "PHB-CH1","PHB-CH1-074",74,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.6,5.1,-1.5 "PHB-CH1","PHB-CH1-074",74,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.9,5.1,-1.2 "PHB-CH1","PHB-CH1-074",74,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.7,5.1,0.6 "PHB-CH1","PHB-CH1-074",74,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.2,5.1,-0.9 "PHB-CH1","PHB-CH1-074",74,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.4,5.1,-0.699999999999999 "PHB-CH1","PHB-CH1-074",74,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.1,5.1,0 "PHB-CH1","PHB-CH1-074",74,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.7,5.1,-1.4 "PHB-CH1","PHB-CH1-074",74,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.7,5.1,-0.399999999999999 "PHB-CH1","PHB-CH1-074",74,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7.1,7.1,0 "PHB-CH1","PHB-CH1-074",74,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.3,7.1,-1.8 "PHB-CH1","PHB-CH1-074",74,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.2,7.1,-0.9 "PHB-CH1","PHB-CH1-074",74,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.5,7.1,-1.6 "PHB-CH1","PHB-CH1-074",74,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.3,7.1,-1.8 "PHB-CH1","PHB-CH1-074",74,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.1,7.1,-1 "PHB-CH1","PHB-CH1-074",74,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.5,7.1,-1.6 "PHB-CH1","PHB-CH1-074",74,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.8,7.1,-1.3 "PHB-CH1","PHB-CH1-074",74,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.5,7.1,-0.6 "PHB-CH1","PHB-CH1-074",74,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.4,7.1,-2.7 "PHB-CH1","PHB-CH1-074",74,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.8,7.1,-0.3 "PHB-CH1","PHB-CH1-074",74,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.5,7.1,0.4 "PHB-CH1","PHB-CH1-074",74,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6,7.1,-1.1 "PHB-CH1","PHB-CH1-074",74,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.8,7.1,-1.3 "PHB-CH1","PHB-CH1-075",75,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,47,47,0 "PHB-CH1","PHB-CH1-075",75,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,48,47,1 "PHB-CH1","PHB-CH1-075",75,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,36,47,-11 "PHB-CH1","PHB-CH1-075",75,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,43,, "PHB-CH1","PHB-CH1-075",75,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,47,, "PHB-CH1","PHB-CH1-075",75,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,39,, "PHB-CH1","PHB-CH1-075",75,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-075",75,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-075",75,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-075",75,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-075",75,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,3,, "PHB-CH1","PHB-CH1-075",75,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,472,, "PHB-CH1","PHB-CH1-075",75,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-075",75,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-075",75,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-075",75,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-075",75,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,49.8,49.8,0 "PHB-CH1","PHB-CH1-075",75,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,33,49.8,-16.8 "PHB-CH1","PHB-CH1-075",75,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,42.4,49.8,-7.4 "PHB-CH1","PHB-CH1-075",75,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,31,49.8,-18.8 "PHB-CH1","PHB-CH1-075",75,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,34.1,34.1,0 "PHB-CH1","PHB-CH1-075",75,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,12.6,34.1,-21.5 "PHB-CH1","PHB-CH1-075",75,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,18.5,34.1,-15.6 "PHB-CH1","PHB-CH1-075",75,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,25.7,34.1,-8.4 "PHB-CH1","PHB-CH1-075",75,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3,3,0 "PHB-CH1","PHB-CH1-075",75,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,1.5,3,-1.5 "PHB-CH1","PHB-CH1-075",75,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.7,3,-0.3 "PHB-CH1","PHB-CH1-075",75,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,1,3,-2 "PHB-CH1","PHB-CH1-075",75,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,1.9,3,-1.1 "PHB-CH1","PHB-CH1-075",75,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.4,3,0.4 "PHB-CH1","PHB-CH1-075",75,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2.3,3,-0.7 "PHB-CH1","PHB-CH1-075",75,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,2.8,3,-0.2 "PHB-CH1","PHB-CH1-075",75,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,1.8,3,-1.2 "PHB-CH1","PHB-CH1-075",75,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.2,3,1.2 "PHB-CH1","PHB-CH1-075",75,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.4,3,0.4 "PHB-CH1","PHB-CH1-075",75,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,2.1,3,-0.9 "PHB-CH1","PHB-CH1-075",75,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.6,3,-0.4 "PHB-CH1","PHB-CH1-075",75,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.6,3,0.6 "PHB-CH1","PHB-CH1-075",75,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5,5,0 "PHB-CH1","PHB-CH1-075",75,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4,5,-1 "PHB-CH1","PHB-CH1-075",75,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.4,5,0.4 "PHB-CH1","PHB-CH1-075",75,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.2,5,0.2 "PHB-CH1","PHB-CH1-075",75,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.7,5,-0.3 "PHB-CH1","PHB-CH1-075",75,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6,5,1 "PHB-CH1","PHB-CH1-075",75,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.6,5,-0.4 "PHB-CH1","PHB-CH1-075",75,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.9,5,-0.0999999999999996 "PHB-CH1","PHB-CH1-075",75,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4,5,-1 "PHB-CH1","PHB-CH1-075",75,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.2,5,0.2 "PHB-CH1","PHB-CH1-075",75,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.5,5,-0.5 "PHB-CH1","PHB-CH1-075",75,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.4,5,-0.6 "PHB-CH1","PHB-CH1-075",75,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.7,5,-1.3 "PHB-CH1","PHB-CH1-075",75,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.5,5,-0.5 "PHB-CH1","PHB-CH1-076",76,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,48,48,0 "PHB-CH1","PHB-CH1-076",76,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,45,48,-3 "PHB-CH1","PHB-CH1-076",76,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,31,48,-17 "PHB-CH1","PHB-CH1-076",76,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,53,, "PHB-CH1","PHB-CH1-076",76,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,44,, "PHB-CH1","PHB-CH1-076",76,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,55,, "PHB-CH1","PHB-CH1-076",76,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-076",76,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-076",76,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-076",76,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-076",76,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,6,, "PHB-CH1","PHB-CH1-076",76,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,451,, "PHB-CH1","PHB-CH1-076",76,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-076",76,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-076",76,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-076",76,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-076",76,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,69.2,69.2,0 "PHB-CH1","PHB-CH1-076",76,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,45.1,69.2,-24.1 "PHB-CH1","PHB-CH1-076",76,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,46.9,69.2,-22.3 "PHB-CH1","PHB-CH1-076",76,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,51.5,69.2,-17.7 "PHB-CH1","PHB-CH1-076",76,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,52.6,52.6,0 "PHB-CH1","PHB-CH1-076",76,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,61.6,52.6,9 "PHB-CH1","PHB-CH1-076",76,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,50.5,52.6,-2.1 "PHB-CH1","PHB-CH1-076",76,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,39.4,52.6,-13.2 "PHB-CH1","PHB-CH1-076",76,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,2.3,2.3,0 "PHB-CH1","PHB-CH1-076",76,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,1.3,2.3,-1 "PHB-CH1","PHB-CH1-076",76,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2,2.3,-0.3 "PHB-CH1","PHB-CH1-076",76,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,0.9,2.3,-1.4 "PHB-CH1","PHB-CH1-076",76,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,0.5,2.3,-1.8 "PHB-CH1","PHB-CH1-076",76,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,1.4,2.3,-0.9 "PHB-CH1","PHB-CH1-076",76,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,1.2,2.3,-1.1 "PHB-CH1","PHB-CH1-076",76,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,2.1,2.3,-0.2 "PHB-CH1","PHB-CH1-076",76,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,1.4,2.3,-0.9 "PHB-CH1","PHB-CH1-076",76,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,0.8,2.3,-1.5 "PHB-CH1","PHB-CH1-076",76,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,0,2.3,-2.3 "PHB-CH1","PHB-CH1-076",76,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,1.2,2.3,-1.1 "PHB-CH1","PHB-CH1-076",76,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,0.2,2.3,-2.1 "PHB-CH1","PHB-CH1-076",76,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2.4,2.3,0.1 "PHB-CH1","PHB-CH1-076",76,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.3,3.3,0 "PHB-CH1","PHB-CH1-076",76,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.1,3.3,-0.2 "PHB-CH1","PHB-CH1-076",76,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.9,3.3,0.6 "PHB-CH1","PHB-CH1-076",76,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,2.4,3.3,-0.9 "PHB-CH1","PHB-CH1-076",76,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,2.1,3.3,-1.2 "PHB-CH1","PHB-CH1-076",76,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,2.3,3.3,-1 "PHB-CH1","PHB-CH1-076",76,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,2.6,3.3,-0.7 "PHB-CH1","PHB-CH1-076",76,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.2,3.3,0.9 "PHB-CH1","PHB-CH1-076",76,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.8,3.3,0.5 "PHB-CH1","PHB-CH1-076",76,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,2.4,3.3,-0.9 "PHB-CH1","PHB-CH1-076",76,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,2.5,3.3,-0.8 "PHB-CH1","PHB-CH1-076",76,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,2.9,3.3,-0.4 "PHB-CH1","PHB-CH1-076",76,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.1,3.3,-0.2 "PHB-CH1","PHB-CH1-076",76,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.1,3.3,1.8 "PHB-CH1","PHB-CH1-077",77,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,34,34,0 "PHB-CH1","PHB-CH1-077",77,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,29,34,-5 "PHB-CH1","PHB-CH1-077",77,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,31,34,-3 "PHB-CH1","PHB-CH1-077",77,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,36,, "PHB-CH1","PHB-CH1-077",77,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,57,, "PHB-CH1","PHB-CH1-077",77,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,53,, "PHB-CH1","PHB-CH1-077",77,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-077",77,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-077",77,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-077",77,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-077",77,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,21,, "PHB-CH1","PHB-CH1-077",77,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,326,, "PHB-CH1","PHB-CH1-077",77,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-077",77,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-077",77,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-077",77,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-077",77,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,21.5,21.5,0 "PHB-CH1","PHB-CH1-077",77,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,35,21.5,13.5 "PHB-CH1","PHB-CH1-077",77,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,45.5,21.5,24 "PHB-CH1","PHB-CH1-077",77,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,39.5,21.5,18 "PHB-CH1","PHB-CH1-077",77,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,40.8,40.8,0 "PHB-CH1","PHB-CH1-077",77,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,44.2,40.8,3.40000000000001 "PHB-CH1","PHB-CH1-077",77,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,33,40.8,-7.8 "PHB-CH1","PHB-CH1-077",77,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,45.7,40.8,4.90000000000001 "PHB-CH1","PHB-CH1-077",77,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,7.8,7.8,0 "PHB-CH1","PHB-CH1-077",77,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,7.3,7.8,-0.5 "PHB-CH1","PHB-CH1-077",77,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.1,7.8,-1.7 "PHB-CH1","PHB-CH1-077",77,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.9,7.8,-1.9 "PHB-CH1","PHB-CH1-077",77,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.4,7.8,-1.4 "PHB-CH1","PHB-CH1-077",77,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.9,7.8,-1.9 "PHB-CH1","PHB-CH1-077",77,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5,7.8,-2.8 "PHB-CH1","PHB-CH1-077",77,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.5,7.8,-2.3 "PHB-CH1","PHB-CH1-077",77,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.8,7.8,-3 "PHB-CH1","PHB-CH1-077",77,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.9,7.8,-1.9 "PHB-CH1","PHB-CH1-077",77,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,7.2,7.8,-0.6 "PHB-CH1","PHB-CH1-077",77,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.4,7.8,-1.4 "PHB-CH1","PHB-CH1-077",77,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.4,7.8,-1.4 "PHB-CH1","PHB-CH1-077",77,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,7.1,7.8,-0.7 "PHB-CH1","PHB-CH1-077",77,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.4,4.4,0 "PHB-CH1","PHB-CH1-077",77,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.5,4.4,0.0999999999999996 "PHB-CH1","PHB-CH1-077",77,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.1,4.4,-1.3 "PHB-CH1","PHB-CH1-077",77,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.1,4.4,-1.3 "PHB-CH1","PHB-CH1-077",77,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.4,4.4,-1 "PHB-CH1","PHB-CH1-077",77,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.6,4.4,0.199999999999999 "PHB-CH1","PHB-CH1-077",77,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.1,4.4,-0.300000000000001 "PHB-CH1","PHB-CH1-077",77,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.9,4.4,-0.5 "PHB-CH1","PHB-CH1-077",77,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.1,4.4,-1.3 "PHB-CH1","PHB-CH1-077",77,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.1,4.4,-1.3 "PHB-CH1","PHB-CH1-077",77,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.5,4.4,0.0999999999999996 "PHB-CH1","PHB-CH1-077",77,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.9,4.4,-0.5 "PHB-CH1","PHB-CH1-077",77,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.2,4.4,-0.2 "PHB-CH1","PHB-CH1-077",77,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.4,4.4,-1 "PHB-CH1","PHB-CH1-078",78,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,51,51,0 "PHB-CH1","PHB-CH1-078",78,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,47,51,-4 "PHB-CH1","PHB-CH1-078",78,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,40,51,-11 "PHB-CH1","PHB-CH1-078",78,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,35,, "PHB-CH1","PHB-CH1-078",78,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,59,, "PHB-CH1","PHB-CH1-078",78,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,48,, "PHB-CH1","PHB-CH1-078",78,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-078",78,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-078",78,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-078",78,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-078",78,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,1,, "PHB-CH1","PHB-CH1-078",78,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,515,, "PHB-CH1","PHB-CH1-078",78,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-078",78,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-078",78,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-078",78,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-078",78,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,49.1,49.1,0 "PHB-CH1","PHB-CH1-078",78,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,50.3,49.1,1.2 "PHB-CH1","PHB-CH1-078",78,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,40.6,49.1,-8.5 "PHB-CH1","PHB-CH1-078",78,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,50.3,49.1,1.2 "PHB-CH1","PHB-CH1-078",78,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,62.4,62.4,0 "PHB-CH1","PHB-CH1-078",78,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,56.7,62.4,-5.7 "PHB-CH1","PHB-CH1-078",78,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,56.4,62.4,-6 "PHB-CH1","PHB-CH1-078",78,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,60.2,62.4,-2.2 "PHB-CH1","PHB-CH1-078",78,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.8,4.8,0 "PHB-CH1","PHB-CH1-078",78,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2.5,4.8,-2.3 "PHB-CH1","PHB-CH1-078",78,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.9,4.8,-0.9 "PHB-CH1","PHB-CH1-078",78,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.8,4.8,-1 "PHB-CH1","PHB-CH1-078",78,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.1,4.8,-1.7 "PHB-CH1","PHB-CH1-078",78,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.3,4.8,-1.5 "PHB-CH1","PHB-CH1-078",78,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.4,4.8,-1.4 "PHB-CH1","PHB-CH1-078",78,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.6,4.8,-0.2 "PHB-CH1","PHB-CH1-078",78,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.1,4.8,0.3 "PHB-CH1","PHB-CH1-078",78,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.1,4.8,1.3 "PHB-CH1","PHB-CH1-078",78,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.8,4.8,0 "PHB-CH1","PHB-CH1-078",78,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.3,4.8,-0.5 "PHB-CH1","PHB-CH1-078",78,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.8,4.8,-1 "PHB-CH1","PHB-CH1-078",78,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.6,4.8,-0.2 "PHB-CH1","PHB-CH1-078",78,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.5,6.5,0 "PHB-CH1","PHB-CH1-078",78,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.5,6.5,-1 "PHB-CH1","PHB-CH1-078",78,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.9,6.5,-0.6 "PHB-CH1","PHB-CH1-078",78,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.9,6.5,-0.6 "PHB-CH1","PHB-CH1-078",78,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.4,6.5,-1.1 "PHB-CH1","PHB-CH1-078",78,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.5,6.5,-1 "PHB-CH1","PHB-CH1-078",78,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.5,6.5,-1 "PHB-CH1","PHB-CH1-078",78,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.6,6.5,0.0999999999999996 "PHB-CH1","PHB-CH1-078",78,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.9,6.5,0.4 "PHB-CH1","PHB-CH1-078",78,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7,6.5,0.5 "PHB-CH1","PHB-CH1-078",78,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.9,6.5,-0.6 "PHB-CH1","PHB-CH1-078",78,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.5,6.5,0 "PHB-CH1","PHB-CH1-078",78,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.1,6.5,-1.4 "PHB-CH1","PHB-CH1-078",78,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.4,6.5,0.9 "PHB-CH1","PHB-CH1-079",79,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,67,67,0 "PHB-CH1","PHB-CH1-079",79,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,53,67,-14 "PHB-CH1","PHB-CH1-079",79,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,64,67,-3 "PHB-CH1","PHB-CH1-079",79,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,62,, "PHB-CH1","PHB-CH1-079",79,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,72,, "PHB-CH1","PHB-CH1-079",79,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,59,, "PHB-CH1","PHB-CH1-079",79,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-079",79,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-079",79,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-079",79,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-079",79,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,1,, "PHB-CH1","PHB-CH1-079",79,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,474,, "PHB-CH1","PHB-CH1-079",79,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-079",79,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-079",79,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-079",79,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-079",79,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,46,46,0 "PHB-CH1","PHB-CH1-079",79,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,47.8,46,1.8 "PHB-CH1","PHB-CH1-079",79,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,45.6,46,-0.399999999999999 "PHB-CH1","PHB-CH1-079",79,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,42.8,46,-3.2 "PHB-CH1","PHB-CH1-079",79,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,43.4,43.4,0 "PHB-CH1","PHB-CH1-079",79,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,52.7,43.4,9.3 "PHB-CH1","PHB-CH1-079",79,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,49.2,43.4,5.8 "PHB-CH1","PHB-CH1-079",79,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,48.8,43.4,5.4 "PHB-CH1","PHB-CH1-079",79,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.3,6.3,0 "PHB-CH1","PHB-CH1-079",79,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.1,6.3,-1.2 "PHB-CH1","PHB-CH1-079",79,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.8,6.3,-0.5 "PHB-CH1","PHB-CH1-079",79,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.6,6.3,-0.7 "PHB-CH1","PHB-CH1-079",79,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.8,6.3,0.5 "PHB-CH1","PHB-CH1-079",79,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,7.4,6.3,1.1 "PHB-CH1","PHB-CH1-079",79,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.4,6.3,0.100000000000001 "PHB-CH1","PHB-CH1-079",79,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.6,6.3,1.3 "PHB-CH1","PHB-CH1-079",79,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.8,6.3,0.5 "PHB-CH1","PHB-CH1-079",79,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.4,6.3,0.100000000000001 "PHB-CH1","PHB-CH1-079",79,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.4,6.3,0.100000000000001 "PHB-CH1","PHB-CH1-079",79,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.2,6.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-079",79,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.8,6.3,-0.5 "PHB-CH1","PHB-CH1-079",79,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,7.3,6.3,1 "PHB-CH1","PHB-CH1-079",79,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.5,4.5,0 "PHB-CH1","PHB-CH1-079",79,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.1,4.5,-0.4 "PHB-CH1","PHB-CH1-079",79,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.3,4.5,-0.2 "PHB-CH1","PHB-CH1-079",79,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.4,4.5,-1.1 "PHB-CH1","PHB-CH1-079",79,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.5,4.5,1 "PHB-CH1","PHB-CH1-079",79,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.1,4.5,0.6 "PHB-CH1","PHB-CH1-079",79,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.4,4.5,0.9 "PHB-CH1","PHB-CH1-079",79,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.1,4.5,1.6 "PHB-CH1","PHB-CH1-079",79,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.4,4.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-079",79,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.2,4.5,0.7 "PHB-CH1","PHB-CH1-079",79,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.6,4.5,0.0999999999999996 "PHB-CH1","PHB-CH1-079",79,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.7,4.5,0.2 "PHB-CH1","PHB-CH1-079",79,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.3,4.5,0.8 "PHB-CH1","PHB-CH1-079",79,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.4,4.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-080",80,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,59,59,0 "PHB-CH1","PHB-CH1-080",80,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,45,59,-14 "PHB-CH1","PHB-CH1-080",80,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,57,59,-2 "PHB-CH1","PHB-CH1-080",80,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,77,, "PHB-CH1","PHB-CH1-080",80,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,55,, "PHB-CH1","PHB-CH1-080",80,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,59,, "PHB-CH1","PHB-CH1-080",80,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-080",80,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-080",80,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-080",80,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-080",80,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,7,, "PHB-CH1","PHB-CH1-080",80,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,417,, "PHB-CH1","PHB-CH1-080",80,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-080",80,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-080",80,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-080",80,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-080",80,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,41,41,0 "PHB-CH1","PHB-CH1-080",80,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,65.8,41,24.8 "PHB-CH1","PHB-CH1-080",80,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,39.5,41,-1.5 "PHB-CH1","PHB-CH1-080",80,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,54.8,41,13.8 "PHB-CH1","PHB-CH1-080",80,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,39,39,0 "PHB-CH1","PHB-CH1-080",80,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,65.6,39,26.6 "PHB-CH1","PHB-CH1-080",80,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,47.9,39,8.9 "PHB-CH1","PHB-CH1-080",80,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,44.7,39,5.7 "PHB-CH1","PHB-CH1-080",80,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.2,4.2,0 "PHB-CH1","PHB-CH1-080",80,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.8,4.2,-0.4 "PHB-CH1","PHB-CH1-080",80,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.9,4.2,-1.3 "PHB-CH1","PHB-CH1-080",80,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3,4.2,-1.2 "PHB-CH1","PHB-CH1-080",80,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,1.6,4.2,-2.6 "PHB-CH1","PHB-CH1-080",80,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.2,4.2,-1 "PHB-CH1","PHB-CH1-080",80,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.2,4.2,0 "PHB-CH1","PHB-CH1-080",80,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,2.9,4.2,-1.3 "PHB-CH1","PHB-CH1-080",80,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,2.9,4.2,-1.3 "PHB-CH1","PHB-CH1-080",80,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,1.8,4.2,-2.4 "PHB-CH1","PHB-CH1-080",80,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3,4.2,-1.2 "PHB-CH1","PHB-CH1-080",80,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.7,4.2,-0.5 "PHB-CH1","PHB-CH1-080",80,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3,4.2,-1.2 "PHB-CH1","PHB-CH1-080",80,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.3,4.2,-0.9 "PHB-CH1","PHB-CH1-080",80,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.6,6.6,0 "PHB-CH1","PHB-CH1-080",80,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.2,6.6,-0.399999999999999 "PHB-CH1","PHB-CH1-080",80,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.7,6.6,-1.9 "PHB-CH1","PHB-CH1-080",80,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.6,6.6,-1 "PHB-CH1","PHB-CH1-080",80,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.3,6.6,-2.3 "PHB-CH1","PHB-CH1-080",80,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.6,6.6,-2 "PHB-CH1","PHB-CH1-080",80,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.7,6.6,-0.9 "PHB-CH1","PHB-CH1-080",80,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.4,6.6,-2.2 "PHB-CH1","PHB-CH1-080",80,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.3,6.6,-1.3 "PHB-CH1","PHB-CH1-080",80,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.3,6.6,-2.3 "PHB-CH1","PHB-CH1-080",80,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.8,6.6,-1.8 "PHB-CH1","PHB-CH1-080",80,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.7,6.6,-1.9 "PHB-CH1","PHB-CH1-080",80,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.9,6.6,-1.7 "PHB-CH1","PHB-CH1-080",80,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.8,6.6,-1.8 "PHB-CH1","PHB-CH1-081",81,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,36,36,0 "PHB-CH1","PHB-CH1-081",81,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,25,36,-11 "PHB-CH1","PHB-CH1-081",81,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,21,36,-15 "PHB-CH1","PHB-CH1-081",81,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,46,, "PHB-CH1","PHB-CH1-081",81,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,50,, "PHB-CH1","PHB-CH1-081",81,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,59,, "PHB-CH1","PHB-CH1-081",81,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-081",81,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-081",81,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-081",81,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-081",81,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,17,, "PHB-CH1","PHB-CH1-081",81,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,310,, "PHB-CH1","PHB-CH1-081",81,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-081",81,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-081",81,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-081",81,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-081",81,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,54.5,54.5,0 "PHB-CH1","PHB-CH1-081",81,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,55.4,54.5,0.899999999999999 "PHB-CH1","PHB-CH1-081",81,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,47.1,54.5,-7.4 "PHB-CH1","PHB-CH1-081",81,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,59.6,54.5,5.1 "PHB-CH1","PHB-CH1-081",81,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,72.2,72.2,0 "PHB-CH1","PHB-CH1-081",81,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,56.8,72.2,-15.4 "PHB-CH1","PHB-CH1-081",81,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,63.9,72.2,-8.3 "PHB-CH1","PHB-CH1-081",81,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,57.8,72.2,-14.4 "PHB-CH1","PHB-CH1-081",81,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.2,4.2,0 "PHB-CH1","PHB-CH1-081",81,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.7,4.2,-0.5 "PHB-CH1","PHB-CH1-081",81,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.5,4.2,1.3 "PHB-CH1","PHB-CH1-081",81,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.2,4.2,1 "PHB-CH1","PHB-CH1-081",81,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.3,4.2,1.1 "PHB-CH1","PHB-CH1-081",81,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5,4.2,0.8 "PHB-CH1","PHB-CH1-081",81,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.4,4.2,1.2 "PHB-CH1","PHB-CH1-081",81,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.9,4.2,0.7 "PHB-CH1","PHB-CH1-081",81,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.3,4.2,-0.9 "PHB-CH1","PHB-CH1-081",81,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.9,4.2,-0.3 "PHB-CH1","PHB-CH1-081",81,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-081",81,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.5,4.2,-0.7 "PHB-CH1","PHB-CH1-081",81,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.9,4.2,-0.3 "PHB-CH1","PHB-CH1-081",81,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.1,4.2,1.9 "PHB-CH1","PHB-CH1-081",81,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.2,4.2,0 "PHB-CH1","PHB-CH1-081",81,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.8,4.2,0.6 "PHB-CH1","PHB-CH1-081",81,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.2,4.2,0 "PHB-CH1","PHB-CH1-081",81,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.7,4.2,0.5 "PHB-CH1","PHB-CH1-081",81,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5,4.2,0.8 "PHB-CH1","PHB-CH1-081",81,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4,4.2,-0.2 "PHB-CH1","PHB-CH1-081",81,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-081",81,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.1,4.2,-1.1 "PHB-CH1","PHB-CH1-081",81,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3,4.2,-1.2 "PHB-CH1","PHB-CH1-081",81,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.6,4.2,0.399999999999999 "PHB-CH1","PHB-CH1-081",81,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.8,4.2,0.6 "PHB-CH1","PHB-CH1-081",81,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.2,4.2,0 "PHB-CH1","PHB-CH1-081",81,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.8,4.2,-0.4 "PHB-CH1","PHB-CH1-081",81,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.9,4.2,0.7 "PHB-CH1","PHB-CH1-082",82,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,78,78,0 "PHB-CH1","PHB-CH1-082",82,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,67,78,-11 "PHB-CH1","PHB-CH1-082",82,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,69,78,-9 "PHB-CH1","PHB-CH1-082",82,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,70,, "PHB-CH1","PHB-CH1-082",82,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,54,, "PHB-CH1","PHB-CH1-082",82,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,49,, "PHB-CH1","PHB-CH1-082",82,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-082",82,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-082",82,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-082",82,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-082",82,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,19,, "PHB-CH1","PHB-CH1-082",82,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,335,, "PHB-CH1","PHB-CH1-082",82,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-082",82,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-082",82,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-082",82,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-082",82,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,40.4,40.4,0 "PHB-CH1","PHB-CH1-082",82,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,54.2,40.4,13.8 "PHB-CH1","PHB-CH1-082",82,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,33.3,40.4,-7.1 "PHB-CH1","PHB-CH1-082",82,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,42.7,40.4,2.3 "PHB-CH1","PHB-CH1-082",82,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,39.3,39.3,0 "PHB-CH1","PHB-CH1-082",82,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,60.7,39.3,21.4 "PHB-CH1","PHB-CH1-082",82,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,37.5,39.3,-1.8 "PHB-CH1","PHB-CH1-082",82,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,46.1,39.3,6.8 "PHB-CH1","PHB-CH1-082",82,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.8,6.8,0 "PHB-CH1","PHB-CH1-082",82,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5,6.8,-1.8 "PHB-CH1","PHB-CH1-082",82,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7.4,6.8,0.6 "PHB-CH1","PHB-CH1-082",82,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,8.5,6.8,1.7 "PHB-CH1","PHB-CH1-082",82,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,7.3,6.8,0.5 "PHB-CH1","PHB-CH1-082",82,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,7.6,6.8,0.8 "PHB-CH1","PHB-CH1-082",82,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,7.6,6.8,0.8 "PHB-CH1","PHB-CH1-082",82,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.9,6.8,1.1 "PHB-CH1","PHB-CH1-082",82,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,7.6,6.8,0.8 "PHB-CH1","PHB-CH1-082",82,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.1,6.8,-0.7 "PHB-CH1","PHB-CH1-082",82,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.4,6.8,-0.399999999999999 "PHB-CH1","PHB-CH1-082",82,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.1,6.8,-0.7 "PHB-CH1","PHB-CH1-082",82,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.3,6.8,-1.5 "PHB-CH1","PHB-CH1-082",82,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.5,6.8,-0.3 "PHB-CH1","PHB-CH1-082",82,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.8,6.8,0 "PHB-CH1","PHB-CH1-082",82,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.4,6.8,-0.399999999999999 "PHB-CH1","PHB-CH1-082",82,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7.6,6.8,0.8 "PHB-CH1","PHB-CH1-082",82,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,8.9,6.8,2.1 "PHB-CH1","PHB-CH1-082",82,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,8.2,6.8,1.4 "PHB-CH1","PHB-CH1-082",82,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,8.1,6.8,1.3 "PHB-CH1","PHB-CH1-082",82,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7.5,6.8,0.7 "PHB-CH1","PHB-CH1-082",82,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,7.7,6.8,0.9 "PHB-CH1","PHB-CH1-082",82,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.5,6.8,-0.3 "PHB-CH1","PHB-CH1-082",82,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7,6.8,0.2 "PHB-CH1","PHB-CH1-082",82,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.8,6.8,1 "PHB-CH1","PHB-CH1-082",82,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7,6.8,0.2 "PHB-CH1","PHB-CH1-082",82,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.5,6.8,-0.3 "PHB-CH1","PHB-CH1-082",82,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.3,6.8,0.5 "PHB-CH1","PHB-CH1-083",83,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,63,63,0 "PHB-CH1","PHB-CH1-083",83,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,60,63,-3 "PHB-CH1","PHB-CH1-083",83,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,50,63,-13 "PHB-CH1","PHB-CH1-083",83,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,58,, "PHB-CH1","PHB-CH1-083",83,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,53,, "PHB-CH1","PHB-CH1-083",83,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,55,, "PHB-CH1","PHB-CH1-083",83,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-083",83,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-083",83,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-083",83,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-083",83,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,6,, "PHB-CH1","PHB-CH1-083",83,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,427,, "PHB-CH1","PHB-CH1-083",83,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-083",83,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-083",83,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-083",83,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-083",83,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,35.1,35.1,0 "PHB-CH1","PHB-CH1-083",83,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,35.2,35.1,0.100000000000001 "PHB-CH1","PHB-CH1-083",83,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,38.4,35.1,3.3 "PHB-CH1","PHB-CH1-083",83,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,48.2,35.1,13.1 "PHB-CH1","PHB-CH1-083",83,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,57.9,57.9,0 "PHB-CH1","PHB-CH1-083",83,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,58.7,57.9,0.800000000000004 "PHB-CH1","PHB-CH1-083",83,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,62.3,57.9,4.4 "PHB-CH1","PHB-CH1-083",83,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,71.5,57.9,13.6 "PHB-CH1","PHB-CH1-083",83,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6,6,0 "PHB-CH1","PHB-CH1-083",83,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.4,6,0.4 "PHB-CH1","PHB-CH1-083",83,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.9,6,0.9 "PHB-CH1","PHB-CH1-083",83,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.9,6,0.9 "PHB-CH1","PHB-CH1-083",83,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.9,6,0.9 "PHB-CH1","PHB-CH1-083",83,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.8,6,0.8 "PHB-CH1","PHB-CH1-083",83,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,7.3,6,1.3 "PHB-CH1","PHB-CH1-083",83,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.8,6,1.8 "PHB-CH1","PHB-CH1-083",83,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,8.4,6,2.4 "PHB-CH1","PHB-CH1-083",83,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,8.8,6,2.8 "PHB-CH1","PHB-CH1-083",83,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,7.3,6,1.3 "PHB-CH1","PHB-CH1-083",83,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,7.4,6,1.4 "PHB-CH1","PHB-CH1-083",83,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.5,6,0.5 "PHB-CH1","PHB-CH1-083",83,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,7.1,6,1.1 "PHB-CH1","PHB-CH1-083",83,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.6,5.6,0 "PHB-CH1","PHB-CH1-083",83,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.7,5.6,0.100000000000001 "PHB-CH1","PHB-CH1-083",83,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7,5.6,1.4 "PHB-CH1","PHB-CH1-083",83,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6,5.6,0.4 "PHB-CH1","PHB-CH1-083",83,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.1,5.6,-0.5 "PHB-CH1","PHB-CH1-083",83,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.2,5.6,0.6 "PHB-CH1","PHB-CH1-083",83,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.6,5.6,0 "PHB-CH1","PHB-CH1-083",83,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.4,5.6,-0.199999999999999 "PHB-CH1","PHB-CH1-083",83,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.7,5.6,0.100000000000001 "PHB-CH1","PHB-CH1-083",83,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.6,5.6,1 "PHB-CH1","PHB-CH1-083",83,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.8,5.6,-0.8 "PHB-CH1","PHB-CH1-083",83,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.2,5.6,0.6 "PHB-CH1","PHB-CH1-083",83,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.2,5.6,0.6 "PHB-CH1","PHB-CH1-083",83,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.3,5.6,0.7 "PHB-CH1","PHB-CH1-084",84,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,74,74,0 "PHB-CH1","PHB-CH1-084",84,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,62,74,-12 "PHB-CH1","PHB-CH1-084",84,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,84,74,10 "PHB-CH1","PHB-CH1-084",84,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,57,, "PHB-CH1","PHB-CH1-084",84,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,69,, "PHB-CH1","PHB-CH1-084",84,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,55,, "PHB-CH1","PHB-CH1-084",84,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-084",84,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-084",84,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-084",84,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,5,, "PHB-CH1","PHB-CH1-084",84,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,3,, "PHB-CH1","PHB-CH1-084",84,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,539,, "PHB-CH1","PHB-CH1-084",84,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-084",84,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-084",84,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-084",84,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-084",84,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,53.5,53.5,0 "PHB-CH1","PHB-CH1-084",84,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,61.2,53.5,7.7 "PHB-CH1","PHB-CH1-084",84,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,57.9,53.5,4.4 "PHB-CH1","PHB-CH1-084",84,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,54,53.5,0.5 "PHB-CH1","PHB-CH1-084",84,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,55.9,55.9,0 "PHB-CH1","PHB-CH1-084",84,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,61.2,55.9,5.3 "PHB-CH1","PHB-CH1-084",84,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,70.1,55.9,14.2 "PHB-CH1","PHB-CH1-084",84,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,57,55.9,1.1 "PHB-CH1","PHB-CH1-084",84,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.8,4.8,0 "PHB-CH1","PHB-CH1-084",84,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.9,4.8,0.100000000000001 "PHB-CH1","PHB-CH1-084",84,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4,4.8,-0.8 "PHB-CH1","PHB-CH1-084",84,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.3,4.8,-1.5 "PHB-CH1","PHB-CH1-084",84,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.3,4.8,-1.5 "PHB-CH1","PHB-CH1-084",84,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.3,4.8,-0.5 "PHB-CH1","PHB-CH1-084",84,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.2,4.8,1.4 "PHB-CH1","PHB-CH1-084",84,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.2,4.8,0.4 "PHB-CH1","PHB-CH1-084",84,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.2,4.8,0.4 "PHB-CH1","PHB-CH1-084",84,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.2,4.8,1.4 "PHB-CH1","PHB-CH1-084",84,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.8,4.8,1 "PHB-CH1","PHB-CH1-084",84,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.5,4.8,1.7 "PHB-CH1","PHB-CH1-084",84,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.9,4.8,2.1 "PHB-CH1","PHB-CH1-084",84,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.6,4.8,-0.2 "PHB-CH1","PHB-CH1-084",84,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-084",84,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.8,5.4,0.399999999999999 "PHB-CH1","PHB-CH1-084",84,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.2,5.4,-0.2 "PHB-CH1","PHB-CH1-084",84,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.2,5.4,0.8 "PHB-CH1","PHB-CH1-084",84,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.1,5.4,-1.3 "PHB-CH1","PHB-CH1-084",84,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.7,5.4,0.3 "PHB-CH1","PHB-CH1-084",84,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.3,5.4,-0.100000000000001 "PHB-CH1","PHB-CH1-084",84,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.3,5.4,0.9 "PHB-CH1","PHB-CH1-084",84,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.1,5.4,-0.300000000000001 "PHB-CH1","PHB-CH1-084",84,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.9,5.4,0.5 "PHB-CH1","PHB-CH1-084",84,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.2,5.4,-0.2 "PHB-CH1","PHB-CH1-084",84,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.2,5.4,0.8 "PHB-CH1","PHB-CH1-084",84,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.7,5.4,1.3 "PHB-CH1","PHB-CH1-084",84,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.6,5.4,0.199999999999999 "PHB-CH1","PHB-CH1-085",85,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,49,49,0 "PHB-CH1","PHB-CH1-085",85,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,57,49,8 "PHB-CH1","PHB-CH1-085",85,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,52,49,3 "PHB-CH1","PHB-CH1-085",85,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,54,, "PHB-CH1","PHB-CH1-085",85,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,49,, "PHB-CH1","PHB-CH1-085",85,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,43,, "PHB-CH1","PHB-CH1-085",85,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-085",85,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-085",85,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-085",85,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-085",85,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,46,, "PHB-CH1","PHB-CH1-085",85,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,163,, "PHB-CH1","PHB-CH1-085",85,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-085",85,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-085",85,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-085",85,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-085",85,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,36.3,36.3,0 "PHB-CH1","PHB-CH1-085",85,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,37.2,36.3,0.900000000000006 "PHB-CH1","PHB-CH1-085",85,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,29.6,36.3,-6.7 "PHB-CH1","PHB-CH1-085",85,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,42.1,36.3,5.8 "PHB-CH1","PHB-CH1-085",85,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,45,45,0 "PHB-CH1","PHB-CH1-085",85,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,44.9,45,-0.100000000000001 "PHB-CH1","PHB-CH1-085",85,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,48.9,45,3.9 "PHB-CH1","PHB-CH1-085",85,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,46.2,45,1.2 "PHB-CH1","PHB-CH1-085",85,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.3,4.3,0 "PHB-CH1","PHB-CH1-085",85,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5,4.3,0.7 "PHB-CH1","PHB-CH1-085",85,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.7,4.3,1.4 "PHB-CH1","PHB-CH1-085",85,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.1,4.3,-0.2 "PHB-CH1","PHB-CH1-085",85,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.3,4.3,0 "PHB-CH1","PHB-CH1-085",85,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.7,4.3,0.4 "PHB-CH1","PHB-CH1-085",85,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5,4.3,0.7 "PHB-CH1","PHB-CH1-085",85,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.6,4.3,0.3 "PHB-CH1","PHB-CH1-085",85,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.3,4.3,1 "PHB-CH1","PHB-CH1-085",85,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.7,4.3,0.4 "PHB-CH1","PHB-CH1-085",85,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.4,4.3,1.1 "PHB-CH1","PHB-CH1-085",85,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.2,4.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-085",85,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.2,4.3,1.9 "PHB-CH1","PHB-CH1-085",85,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.4,4.3,1.1 "PHB-CH1","PHB-CH1-085",85,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.3,3.3,0 "PHB-CH1","PHB-CH1-085",85,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3,3.3,-0.3 "PHB-CH1","PHB-CH1-085",85,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,2.4,3.3,-0.9 "PHB-CH1","PHB-CH1-085",85,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,1.7,3.3,-1.6 "PHB-CH1","PHB-CH1-085",85,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.4,3.3,0.1 "PHB-CH1","PHB-CH1-085",85,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.3,3.3,0 "PHB-CH1","PHB-CH1-085",85,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.6,3.3,0.3 "PHB-CH1","PHB-CH1-085",85,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.9,3.3,-0.4 "PHB-CH1","PHB-CH1-085",85,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.5,3.3,0.2 "PHB-CH1","PHB-CH1-085",85,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3,3.3,-0.3 "PHB-CH1","PHB-CH1-085",85,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,2.7,3.3,-0.6 "PHB-CH1","PHB-CH1-085",85,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,2.9,3.3,-0.4 "PHB-CH1","PHB-CH1-085",85,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.6,3.3,1.3 "PHB-CH1","PHB-CH1-085",85,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,2.2,3.3,-1.1 "PHB-CH1","PHB-CH1-086",86,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,68,68,0 "PHB-CH1","PHB-CH1-086",86,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,61,68,-7 "PHB-CH1","PHB-CH1-086",86,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,61,68,-7 "PHB-CH1","PHB-CH1-086",86,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,73,, "PHB-CH1","PHB-CH1-086",86,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,55,, "PHB-CH1","PHB-CH1-086",86,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,45,, "PHB-CH1","PHB-CH1-086",86,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-086",86,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-086",86,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-086",86,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-086",86,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,15,, "PHB-CH1","PHB-CH1-086",86,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,303,, "PHB-CH1","PHB-CH1-086",86,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-086",86,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-086",86,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-086",86,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-086",86,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,38.9,38.9,0 "PHB-CH1","PHB-CH1-086",86,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,51.2,38.9,12.3 "PHB-CH1","PHB-CH1-086",86,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,34.2,38.9,-4.7 "PHB-CH1","PHB-CH1-086",86,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,58.1,38.9,19.2 "PHB-CH1","PHB-CH1-086",86,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,21.7,21.7,0 "PHB-CH1","PHB-CH1-086",86,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,39.3,21.7,17.6 "PHB-CH1","PHB-CH1-086",86,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,26.9,21.7,5.2 "PHB-CH1","PHB-CH1-086",86,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,28.8,21.7,7.1 "PHB-CH1","PHB-CH1-086",86,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5,5,0 "PHB-CH1","PHB-CH1-086",86,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.4,5,0.4 "PHB-CH1","PHB-CH1-086",86,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.7,5,-0.3 "PHB-CH1","PHB-CH1-086",86,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.2,5,0.2 "PHB-CH1","PHB-CH1-086",86,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.6,5,-0.4 "PHB-CH1","PHB-CH1-086",86,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.3,5,-0.7 "PHB-CH1","PHB-CH1-086",86,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.1,5,-0.9 "PHB-CH1","PHB-CH1-086",86,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4,5,-1 "PHB-CH1","PHB-CH1-086",86,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.7,5,-0.3 "PHB-CH1","PHB-CH1-086",86,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.3,5,-1.7 "PHB-CH1","PHB-CH1-086",86,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.2,5,-1.8 "PHB-CH1","PHB-CH1-086",86,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,2.8,5,-2.2 "PHB-CH1","PHB-CH1-086",86,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.8,5,-2.2 "PHB-CH1","PHB-CH1-086",86,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.1,5,-1.9 "PHB-CH1","PHB-CH1-086",86,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.8,3.8,0 "PHB-CH1","PHB-CH1-086",86,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.4,3.8,0.6 "PHB-CH1","PHB-CH1-086",86,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.9,3.8,0.1 "PHB-CH1","PHB-CH1-086",86,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.5,3.8,0.7 "PHB-CH1","PHB-CH1-086",86,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.8,3.8,0 "PHB-CH1","PHB-CH1-086",86,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.3,3.8,0.5 "PHB-CH1","PHB-CH1-086",86,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.4,3.8,-0.4 "PHB-CH1","PHB-CH1-086",86,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.3,3.8,-0.5 "PHB-CH1","PHB-CH1-086",86,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.9,3.8,-0.9 "PHB-CH1","PHB-CH1-086",86,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.1,3.8,-0.7 "PHB-CH1","PHB-CH1-086",86,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,2.4,3.8,-1.4 "PHB-CH1","PHB-CH1-086",86,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,1.9,3.8,-1.9 "PHB-CH1","PHB-CH1-086",86,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2.7,3.8,-1.1 "PHB-CH1","PHB-CH1-086",86,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,2.4,3.8,-1.4 "PHB-CH1","PHB-CH1-087",87,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,66,66,0 "PHB-CH1","PHB-CH1-087",87,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,58,66,-8 "PHB-CH1","PHB-CH1-087",87,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,72,66,6 "PHB-CH1","PHB-CH1-087",87,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,54,, "PHB-CH1","PHB-CH1-087",87,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,73,, "PHB-CH1","PHB-CH1-087",87,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,52,, "PHB-CH1","PHB-CH1-087",87,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-087",87,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-087",87,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-087",87,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-087",87,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,10,, "PHB-CH1","PHB-CH1-087",87,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,344,, "PHB-CH1","PHB-CH1-087",87,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-087",87,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-087",87,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-087",87,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-087",87,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,59.7,59.7,0 "PHB-CH1","PHB-CH1-087",87,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,59.6,59.7,-0.100000000000001 "PHB-CH1","PHB-CH1-087",87,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,67.3,59.7,7.59999999999999 "PHB-CH1","PHB-CH1-087",87,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,46.6,59.7,-13.1 "PHB-CH1","PHB-CH1-087",87,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,85,85,0 "PHB-CH1","PHB-CH1-087",87,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,76.5,85,-8.5 "PHB-CH1","PHB-CH1-087",87,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,70.6,85,-14.4 "PHB-CH1","PHB-CH1-087",87,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,81.4,85,-3.59999999999999 "PHB-CH1","PHB-CH1-087",87,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.9,4.9,0 "PHB-CH1","PHB-CH1-087",87,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.7,4.9,-1.2 "PHB-CH1","PHB-CH1-087",87,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.1,4.9,0.199999999999999 "PHB-CH1","PHB-CH1-087",87,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.7,4.9,-0.2 "PHB-CH1","PHB-CH1-087",87,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.3,4.9,1.4 "PHB-CH1","PHB-CH1-087",87,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.1,4.9,0.199999999999999 "PHB-CH1","PHB-CH1-087",87,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.1,4.9,0.199999999999999 "PHB-CH1","PHB-CH1-087",87,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.9,4.9,0 "PHB-CH1","PHB-CH1-087",87,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.3,4.9,1.4 "PHB-CH1","PHB-CH1-087",87,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.8,4.9,0.9 "PHB-CH1","PHB-CH1-087",87,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.1,4.9,1.2 "PHB-CH1","PHB-CH1-087",87,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.9,4.9,2 "PHB-CH1","PHB-CH1-087",87,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.8,4.9,0.9 "PHB-CH1","PHB-CH1-087",87,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5,4.9,0.0999999999999996 "PHB-CH1","PHB-CH1-087",87,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-087",87,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.4,4.7,-0.3 "PHB-CH1","PHB-CH1-087",87,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.7,4.7,1 "PHB-CH1","PHB-CH1-087",87,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-087",87,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.2,4.7,1.5 "PHB-CH1","PHB-CH1-087",87,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.9,4.7,2.2 "PHB-CH1","PHB-CH1-087",87,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.8,4.7,2.1 "PHB-CH1","PHB-CH1-087",87,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.9,4.7,1.2 "PHB-CH1","PHB-CH1-087",87,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.5,4.7,2.8 "PHB-CH1","PHB-CH1-087",87,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.4,4.7,2.7 "PHB-CH1","PHB-CH1-087",87,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.6,4.7,1.9 "PHB-CH1","PHB-CH1-087",87,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.6,4.7,2.9 "PHB-CH1","PHB-CH1-087",87,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.6,4.7,1.9 "PHB-CH1","PHB-CH1-087",87,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7,4.7,2.3 "PHB-CH1","PHB-CH1-088",88,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,69,69,0 "PHB-CH1","PHB-CH1-088",88,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,67,69,-2 "PHB-CH1","PHB-CH1-088",88,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,70,69,1 "PHB-CH1","PHB-CH1-088",88,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,70,, "PHB-CH1","PHB-CH1-088",88,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,53,, "PHB-CH1","PHB-CH1-088",88,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,48,, "PHB-CH1","PHB-CH1-088",88,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-088",88,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-088",88,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-088",88,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-088",88,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,17,, "PHB-CH1","PHB-CH1-088",88,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,343,, "PHB-CH1","PHB-CH1-088",88,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-088",88,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-088",88,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-088",88,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-088",88,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,38.3,38.3,0 "PHB-CH1","PHB-CH1-088",88,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,56.9,38.3,18.6 "PHB-CH1","PHB-CH1-088",88,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,46.3,38.3,8 "PHB-CH1","PHB-CH1-088",88,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,34.1,38.3,-4.2 "PHB-CH1","PHB-CH1-088",88,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,46.1,46.1,0 "PHB-CH1","PHB-CH1-088",88,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,53.8,46.1,7.7 "PHB-CH1","PHB-CH1-088",88,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,58.4,46.1,12.3 "PHB-CH1","PHB-CH1-088",88,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,37.6,46.1,-8.5 "PHB-CH1","PHB-CH1-088",88,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.3,4.3,0 "PHB-CH1","PHB-CH1-088",88,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.2,4.3,-1.1 "PHB-CH1","PHB-CH1-088",88,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.6,4.3,0.3 "PHB-CH1","PHB-CH1-088",88,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.5,4.3,-0.8 "PHB-CH1","PHB-CH1-088",88,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.9,4.3,-0.4 "PHB-CH1","PHB-CH1-088",88,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.6,4.3,0.3 "PHB-CH1","PHB-CH1-088",88,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2.5,4.3,-1.8 "PHB-CH1","PHB-CH1-088",88,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4,4.3,-0.3 "PHB-CH1","PHB-CH1-088",88,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,2.7,4.3,-1.6 "PHB-CH1","PHB-CH1-088",88,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3,4.3,-1.3 "PHB-CH1","PHB-CH1-088",88,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.9,4.3,-1.4 "PHB-CH1","PHB-CH1-088",88,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.2,4.3,-1.1 "PHB-CH1","PHB-CH1-088",88,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.5,4.3,-1.8 "PHB-CH1","PHB-CH1-088",88,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4,4.3,-0.3 "PHB-CH1","PHB-CH1-088",88,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.1,6.1,0 "PHB-CH1","PHB-CH1-088",88,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.7,6.1,-0.399999999999999 "PHB-CH1","PHB-CH1-088",88,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.5,6.1,0.4 "PHB-CH1","PHB-CH1-088",88,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.6,6.1,-0.5 "PHB-CH1","PHB-CH1-088",88,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.5,6.1,-0.6 "PHB-CH1","PHB-CH1-088",88,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.5,6.1,-0.6 "PHB-CH1","PHB-CH1-088",88,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.6,6.1,-2.5 "PHB-CH1","PHB-CH1-088",88,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.1,6.1,-2 "PHB-CH1","PHB-CH1-088",88,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.4,6.1,-2.7 "PHB-CH1","PHB-CH1-088",88,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4,6.1,-2.1 "PHB-CH1","PHB-CH1-088",88,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.9,6.1,-2.2 "PHB-CH1","PHB-CH1-088",88,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.5,6.1,-1.6 "PHB-CH1","PHB-CH1-088",88,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.6,6.1,-0.5 "PHB-CH1","PHB-CH1-088",88,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.4,6.1,-0.699999999999999 "PHB-CH1","PHB-CH1-089",89,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,51,51,0 "PHB-CH1","PHB-CH1-089",89,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,51,51,0 "PHB-CH1","PHB-CH1-089",89,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,45,51,-6 "PHB-CH1","PHB-CH1-089",89,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,49,, "PHB-CH1","PHB-CH1-089",89,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,56,, "PHB-CH1","PHB-CH1-089",89,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,47,, "PHB-CH1","PHB-CH1-089",89,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-089",89,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-089",89,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-089",89,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-089",89,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,4,, "PHB-CH1","PHB-CH1-089",89,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,474,, "PHB-CH1","PHB-CH1-089",89,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-089",89,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-089",89,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-089",89,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-089",89,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,63.3,63.3,0 "PHB-CH1","PHB-CH1-089",89,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,56,63.3,-7.3 "PHB-CH1","PHB-CH1-089",89,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,58.3,63.3,-5 "PHB-CH1","PHB-CH1-089",89,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,52.2,63.3,-11.1 "PHB-CH1","PHB-CH1-089",89,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,54.6,54.6,0 "PHB-CH1","PHB-CH1-089",89,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,43.3,54.6,-11.3 "PHB-CH1","PHB-CH1-089",89,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,43.3,54.6,-11.3 "PHB-CH1","PHB-CH1-089",89,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,40.5,54.6,-14.1 "PHB-CH1","PHB-CH1-089",89,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,1.8,1.8,0 "PHB-CH1","PHB-CH1-089",89,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2.9,1.8,1.1 "PHB-CH1","PHB-CH1-089",89,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.6,1.8,1.8 "PHB-CH1","PHB-CH1-089",89,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.7,1.8,0.9 "PHB-CH1","PHB-CH1-089",89,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.3,1.8,1.5 "PHB-CH1","PHB-CH1-089",89,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3,1.8,1.2 "PHB-CH1","PHB-CH1-089",89,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.2,1.8,1.4 "PHB-CH1","PHB-CH1-089",89,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.5,1.8,1.7 "PHB-CH1","PHB-CH1-089",89,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,1.4,1.8,-0.4 "PHB-CH1","PHB-CH1-089",89,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,1.4,1.8,-0.4 "PHB-CH1","PHB-CH1-089",89,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,1.9,1.8,0.0999999999999999 "PHB-CH1","PHB-CH1-089",89,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,1.5,1.8,-0.3 "PHB-CH1","PHB-CH1-089",89,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.3,1.8,0.5 "PHB-CH1","PHB-CH1-089",89,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.1,1.8,1.3 "PHB-CH1","PHB-CH1-089",89,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.8,4.8,0 "PHB-CH1","PHB-CH1-089",89,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.2,4.8,1.4 "PHB-CH1","PHB-CH1-089",89,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.7,4.8,0.9 "PHB-CH1","PHB-CH1-089",89,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.9,4.8,1.1 "PHB-CH1","PHB-CH1-089",89,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.4,4.8,0.6 "PHB-CH1","PHB-CH1-089",89,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5,4.8,0.2 "PHB-CH1","PHB-CH1-089",89,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.3,4.8,-0.5 "PHB-CH1","PHB-CH1-089",89,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.9,4.8,0.100000000000001 "PHB-CH1","PHB-CH1-089",89,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.7,4.8,-1.1 "PHB-CH1","PHB-CH1-089",89,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.1,4.8,0.3 "PHB-CH1","PHB-CH1-089",89,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.8,4.8,0 "PHB-CH1","PHB-CH1-089",89,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.3,4.8,-1.5 "PHB-CH1","PHB-CH1-089",89,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.4,4.8,-0.399999999999999 "PHB-CH1","PHB-CH1-089",89,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.5,4.8,0.7 "PHB-CH1","PHB-CH1-090",90,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,37,37,0 "PHB-CH1","PHB-CH1-090",90,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,30,37,-7 "PHB-CH1","PHB-CH1-090",90,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,29,37,-8 "PHB-CH1","PHB-CH1-090",90,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,48,, "PHB-CH1","PHB-CH1-090",90,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,46,, "PHB-CH1","PHB-CH1-090",90,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,51,, "PHB-CH1","PHB-CH1-090",90,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-090",90,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-090",90,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-090",90,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-090",90,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,12,, "PHB-CH1","PHB-CH1-090",90,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,422,, "PHB-CH1","PHB-CH1-090",90,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-090",90,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-090",90,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-090",90,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-090",90,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,60.9,60.9,0 "PHB-CH1","PHB-CH1-090",90,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,70,60.9,9.1 "PHB-CH1","PHB-CH1-090",90,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,70.8,60.9,9.9 "PHB-CH1","PHB-CH1-090",90,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,65.9,60.9,5.00000000000001 "PHB-CH1","PHB-CH1-090",90,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,72.1,72.1,0 "PHB-CH1","PHB-CH1-090",90,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,51.3,72.1,-20.8 "PHB-CH1","PHB-CH1-090",90,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,59.5,72.1,-12.6 "PHB-CH1","PHB-CH1-090",90,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,59.6,72.1,-12.5 "PHB-CH1","PHB-CH1-090",90,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.5,4.5,0 "PHB-CH1","PHB-CH1-090",90,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.2,4.5,0.7 "PHB-CH1","PHB-CH1-090",90,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5,4.5,0.5 "PHB-CH1","PHB-CH1-090",90,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.4,4.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-090",90,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.8,4.5,0.3 "PHB-CH1","PHB-CH1-090",90,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.7,4.5,0.2 "PHB-CH1","PHB-CH1-090",90,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.6,4.5,0.0999999999999996 "PHB-CH1","PHB-CH1-090",90,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.3,4.5,-0.2 "PHB-CH1","PHB-CH1-090",90,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.8,4.5,-0.7 "PHB-CH1","PHB-CH1-090",90,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,2.4,4.5,-2.1 "PHB-CH1","PHB-CH1-090",90,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.4,4.5,-1.1 "PHB-CH1","PHB-CH1-090",90,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.7,4.5,-0.8 "PHB-CH1","PHB-CH1-090",90,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.4,4.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-090",90,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4,4.5,-0.5 "PHB-CH1","PHB-CH1-090",90,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.1,4.1,0 "PHB-CH1","PHB-CH1-090",90,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5,4.1,0.9 "PHB-CH1","PHB-CH1-090",90,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.4,4.1,0.300000000000001 "PHB-CH1","PHB-CH1-090",90,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.6,4.1,0.5 "PHB-CH1","PHB-CH1-090",90,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.3,4.1,-0.8 "PHB-CH1","PHB-CH1-090",90,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.8,4.1,-0.3 "PHB-CH1","PHB-CH1-090",90,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.3,4.1,1.2 "PHB-CH1","PHB-CH1-090",90,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.3,4.1,0.2 "PHB-CH1","PHB-CH1-090",90,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.2,4.1,1.1 "PHB-CH1","PHB-CH1-090",90,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.8,4.1,-0.3 "PHB-CH1","PHB-CH1-090",90,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.4,4.1,-0.7 "PHB-CH1","PHB-CH1-090",90,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4,4.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-090",90,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.6,4.1,0.5 "PHB-CH1","PHB-CH1-090",90,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.4,4.1,0.300000000000001 "PHB-CH1","PHB-CH1-091",91,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,68,68,0 "PHB-CH1","PHB-CH1-091",91,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,74,68,6 "PHB-CH1","PHB-CH1-091",91,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,55,68,-13 "PHB-CH1","PHB-CH1-091",91,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,78,, "PHB-CH1","PHB-CH1-091",91,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,57,, "PHB-CH1","PHB-CH1-091",91,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,67,, "PHB-CH1","PHB-CH1-091",91,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-091",91,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-091",91,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-091",91,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-091",91,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,15,, "PHB-CH1","PHB-CH1-091",91,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,419,, "PHB-CH1","PHB-CH1-091",91,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-091",91,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-091",91,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-091",91,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-091",91,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,47.4,47.4,0 "PHB-CH1","PHB-CH1-091",91,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,53.9,47.4,6.5 "PHB-CH1","PHB-CH1-091",91,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,52,47.4,4.6 "PHB-CH1","PHB-CH1-091",91,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,46.5,47.4,-0.899999999999999 "PHB-CH1","PHB-CH1-091",91,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,56.8,56.8,0 "PHB-CH1","PHB-CH1-091",91,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,60.2,56.8,3.40000000000001 "PHB-CH1","PHB-CH1-091",91,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,48.9,56.8,-7.9 "PHB-CH1","PHB-CH1-091",91,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,47.5,56.8,-9.3 "PHB-CH1","PHB-CH1-091",91,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.8,5.8,0 "PHB-CH1","PHB-CH1-091",91,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.9,5.8,-0.9 "PHB-CH1","PHB-CH1-091",91,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.5,5.8,-1.3 "PHB-CH1","PHB-CH1-091",91,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.6,5.8,-0.2 "PHB-CH1","PHB-CH1-091",91,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.3,5.8,-0.5 "PHB-CH1","PHB-CH1-091",91,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.8,5.8,0 "PHB-CH1","PHB-CH1-091",91,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.5,5.8,0.7 "PHB-CH1","PHB-CH1-091",91,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.6,5.8,0.8 "PHB-CH1","PHB-CH1-091",91,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.1,5.8,-0.7 "PHB-CH1","PHB-CH1-091",91,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.6,5.8,0.8 "PHB-CH1","PHB-CH1-091",91,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.9,5.8,1.1 "PHB-CH1","PHB-CH1-091",91,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.9,5.8,1.1 "PHB-CH1","PHB-CH1-091",91,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.3,5.8,0.5 "PHB-CH1","PHB-CH1-091",91,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.8,5.8,0 "PHB-CH1","PHB-CH1-091",91,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.8,4.8,0 "PHB-CH1","PHB-CH1-091",91,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.6,4.8,-1.2 "PHB-CH1","PHB-CH1-091",91,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.5,4.8,-0.3 "PHB-CH1","PHB-CH1-091",91,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.9,4.8,0.100000000000001 "PHB-CH1","PHB-CH1-091",91,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.8,4.8,0 "PHB-CH1","PHB-CH1-091",91,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.3,4.8,-0.5 "PHB-CH1","PHB-CH1-091",91,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.4,4.8,0.6 "PHB-CH1","PHB-CH1-091",91,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.5,4.8,-0.3 "PHB-CH1","PHB-CH1-091",91,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.3,4.8,-1.5 "PHB-CH1","PHB-CH1-091",91,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.5,4.8,-1.3 "PHB-CH1","PHB-CH1-091",91,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.5,4.8,-0.3 "PHB-CH1","PHB-CH1-091",91,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.8,4.8,0 "PHB-CH1","PHB-CH1-091",91,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.7,4.8,-1.1 "PHB-CH1","PHB-CH1-091",91,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5,4.8,0.2 "PHB-CH1","PHB-CH1-092",92,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,54,54,0 "PHB-CH1","PHB-CH1-092",92,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,54,54,0 "PHB-CH1","PHB-CH1-092",92,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,52,54,-2 "PHB-CH1","PHB-CH1-092",92,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,61,, "PHB-CH1","PHB-CH1-092",92,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,69,, "PHB-CH1","PHB-CH1-092",92,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,58,, "PHB-CH1","PHB-CH1-092",92,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-092",92,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-092",92,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-092",92,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-092",92,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,4,, "PHB-CH1","PHB-CH1-092",92,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,456,, "PHB-CH1","PHB-CH1-092",92,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-092",92,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-092",92,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-092",92,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-092",92,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,32.5,32.5,0 "PHB-CH1","PHB-CH1-092",92,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,39.6,32.5,7.1 "PHB-CH1","PHB-CH1-092",92,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,22.4,32.5,-10.1 "PHB-CH1","PHB-CH1-092",92,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,30,32.5,-2.5 "PHB-CH1","PHB-CH1-092",92,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,38.7,38.7,0 "PHB-CH1","PHB-CH1-092",92,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,46.4,38.7,7.7 "PHB-CH1","PHB-CH1-092",92,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,47.8,38.7,9.09999999999999 "PHB-CH1","PHB-CH1-092",92,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,38.4,38.7,-0.300000000000004 "PHB-CH1","PHB-CH1-092",92,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.8,4.8,0 "PHB-CH1","PHB-CH1-092",92,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.2,4.8,-0.6 "PHB-CH1","PHB-CH1-092",92,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.1,4.8,0.3 "PHB-CH1","PHB-CH1-092",92,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.6,4.8,-0.2 "PHB-CH1","PHB-CH1-092",92,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.2,4.8,-0.6 "PHB-CH1","PHB-CH1-092",92,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.4,4.8,-1.4 "PHB-CH1","PHB-CH1-092",92,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.9,4.8,0.100000000000001 "PHB-CH1","PHB-CH1-092",92,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.2,4.8,0.4 "PHB-CH1","PHB-CH1-092",92,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5,4.8,0.2 "PHB-CH1","PHB-CH1-092",92,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.6,4.8,0.8 "PHB-CH1","PHB-CH1-092",92,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.2,4.8,0.4 "PHB-CH1","PHB-CH1-092",92,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.3,4.8,0.5 "PHB-CH1","PHB-CH1-092",92,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.5,4.8,0.7 "PHB-CH1","PHB-CH1-092",92,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4,4.8,-0.8 "PHB-CH1","PHB-CH1-092",92,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.7,2.7,0 "PHB-CH1","PHB-CH1-092",92,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,2.3,2.7,-0.4 "PHB-CH1","PHB-CH1-092",92,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.9,2.7,1.2 "PHB-CH1","PHB-CH1-092",92,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.1,2.7,1.4 "PHB-CH1","PHB-CH1-092",92,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.4,2.7,0.7 "PHB-CH1","PHB-CH1-092",92,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,1.9,2.7,-0.8 "PHB-CH1","PHB-CH1-092",92,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.3,2.7,0.6 "PHB-CH1","PHB-CH1-092",92,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.9,2.7,0.2 "PHB-CH1","PHB-CH1-092",92,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.2,2.7,0.5 "PHB-CH1","PHB-CH1-092",92,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.5,2.7,1.8 "PHB-CH1","PHB-CH1-092",92,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.5,2.7,1.8 "PHB-CH1","PHB-CH1-092",92,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.6,2.7,1.9 "PHB-CH1","PHB-CH1-092",92,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.6,2.7,0.9 "PHB-CH1","PHB-CH1-092",92,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.5,2.7,0.8 "PHB-CH1","PHB-CH1-093",93,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,90,90,0 "PHB-CH1","PHB-CH1-093",93,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,92,90,2 "PHB-CH1","PHB-CH1-093",93,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,82,90,-8 "PHB-CH1","PHB-CH1-093",93,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,75,, "PHB-CH1","PHB-CH1-093",93,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,72,, "PHB-CH1","PHB-CH1-093",93,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,65,, "PHB-CH1","PHB-CH1-093",93,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-093",93,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-093",93,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-093",93,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-093",93,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,7,, "PHB-CH1","PHB-CH1-093",93,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,453,, "PHB-CH1","PHB-CH1-093",93,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-093",93,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-093",93,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-093",93,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-093",93,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,32.5,32.5,0 "PHB-CH1","PHB-CH1-093",93,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,37.6,32.5,5.1 "PHB-CH1","PHB-CH1-093",93,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,37,32.5,4.5 "PHB-CH1","PHB-CH1-093",93,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,34.4,32.5,1.9 "PHB-CH1","PHB-CH1-093",93,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,47.6,47.6,0 "PHB-CH1","PHB-CH1-093",93,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,38.7,47.6,-8.9 "PHB-CH1","PHB-CH1-093",93,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,55.8,47.6,8.2 "PHB-CH1","PHB-CH1-093",93,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,37.1,47.6,-10.5 "PHB-CH1","PHB-CH1-093",93,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-093",93,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.6,5.1,0.5 "PHB-CH1","PHB-CH1-093",93,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.6,5.1,-0.5 "PHB-CH1","PHB-CH1-093",93,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.4,5.1,1.3 "PHB-CH1","PHB-CH1-093",93,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.7,5.1,1.6 "PHB-CH1","PHB-CH1-093",93,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.1,5.1,1 "PHB-CH1","PHB-CH1-093",93,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.1,5.1,1 "PHB-CH1","PHB-CH1-093",93,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.5,5.1,1.4 "PHB-CH1","PHB-CH1-093",93,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.4,5.1,-0.699999999999999 "PHB-CH1","PHB-CH1-093",93,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.2,5.1,0.100000000000001 "PHB-CH1","PHB-CH1-093",93,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.6,5.1,0.5 "PHB-CH1","PHB-CH1-093",93,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.5,5.1,0.4 "PHB-CH1","PHB-CH1-093",93,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.1,5.1,-1 "PHB-CH1","PHB-CH1-093",93,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.7,5.1,0.6 "PHB-CH1","PHB-CH1-093",93,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.5,4.5,0 "PHB-CH1","PHB-CH1-093",93,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.7,4.5,0.2 "PHB-CH1","PHB-CH1-093",93,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.2,4.5,0.7 "PHB-CH1","PHB-CH1-093",93,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.9,4.5,2.4 "PHB-CH1","PHB-CH1-093",93,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.3,4.5,0.8 "PHB-CH1","PHB-CH1-093",93,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.7,4.5,2.2 "PHB-CH1","PHB-CH1-093",93,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6,4.5,1.5 "PHB-CH1","PHB-CH1-093",93,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.5,4.5,1 "PHB-CH1","PHB-CH1-093",93,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.5,4.5,-1 "PHB-CH1","PHB-CH1-093",93,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.2,4.5,-0.3 "PHB-CH1","PHB-CH1-093",93,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.6,4.5,0.0999999999999996 "PHB-CH1","PHB-CH1-093",93,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.6,4.5,1.1 "PHB-CH1","PHB-CH1-093",93,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.3,4.5,0.8 "PHB-CH1","PHB-CH1-093",93,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.1,4.5,1.6 "PHB-CH1","PHB-CH1-094",94,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,51,51,0 "PHB-CH1","PHB-CH1-094",94,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,55,51,4 "PHB-CH1","PHB-CH1-094",94,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,48,51,-3 "PHB-CH1","PHB-CH1-094",94,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,56,, "PHB-CH1","PHB-CH1-094",94,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,49,, "PHB-CH1","PHB-CH1-094",94,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,61,, "PHB-CH1","PHB-CH1-094",94,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-094",94,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-094",94,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-094",94,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-094",94,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,16,, "PHB-CH1","PHB-CH1-094",94,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,338,, "PHB-CH1","PHB-CH1-094",94,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-094",94,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-094",94,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-094",94,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-094",94,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,42.5,42.5,0 "PHB-CH1","PHB-CH1-094",94,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,23.7,42.5,-18.8 "PHB-CH1","PHB-CH1-094",94,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,33.7,42.5,-8.8 "PHB-CH1","PHB-CH1-094",94,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,25.1,42.5,-17.4 "PHB-CH1","PHB-CH1-094",94,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,26.4,26.4,0 "PHB-CH1","PHB-CH1-094",94,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,29.7,26.4,3.3 "PHB-CH1","PHB-CH1-094",94,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,47.5,26.4,21.1 "PHB-CH1","PHB-CH1-094",94,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,23.2,26.4,-3.2 "PHB-CH1","PHB-CH1-094",94,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.3,6.3,0 "PHB-CH1","PHB-CH1-094",94,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,7.8,6.3,1.5 "PHB-CH1","PHB-CH1-094",94,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7.5,6.3,1.2 "PHB-CH1","PHB-CH1-094",94,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,7.5,6.3,1.2 "PHB-CH1","PHB-CH1-094",94,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.8,6.3,0.5 "PHB-CH1","PHB-CH1-094",94,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.7,6.3,0.4 "PHB-CH1","PHB-CH1-094",94,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.6,6.3,0.3 "PHB-CH1","PHB-CH1-094",94,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.5,6.3,1.2 "PHB-CH1","PHB-CH1-094",94,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,8.3,6.3,2 "PHB-CH1","PHB-CH1-094",94,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.8,6.3,0.5 "PHB-CH1","PHB-CH1-094",94,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,9.4,6.3,3.1 "PHB-CH1","PHB-CH1-094",94,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.2,6.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-094",94,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.4,6.3,0.100000000000001 "PHB-CH1","PHB-CH1-094",94,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.5,6.3,0.2 "PHB-CH1","PHB-CH1-094",94,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.3,3.3,0 "PHB-CH1","PHB-CH1-094",94,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.9,3.3,0.6 "PHB-CH1","PHB-CH1-094",94,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.7,3.3,0.4 "PHB-CH1","PHB-CH1-094",94,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.5,3.3,0.2 "PHB-CH1","PHB-CH1-094",94,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.3,3.3,0 "PHB-CH1","PHB-CH1-094",94,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,2.9,3.3,-0.4 "PHB-CH1","PHB-CH1-094",94,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,2.1,3.3,-1.2 "PHB-CH1","PHB-CH1-094",94,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.4,3.3,0.1 "PHB-CH1","PHB-CH1-094",94,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.9,3.3,1.6 "PHB-CH1","PHB-CH1-094",94,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,2.5,3.3,-0.8 "PHB-CH1","PHB-CH1-094",94,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,2.9,3.3,-0.4 "PHB-CH1","PHB-CH1-094",94,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,2.3,3.3,-1 "PHB-CH1","PHB-CH1-094",94,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2.5,3.3,-0.8 "PHB-CH1","PHB-CH1-094",94,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,2,3.3,-1.3 "PHB-CH1","PHB-CH1-095",95,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,35,35,0 "PHB-CH1","PHB-CH1-095",95,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,44,35,9 "PHB-CH1","PHB-CH1-095",95,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,39,35,4 "PHB-CH1","PHB-CH1-095",95,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,46,, "PHB-CH1","PHB-CH1-095",95,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,50,, "PHB-CH1","PHB-CH1-095",95,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,82,, "PHB-CH1","PHB-CH1-095",95,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-095",95,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-095",95,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-095",95,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-095",95,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,1,, "PHB-CH1","PHB-CH1-095",95,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,544,, "PHB-CH1","PHB-CH1-095",95,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-095",95,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-095",95,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-095",95,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-095",95,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,27.6,27.6,0 "PHB-CH1","PHB-CH1-095",95,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,37.9,27.6,10.3 "PHB-CH1","PHB-CH1-095",95,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,30.4,27.6,2.8 "PHB-CH1","PHB-CH1-095",95,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,21.1,27.6,-6.5 "PHB-CH1","PHB-CH1-095",95,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,43.7,43.7,0 "PHB-CH1","PHB-CH1-095",95,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,28.1,43.7,-15.6 "PHB-CH1","PHB-CH1-095",95,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,43.6,43.7,-0.100000000000001 "PHB-CH1","PHB-CH1-095",95,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,30.9,43.7,-12.8 "PHB-CH1","PHB-CH1-095",95,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-095",95,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2.6,4.7,-2.1 "PHB-CH1","PHB-CH1-095",95,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.8,4.7,-0.9 "PHB-CH1","PHB-CH1-095",95,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-095",95,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4,4.7,-0.7 "PHB-CH1","PHB-CH1-095",95,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.1,4.7,-0.6 "PHB-CH1","PHB-CH1-095",95,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.2,4.7,-1.5 "PHB-CH1","PHB-CH1-095",95,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.6,4.7,-1.1 "PHB-CH1","PHB-CH1-095",95,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.1,4.7,-0.6 "PHB-CH1","PHB-CH1-095",95,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.9,4.7,-0.8 "PHB-CH1","PHB-CH1-095",95,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.8,4.7,0.0999999999999996 "PHB-CH1","PHB-CH1-095",95,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-095",95,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.1,4.7,-0.6 "PHB-CH1","PHB-CH1-095",95,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.3,4.7,-1.4 "PHB-CH1","PHB-CH1-095",95,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.4,6.4,0 "PHB-CH1","PHB-CH1-095",95,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.3,6.4,-1.1 "PHB-CH1","PHB-CH1-095",95,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.9,6.4,-0.5 "PHB-CH1","PHB-CH1-095",95,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.9,6.4,-0.5 "PHB-CH1","PHB-CH1-095",95,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.3,6.4,-0.100000000000001 "PHB-CH1","PHB-CH1-095",95,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.2,6.4,-1.2 "PHB-CH1","PHB-CH1-095",95,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.9,6.4,-1.5 "PHB-CH1","PHB-CH1-095",95,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.8,6.4,-0.6 "PHB-CH1","PHB-CH1-095",95,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.8,6.4,-0.6 "PHB-CH1","PHB-CH1-095",95,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.3,6.4,-0.100000000000001 "PHB-CH1","PHB-CH1-095",95,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.6,6.4,0.199999999999999 "PHB-CH1","PHB-CH1-095",95,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.3,6.4,-0.100000000000001 "PHB-CH1","PHB-CH1-095",95,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.1,6.4,0.699999999999999 "PHB-CH1","PHB-CH1-095",95,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.4,6.4,-1 "PHB-CH1","PHB-CH1-096",96,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,69,69,0 "PHB-CH1","PHB-CH1-096",96,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,57,69,-12 "PHB-CH1","PHB-CH1-096",96,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,73,69,4 "PHB-CH1","PHB-CH1-096",96,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,63,, "PHB-CH1","PHB-CH1-096",96,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,56,, "PHB-CH1","PHB-CH1-096",96,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,58,, "PHB-CH1","PHB-CH1-096",96,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-096",96,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-096",96,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-096",96,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-096",96,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,26,, "PHB-CH1","PHB-CH1-096",96,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,232,, "PHB-CH1","PHB-CH1-096",96,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-096",96,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-096",96,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-096",96,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-096",96,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,65.4,65.4,0 "PHB-CH1","PHB-CH1-096",96,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,58.1,65.4,-7.3 "PHB-CH1","PHB-CH1-096",96,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,56,65.4,-9.40000000000001 "PHB-CH1","PHB-CH1-096",96,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,49.8,65.4,-15.6 "PHB-CH1","PHB-CH1-096",96,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,75.1,75.1,0 "PHB-CH1","PHB-CH1-096",96,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,83.5,75.1,8.40000000000001 "PHB-CH1","PHB-CH1-096",96,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,69.2,75.1,-5.89999999999999 "PHB-CH1","PHB-CH1-096",96,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,70.3,75.1,-4.8 "PHB-CH1","PHB-CH1-096",96,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,7.7,7.7,0 "PHB-CH1","PHB-CH1-096",96,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,8.9,7.7,1.2 "PHB-CH1","PHB-CH1-096",96,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,8.7,7.7,0.999999999999999 "PHB-CH1","PHB-CH1-096",96,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,9.8,7.7,2.1 "PHB-CH1","PHB-CH1-096",96,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,7.7,7.7,0 "PHB-CH1","PHB-CH1-096",96,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,8.3,7.7,0.6 "PHB-CH1","PHB-CH1-096",96,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,8.2,7.7,0.499999999999999 "PHB-CH1","PHB-CH1-096",96,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.8,7.7,0.0999999999999996 "PHB-CH1","PHB-CH1-096",96,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,8.5,7.7,0.8 "PHB-CH1","PHB-CH1-096",96,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,7.5,7.7,-0.2 "PHB-CH1","PHB-CH1-096",96,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,8.9,7.7,1.2 "PHB-CH1","PHB-CH1-096",96,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,7.8,7.7,0.0999999999999996 "PHB-CH1","PHB-CH1-096",96,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,7.8,7.7,0.0999999999999996 "PHB-CH1","PHB-CH1-096",96,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,8,7.7,0.3 "PHB-CH1","PHB-CH1-096",96,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.2,5.2,0 "PHB-CH1","PHB-CH1-096",96,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.6,5.2,0.399999999999999 "PHB-CH1","PHB-CH1-096",96,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.9,5.2,0.7 "PHB-CH1","PHB-CH1-096",96,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.3,5.2,1.1 "PHB-CH1","PHB-CH1-096",96,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.6,5.2,0.399999999999999 "PHB-CH1","PHB-CH1-096",96,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.2,5.2,1 "PHB-CH1","PHB-CH1-096",96,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.6,5.2,0.399999999999999 "PHB-CH1","PHB-CH1-096",96,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.8,5.2,-0.4 "PHB-CH1","PHB-CH1-096",96,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.9,5.2,-0.3 "PHB-CH1","PHB-CH1-096",96,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.7,5.2,-1.5 "PHB-CH1","PHB-CH1-096",96,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.4,5.2,1.2 "PHB-CH1","PHB-CH1-096",96,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.7,5.2,-0.5 "PHB-CH1","PHB-CH1-096",96,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.8,5.2,-0.4 "PHB-CH1","PHB-CH1-096",96,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.3,5.2,-0.9 "PHB-CH1","PHB-CH1-097",97,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,53,53,0 "PHB-CH1","PHB-CH1-097",97,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,47,53,-6 "PHB-CH1","PHB-CH1-097",97,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,50,53,-3 "PHB-CH1","PHB-CH1-097",97,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,50,, "PHB-CH1","PHB-CH1-097",97,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,44,, "PHB-CH1","PHB-CH1-097",97,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,45,, "PHB-CH1","PHB-CH1-097",97,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-097",97,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-097",97,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-097",97,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-097",97,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,8,, "PHB-CH1","PHB-CH1-097",97,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,378,, "PHB-CH1","PHB-CH1-097",97,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-097",97,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-097",97,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-097",97,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-097",97,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,39.4,39.4,0 "PHB-CH1","PHB-CH1-097",97,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,36.8,39.4,-2.6 "PHB-CH1","PHB-CH1-097",97,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,44.2,39.4,4.8 "PHB-CH1","PHB-CH1-097",97,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,36.8,39.4,-2.6 "PHB-CH1","PHB-CH1-097",97,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,41.5,41.5,0 "PHB-CH1","PHB-CH1-097",97,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,45.7,41.5,4.2 "PHB-CH1","PHB-CH1-097",97,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,51.6,41.5,10.1 "PHB-CH1","PHB-CH1-097",97,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,41.9,41.5,0.399999999999999 "PHB-CH1","PHB-CH1-097",97,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.9,3.9,0 "PHB-CH1","PHB-CH1-097",97,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,1.7,3.9,-2.2 "PHB-CH1","PHB-CH1-097",97,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.1,3.9,-0.8 "PHB-CH1","PHB-CH1-097",97,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.1,3.9,-1.8 "PHB-CH1","PHB-CH1-097",97,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.2,3.9,-0.7 "PHB-CH1","PHB-CH1-097",97,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5,3.9,1.1 "PHB-CH1","PHB-CH1-097",97,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.7,3.9,0.8 "PHB-CH1","PHB-CH1-097",97,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.1,3.9,0.2 "PHB-CH1","PHB-CH1-097",97,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.5,3.9,0.6 "PHB-CH1","PHB-CH1-097",97,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.6,3.9,0.7 "PHB-CH1","PHB-CH1-097",97,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.1,3.9,1.2 "PHB-CH1","PHB-CH1-097",97,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.7,3.9,-0.2 "PHB-CH1","PHB-CH1-097",97,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.1,3.9,-1.8 "PHB-CH1","PHB-CH1-097",97,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.9,3.9,1 "PHB-CH1","PHB-CH1-097",97,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.9,6.9,0 "PHB-CH1","PHB-CH1-097",97,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.3,6.9,-1.6 "PHB-CH1","PHB-CH1-097",97,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.3,6.9,-1.6 "PHB-CH1","PHB-CH1-097",97,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.1,6.9,-0.800000000000001 "PHB-CH1","PHB-CH1-097",97,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.3,6.9,-0.6 "PHB-CH1","PHB-CH1-097",97,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,7,6.9,0.0999999999999996 "PHB-CH1","PHB-CH1-097",97,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.7,6.9,-0.2 "PHB-CH1","PHB-CH1-097",97,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.3,6.9,-1.6 "PHB-CH1","PHB-CH1-097",97,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.4,6.9,0.5 "PHB-CH1","PHB-CH1-097",97,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.7,6.9,0.8 "PHB-CH1","PHB-CH1-097",97,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,8.3,6.9,1.4 "PHB-CH1","PHB-CH1-097",97,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.7,6.9,-0.2 "PHB-CH1","PHB-CH1-097",97,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.4,6.9,-0.5 "PHB-CH1","PHB-CH1-097",97,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.9,6.9,1 "PHB-CH1","PHB-CH1-098",98,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,24,24,0 "PHB-CH1","PHB-CH1-098",98,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,26,24,2 "PHB-CH1","PHB-CH1-098",98,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,19,24,-5 "PHB-CH1","PHB-CH1-098",98,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,36,, "PHB-CH1","PHB-CH1-098",98,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,46,, "PHB-CH1","PHB-CH1-098",98,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,52,, "PHB-CH1","PHB-CH1-098",98,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-098",98,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-098",98,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-098",98,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-098",98,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,5,, "PHB-CH1","PHB-CH1-098",98,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,430,, "PHB-CH1","PHB-CH1-098",98,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-098",98,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-098",98,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-098",98,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-098",98,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,44.4,44.4,0 "PHB-CH1","PHB-CH1-098",98,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,56.4,44.4,12 "PHB-CH1","PHB-CH1-098",98,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,43.5,44.4,-0.899999999999999 "PHB-CH1","PHB-CH1-098",98,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,47.4,44.4,3 "PHB-CH1","PHB-CH1-098",98,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,40.8,40.8,0 "PHB-CH1","PHB-CH1-098",98,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,55.4,40.8,14.6 "PHB-CH1","PHB-CH1-098",98,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,53.1,40.8,12.3 "PHB-CH1","PHB-CH1-098",98,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,41.1,40.8,0.300000000000004 "PHB-CH1","PHB-CH1-098",98,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.7,5.7,0 "PHB-CH1","PHB-CH1-098",98,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.5,5.7,-0.2 "PHB-CH1","PHB-CH1-098",98,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.1,5.7,0.399999999999999 "PHB-CH1","PHB-CH1-098",98,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.7,5.7,0 "PHB-CH1","PHB-CH1-098",98,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.8,5.7,0.0999999999999996 "PHB-CH1","PHB-CH1-098",98,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.2,5.7,-0.5 "PHB-CH1","PHB-CH1-098",98,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.5,5.7,-0.2 "PHB-CH1","PHB-CH1-098",98,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.8,5.7,0.0999999999999996 "PHB-CH1","PHB-CH1-098",98,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.3,5.7,-1.4 "PHB-CH1","PHB-CH1-098",98,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.6,5.7,-0.100000000000001 "PHB-CH1","PHB-CH1-098",98,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.2,5.7,-0.5 "PHB-CH1","PHB-CH1-098",98,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.1,5.7,-1.6 "PHB-CH1","PHB-CH1-098",98,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.9,5.7,0.2 "PHB-CH1","PHB-CH1-098",98,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.3,5.7,-0.4 "PHB-CH1","PHB-CH1-098",98,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,8.5,8.5,0 "PHB-CH1","PHB-CH1-098",98,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,8.2,8.5,-0.300000000000001 "PHB-CH1","PHB-CH1-098",98,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7.4,8.5,-1.1 "PHB-CH1","PHB-CH1-098",98,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.6,8.5,-1.9 "PHB-CH1","PHB-CH1-098",98,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.9,8.5,-2.6 "PHB-CH1","PHB-CH1-098",98,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.2,8.5,-2.3 "PHB-CH1","PHB-CH1-098",98,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.6,8.5,-2.9 "PHB-CH1","PHB-CH1-098",98,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.3,8.5,-3.2 "PHB-CH1","PHB-CH1-098",98,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.1,8.5,-3.4 "PHB-CH1","PHB-CH1-098",98,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.9,8.5,-2.6 "PHB-CH1","PHB-CH1-098",98,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.4,8.5,-3.1 "PHB-CH1","PHB-CH1-098",98,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.9,8.5,-3.6 "PHB-CH1","PHB-CH1-098",98,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.7,8.5,-3.8 "PHB-CH1","PHB-CH1-098",98,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.7,8.5,-3.8 "PHB-CH1","PHB-CH1-099",99,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,45,45,0 "PHB-CH1","PHB-CH1-099",99,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,34,45,-11 "PHB-CH1","PHB-CH1-099",99,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,52,45,7 "PHB-CH1","PHB-CH1-099",99,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,40,, "PHB-CH1","PHB-CH1-099",99,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,45,, "PHB-CH1","PHB-CH1-099",99,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,30,, "PHB-CH1","PHB-CH1-099",99,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-099",99,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-099",99,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-099",99,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-099",99,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,4,, "PHB-CH1","PHB-CH1-099",99,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,492,, "PHB-CH1","PHB-CH1-099",99,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-099",99,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-099",99,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-099",99,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-099",99,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,47.5,47.5,0 "PHB-CH1","PHB-CH1-099",99,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,51.9,47.5,4.4 "PHB-CH1","PHB-CH1-099",99,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,58.3,47.5,10.8 "PHB-CH1","PHB-CH1-099",99,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,41.8,47.5,-5.7 "PHB-CH1","PHB-CH1-099",99,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,50.4,50.4,0 "PHB-CH1","PHB-CH1-099",99,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,73,50.4,22.6 "PHB-CH1","PHB-CH1-099",99,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,50,50.4,-0.399999999999999 "PHB-CH1","PHB-CH1-099",99,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,37.8,50.4,-12.6 "PHB-CH1","PHB-CH1-099",99,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.4,6.4,0 "PHB-CH1","PHB-CH1-099",99,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.4,6.4,0 "PHB-CH1","PHB-CH1-099",99,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7.4,6.4,1 "PHB-CH1","PHB-CH1-099",99,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.9,6.4,-0.5 "PHB-CH1","PHB-CH1-099",99,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6,6.4,-0.4 "PHB-CH1","PHB-CH1-099",99,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.7,6.4,0.3 "PHB-CH1","PHB-CH1-099",99,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.7,6.4,-0.7 "PHB-CH1","PHB-CH1-099",99,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.8,6.4,-0.6 "PHB-CH1","PHB-CH1-099",99,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.8,6.4,0.399999999999999 "PHB-CH1","PHB-CH1-099",99,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6,6.4,-0.4 "PHB-CH1","PHB-CH1-099",99,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.9,6.4,-0.5 "PHB-CH1","PHB-CH1-099",99,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.4,6.4,-2 "PHB-CH1","PHB-CH1-099",99,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.7,6.4,-0.7 "PHB-CH1","PHB-CH1-099",99,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.5,6.4,0.0999999999999996 "PHB-CH1","PHB-CH1-099",99,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.8,2.8,0 "PHB-CH1","PHB-CH1-099",99,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.1,2.8,0.3 "PHB-CH1","PHB-CH1-099",99,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.1,2.8,1.3 "PHB-CH1","PHB-CH1-099",99,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3,2.8,0.2 "PHB-CH1","PHB-CH1-099",99,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.5,2.8,1.7 "PHB-CH1","PHB-CH1-099",99,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.4,2.8,0.6 "PHB-CH1","PHB-CH1-099",99,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.6,2.8,0.8 "PHB-CH1","PHB-CH1-099",99,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.7,2.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-099",99,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.2,2.8,0.4 "PHB-CH1","PHB-CH1-099",99,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.2,2.8,0.4 "PHB-CH1","PHB-CH1-099",99,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,2.2,2.8,-0.6 "PHB-CH1","PHB-CH1-099",99,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,1.5,2.8,-1.3 "PHB-CH1","PHB-CH1-099",99,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2,2.8,-0.8 "PHB-CH1","PHB-CH1-099",99,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.1,2.8,1.3 "PHB-CH1","PHB-CH1-100",100,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,47,47,0 "PHB-CH1","PHB-CH1-100",100,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,51,47,4 "PHB-CH1","PHB-CH1-100",100,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,36,47,-11 "PHB-CH1","PHB-CH1-100",100,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,46,, "PHB-CH1","PHB-CH1-100",100,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,36,, "PHB-CH1","PHB-CH1-100",100,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,32,, "PHB-CH1","PHB-CH1-100",100,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-100",100,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-100",100,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-100",100,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-100",100,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,33,, "PHB-CH1","PHB-CH1-100",100,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,199,, "PHB-CH1","PHB-CH1-100",100,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-100",100,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-100",100,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-100",100,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-100",100,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,29.6,29.6,0 "PHB-CH1","PHB-CH1-100",100,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,16.6,29.6,-13 "PHB-CH1","PHB-CH1-100",100,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,27.7,29.6,-1.9 "PHB-CH1","PHB-CH1-100",100,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,40.5,29.6,10.9 "PHB-CH1","PHB-CH1-100",100,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,37.9,37.9,0 "PHB-CH1","PHB-CH1-100",100,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,39.7,37.9,1.8 "PHB-CH1","PHB-CH1-100",100,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,33.5,37.9,-4.4 "PHB-CH1","PHB-CH1-100",100,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,45.7,37.9,7.8 "PHB-CH1","PHB-CH1-100",100,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.3,6.3,0 "PHB-CH1","PHB-CH1-100",100,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,7.2,6.3,0.9 "PHB-CH1","PHB-CH1-100",100,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.7,6.3,-0.6 "PHB-CH1","PHB-CH1-100",100,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.6,6.3,-0.7 "PHB-CH1","PHB-CH1-100",100,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.1,6.3,-1.2 "PHB-CH1","PHB-CH1-100",100,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.1,6.3,-1.2 "PHB-CH1","PHB-CH1-100",100,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.3,6.3,-1 "PHB-CH1","PHB-CH1-100",100,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.9,6.3,-0.399999999999999 "PHB-CH1","PHB-CH1-100",100,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6,6.3,-0.3 "PHB-CH1","PHB-CH1-100",100,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.4,6.3,-0.9 "PHB-CH1","PHB-CH1-100",100,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.8,6.3,0.5 "PHB-CH1","PHB-CH1-100",100,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.2,6.3,-1.1 "PHB-CH1","PHB-CH1-100",100,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.3,6.3,0 "PHB-CH1","PHB-CH1-100",100,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.8,6.3,0.5 "PHB-CH1","PHB-CH1-100",100,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.8,5.8,0 "PHB-CH1","PHB-CH1-100",100,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.4,5.8,0.6 "PHB-CH1","PHB-CH1-100",100,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.5,5.8,0.7 "PHB-CH1","PHB-CH1-100",100,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.2,5.8,0.4 "PHB-CH1","PHB-CH1-100",100,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,7.2,5.8,1.4 "PHB-CH1","PHB-CH1-100",100,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.7,5.8,0.9 "PHB-CH1","PHB-CH1-100",100,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.1,5.8,0.3 "PHB-CH1","PHB-CH1-100",100,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.3,5.8,0.5 "PHB-CH1","PHB-CH1-100",100,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,8.8,5.8,3 "PHB-CH1","PHB-CH1-100",100,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7,5.8,1.2 "PHB-CH1","PHB-CH1-100",100,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.9,5.8,2.1 "PHB-CH1","PHB-CH1-100",100,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.9,5.8,1.1 "PHB-CH1","PHB-CH1-100",100,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.9,5.8,1.1 "PHB-CH1","PHB-CH1-100",100,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.7,5.8,1.9 "PHB-CH1","PHB-CH1-101",101,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,40,40,0 "PHB-CH1","PHB-CH1-101",101,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,44,40,4 "PHB-CH1","PHB-CH1-101",101,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,19,40,-21 "PHB-CH1","PHB-CH1-101",101,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,52,, "PHB-CH1","PHB-CH1-101",101,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,45,, "PHB-CH1","PHB-CH1-101",101,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,50,, "PHB-CH1","PHB-CH1-101",101,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-101",101,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-101",101,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-101",101,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-101",101,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,6,, "PHB-CH1","PHB-CH1-101",101,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,467,, "PHB-CH1","PHB-CH1-101",101,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-101",101,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-101",101,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-101",101,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-101",101,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,29.8,29.8,0 "PHB-CH1","PHB-CH1-101",101,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,33.5,29.8,3.7 "PHB-CH1","PHB-CH1-101",101,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,34.5,29.8,4.7 "PHB-CH1","PHB-CH1-101",101,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,12,29.8,-17.8 "PHB-CH1","PHB-CH1-101",101,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,37.9,37.9,0 "PHB-CH1","PHB-CH1-101",101,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,28.2,37.9,-9.7 "PHB-CH1","PHB-CH1-101",101,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,54.6,37.9,16.7 "PHB-CH1","PHB-CH1-101",101,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,40.4,37.9,2.5 "PHB-CH1","PHB-CH1-101",101,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,2.6,2.6,0 "PHB-CH1","PHB-CH1-101",101,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.1,2.6,0.5 "PHB-CH1","PHB-CH1-101",101,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.3,2.6,1.7 "PHB-CH1","PHB-CH1-101",101,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.5,2.6,1.9 "PHB-CH1","PHB-CH1-101",101,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.1,2.6,1.5 "PHB-CH1","PHB-CH1-101",101,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.3,2.6,1.7 "PHB-CH1","PHB-CH1-101",101,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.5,2.6,1.9 "PHB-CH1","PHB-CH1-101",101,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.6,2.6,1 "PHB-CH1","PHB-CH1-101",101,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.6,2.6,1 "PHB-CH1","PHB-CH1-101",101,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.8,2.6,1.2 "PHB-CH1","PHB-CH1-101",101,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.3,2.6,0.7 "PHB-CH1","PHB-CH1-101",101,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.2,2.6,1.6 "PHB-CH1","PHB-CH1-101",101,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.6,2.6,1 "PHB-CH1","PHB-CH1-101",101,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.3,2.6,1.7 "PHB-CH1","PHB-CH1-101",101,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.4,3.4,0 "PHB-CH1","PHB-CH1-101",101,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.2,3.4,-0.2 "PHB-CH1","PHB-CH1-101",101,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4,3.4,0.6 "PHB-CH1","PHB-CH1-101",101,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,2.6,3.4,-0.8 "PHB-CH1","PHB-CH1-101",101,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,2.6,3.4,-0.8 "PHB-CH1","PHB-CH1-101",101,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.6,3.4,0.2 "PHB-CH1","PHB-CH1-101",101,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.3,3.4,0.9 "PHB-CH1","PHB-CH1-101",101,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3,3.4,-0.4 "PHB-CH1","PHB-CH1-101",101,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.8,3.4,-0.6 "PHB-CH1","PHB-CH1-101",101,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,2.1,3.4,-1.3 "PHB-CH1","PHB-CH1-101",101,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,2.1,3.4,-1.3 "PHB-CH1","PHB-CH1-101",101,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.9,3.4,1.5 "PHB-CH1","PHB-CH1-101",101,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.3,3.4,0.9 "PHB-CH1","PHB-CH1-101",101,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.4,3.4,1 "PHB-CH1","PHB-CH1-102",102,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,66,66,0 "PHB-CH1","PHB-CH1-102",102,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,64,66,-2 "PHB-CH1","PHB-CH1-102",102,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,56,66,-10 "PHB-CH1","PHB-CH1-102",102,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,63,, "PHB-CH1","PHB-CH1-102",102,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,55,, "PHB-CH1","PHB-CH1-102",102,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,50,, "PHB-CH1","PHB-CH1-102",102,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-102",102,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,1,, "PHB-CH1","PHB-CH1-102",102,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-102",102,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-102",102,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,10,, "PHB-CH1","PHB-CH1-102",102,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,425,, "PHB-CH1","PHB-CH1-102",102,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-102",102,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-102",102,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-102",102,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-102",102,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,54.6,54.6,0 "PHB-CH1","PHB-CH1-102",102,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,46.9,54.6,-7.7 "PHB-CH1","PHB-CH1-102",102,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,47.4,54.6,-7.2 "PHB-CH1","PHB-CH1-102",102,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,50.9,54.6,-3.7 "PHB-CH1","PHB-CH1-102",102,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,43.2,43.2,0 "PHB-CH1","PHB-CH1-102",102,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,39,43.2,-4.2 "PHB-CH1","PHB-CH1-102",102,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,59.2,43.2,16 "PHB-CH1","PHB-CH1-102",102,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,46.4,43.2,3.2 "PHB-CH1","PHB-CH1-102",102,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,2.4,2.4,0 "PHB-CH1","PHB-CH1-102",102,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.3,2.4,0.9 "PHB-CH1","PHB-CH1-102",102,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.3,2.4,0.9 "PHB-CH1","PHB-CH1-102",102,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.6,2.4,0.2 "PHB-CH1","PHB-CH1-102",102,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,2.7,2.4,0.3 "PHB-CH1","PHB-CH1-102",102,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2.2,2.4,-0.2 "PHB-CH1","PHB-CH1-102",102,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.2,2.4,0.8 "PHB-CH1","PHB-CH1-102",102,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,2.4,2.4,0 "PHB-CH1","PHB-CH1-102",102,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,2.6,2.4,0.2 "PHB-CH1","PHB-CH1-102",102,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.5,2.4,1.1 "PHB-CH1","PHB-CH1-102",102,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.7,2.4,0.3 "PHB-CH1","PHB-CH1-102",102,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.2,2.4,1.8 "PHB-CH1","PHB-CH1-102",102,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.8,2.4,0.4 "PHB-CH1","PHB-CH1-102",102,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2,2.4,-0.4 "PHB-CH1","PHB-CH1-102",102,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.6,4.6,0 "PHB-CH1","PHB-CH1-102",102,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.5,4.6,-0.0999999999999996 "PHB-CH1","PHB-CH1-102",102,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.2,4.6,0.6 "PHB-CH1","PHB-CH1-102",102,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.7,4.6,1.1 "PHB-CH1","PHB-CH1-102",102,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6,4.6,1.4 "PHB-CH1","PHB-CH1-102",102,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.6,4.6,1 "PHB-CH1","PHB-CH1-102",102,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.5,4.6,1.9 "PHB-CH1","PHB-CH1-102",102,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.7,4.6,1.1 "PHB-CH1","PHB-CH1-102",102,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.6,4.6,0 "PHB-CH1","PHB-CH1-102",102,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.7,4.6,0.100000000000001 "PHB-CH1","PHB-CH1-102",102,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.9,4.6,-0.7 "PHB-CH1","PHB-CH1-102",102,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.1,4.6,1.5 "PHB-CH1","PHB-CH1-102",102,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.9,4.6,0.300000000000001 "PHB-CH1","PHB-CH1-102",102,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.8,4.6,0.2 "PHB-CH1","PHB-CH1-103",103,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,43,43,0 "PHB-CH1","PHB-CH1-103",103,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,32,43,-11 "PHB-CH1","PHB-CH1-103",103,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,25,43,-18 "PHB-CH1","PHB-CH1-103",103,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,41,, "PHB-CH1","PHB-CH1-103",103,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,42,, "PHB-CH1","PHB-CH1-103",103,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,36,, "PHB-CH1","PHB-CH1-103",103,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-103",103,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-103",103,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-103",103,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,5,, "PHB-CH1","PHB-CH1-103",103,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,4,, "PHB-CH1","PHB-CH1-103",103,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,504,, "PHB-CH1","PHB-CH1-103",103,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-103",103,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-103",103,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-103",103,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-103",103,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,40.5,40.5,0 "PHB-CH1","PHB-CH1-103",103,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,37.7,40.5,-2.8 "PHB-CH1","PHB-CH1-103",103,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,36.1,40.5,-4.4 "PHB-CH1","PHB-CH1-103",103,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,25.8,40.5,-14.7 "PHB-CH1","PHB-CH1-103",103,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,43.2,43.2,0 "PHB-CH1","PHB-CH1-103",103,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,33.5,43.2,-9.7 "PHB-CH1","PHB-CH1-103",103,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,31.3,43.2,-11.9 "PHB-CH1","PHB-CH1-103",103,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,30.6,43.2,-12.6 "PHB-CH1","PHB-CH1-103",103,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-103",103,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.3,4.7,-0.4 "PHB-CH1","PHB-CH1-103",103,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.7,4.7,0 "PHB-CH1","PHB-CH1-103",103,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.6,4.7,-1.1 "PHB-CH1","PHB-CH1-103",103,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-103",103,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.8,4.7,1.1 "PHB-CH1","PHB-CH1-103",103,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.3,4.7,-0.4 "PHB-CH1","PHB-CH1-103",103,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.3,4.7,-1.4 "PHB-CH1","PHB-CH1-103",103,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.1,4.7,-0.6 "PHB-CH1","PHB-CH1-103",103,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.1,4.7,-1.6 "PHB-CH1","PHB-CH1-103",103,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.7,4.7,-1 "PHB-CH1","PHB-CH1-103",103,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.1,4.7,-0.6 "PHB-CH1","PHB-CH1-103",103,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.4,4.7,1.7 "PHB-CH1","PHB-CH1-103",103,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.2,4.7,1.5 "PHB-CH1","PHB-CH1-103",103,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.7,3.7,0 "PHB-CH1","PHB-CH1-103",103,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.4,3.7,-0.3 "PHB-CH1","PHB-CH1-103",103,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.7,3.7,1 "PHB-CH1","PHB-CH1-103",103,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3,3.7,-0.7 "PHB-CH1","PHB-CH1-103",103,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.9,3.7,0.2 "PHB-CH1","PHB-CH1-103",103,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.3,3.7,0.6 "PHB-CH1","PHB-CH1-103",103,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.8,3.7,0.0999999999999996 "PHB-CH1","PHB-CH1-103",103,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.5,3.7,-1.2 "PHB-CH1","PHB-CH1-103",103,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.2,3.7,-1.5 "PHB-CH1","PHB-CH1-103",103,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,1.4,3.7,-2.3 "PHB-CH1","PHB-CH1-103",103,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.1,3.7,-0.6 "PHB-CH1","PHB-CH1-103",103,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,2.9,3.7,-0.8 "PHB-CH1","PHB-CH1-103",103,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.1,3.7,0.399999999999999 "PHB-CH1","PHB-CH1-103",103,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.4,3.7,0.7 "PHB-CH1","PHB-CH1-104",104,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,21,21,0 "PHB-CH1","PHB-CH1-104",104,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,21,21,0 "PHB-CH1","PHB-CH1-104",104,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,12,21,-9 "PHB-CH1","PHB-CH1-104",104,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,40,, "PHB-CH1","PHB-CH1-104",104,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,42,, "PHB-CH1","PHB-CH1-104",104,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,38,, "PHB-CH1","PHB-CH1-104",104,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-104",104,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-104",104,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-104",104,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-104",104,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,3,, "PHB-CH1","PHB-CH1-104",104,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,496,, "PHB-CH1","PHB-CH1-104",104,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-104",104,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-104",104,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-104",104,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-104",104,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,51.7,51.7,0 "PHB-CH1","PHB-CH1-104",104,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,26,51.7,-25.7 "PHB-CH1","PHB-CH1-104",104,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,46.2,51.7,-5.5 "PHB-CH1","PHB-CH1-104",104,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,45.1,51.7,-6.6 "PHB-CH1","PHB-CH1-104",104,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,36.3,36.3,0 "PHB-CH1","PHB-CH1-104",104,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,30.9,36.3,-5.4 "PHB-CH1","PHB-CH1-104",104,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,47.4,36.3,11.1 "PHB-CH1","PHB-CH1-104",104,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,44.9,36.3,8.6 "PHB-CH1","PHB-CH1-104",104,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,2.4,2.4,0 "PHB-CH1","PHB-CH1-104",104,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2.6,2.4,0.2 "PHB-CH1","PHB-CH1-104",104,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.6,2.4,0.2 "PHB-CH1","PHB-CH1-104",104,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.5,2.4,2.1 "PHB-CH1","PHB-CH1-104",104,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.2,2.4,1.8 "PHB-CH1","PHB-CH1-104",104,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3,2.4,0.6 "PHB-CH1","PHB-CH1-104",104,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.1,2.4,2.7 "PHB-CH1","PHB-CH1-104",104,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.4,2.4,3 "PHB-CH1","PHB-CH1-104",104,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.9,2.4,2.5 "PHB-CH1","PHB-CH1-104",104,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.4,2.4,2 "PHB-CH1","PHB-CH1-104",104,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.6,2.4,0.2 "PHB-CH1","PHB-CH1-104",104,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,2.9,2.4,0.5 "PHB-CH1","PHB-CH1-104",104,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.3,2.4,1.9 "PHB-CH1","PHB-CH1-104",104,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.7,2.4,1.3 "PHB-CH1","PHB-CH1-104",104,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-104",104,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.7,5.4,0.3 "PHB-CH1","PHB-CH1-104",104,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.8,5.4,0.399999999999999 "PHB-CH1","PHB-CH1-104",104,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.7,5.4,1.3 "PHB-CH1","PHB-CH1-104",104,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.1,5.4,0.699999999999999 "PHB-CH1","PHB-CH1-104",104,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.5,5.4,-0.9 "PHB-CH1","PHB-CH1-104",104,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7.1,5.4,1.7 "PHB-CH1","PHB-CH1-104",104,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.8,5.4,1.4 "PHB-CH1","PHB-CH1-104",104,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.3,5.4,1.9 "PHB-CH1","PHB-CH1-104",104,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.1,5.4,0.699999999999999 "PHB-CH1","PHB-CH1-104",104,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.4,5.4,0 "PHB-CH1","PHB-CH1-104",104,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.6,5.4,0.199999999999999 "PHB-CH1","PHB-CH1-104",104,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7,5.4,1.6 "PHB-CH1","PHB-CH1-104",104,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.5,5.4,1.1 "PHB-CH1","PHB-CH1-105",105,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,42,42,0 "PHB-CH1","PHB-CH1-105",105,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,48,42,6 "PHB-CH1","PHB-CH1-105",105,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,38,42,-4 "PHB-CH1","PHB-CH1-105",105,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,60,, "PHB-CH1","PHB-CH1-105",105,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,47,, "PHB-CH1","PHB-CH1-105",105,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,48,, "PHB-CH1","PHB-CH1-105",105,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-105",105,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-105",105,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-105",105,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-105",105,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,17,, "PHB-CH1","PHB-CH1-105",105,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,319,, "PHB-CH1","PHB-CH1-105",105,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-105",105,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-105",105,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-105",105,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-105",105,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,2.9,2.9,0 "PHB-CH1","PHB-CH1-105",105,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,19.2,2.9,16.3 "PHB-CH1","PHB-CH1-105",105,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,23,2.9,20.1 "PHB-CH1","PHB-CH1-105",105,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,22.7,2.9,19.8 "PHB-CH1","PHB-CH1-105",105,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,27.5,27.5,0 "PHB-CH1","PHB-CH1-105",105,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,12.1,27.5,-15.4 "PHB-CH1","PHB-CH1-105",105,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,34,27.5,6.5 "PHB-CH1","PHB-CH1-105",105,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,33.4,27.5,5.9 "PHB-CH1","PHB-CH1-105",105,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-105",105,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6,5.4,0.6 "PHB-CH1","PHB-CH1-105",105,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.1,5.4,-1.3 "PHB-CH1","PHB-CH1-105",105,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.3,5.4,-0.100000000000001 "PHB-CH1","PHB-CH1-105",105,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.7,5.4,-0.7 "PHB-CH1","PHB-CH1-105",105,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.1,5.4,-2.3 "PHB-CH1","PHB-CH1-105",105,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.9,5.4,-1.5 "PHB-CH1","PHB-CH1-105",105,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5,5.4,-0.4 "PHB-CH1","PHB-CH1-105",105,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.9,5.4,-1.5 "PHB-CH1","PHB-CH1-105",105,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.5,5.4,-1.9 "PHB-CH1","PHB-CH1-105",105,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.9,5.4,-1.5 "PHB-CH1","PHB-CH1-105",105,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.2,5.4,-1.2 "PHB-CH1","PHB-CH1-105",105,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.4,5.4,0 "PHB-CH1","PHB-CH1-105",105,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.4,5.4,-1 "PHB-CH1","PHB-CH1-105",105,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-105",105,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.7,4.7,1 "PHB-CH1","PHB-CH1-105",105,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.6,4.7,0.9 "PHB-CH1","PHB-CH1-105",105,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.5,4.7,1.8 "PHB-CH1","PHB-CH1-105",105,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.3,4.7,1.6 "PHB-CH1","PHB-CH1-105",105,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-105",105,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.6,4.7,0.9 "PHB-CH1","PHB-CH1-105",105,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.9,4.7,1.2 "PHB-CH1","PHB-CH1-105",105,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.7,4.7,-1 "PHB-CH1","PHB-CH1-105",105,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.9,4.7,-0.8 "PHB-CH1","PHB-CH1-105",105,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.7,4.7,1 "PHB-CH1","PHB-CH1-105",105,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.4,4.7,0.7 "PHB-CH1","PHB-CH1-105",105,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.9,4.7,2.2 "PHB-CH1","PHB-CH1-105",105,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.7,4.7,2 "PHB-CH1","PHB-CH1-106",106,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,71,71,0 "PHB-CH1","PHB-CH1-106",106,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,63,71,-8 "PHB-CH1","PHB-CH1-106",106,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,75,71,4 "PHB-CH1","PHB-CH1-106",106,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,49,, "PHB-CH1","PHB-CH1-106",106,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,58,, "PHB-CH1","PHB-CH1-106",106,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,40,, "PHB-CH1","PHB-CH1-106",106,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-106",106,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-106",106,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-106",106,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-106",106,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,9,, "PHB-CH1","PHB-CH1-106",106,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,371,, "PHB-CH1","PHB-CH1-106",106,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-106",106,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-106",106,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-106",106,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-106",106,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,17.6,17.6,0 "PHB-CH1","PHB-CH1-106",106,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,20.3,17.6,2.7 "PHB-CH1","PHB-CH1-106",106,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,17.3,17.6,-0.300000000000001 "PHB-CH1","PHB-CH1-106",106,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,31.2,17.6,13.6 "PHB-CH1","PHB-CH1-106",106,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,31.1,31.1,0 "PHB-CH1","PHB-CH1-106",106,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,41.2,31.1,10.1 "PHB-CH1","PHB-CH1-106",106,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,36.3,31.1,5.2 "PHB-CH1","PHB-CH1-106",106,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,30.7,31.1,-0.400000000000002 "PHB-CH1","PHB-CH1-106",106,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.5,5.5,0 "PHB-CH1","PHB-CH1-106",106,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.4,5.5,0.9 "PHB-CH1","PHB-CH1-106",106,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.3,5.5,0.8 "PHB-CH1","PHB-CH1-106",106,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,7.1,5.5,1.6 "PHB-CH1","PHB-CH1-106",106,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,7.7,5.5,2.2 "PHB-CH1","PHB-CH1-106",106,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.7,5.5,1.2 "PHB-CH1","PHB-CH1-106",106,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.2,5.5,0.7 "PHB-CH1","PHB-CH1-106",106,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.5,5.5,1 "PHB-CH1","PHB-CH1-106",106,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,7,5.5,1.5 "PHB-CH1","PHB-CH1-106",106,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.6,5.5,0.0999999999999996 "PHB-CH1","PHB-CH1-106",106,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.5,5.5,1 "PHB-CH1","PHB-CH1-106",106,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,7.3,5.5,1.8 "PHB-CH1","PHB-CH1-106",106,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.2,5.5,0.7 "PHB-CH1","PHB-CH1-106",106,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6,5.5,0.5 "PHB-CH1","PHB-CH1-106",106,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.2,4.2,0 "PHB-CH1","PHB-CH1-106",106,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.6,4.2,-0.6 "PHB-CH1","PHB-CH1-106",106,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.8,4.2,0.6 "PHB-CH1","PHB-CH1-106",106,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.2,4.2,1 "PHB-CH1","PHB-CH1-106",106,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.1,4.2,0.9 "PHB-CH1","PHB-CH1-106",106,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.2,4.2,1 "PHB-CH1","PHB-CH1-106",106,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-106",106,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5,4.2,0.8 "PHB-CH1","PHB-CH1-106",106,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6,4.2,1.8 "PHB-CH1","PHB-CH1-106",106,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.5,4.2,2.3 "PHB-CH1","PHB-CH1-106",106,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6,4.2,1.8 "PHB-CH1","PHB-CH1-106",106,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.6,4.2,1.4 "PHB-CH1","PHB-CH1-106",106,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.2,4.2,1 "PHB-CH1","PHB-CH1-106",106,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6,4.2,1.8 "PHB-CH1","PHB-CH1-107",107,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,54,54,0 "PHB-CH1","PHB-CH1-107",107,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,52,54,-2 "PHB-CH1","PHB-CH1-107",107,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,50,54,-4 "PHB-CH1","PHB-CH1-107",107,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,55,, "PHB-CH1","PHB-CH1-107",107,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,54,, "PHB-CH1","PHB-CH1-107",107,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,61,, "PHB-CH1","PHB-CH1-107",107,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-107",107,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-107",107,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-107",107,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-107",107,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,11,, "PHB-CH1","PHB-CH1-107",107,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,347,, "PHB-CH1","PHB-CH1-107",107,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-107",107,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-107",107,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-107",107,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-107",107,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,68.2,68.2,0 "PHB-CH1","PHB-CH1-107",107,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,57.3,68.2,-10.9 "PHB-CH1","PHB-CH1-107",107,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,56.2,68.2,-12 "PHB-CH1","PHB-CH1-107",107,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,56.9,68.2,-11.3 "PHB-CH1","PHB-CH1-107",107,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,58.6,58.6,0 "PHB-CH1","PHB-CH1-107",107,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,40.4,58.6,-18.2 "PHB-CH1","PHB-CH1-107",107,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,49.7,58.6,-8.9 "PHB-CH1","PHB-CH1-107",107,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,48.9,58.6,-9.7 "PHB-CH1","PHB-CH1-107",107,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.8,3.8,0 "PHB-CH1","PHB-CH1-107",107,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2.6,3.8,-1.2 "PHB-CH1","PHB-CH1-107",107,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.5,3.8,-1.3 "PHB-CH1","PHB-CH1-107",107,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.5,3.8,-1.3 "PHB-CH1","PHB-CH1-107",107,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,1.4,3.8,-2.4 "PHB-CH1","PHB-CH1-107",107,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.6,3.8,0.8 "PHB-CH1","PHB-CH1-107",107,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2.7,3.8,-1.1 "PHB-CH1","PHB-CH1-107",107,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.8,3.8,0 "PHB-CH1","PHB-CH1-107",107,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.4,3.8,-0.4 "PHB-CH1","PHB-CH1-107",107,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,2.5,3.8,-1.3 "PHB-CH1","PHB-CH1-107",107,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.9,3.8,-0.9 "PHB-CH1","PHB-CH1-107",107,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.4,3.8,-0.4 "PHB-CH1","PHB-CH1-107",107,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.2,3.8,-1.6 "PHB-CH1","PHB-CH1-107",107,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.1,3.8,-0.7 "PHB-CH1","PHB-CH1-107",107,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.9,4.9,0 "PHB-CH1","PHB-CH1-107",107,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.1,4.9,-0.800000000000001 "PHB-CH1","PHB-CH1-107",107,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.2,4.9,-1.7 "PHB-CH1","PHB-CH1-107",107,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.1,4.9,-0.800000000000001 "PHB-CH1","PHB-CH1-107",107,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3,4.9,-1.9 "PHB-CH1","PHB-CH1-107",107,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.7,4.9,-0.2 "PHB-CH1","PHB-CH1-107",107,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.2,4.9,-0.7 "PHB-CH1","PHB-CH1-107",107,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.7,4.9,-1.2 "PHB-CH1","PHB-CH1-107",107,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.7,4.9,-2.2 "PHB-CH1","PHB-CH1-107",107,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,2.1,4.9,-2.8 "PHB-CH1","PHB-CH1-107",107,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.8,4.9,-1.1 "PHB-CH1","PHB-CH1-107",107,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.5,4.9,-0.4 "PHB-CH1","PHB-CH1-107",107,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.2,4.9,-1.7 "PHB-CH1","PHB-CH1-107",107,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.7,4.9,-0.2 "PHB-CH1","PHB-CH1-108",108,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,38,38,0 "PHB-CH1","PHB-CH1-108",108,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,41,38,3 "PHB-CH1","PHB-CH1-108",108,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,36,38,-2 "PHB-CH1","PHB-CH1-108",108,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,38,, "PHB-CH1","PHB-CH1-108",108,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,28,, "PHB-CH1","PHB-CH1-108",108,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,50,, "PHB-CH1","PHB-CH1-108",108,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-108",108,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-108",108,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-108",108,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-108",108,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,4,, "PHB-CH1","PHB-CH1-108",108,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,466,, "PHB-CH1","PHB-CH1-108",108,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-108",108,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-108",108,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-108",108,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-108",108,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,53.9,53.9,0 "PHB-CH1","PHB-CH1-108",108,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,42.1,53.9,-11.8 "PHB-CH1","PHB-CH1-108",108,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,41.8,53.9,-12.1 "PHB-CH1","PHB-CH1-108",108,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,48.9,53.9,-5 "PHB-CH1","PHB-CH1-108",108,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,58.9,58.9,0 "PHB-CH1","PHB-CH1-108",108,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,48.3,58.9,-10.6 "PHB-CH1","PHB-CH1-108",108,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,47.3,58.9,-11.6 "PHB-CH1","PHB-CH1-108",108,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,66.3,58.9,7.4 "PHB-CH1","PHB-CH1-108",108,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,2.9,2.9,0 "PHB-CH1","PHB-CH1-108",108,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.9,2.9,1 "PHB-CH1","PHB-CH1-108",108,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.9,2.9,0 "PHB-CH1","PHB-CH1-108",108,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5,2.9,2.1 "PHB-CH1","PHB-CH1-108",108,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.6,2.9,1.7 "PHB-CH1","PHB-CH1-108",108,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.3,2.9,1.4 "PHB-CH1","PHB-CH1-108",108,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.2,2.9,1.3 "PHB-CH1","PHB-CH1-108",108,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.6,2.9,1.7 "PHB-CH1","PHB-CH1-108",108,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.9,2.9,1 "PHB-CH1","PHB-CH1-108",108,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.6,2.9,1.7 "PHB-CH1","PHB-CH1-108",108,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.7,2.9,1.8 "PHB-CH1","PHB-CH1-108",108,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.2,2.9,2.3 "PHB-CH1","PHB-CH1-108",108,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4,2.9,1.1 "PHB-CH1","PHB-CH1-108",108,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.2,2.9,1.3 "PHB-CH1","PHB-CH1-108",108,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-108",108,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.1,4.7,-0.6 "PHB-CH1","PHB-CH1-108",108,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.9,4.7,-0.8 "PHB-CH1","PHB-CH1-108",108,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.7,4.7,0 "PHB-CH1","PHB-CH1-108",108,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.8,4.7,0.0999999999999996 "PHB-CH1","PHB-CH1-108",108,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.3,4.7,-0.4 "PHB-CH1","PHB-CH1-108",108,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.4,4.7,-0.3 "PHB-CH1","PHB-CH1-108",108,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.6,4.7,0.9 "PHB-CH1","PHB-CH1-108",108,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.1,4.7,0.399999999999999 "PHB-CH1","PHB-CH1-108",108,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.5,4.7,0.8 "PHB-CH1","PHB-CH1-108",108,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.2,4.7,-0.5 "PHB-CH1","PHB-CH1-108",108,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.7,4.7,1 "PHB-CH1","PHB-CH1-108",108,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.8,4.7,0.0999999999999996 "PHB-CH1","PHB-CH1-108",108,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.8,4.7,1.1 "PHB-CH1","PHB-CH1-109",109,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,45,45,0 "PHB-CH1","PHB-CH1-109",109,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,55,45,10 "PHB-CH1","PHB-CH1-109",109,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,49,45,4 "PHB-CH1","PHB-CH1-109",109,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,51,, "PHB-CH1","PHB-CH1-109",109,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,59,, "PHB-CH1","PHB-CH1-109",109,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,49,, "PHB-CH1","PHB-CH1-109",109,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-109",109,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-109",109,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-109",109,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-109",109,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,23,, "PHB-CH1","PHB-CH1-109",109,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,307,, "PHB-CH1","PHB-CH1-109",109,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-109",109,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-109",109,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-109",109,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-109",109,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,55.2,55.2,0 "PHB-CH1","PHB-CH1-109",109,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,53.2,55.2,-2 "PHB-CH1","PHB-CH1-109",109,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,65.5,55.2,10.3 "PHB-CH1","PHB-CH1-109",109,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,57.1,55.2,1.9 "PHB-CH1","PHB-CH1-109",109,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,41.9,41.9,0 "PHB-CH1","PHB-CH1-109",109,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,44.5,41.9,2.6 "PHB-CH1","PHB-CH1-109",109,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,49.3,41.9,7.4 "PHB-CH1","PHB-CH1-109",109,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,38.1,41.9,-3.8 "PHB-CH1","PHB-CH1-109",109,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,2.2,2.2,0 "PHB-CH1","PHB-CH1-109",109,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2.5,2.2,0.3 "PHB-CH1","PHB-CH1-109",109,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.1,2.2,0.9 "PHB-CH1","PHB-CH1-109",109,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.2,2.2,0 "PHB-CH1","PHB-CH1-109",109,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.7,2.2,1.5 "PHB-CH1","PHB-CH1-109",109,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4,2.2,1.8 "PHB-CH1","PHB-CH1-109",109,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2.6,2.2,0.4 "PHB-CH1","PHB-CH1-109",109,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.1,2.2,0.9 "PHB-CH1","PHB-CH1-109",109,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.9,2.2,1.7 "PHB-CH1","PHB-CH1-109",109,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.9,2.2,2.7 "PHB-CH1","PHB-CH1-109",109,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.6,2.2,0.4 "PHB-CH1","PHB-CH1-109",109,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,2.7,2.2,0.5 "PHB-CH1","PHB-CH1-109",109,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.2,2.2,0 "PHB-CH1","PHB-CH1-109",109,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.5,2.2,1.3 "PHB-CH1","PHB-CH1-109",109,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.7,6.7,0 "PHB-CH1","PHB-CH1-109",109,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.3,6.7,-0.4 "PHB-CH1","PHB-CH1-109",109,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.7,6.7,0 "PHB-CH1","PHB-CH1-109",109,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.7,6.7,-1 "PHB-CH1","PHB-CH1-109",109,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.3,6.7,-0.4 "PHB-CH1","PHB-CH1-109",109,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6,6.7,-0.7 "PHB-CH1","PHB-CH1-109",109,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.2,6.7,-0.5 "PHB-CH1","PHB-CH1-109",109,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.1,6.7,-1.6 "PHB-CH1","PHB-CH1-109",109,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.7,6.7,-1 "PHB-CH1","PHB-CH1-109",109,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.2,6.7,0.5 "PHB-CH1","PHB-CH1-109",109,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.5,6.7,-0.2 "PHB-CH1","PHB-CH1-109",109,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.2,6.7,0.5 "PHB-CH1","PHB-CH1-109",109,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.9,6.7,0.2 "PHB-CH1","PHB-CH1-109",109,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.3,6.7,0.6 "PHB-CH1","PHB-CH1-110",110,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,69,69,0 "PHB-CH1","PHB-CH1-110",110,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,66,69,-3 "PHB-CH1","PHB-CH1-110",110,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,58,69,-11 "PHB-CH1","PHB-CH1-110",110,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,65,, "PHB-CH1","PHB-CH1-110",110,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,65,, "PHB-CH1","PHB-CH1-110",110,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,48,, "PHB-CH1","PHB-CH1-110",110,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-110",110,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-110",110,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,5,, "PHB-CH1","PHB-CH1-110",110,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-110",110,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,16,, "PHB-CH1","PHB-CH1-110",110,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,344,, "PHB-CH1","PHB-CH1-110",110,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-110",110,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-110",110,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-110",110,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-110",110,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,7.5,7.5,0 "PHB-CH1","PHB-CH1-110",110,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,4.5,7.5,-3 "PHB-CH1","PHB-CH1-110",110,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,22.6,7.5,15.1 "PHB-CH1","PHB-CH1-110",110,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,19,7.5,11.5 "PHB-CH1","PHB-CH1-110",110,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,24.2,24.2,0 "PHB-CH1","PHB-CH1-110",110,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,31.9,24.2,7.7 "PHB-CH1","PHB-CH1-110",110,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,14.1,24.2,-10.1 "PHB-CH1","PHB-CH1-110",110,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,16.5,24.2,-7.7 "PHB-CH1","PHB-CH1-110",110,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.3,6.3,0 "PHB-CH1","PHB-CH1-110",110,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.5,6.3,0.2 "PHB-CH1","PHB-CH1-110",110,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.5,6.3,0.2 "PHB-CH1","PHB-CH1-110",110,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,7,6.3,0.7 "PHB-CH1","PHB-CH1-110",110,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,7.5,6.3,1.2 "PHB-CH1","PHB-CH1-110",110,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.7,6.3,0.4 "PHB-CH1","PHB-CH1-110",110,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,7.6,6.3,1.3 "PHB-CH1","PHB-CH1-110",110,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.8,6.3,0.5 "PHB-CH1","PHB-CH1-110",110,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.5,6.3,0.2 "PHB-CH1","PHB-CH1-110",110,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.2,6.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-110",110,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,7.4,6.3,1.1 "PHB-CH1","PHB-CH1-110",110,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,7.4,6.3,1.1 "PHB-CH1","PHB-CH1-110",110,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,7.1,6.3,0.8 "PHB-CH1","PHB-CH1-110",110,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.7,6.3,-0.6 "PHB-CH1","PHB-CH1-110",110,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-110",110,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5,4.7,0.3 "PHB-CH1","PHB-CH1-110",110,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.3,4.7,-0.4 "PHB-CH1","PHB-CH1-110",110,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.3,4.7,0.6 "PHB-CH1","PHB-CH1-110",110,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.9,4.7,1.2 "PHB-CH1","PHB-CH1-110",110,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.2,4.7,-0.5 "PHB-CH1","PHB-CH1-110",110,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.7,4.7,0 "PHB-CH1","PHB-CH1-110",110,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-110",110,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.4,4.7,0.7 "PHB-CH1","PHB-CH1-110",110,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.3,4.7,-0.4 "PHB-CH1","PHB-CH1-110",110,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.7,4.7,1 "PHB-CH1","PHB-CH1-110",110,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.8,4.7,0.0999999999999996 "PHB-CH1","PHB-CH1-110",110,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-110",110,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.3,4.7,-0.4 "PHB-CH1","PHB-CH1-111",111,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,34,34,0 "PHB-CH1","PHB-CH1-111",111,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,34,34,0 "PHB-CH1","PHB-CH1-111",111,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,38,34,4 "PHB-CH1","PHB-CH1-111",111,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,28,, "PHB-CH1","PHB-CH1-111",111,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,33,, "PHB-CH1","PHB-CH1-111",111,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,46,, "PHB-CH1","PHB-CH1-111",111,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-111",111,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-111",111,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-111",111,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-111",111,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,14,, "PHB-CH1","PHB-CH1-111",111,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,338,, "PHB-CH1","PHB-CH1-111",111,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-111",111,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-111",111,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-111",111,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-111",111,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,40.9,40.9,0 "PHB-CH1","PHB-CH1-111",111,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,51.5,40.9,10.6 "PHB-CH1","PHB-CH1-111",111,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,49.1,40.9,8.2 "PHB-CH1","PHB-CH1-111",111,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,38.8,40.9,-2.1 "PHB-CH1","PHB-CH1-111",111,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,34.6,34.6,0 "PHB-CH1","PHB-CH1-111",111,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,40.6,34.6,6 "PHB-CH1","PHB-CH1-111",111,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,54.2,34.6,19.6 "PHB-CH1","PHB-CH1-111",111,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,46,34.6,11.4 "PHB-CH1","PHB-CH1-111",111,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-111",111,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.5,5.4,-0.9 "PHB-CH1","PHB-CH1-111",111,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.7,5.4,-0.7 "PHB-CH1","PHB-CH1-111",111,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.4,5.4,0 "PHB-CH1","PHB-CH1-111",111,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6,5.4,0.6 "PHB-CH1","PHB-CH1-111",111,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.3,5.4,-1.1 "PHB-CH1","PHB-CH1-111",111,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.4,5.4,-2 "PHB-CH1","PHB-CH1-111",111,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.3,5.4,-0.100000000000001 "PHB-CH1","PHB-CH1-111",111,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.7,5.4,0.3 "PHB-CH1","PHB-CH1-111",111,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.8,5.4,1.4 "PHB-CH1","PHB-CH1-111",111,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.1,5.4,-0.300000000000001 "PHB-CH1","PHB-CH1-111",111,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.1,5.4,-0.300000000000001 "PHB-CH1","PHB-CH1-111",111,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.1,5.4,-0.300000000000001 "PHB-CH1","PHB-CH1-111",111,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.4,5.4,-1 "PHB-CH1","PHB-CH1-111",111,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-111",111,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.4,5.4,1 "PHB-CH1","PHB-CH1-111",111,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.2,5.4,0.8 "PHB-CH1","PHB-CH1-111",111,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.3,5.4,0.9 "PHB-CH1","PHB-CH1-111",111,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.5,5.4,0.0999999999999996 "PHB-CH1","PHB-CH1-111",111,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.9,5.4,-0.5 "PHB-CH1","PHB-CH1-111",111,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.9,5.4,-1.5 "PHB-CH1","PHB-CH1-111",111,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.1,5.4,-0.300000000000001 "PHB-CH1","PHB-CH1-111",111,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.6,5.4,0.199999999999999 "PHB-CH1","PHB-CH1-111",111,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6,5.4,0.6 "PHB-CH1","PHB-CH1-111",111,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.5,5.4,0.0999999999999996 "PHB-CH1","PHB-CH1-111",111,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.1,5.4,0.699999999999999 "PHB-CH1","PHB-CH1-111",111,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.7,5.4,0.3 "PHB-CH1","PHB-CH1-111",111,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.9,5.4,-0.5 "PHB-CH1","PHB-CH1-112",112,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,70,70,0 "PHB-CH1","PHB-CH1-112",112,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,70,70,0 "PHB-CH1","PHB-CH1-112",112,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,66,70,-4 "PHB-CH1","PHB-CH1-112",112,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,63,, "PHB-CH1","PHB-CH1-112",112,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,49,, "PHB-CH1","PHB-CH1-112",112,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,51,, "PHB-CH1","PHB-CH1-112",112,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-112",112,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-112",112,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-112",112,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-112",112,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,15,, "PHB-CH1","PHB-CH1-112",112,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,317,, "PHB-CH1","PHB-CH1-112",112,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-112",112,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-112",112,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-112",112,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-112",112,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,39.9,39.9,0 "PHB-CH1","PHB-CH1-112",112,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,53.4,39.9,13.5 "PHB-CH1","PHB-CH1-112",112,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,44.5,39.9,4.6 "PHB-CH1","PHB-CH1-112",112,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,59.7,39.9,19.8 "PHB-CH1","PHB-CH1-112",112,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,52.2,52.2,0 "PHB-CH1","PHB-CH1-112",112,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,73.7,52.2,21.5 "PHB-CH1","PHB-CH1-112",112,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,80.3,52.2,28.1 "PHB-CH1","PHB-CH1-112",112,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,82.3,52.2,30.1 "PHB-CH1","PHB-CH1-112",112,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,7.7,7.7,0 "PHB-CH1","PHB-CH1-112",112,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6,7.7,-1.7 "PHB-CH1","PHB-CH1-112",112,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.7,7.7,-2 "PHB-CH1","PHB-CH1-112",112,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.1,7.7,-2.6 "PHB-CH1","PHB-CH1-112",112,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.6,7.7,-2.1 "PHB-CH1","PHB-CH1-112",112,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4,7.7,-3.7 "PHB-CH1","PHB-CH1-112",112,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.3,7.7,-3.4 "PHB-CH1","PHB-CH1-112",112,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.1,7.7,-2.6 "PHB-CH1","PHB-CH1-112",112,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.9,7.7,-2.8 "PHB-CH1","PHB-CH1-112",112,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.8,7.7,-1.9 "PHB-CH1","PHB-CH1-112",112,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.5,7.7,-1.2 "PHB-CH1","PHB-CH1-112",112,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.2,7.7,-2.5 "PHB-CH1","PHB-CH1-112",112,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.9,7.7,-1.8 "PHB-CH1","PHB-CH1-112",112,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.8,7.7,-2.9 "PHB-CH1","PHB-CH1-112",112,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,9,9,0 "PHB-CH1","PHB-CH1-112",112,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,7.7,9,-1.3 "PHB-CH1","PHB-CH1-112",112,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,8.1,9,-0.9 "PHB-CH1","PHB-CH1-112",112,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,7.1,9,-1.9 "PHB-CH1","PHB-CH1-112",112,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,7.5,9,-1.5 "PHB-CH1","PHB-CH1-112",112,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,7.3,9,-1.7 "PHB-CH1","PHB-CH1-112",112,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.7,9,-2.3 "PHB-CH1","PHB-CH1-112",112,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,7.2,9,-1.8 "PHB-CH1","PHB-CH1-112",112,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.3,9,-2.7 "PHB-CH1","PHB-CH1-112",112,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.8,9,-2.2 "PHB-CH1","PHB-CH1-112",112,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.7,9,-1.3 "PHB-CH1","PHB-CH1-112",112,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.3,9,-1.7 "PHB-CH1","PHB-CH1-112",112,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.7,9,-1.3 "PHB-CH1","PHB-CH1-112",112,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.4,9,-1.6 "PHB-CH1","PHB-CH1-113",113,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,38,38,0 "PHB-CH1","PHB-CH1-113",113,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,32,38,-6 "PHB-CH1","PHB-CH1-113",113,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,37,38,-1 "PHB-CH1","PHB-CH1-113",113,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,34,, "PHB-CH1","PHB-CH1-113",113,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,48,, "PHB-CH1","PHB-CH1-113",113,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,48,, "PHB-CH1","PHB-CH1-113",113,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-113",113,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-113",113,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-113",113,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-113",113,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,27,, "PHB-CH1","PHB-CH1-113",113,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,293,, "PHB-CH1","PHB-CH1-113",113,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-113",113,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-113",113,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-113",113,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-113",113,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,38.1,38.1,0 "PHB-CH1","PHB-CH1-113",113,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,27,38.1,-11.1 "PHB-CH1","PHB-CH1-113",113,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,34,38.1,-4.1 "PHB-CH1","PHB-CH1-113",113,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,30,38.1,-8.1 "PHB-CH1","PHB-CH1-113",113,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,47,47,0 "PHB-CH1","PHB-CH1-113",113,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,40.5,47,-6.5 "PHB-CH1","PHB-CH1-113",113,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,27.9,47,-19.1 "PHB-CH1","PHB-CH1-113",113,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,39.3,47,-7.7 "PHB-CH1","PHB-CH1-113",113,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4,4,0 "PHB-CH1","PHB-CH1-113",113,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.1,4,0.0999999999999996 "PHB-CH1","PHB-CH1-113",113,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.4,4,0.4 "PHB-CH1","PHB-CH1-113",113,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.4,4,0.4 "PHB-CH1","PHB-CH1-113",113,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.7,4,0.7 "PHB-CH1","PHB-CH1-113",113,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5,4,1 "PHB-CH1","PHB-CH1-113",113,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.4,4,1.4 "PHB-CH1","PHB-CH1-113",113,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.4,4,0.4 "PHB-CH1","PHB-CH1-113",113,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,2.5,4,-1.5 "PHB-CH1","PHB-CH1-113",113,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.7,4,-0.3 "PHB-CH1","PHB-CH1-113",113,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5,4,1 "PHB-CH1","PHB-CH1-113",113,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.2,4,1.2 "PHB-CH1","PHB-CH1-113",113,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.2,4,1.2 "PHB-CH1","PHB-CH1-113",113,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.9,4,-0.1 "PHB-CH1","PHB-CH1-113",113,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.1,6.1,0 "PHB-CH1","PHB-CH1-113",113,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.5,6.1,0.4 "PHB-CH1","PHB-CH1-113",113,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.5,6.1,0.4 "PHB-CH1","PHB-CH1-113",113,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.9,6.1,0.800000000000001 "PHB-CH1","PHB-CH1-113",113,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,7.7,6.1,1.6 "PHB-CH1","PHB-CH1-113",113,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,7.7,6.1,1.6 "PHB-CH1","PHB-CH1-113",113,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.3,6.1,0.2 "PHB-CH1","PHB-CH1-113",113,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6,6.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-113",113,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.5,6.1,-0.6 "PHB-CH1","PHB-CH1-113",113,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.3,6.1,0.2 "PHB-CH1","PHB-CH1-113",113,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.2,6.1,1.1 "PHB-CH1","PHB-CH1-113",113,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.3,6.1,1.2 "PHB-CH1","PHB-CH1-113",113,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,8,6.1,1.9 "PHB-CH1","PHB-CH1-113",113,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.6,6.1,0.5 "PHB-CH1","PHB-CH1-114",114,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,42,42,0 "PHB-CH1","PHB-CH1-114",114,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,22,42,-20 "PHB-CH1","PHB-CH1-114",114,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,36,42,-6 "PHB-CH1","PHB-CH1-114",114,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,41,, "PHB-CH1","PHB-CH1-114",114,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,50,, "PHB-CH1","PHB-CH1-114",114,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,39,, "PHB-CH1","PHB-CH1-114",114,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-114",114,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-114",114,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-114",114,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-114",114,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,20,, "PHB-CH1","PHB-CH1-114",114,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,354,, "PHB-CH1","PHB-CH1-114",114,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-114",114,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-114",114,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-114",114,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-114",114,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,53.5,53.5,0 "PHB-CH1","PHB-CH1-114",114,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,64.2,53.5,10.7 "PHB-CH1","PHB-CH1-114",114,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,51.3,53.5,-2.2 "PHB-CH1","PHB-CH1-114",114,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,72.2,53.5,18.7 "PHB-CH1","PHB-CH1-114",114,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,62.4,62.4,0 "PHB-CH1","PHB-CH1-114",114,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,84.4,62.4,22 "PHB-CH1","PHB-CH1-114",114,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,63.9,62.4,1.5 "PHB-CH1","PHB-CH1-114",114,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,71.7,62.4,9.3 "PHB-CH1","PHB-CH1-114",114,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.8,3.8,0 "PHB-CH1","PHB-CH1-114",114,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.7,3.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-114",114,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.3,3.8,-0.5 "PHB-CH1","PHB-CH1-114",114,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,0.8,3.8,-3 "PHB-CH1","PHB-CH1-114",114,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.1,3.8,0.3 "PHB-CH1","PHB-CH1-114",114,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.3,3.8,1.5 "PHB-CH1","PHB-CH1-114",114,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.1,3.8,-0.7 "PHB-CH1","PHB-CH1-114",114,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.8,3.8,0 "PHB-CH1","PHB-CH1-114",114,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.2,3.8,-0.6 "PHB-CH1","PHB-CH1-114",114,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.9,3.8,2.1 "PHB-CH1","PHB-CH1-114",114,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3,3.8,-0.8 "PHB-CH1","PHB-CH1-114",114,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,2.4,3.8,-1.4 "PHB-CH1","PHB-CH1-114",114,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3,3.8,-0.8 "PHB-CH1","PHB-CH1-114",114,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2.6,3.8,-1.2 "PHB-CH1","PHB-CH1-114",114,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.9,6.9,0 "PHB-CH1","PHB-CH1-114",114,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,7.3,6.9,0.399999999999999 "PHB-CH1","PHB-CH1-114",114,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.5,6.9,-0.4 "PHB-CH1","PHB-CH1-114",114,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.7,6.9,-2.2 "PHB-CH1","PHB-CH1-114",114,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,7.3,6.9,0.399999999999999 "PHB-CH1","PHB-CH1-114",114,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,7.8,6.9,0.9 "PHB-CH1","PHB-CH1-114",114,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.6,6.9,-0.300000000000001 "PHB-CH1","PHB-CH1-114",114,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.6,6.9,-1.3 "PHB-CH1","PHB-CH1-114",114,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.6,6.9,-1.3 "PHB-CH1","PHB-CH1-114",114,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.4,6.9,-0.5 "PHB-CH1","PHB-CH1-114",114,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.6,6.9,-2.3 "PHB-CH1","PHB-CH1-114",114,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4,6.9,-2.9 "PHB-CH1","PHB-CH1-114",114,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.9,6.9,-1 "PHB-CH1","PHB-CH1-114",114,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6,6.9,-0.9 "PHB-CH1","PHB-CH1-115",115,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,41,41,0 "PHB-CH1","PHB-CH1-115",115,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,42,41,1 "PHB-CH1","PHB-CH1-115",115,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,30,41,-11 "PHB-CH1","PHB-CH1-115",115,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,55,, "PHB-CH1","PHB-CH1-115",115,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,41,, "PHB-CH1","PHB-CH1-115",115,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,29,, "PHB-CH1","PHB-CH1-115",115,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-115",115,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-115",115,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-115",115,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-115",115,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,5,, "PHB-CH1","PHB-CH1-115",115,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,517,, "PHB-CH1","PHB-CH1-115",115,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-115",115,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-115",115,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-115",115,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-115",115,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,52.1,52.1,0 "PHB-CH1","PHB-CH1-115",115,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,34.8,52.1,-17.3 "PHB-CH1","PHB-CH1-115",115,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,54.5,52.1,2.4 "PHB-CH1","PHB-CH1-115",115,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,44.1,52.1,-8 "PHB-CH1","PHB-CH1-115",115,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,47.2,47.2,0 "PHB-CH1","PHB-CH1-115",115,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,39,47.2,-8.2 "PHB-CH1","PHB-CH1-115",115,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,59.2,47.2,12 "PHB-CH1","PHB-CH1-115",115,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,51.2,47.2,4 "PHB-CH1","PHB-CH1-115",115,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.1,6.1,0 "PHB-CH1","PHB-CH1-115",115,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.4,6.1,0.300000000000001 "PHB-CH1","PHB-CH1-115",115,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.2,6.1,-1.9 "PHB-CH1","PHB-CH1-115",115,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.6,6.1,-0.5 "PHB-CH1","PHB-CH1-115",115,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.6,6.1,-1.5 "PHB-CH1","PHB-CH1-115",115,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.1,6.1,-1 "PHB-CH1","PHB-CH1-115",115,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6,6.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-115",115,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.3,6.1,1.2 "PHB-CH1","PHB-CH1-115",115,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.9,6.1,-0.199999999999999 "PHB-CH1","PHB-CH1-115",115,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.3,6.1,-0.8 "PHB-CH1","PHB-CH1-115",115,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.8,6.1,-0.3 "PHB-CH1","PHB-CH1-115",115,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.9,6.1,-0.199999999999999 "PHB-CH1","PHB-CH1-115",115,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.2,6.1,-0.9 "PHB-CH1","PHB-CH1-115",115,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.8,6.1,0.7 "PHB-CH1","PHB-CH1-115",115,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.6,2.6,0 "PHB-CH1","PHB-CH1-115",115,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.7,2.6,1.1 "PHB-CH1","PHB-CH1-115",115,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,2.7,2.6,0.1 "PHB-CH1","PHB-CH1-115",115,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.1,2.6,0.5 "PHB-CH1","PHB-CH1-115",115,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.2,2.6,0.6 "PHB-CH1","PHB-CH1-115",115,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.6,2.6,1 "PHB-CH1","PHB-CH1-115",115,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,2.8,2.6,0.2 "PHB-CH1","PHB-CH1-115",115,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.3,2.6,1.7 "PHB-CH1","PHB-CH1-115",115,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.6,2.6,1 "PHB-CH1","PHB-CH1-115",115,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3,2.6,0.4 "PHB-CH1","PHB-CH1-115",115,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.6,2.6,1 "PHB-CH1","PHB-CH1-115",115,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.2,2.6,1.6 "PHB-CH1","PHB-CH1-115",115,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2.8,2.6,0.2 "PHB-CH1","PHB-CH1-115",115,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.3,2.6,1.7 "PHB-CH1","PHB-CH1-116",116,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,57,57,0 "PHB-CH1","PHB-CH1-116",116,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,49,57,-8 "PHB-CH1","PHB-CH1-116",116,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,59,57,2 "PHB-CH1","PHB-CH1-116",116,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,46,, "PHB-CH1","PHB-CH1-116",116,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,49,, "PHB-CH1","PHB-CH1-116",116,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,47,, "PHB-CH1","PHB-CH1-116",116,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-116",116,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-116",116,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-116",116,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-116",116,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,14,, "PHB-CH1","PHB-CH1-116",116,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,402,, "PHB-CH1","PHB-CH1-116",116,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-116",116,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-116",116,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-116",116,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-116",116,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,62.2,62.2,0 "PHB-CH1","PHB-CH1-116",116,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,54.7,62.2,-7.5 "PHB-CH1","PHB-CH1-116",116,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,64.7,62.2,2.5 "PHB-CH1","PHB-CH1-116",116,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,50.8,62.2,-11.4 "PHB-CH1","PHB-CH1-116",116,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,53.5,53.5,0 "PHB-CH1","PHB-CH1-116",116,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,46.4,53.5,-7.1 "PHB-CH1","PHB-CH1-116",116,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,40.7,53.5,-12.8 "PHB-CH1","PHB-CH1-116",116,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,46,53.5,-7.5 "PHB-CH1","PHB-CH1-116",116,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.9,6.9,0 "PHB-CH1","PHB-CH1-116",116,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.7,6.9,-1.2 "PHB-CH1","PHB-CH1-116",116,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6,6.9,-0.9 "PHB-CH1","PHB-CH1-116",116,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.8,6.9,-2.1 "PHB-CH1","PHB-CH1-116",116,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,7,6.9,0.0999999999999996 "PHB-CH1","PHB-CH1-116",116,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.3,6.9,-0.6 "PHB-CH1","PHB-CH1-116",116,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.7,6.9,-1.2 "PHB-CH1","PHB-CH1-116",116,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.9,6.9,0 "PHB-CH1","PHB-CH1-116",116,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.1,6.9,-0.800000000000001 "PHB-CH1","PHB-CH1-116",116,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.4,6.9,-0.5 "PHB-CH1","PHB-CH1-116",116,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.3,6.9,-0.6 "PHB-CH1","PHB-CH1-116",116,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,7.5,6.9,0.6 "PHB-CH1","PHB-CH1-116",116,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,7,6.9,0.0999999999999996 "PHB-CH1","PHB-CH1-116",116,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.8,6.9,-0.100000000000001 "PHB-CH1","PHB-CH1-116",116,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.7,3.7,0 "PHB-CH1","PHB-CH1-116",116,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,2.2,3.7,-1.5 "PHB-CH1","PHB-CH1-116",116,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.2,3.7,0.5 "PHB-CH1","PHB-CH1-116",116,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,2.7,3.7,-1 "PHB-CH1","PHB-CH1-116",116,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.2,3.7,0.5 "PHB-CH1","PHB-CH1-116",116,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.3,3.7,0.6 "PHB-CH1","PHB-CH1-116",116,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.4,3.7,-0.3 "PHB-CH1","PHB-CH1-116",116,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.4,3.7,0.7 "PHB-CH1","PHB-CH1-116",116,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.9,3.7,-0.8 "PHB-CH1","PHB-CH1-116",116,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.5,3.7,0.8 "PHB-CH1","PHB-CH1-116",116,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.2,3.7,0.5 "PHB-CH1","PHB-CH1-116",116,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.1,3.7,1.4 "PHB-CH1","PHB-CH1-116",116,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.4,3.7,-0.3 "PHB-CH1","PHB-CH1-116",116,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.3,3.7,0.6 "PHB-CH1","PHB-CH1-117",117,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,55,55,0 "PHB-CH1","PHB-CH1-117",117,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,48,55,-7 "PHB-CH1","PHB-CH1-117",117,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,46,55,-9 "PHB-CH1","PHB-CH1-117",117,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,46,, "PHB-CH1","PHB-CH1-117",117,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,47,, "PHB-CH1","PHB-CH1-117",117,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,52,, "PHB-CH1","PHB-CH1-117",117,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-117",117,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-117",117,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-117",117,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-117",117,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,10,, "PHB-CH1","PHB-CH1-117",117,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,420,, "PHB-CH1","PHB-CH1-117",117,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-117",117,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-117",117,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-117",117,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-117",117,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,40.6,40.6,0 "PHB-CH1","PHB-CH1-117",117,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,37.7,40.6,-2.9 "PHB-CH1","PHB-CH1-117",117,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,62,40.6,21.4 "PHB-CH1","PHB-CH1-117",117,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,47.3,40.6,6.7 "PHB-CH1","PHB-CH1-117",117,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,49,49,0 "PHB-CH1","PHB-CH1-117",117,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,47.9,49,-1.1 "PHB-CH1","PHB-CH1-117",117,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,51.3,49,2.3 "PHB-CH1","PHB-CH1-117",117,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,68.1,49,19.1 "PHB-CH1","PHB-CH1-117",117,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,7.5,7.5,0 "PHB-CH1","PHB-CH1-117",117,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,7.3,7.5,-0.2 "PHB-CH1","PHB-CH1-117",117,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7.8,7.5,0.3 "PHB-CH1","PHB-CH1-117",117,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.6,7.5,-0.9 "PHB-CH1","PHB-CH1-117",117,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.9,7.5,-2.6 "PHB-CH1","PHB-CH1-117",117,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.4,7.5,-2.1 "PHB-CH1","PHB-CH1-117",117,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.8,7.5,-0.7 "PHB-CH1","PHB-CH1-117",117,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,8.1,7.5,0.6 "PHB-CH1","PHB-CH1-117",117,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,7.3,7.5,-0.2 "PHB-CH1","PHB-CH1-117",117,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,7.2,7.5,-0.3 "PHB-CH1","PHB-CH1-117",117,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.4,7.5,-1.1 "PHB-CH1","PHB-CH1-117",117,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.9,7.5,-0.6 "PHB-CH1","PHB-CH1-117",117,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,7,7.5,-0.5 "PHB-CH1","PHB-CH1-117",117,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.6,7.5,-0.9 "PHB-CH1","PHB-CH1-117",117,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,9.4,9.4,0 "PHB-CH1","PHB-CH1-117",117,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,8,9.4,-1.4 "PHB-CH1","PHB-CH1-117",117,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7.8,9.4,-1.6 "PHB-CH1","PHB-CH1-117",117,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,7.5,9.4,-1.9 "PHB-CH1","PHB-CH1-117",117,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,8.7,9.4,-0.700000000000001 "PHB-CH1","PHB-CH1-117",117,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,8.4,9.4,-1 "PHB-CH1","PHB-CH1-117",117,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7.9,9.4,-1.5 "PHB-CH1","PHB-CH1-117",117,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,8.5,9.4,-0.9 "PHB-CH1","PHB-CH1-117",117,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,8.8,9.4,-0.6 "PHB-CH1","PHB-CH1-117",117,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.9,9.4,-1.5 "PHB-CH1","PHB-CH1-117",117,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.8,9.4,-1.6 "PHB-CH1","PHB-CH1-117",117,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,8.5,9.4,-0.9 "PHB-CH1","PHB-CH1-117",117,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,8.2,9.4,-1.2 "PHB-CH1","PHB-CH1-117",117,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.8,9.4,-2.6 "PHB-CH1","PHB-CH1-118",118,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,61,61,0 "PHB-CH1","PHB-CH1-118",118,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,70,61,9 "PHB-CH1","PHB-CH1-118",118,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,59,61,-2 "PHB-CH1","PHB-CH1-118",118,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,59,, "PHB-CH1","PHB-CH1-118",118,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,57,, "PHB-CH1","PHB-CH1-118",118,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,41,, "PHB-CH1","PHB-CH1-118",118,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-118",118,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-118",118,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-118",118,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-118",118,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,37,, "PHB-CH1","PHB-CH1-118",118,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,233,, "PHB-CH1","PHB-CH1-118",118,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-118",118,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-118",118,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-118",118,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-118",118,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,61.2,61.2,0 "PHB-CH1","PHB-CH1-118",118,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,54.2,61.2,-7 "PHB-CH1","PHB-CH1-118",118,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,53.9,61.2,-7.3 "PHB-CH1","PHB-CH1-118",118,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,57.4,61.2,-3.8 "PHB-CH1","PHB-CH1-118",118,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,56.8,56.8,0 "PHB-CH1","PHB-CH1-118",118,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,40.7,56.8,-16.1 "PHB-CH1","PHB-CH1-118",118,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,52.2,56.8,-4.59999999999999 "PHB-CH1","PHB-CH1-118",118,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,61,56.8,4.2 "PHB-CH1","PHB-CH1-118",118,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.4,3.4,0 "PHB-CH1","PHB-CH1-118",118,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2.2,3.4,-1.2 "PHB-CH1","PHB-CH1-118",118,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3,3.4,-0.4 "PHB-CH1","PHB-CH1-118",118,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,1.6,3.4,-1.8 "PHB-CH1","PHB-CH1-118",118,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,2.1,3.4,-1.3 "PHB-CH1","PHB-CH1-118",118,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2,3.4,-1.4 "PHB-CH1","PHB-CH1-118",118,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2.6,3.4,-0.8 "PHB-CH1","PHB-CH1-118",118,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.1,3.4,-0.3 "PHB-CH1","PHB-CH1-118",118,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.1,3.4,0.7 "PHB-CH1","PHB-CH1-118",118,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.1,3.4,0.7 "PHB-CH1","PHB-CH1-118",118,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.3,3.4,1.9 "PHB-CH1","PHB-CH1-118",118,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,2.4,3.4,-1 "PHB-CH1","PHB-CH1-118",118,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.7,3.4,0.3 "PHB-CH1","PHB-CH1-118",118,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.3,3.4,-0.1 "PHB-CH1","PHB-CH1-118",118,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.3,5.3,0 "PHB-CH1","PHB-CH1-118",118,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,2.8,5.3,-2.5 "PHB-CH1","PHB-CH1-118",118,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,2.2,5.3,-3.1 "PHB-CH1","PHB-CH1-118",118,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,2.3,5.3,-3 "PHB-CH1","PHB-CH1-118",118,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.3,5.3,-2 "PHB-CH1","PHB-CH1-118",118,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.1,5.3,-2.2 "PHB-CH1","PHB-CH1-118",118,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.8,5.3,-1.5 "PHB-CH1","PHB-CH1-118",118,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.3,5.3,-2 "PHB-CH1","PHB-CH1-118",118,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.9,5.3,-2.4 "PHB-CH1","PHB-CH1-118",118,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.4,5.3,-0.9 "PHB-CH1","PHB-CH1-118",118,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.7,5.3,-0.6 "PHB-CH1","PHB-CH1-118",118,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.5,5.3,-1.8 "PHB-CH1","PHB-CH1-118",118,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.1,5.3,-2.2 "PHB-CH1","PHB-CH1-118",118,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,2.7,5.3,-2.6 "PHB-CH1","PHB-CH1-119",119,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,61,61,0 "PHB-CH1","PHB-CH1-119",119,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,64,61,3 "PHB-CH1","PHB-CH1-119",119,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,55,61,-6 "PHB-CH1","PHB-CH1-119",119,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,58,, "PHB-CH1","PHB-CH1-119",119,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,69,, "PHB-CH1","PHB-CH1-119",119,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,44,, "PHB-CH1","PHB-CH1-119",119,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-119",119,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-119",119,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-119",119,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-119",119,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,1,, "PHB-CH1","PHB-CH1-119",119,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,529,, "PHB-CH1","PHB-CH1-119",119,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-119",119,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-119",119,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-119",119,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-119",119,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,43.2,43.2,0 "PHB-CH1","PHB-CH1-119",119,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,49.1,43.2,5.9 "PHB-CH1","PHB-CH1-119",119,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,49,43.2,5.8 "PHB-CH1","PHB-CH1-119",119,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,38.9,43.2,-4.3 "PHB-CH1","PHB-CH1-119",119,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,55.2,55.2,0 "PHB-CH1","PHB-CH1-119",119,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,48.3,55.2,-6.90000000000001 "PHB-CH1","PHB-CH1-119",119,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,48.5,55.2,-6.7 "PHB-CH1","PHB-CH1-119",119,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,58.2,55.2,3 "PHB-CH1","PHB-CH1-119",119,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-119",119,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.6,4.7,0.9 "PHB-CH1","PHB-CH1-119",119,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-119",119,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.6,4.7,0.9 "PHB-CH1","PHB-CH1-119",119,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.1,4.7,0.399999999999999 "PHB-CH1","PHB-CH1-119",119,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.5,4.7,-1.2 "PHB-CH1","PHB-CH1-119",119,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.7,4.7,0 "PHB-CH1","PHB-CH1-119",119,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.3,4.7,-0.4 "PHB-CH1","PHB-CH1-119",119,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.6,4.7,1.9 "PHB-CH1","PHB-CH1-119",119,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5,4.7,0.3 "PHB-CH1","PHB-CH1-119",119,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.1,4.7,0.399999999999999 "PHB-CH1","PHB-CH1-119",119,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.2,4.7,0.5 "PHB-CH1","PHB-CH1-119",119,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.8,4.7,0.0999999999999996 "PHB-CH1","PHB-CH1-119",119,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-119",119,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-119",119,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.9,5.1,1.8 "PHB-CH1","PHB-CH1-119",119,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.8,5.1,0.7 "PHB-CH1","PHB-CH1-119",119,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.2,5.1,1.1 "PHB-CH1","PHB-CH1-119",119,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.1,5.1,1 "PHB-CH1","PHB-CH1-119",119,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5,5.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-119",119,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.9,5.1,0.800000000000001 "PHB-CH1","PHB-CH1-119",119,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.2,5.1,0.100000000000001 "PHB-CH1","PHB-CH1-119",119,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.6,5.1,2.5 "PHB-CH1","PHB-CH1-119",119,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6,5.1,0.9 "PHB-CH1","PHB-CH1-119",119,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.9,5.1,-0.199999999999999 "PHB-CH1","PHB-CH1-119",119,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.4,5.1,1.3 "PHB-CH1","PHB-CH1-119",119,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.9,5.1,0.800000000000001 "PHB-CH1","PHB-CH1-119",119,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.2,5.1,0.100000000000001 "PHB-CH1","PHB-CH1-120",120,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,89,89,0 "PHB-CH1","PHB-CH1-120",120,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,90,89,1 "PHB-CH1","PHB-CH1-120",120,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,77,89,-12 "PHB-CH1","PHB-CH1-120",120,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,89,, "PHB-CH1","PHB-CH1-120",120,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,82,, "PHB-CH1","PHB-CH1-120",120,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,45,, "PHB-CH1","PHB-CH1-120",120,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-120",120,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-120",120,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,5,, "PHB-CH1","PHB-CH1-120",120,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,5,, "PHB-CH1","PHB-CH1-120",120,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,12,, "PHB-CH1","PHB-CH1-120",120,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,400,, "PHB-CH1","PHB-CH1-120",120,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-120",120,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-120",120,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-120",120,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-120",120,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,49.2,49.2,0 "PHB-CH1","PHB-CH1-120",120,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,45.8,49.2,-3.40000000000001 "PHB-CH1","PHB-CH1-120",120,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,39.2,49.2,-10 "PHB-CH1","PHB-CH1-120",120,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,53.5,49.2,4.3 "PHB-CH1","PHB-CH1-120",120,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,50.1,50.1,0 "PHB-CH1","PHB-CH1-120",120,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,48.1,50.1,-2 "PHB-CH1","PHB-CH1-120",120,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,33,50.1,-17.1 "PHB-CH1","PHB-CH1-120",120,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,19.3,50.1,-30.8 "PHB-CH1","PHB-CH1-120",120,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,2.3,2.3,0 "PHB-CH1","PHB-CH1-120",120,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.7,2.3,1.4 "PHB-CH1","PHB-CH1-120",120,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.6,2.3,3.3 "PHB-CH1","PHB-CH1-120",120,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.1,2.3,1.8 "PHB-CH1","PHB-CH1-120",120,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.6,2.3,2.3 "PHB-CH1","PHB-CH1-120",120,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.6,2.3,2.3 "PHB-CH1","PHB-CH1-120",120,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.9,2.3,2.6 "PHB-CH1","PHB-CH1-120",120,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5,2.3,2.7 "PHB-CH1","PHB-CH1-120",120,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.7,2.3,2.4 "PHB-CH1","PHB-CH1-120",120,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.4,2.3,2.1 "PHB-CH1","PHB-CH1-120",120,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.5,2.3,1.2 "PHB-CH1","PHB-CH1-120",120,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3,2.3,0.7 "PHB-CH1","PHB-CH1-120",120,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.9,2.3,1.6 "PHB-CH1","PHB-CH1-120",120,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.6,2.3,3.3 "PHB-CH1","PHB-CH1-120",120,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7,7,0 "PHB-CH1","PHB-CH1-120",120,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,7.6,7,0.6 "PHB-CH1","PHB-CH1-120",120,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,9.3,7,2.3 "PHB-CH1","PHB-CH1-120",120,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,9.1,7,2.1 "PHB-CH1","PHB-CH1-120",120,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,8.8,7,1.8 "PHB-CH1","PHB-CH1-120",120,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,7.8,7,0.8 "PHB-CH1","PHB-CH1-120",120,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,8.2,7,1.2 "PHB-CH1","PHB-CH1-120",120,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,7.3,7,0.3 "PHB-CH1","PHB-CH1-120",120,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.9,7,0.9 "PHB-CH1","PHB-CH1-120",120,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,8.3,7,1.3 "PHB-CH1","PHB-CH1-120",120,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,8.4,7,1.4 "PHB-CH1","PHB-CH1-120",120,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.3,7,0.3 "PHB-CH1","PHB-CH1-120",120,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,9.6,7,2.6 "PHB-CH1","PHB-CH1-120",120,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,10,7,3 "PHB-CH1","PHB-CH1-121",121,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,47,47,0 "PHB-CH1","PHB-CH1-121",121,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,60,47,13 "PHB-CH1","PHB-CH1-121",121,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,23,47,-24 "PHB-CH1","PHB-CH1-121",121,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,40,, "PHB-CH1","PHB-CH1-121",121,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,44,, "PHB-CH1","PHB-CH1-121",121,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,48,, "PHB-CH1","PHB-CH1-121",121,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-121",121,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-121",121,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-121",121,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-121",121,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,3,, "PHB-CH1","PHB-CH1-121",121,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,493,, "PHB-CH1","PHB-CH1-121",121,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-121",121,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-121",121,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-121",121,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-121",121,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,64.5,64.5,0 "PHB-CH1","PHB-CH1-121",121,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,46.8,64.5,-17.7 "PHB-CH1","PHB-CH1-121",121,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,55.4,64.5,-9.1 "PHB-CH1","PHB-CH1-121",121,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,48.5,64.5,-16 "PHB-CH1","PHB-CH1-121",121,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,50.6,50.6,0 "PHB-CH1","PHB-CH1-121",121,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,47.5,50.6,-3.1 "PHB-CH1","PHB-CH1-121",121,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,47.3,50.6,-3.3 "PHB-CH1","PHB-CH1-121",121,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,43.1,50.6,-7.5 "PHB-CH1","PHB-CH1-121",121,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.6,4.6,0 "PHB-CH1","PHB-CH1-121",121,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.3,4.6,-0.3 "PHB-CH1","PHB-CH1-121",121,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.8,4.6,0.2 "PHB-CH1","PHB-CH1-121",121,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.8,4.6,0.2 "PHB-CH1","PHB-CH1-121",121,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.6,4.6,1 "PHB-CH1","PHB-CH1-121",121,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.4,4.6,0.800000000000001 "PHB-CH1","PHB-CH1-121",121,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.3,4.6,0.7 "PHB-CH1","PHB-CH1-121",121,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.3,4.6,-1.3 "PHB-CH1","PHB-CH1-121",121,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.4,4.6,-1.2 "PHB-CH1","PHB-CH1-121",121,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.4,4.6,0.800000000000001 "PHB-CH1","PHB-CH1-121",121,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.6,4.6,-1 "PHB-CH1","PHB-CH1-121",121,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.1,4.6,-0.5 "PHB-CH1","PHB-CH1-121",121,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.9,4.6,-0.7 "PHB-CH1","PHB-CH1-121",121,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.1,4.6,-1.5 "PHB-CH1","PHB-CH1-121",121,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.6,3.6,0 "PHB-CH1","PHB-CH1-121",121,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.5,3.6,-0.1 "PHB-CH1","PHB-CH1-121",121,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.3,3.6,0.7 "PHB-CH1","PHB-CH1-121",121,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.3,3.6,1.7 "PHB-CH1","PHB-CH1-121",121,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.9,3.6,1.3 "PHB-CH1","PHB-CH1-121",121,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.4,3.6,-0.2 "PHB-CH1","PHB-CH1-121",121,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3,3.6,-0.6 "PHB-CH1","PHB-CH1-121",121,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.5,3.6,-0.1 "PHB-CH1","PHB-CH1-121",121,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.5,3.6,-1.1 "PHB-CH1","PHB-CH1-121",121,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.2,3.6,0.6 "PHB-CH1","PHB-CH1-121",121,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,1.9,3.6,-1.7 "PHB-CH1","PHB-CH1-121",121,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,1.8,3.6,-1.8 "PHB-CH1","PHB-CH1-121",121,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2.1,3.6,-1.5 "PHB-CH1","PHB-CH1-121",121,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,2.4,3.6,-1.2 "PHB-CH1","PHB-CH1-122",122,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,11,11,0 "PHB-CH1","PHB-CH1-122",122,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,9,11,-2 "PHB-CH1","PHB-CH1-122",122,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,2,11,-9 "PHB-CH1","PHB-CH1-122",122,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,20,, "PHB-CH1","PHB-CH1-122",122,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,22,, "PHB-CH1","PHB-CH1-122",122,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,47,, "PHB-CH1","PHB-CH1-122",122,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-122",122,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-122",122,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-122",122,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-122",122,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,1,, "PHB-CH1","PHB-CH1-122",122,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,618,, "PHB-CH1","PHB-CH1-122",122,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-122",122,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-122",122,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-122",122,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-122",122,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,26.8,26.8,0 "PHB-CH1","PHB-CH1-122",122,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,27.4,26.8,0.599999999999998 "PHB-CH1","PHB-CH1-122",122,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,28.4,26.8,1.6 "PHB-CH1","PHB-CH1-122",122,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,34.7,26.8,7.9 "PHB-CH1","PHB-CH1-122",122,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,45.3,45.3,0 "PHB-CH1","PHB-CH1-122",122,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,50.8,45.3,5.5 "PHB-CH1","PHB-CH1-122",122,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,28.1,45.3,-17.2 "PHB-CH1","PHB-CH1-122",122,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,31.1,45.3,-14.2 "PHB-CH1","PHB-CH1-122",122,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.8,5.8,0 "PHB-CH1","PHB-CH1-122",122,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.6,5.8,-0.2 "PHB-CH1","PHB-CH1-122",122,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.6,5.8,0.8 "PHB-CH1","PHB-CH1-122",122,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.6,5.8,-0.2 "PHB-CH1","PHB-CH1-122",122,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.5,5.8,-0.3 "PHB-CH1","PHB-CH1-122",122,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.8,5.8,-1 "PHB-CH1","PHB-CH1-122",122,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.4,5.8,-0.399999999999999 "PHB-CH1","PHB-CH1-122",122,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.7,5.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-122",122,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.5,5.8,-0.3 "PHB-CH1","PHB-CH1-122",122,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.6,5.8,-1.2 "PHB-CH1","PHB-CH1-122",122,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.5,5.8,-0.3 "PHB-CH1","PHB-CH1-122",122,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.2,5.8,-0.6 "PHB-CH1","PHB-CH1-122",122,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.8,5.8,0 "PHB-CH1","PHB-CH1-122",122,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.2,5.8,-0.6 "PHB-CH1","PHB-CH1-122",122,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.3,6.3,0 "PHB-CH1","PHB-CH1-122",122,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.3,6.3,-1 "PHB-CH1","PHB-CH1-122",122,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7.2,6.3,0.9 "PHB-CH1","PHB-CH1-122",122,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.5,6.3,0.2 "PHB-CH1","PHB-CH1-122",122,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.5,6.3,0.2 "PHB-CH1","PHB-CH1-122",122,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.8,6.3,0.5 "PHB-CH1","PHB-CH1-122",122,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7.8,6.3,1.5 "PHB-CH1","PHB-CH1-122",122,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,7.4,6.3,1.1 "PHB-CH1","PHB-CH1-122",122,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7,6.3,0.7 "PHB-CH1","PHB-CH1-122",122,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.7,6.3,-0.6 "PHB-CH1","PHB-CH1-122",122,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.7,6.3,1.4 "PHB-CH1","PHB-CH1-122",122,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,8.2,6.3,1.9 "PHB-CH1","PHB-CH1-122",122,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.1,6.3,0.8 "PHB-CH1","PHB-CH1-122",122,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.2,6.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-123",123,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,39,39,0 "PHB-CH1","PHB-CH1-123",123,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,40,39,1 "PHB-CH1","PHB-CH1-123",123,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,35,39,-4 "PHB-CH1","PHB-CH1-123",123,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,46,, "PHB-CH1","PHB-CH1-123",123,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,38,, "PHB-CH1","PHB-CH1-123",123,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,43,, "PHB-CH1","PHB-CH1-123",123,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-123",123,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-123",123,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-123",123,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-123",123,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,5,, "PHB-CH1","PHB-CH1-123",123,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,487,, "PHB-CH1","PHB-CH1-123",123,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-123",123,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-123",123,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-123",123,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-123",123,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,57.2,57.2,0 "PHB-CH1","PHB-CH1-123",123,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,50,57.2,-7.2 "PHB-CH1","PHB-CH1-123",123,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,56.6,57.2,-0.600000000000001 "PHB-CH1","PHB-CH1-123",123,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,59.3,57.2,2.09999999999999 "PHB-CH1","PHB-CH1-123",123,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,67.4,67.4,0 "PHB-CH1","PHB-CH1-123",123,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,74,67.4,6.59999999999999 "PHB-CH1","PHB-CH1-123",123,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,74.2,67.4,6.8 "PHB-CH1","PHB-CH1-123",123,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,53.3,67.4,-14.1 "PHB-CH1","PHB-CH1-123",123,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,2.8,2.8,0 "PHB-CH1","PHB-CH1-123",123,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.9,2.8,1.1 "PHB-CH1","PHB-CH1-123",123,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.6,2.8,1.8 "PHB-CH1","PHB-CH1-123",123,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.4,2.8,1.6 "PHB-CH1","PHB-CH1-123",123,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.5,2.8,0.7 "PHB-CH1","PHB-CH1-123",123,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3,2.8,0.2 "PHB-CH1","PHB-CH1-123",123,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.5,2.8,0.7 "PHB-CH1","PHB-CH1-123",123,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.2,2.8,1.4 "PHB-CH1","PHB-CH1-123",123,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.2,2.8,0.4 "PHB-CH1","PHB-CH1-123",123,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.1,2.8,0.3 "PHB-CH1","PHB-CH1-123",123,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.4,2.8,2.6 "PHB-CH1","PHB-CH1-123",123,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.3,2.8,2.5 "PHB-CH1","PHB-CH1-123",123,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.6,2.8,1.8 "PHB-CH1","PHB-CH1-123",123,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.8,2.8,1 "PHB-CH1","PHB-CH1-123",123,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.9,4.9,0 "PHB-CH1","PHB-CH1-123",123,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.5,4.9,-0.4 "PHB-CH1","PHB-CH1-123",123,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.5,4.9,-1.4 "PHB-CH1","PHB-CH1-123",123,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.1,4.9,-0.800000000000001 "PHB-CH1","PHB-CH1-123",123,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5,4.9,0.0999999999999996 "PHB-CH1","PHB-CH1-123",123,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,2.5,4.9,-2.4 "PHB-CH1","PHB-CH1-123",123,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.5,4.9,-1.4 "PHB-CH1","PHB-CH1-123",123,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.7,4.9,-2.2 "PHB-CH1","PHB-CH1-123",123,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.4,4.9,-1.5 "PHB-CH1","PHB-CH1-123",123,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.5,4.9,-1.4 "PHB-CH1","PHB-CH1-123",123,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.3,4.9,0.399999999999999 "PHB-CH1","PHB-CH1-123",123,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.1,4.9,0.199999999999999 "PHB-CH1","PHB-CH1-123",123,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5,4.9,0.0999999999999996 "PHB-CH1","PHB-CH1-123",123,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.9,4.9,-1 "PHB-CH1","PHB-CH1-124",124,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,49,49,0 "PHB-CH1","PHB-CH1-124",124,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,57,49,8 "PHB-CH1","PHB-CH1-124",124,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,41,49,-8 "PHB-CH1","PHB-CH1-124",124,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,42,, "PHB-CH1","PHB-CH1-124",124,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,24,, "PHB-CH1","PHB-CH1-124",124,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,39,, "PHB-CH1","PHB-CH1-124",124,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-124",124,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-124",124,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-124",124,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-124",124,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,2,, "PHB-CH1","PHB-CH1-124",124,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,517,, "PHB-CH1","PHB-CH1-124",124,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-124",124,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-124",124,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-124",124,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-124",124,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,59.3,59.3,0 "PHB-CH1","PHB-CH1-124",124,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,67.8,59.3,8.5 "PHB-CH1","PHB-CH1-124",124,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,50.4,59.3,-8.9 "PHB-CH1","PHB-CH1-124",124,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,59.6,59.3,0.300000000000004 "PHB-CH1","PHB-CH1-124",124,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,66.1,66.1,0 "PHB-CH1","PHB-CH1-124",124,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,80.5,66.1,14.4 "PHB-CH1","PHB-CH1-124",124,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,65.3,66.1,-0.799999999999997 "PHB-CH1","PHB-CH1-124",124,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,67.7,66.1,1.60000000000001 "PHB-CH1","PHB-CH1-124",124,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.7,5.7,0 "PHB-CH1","PHB-CH1-124",124,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.8,5.7,-0.9 "PHB-CH1","PHB-CH1-124",124,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.8,5.7,-0.9 "PHB-CH1","PHB-CH1-124",124,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.2,5.7,-0.5 "PHB-CH1","PHB-CH1-124",124,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.9,5.7,-0.8 "PHB-CH1","PHB-CH1-124",124,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.4,5.7,-1.3 "PHB-CH1","PHB-CH1-124",124,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4,5.7,-1.7 "PHB-CH1","PHB-CH1-124",124,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.7,5.7,-2 "PHB-CH1","PHB-CH1-124",124,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.9,5.7,-1.8 "PHB-CH1","PHB-CH1-124",124,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5,5.7,-0.7 "PHB-CH1","PHB-CH1-124",124,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.8,5.7,-0.9 "PHB-CH1","PHB-CH1-124",124,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.8,5.7,0.0999999999999996 "PHB-CH1","PHB-CH1-124",124,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.2,5.7,-0.5 "PHB-CH1","PHB-CH1-124",124,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5,5.7,-0.7 "PHB-CH1","PHB-CH1-124",124,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.4,4.4,0 "PHB-CH1","PHB-CH1-124",124,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.8,4.4,-0.6 "PHB-CH1","PHB-CH1-124",124,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.7,4.4,0.3 "PHB-CH1","PHB-CH1-124",124,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.3,4.4,-0.100000000000001 "PHB-CH1","PHB-CH1-124",124,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.3,4.4,-0.100000000000001 "PHB-CH1","PHB-CH1-124",124,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.8,4.4,-0.6 "PHB-CH1","PHB-CH1-124",124,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3,4.4,-1.4 "PHB-CH1","PHB-CH1-124",124,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.6,4.4,-1.8 "PHB-CH1","PHB-CH1-124",124,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.1,4.4,-1.3 "PHB-CH1","PHB-CH1-124",124,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3,4.4,-1.4 "PHB-CH1","PHB-CH1-124",124,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3,4.4,-1.4 "PHB-CH1","PHB-CH1-124",124,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.5,4.4,0.0999999999999996 "PHB-CH1","PHB-CH1-124",124,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.5,4.4,0.0999999999999996 "PHB-CH1","PHB-CH1-124",124,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.6,4.4,1.2 "PHB-CH1","PHB-CH1-125",125,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,42,42,0 "PHB-CH1","PHB-CH1-125",125,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,46,42,4 "PHB-CH1","PHB-CH1-125",125,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,30,42,-12 "PHB-CH1","PHB-CH1-125",125,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,40,, "PHB-CH1","PHB-CH1-125",125,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,44,, "PHB-CH1","PHB-CH1-125",125,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,36,, "PHB-CH1","PHB-CH1-125",125,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-125",125,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-125",125,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-125",125,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-125",125,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,10,, "PHB-CH1","PHB-CH1-125",125,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,440,, "PHB-CH1","PHB-CH1-125",125,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-125",125,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-125",125,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-125",125,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-125",125,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,54.9,54.9,0 "PHB-CH1","PHB-CH1-125",125,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,52.6,54.9,-2.3 "PHB-CH1","PHB-CH1-125",125,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,58.7,54.9,3.8 "PHB-CH1","PHB-CH1-125",125,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,56.2,54.9,1.3 "PHB-CH1","PHB-CH1-125",125,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,54.9,54.9,0 "PHB-CH1","PHB-CH1-125",125,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,65.9,54.9,11 "PHB-CH1","PHB-CH1-125",125,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,63.1,54.9,8.2 "PHB-CH1","PHB-CH1-125",125,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,63.8,54.9,8.9 "PHB-CH1","PHB-CH1-125",125,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,2.9,2.9,0 "PHB-CH1","PHB-CH1-125",125,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.5,2.9,0.6 "PHB-CH1","PHB-CH1-125",125,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.1,2.9,1.2 "PHB-CH1","PHB-CH1-125",125,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.1,2.9,2.2 "PHB-CH1","PHB-CH1-125",125,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.5,2.9,1.6 "PHB-CH1","PHB-CH1-125",125,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2.4,2.9,-0.5 "PHB-CH1","PHB-CH1-125",125,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.1,2.9,0.2 "PHB-CH1","PHB-CH1-125",125,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,2.9,2.9,0 "PHB-CH1","PHB-CH1-125",125,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.6,2.9,0.7 "PHB-CH1","PHB-CH1-125",125,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.9,2.9,1 "PHB-CH1","PHB-CH1-125",125,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6,2.9,3.1 "PHB-CH1","PHB-CH1-125",125,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.2,2.9,2.3 "PHB-CH1","PHB-CH1-125",125,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.8,2.9,0.9 "PHB-CH1","PHB-CH1-125",125,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.1,2.9,1.2 "PHB-CH1","PHB-CH1-125",125,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.8,4.8,0 "PHB-CH1","PHB-CH1-125",125,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.4,4.8,0.6 "PHB-CH1","PHB-CH1-125",125,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.7,4.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-125",125,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.7,4.8,-1.1 "PHB-CH1","PHB-CH1-125",125,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.3,4.8,-0.5 "PHB-CH1","PHB-CH1-125",125,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.1,4.8,-0.7 "PHB-CH1","PHB-CH1-125",125,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.7,4.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-125",125,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.1,4.8,0.3 "PHB-CH1","PHB-CH1-125",125,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.7,4.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-125",125,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5,4.8,0.2 "PHB-CH1","PHB-CH1-125",125,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.1,4.8,0.3 "PHB-CH1","PHB-CH1-125",125,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.2,4.8,0.4 "PHB-CH1","PHB-CH1-125",125,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.8,4.8,0 "PHB-CH1","PHB-CH1-125",125,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.6,4.8,0.8 "PHB-CH1","PHB-CH1-126",126,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,62,62,0 "PHB-CH1","PHB-CH1-126",126,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,56,62,-6 "PHB-CH1","PHB-CH1-126",126,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,44,62,-18 "PHB-CH1","PHB-CH1-126",126,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,61,, "PHB-CH1","PHB-CH1-126",126,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,45,, "PHB-CH1","PHB-CH1-126",126,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,70,, "PHB-CH1","PHB-CH1-126",126,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-126",126,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-126",126,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,5,, "PHB-CH1","PHB-CH1-126",126,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-126",126,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,14,, "PHB-CH1","PHB-CH1-126",126,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,382,, "PHB-CH1","PHB-CH1-126",126,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-126",126,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-126",126,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-126",126,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-126",126,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,32.1,32.1,0 "PHB-CH1","PHB-CH1-126",126,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,24.5,32.1,-7.6 "PHB-CH1","PHB-CH1-126",126,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,44.6,32.1,12.5 "PHB-CH1","PHB-CH1-126",126,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,33.2,32.1,1.1 "PHB-CH1","PHB-CH1-126",126,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,38.9,38.9,0 "PHB-CH1","PHB-CH1-126",126,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,21.9,38.9,-17 "PHB-CH1","PHB-CH1-126",126,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,46.6,38.9,7.7 "PHB-CH1","PHB-CH1-126",126,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,37.8,38.9,-1.1 "PHB-CH1","PHB-CH1-126",126,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,7.2,7.2,0 "PHB-CH1","PHB-CH1-126",126,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,7,7.2,-0.2 "PHB-CH1","PHB-CH1-126",126,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.8,7.2,-0.4 "PHB-CH1","PHB-CH1-126",126,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,7.6,7.2,0.399999999999999 "PHB-CH1","PHB-CH1-126",126,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.5,7.2,-1.7 "PHB-CH1","PHB-CH1-126",126,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.8,7.2,-0.4 "PHB-CH1","PHB-CH1-126",126,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,8.7,7.2,1.5 "PHB-CH1","PHB-CH1-126",126,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.6,7.2,-0.6 "PHB-CH1","PHB-CH1-126",126,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.8,7.2,-1.4 "PHB-CH1","PHB-CH1-126",126,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,7.6,7.2,0.399999999999999 "PHB-CH1","PHB-CH1-126",126,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,7.8,7.2,0.6 "PHB-CH1","PHB-CH1-126",126,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.8,7.2,-0.4 "PHB-CH1","PHB-CH1-126",126,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,7.2,7.2,0 "PHB-CH1","PHB-CH1-126",126,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.2,7.2,-1 "PHB-CH1","PHB-CH1-126",126,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.3,6.3,0 "PHB-CH1","PHB-CH1-126",126,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.6,6.3,-0.7 "PHB-CH1","PHB-CH1-126",126,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.6,6.3,-1.7 "PHB-CH1","PHB-CH1-126",126,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.1,6.3,-0.2 "PHB-CH1","PHB-CH1-126",126,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.1,6.3,-2.2 "PHB-CH1","PHB-CH1-126",126,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.9,6.3,-2.4 "PHB-CH1","PHB-CH1-126",126,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7,6.3,0.7 "PHB-CH1","PHB-CH1-126",126,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.3,6.3,0 "PHB-CH1","PHB-CH1-126",126,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.2,6.3,-2.1 "PHB-CH1","PHB-CH1-126",126,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.4,6.3,0.100000000000001 "PHB-CH1","PHB-CH1-126",126,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.4,6.3,0.100000000000001 "PHB-CH1","PHB-CH1-126",126,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.5,6.3,-0.8 "PHB-CH1","PHB-CH1-126",126,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.4,6.3,-0.9 "PHB-CH1","PHB-CH1-126",126,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5,6.3,-1.3 "PHB-CH1","PHB-CH1-127",127,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,38,38,0 "PHB-CH1","PHB-CH1-127",127,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,40,38,2 "PHB-CH1","PHB-CH1-127",127,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,33,38,-5 "PHB-CH1","PHB-CH1-127",127,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,34,, "PHB-CH1","PHB-CH1-127",127,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,46,, "PHB-CH1","PHB-CH1-127",127,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,69,, "PHB-CH1","PHB-CH1-127",127,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-127",127,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-127",127,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-127",127,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-127",127,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,10,, "PHB-CH1","PHB-CH1-127",127,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,310,, "PHB-CH1","PHB-CH1-127",127,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-127",127,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-127",127,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-127",127,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-127",127,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,24.1,24.1,0 "PHB-CH1","PHB-CH1-127",127,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,33,24.1,8.9 "PHB-CH1","PHB-CH1-127",127,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,32.6,24.1,8.5 "PHB-CH1","PHB-CH1-127",127,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,24.6,24.1,0.5 "PHB-CH1","PHB-CH1-127",127,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,50.7,50.7,0 "PHB-CH1","PHB-CH1-127",127,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,60.4,50.7,9.7 "PHB-CH1","PHB-CH1-127",127,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,58.7,50.7,8 "PHB-CH1","PHB-CH1-127",127,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,61.8,50.7,11.1 "PHB-CH1","PHB-CH1-127",127,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,1.3,1.3,0 "PHB-CH1","PHB-CH1-127",127,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,1.2,1.3,-0.1 "PHB-CH1","PHB-CH1-127",127,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.3,1.3,1 "PHB-CH1","PHB-CH1-127",127,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.5,1.3,1.2 "PHB-CH1","PHB-CH1-127",127,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.8,1.3,2.5 "PHB-CH1","PHB-CH1-127",127,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,1.7,1.3,0.4 "PHB-CH1","PHB-CH1-127",127,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2.2,1.3,0.9 "PHB-CH1","PHB-CH1-127",127,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,2,1.3,0.7 "PHB-CH1","PHB-CH1-127",127,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,1.7,1.3,0.4 "PHB-CH1","PHB-CH1-127",127,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,2.3,1.3,1 "PHB-CH1","PHB-CH1-127",127,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,1.2,1.3,-0.1 "PHB-CH1","PHB-CH1-127",127,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,2.2,1.3,0.9 "PHB-CH1","PHB-CH1-127",127,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.4,1.3,1.1 "PHB-CH1","PHB-CH1-127",127,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,1.9,1.3,0.6 "PHB-CH1","PHB-CH1-127",127,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.5,3.5,0 "PHB-CH1","PHB-CH1-127",127,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.6,3.5,1.1 "PHB-CH1","PHB-CH1-127",127,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.6,3.5,1.1 "PHB-CH1","PHB-CH1-127",127,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.5,3.5,2 "PHB-CH1","PHB-CH1-127",127,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.8,3.5,2.3 "PHB-CH1","PHB-CH1-127",127,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.1,3.5,1.6 "PHB-CH1","PHB-CH1-127",127,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.2,3.5,1.7 "PHB-CH1","PHB-CH1-127",127,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.6,3.5,1.1 "PHB-CH1","PHB-CH1-127",127,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.9,3.5,1.4 "PHB-CH1","PHB-CH1-127",127,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.3,3.5,2.8 "PHB-CH1","PHB-CH1-127",127,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.1,3.5,0.6 "PHB-CH1","PHB-CH1-127",127,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.5,3.5,0 "PHB-CH1","PHB-CH1-127",127,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.2,3.5,0.7 "PHB-CH1","PHB-CH1-127",127,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4,3.5,0.5 "PHB-CH1","PHB-CH1-128",128,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,35,35,0 "PHB-CH1","PHB-CH1-128",128,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,28,35,-7 "PHB-CH1","PHB-CH1-128",128,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,31,35,-4 "PHB-CH1","PHB-CH1-128",128,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,36,, "PHB-CH1","PHB-CH1-128",128,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,38,, "PHB-CH1","PHB-CH1-128",128,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,38,, "PHB-CH1","PHB-CH1-128",128,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-128",128,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-128",128,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-128",128,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-128",128,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,9,, "PHB-CH1","PHB-CH1-128",128,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,395,, "PHB-CH1","PHB-CH1-128",128,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-128",128,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-128",128,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-128",128,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-128",128,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,34.9,34.9,0 "PHB-CH1","PHB-CH1-128",128,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,39.3,34.9,4.4 "PHB-CH1","PHB-CH1-128",128,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,24.6,34.9,-10.3 "PHB-CH1","PHB-CH1-128",128,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,21.3,34.9,-13.6 "PHB-CH1","PHB-CH1-128",128,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,42,42,0 "PHB-CH1","PHB-CH1-128",128,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,32.9,42,-9.1 "PHB-CH1","PHB-CH1-128",128,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,27.6,42,-14.4 "PHB-CH1","PHB-CH1-128",128,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,20.1,42,-21.9 "PHB-CH1","PHB-CH1-128",128,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.3,3.3,0 "PHB-CH1","PHB-CH1-128",128,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.9,3.3,1.6 "PHB-CH1","PHB-CH1-128",128,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.9,3.3,1.6 "PHB-CH1","PHB-CH1-128",128,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.4,3.3,3.1 "PHB-CH1","PHB-CH1-128",128,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.8,3.3,1.5 "PHB-CH1","PHB-CH1-128",128,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.2,3.3,0.9 "PHB-CH1","PHB-CH1-128",128,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.7,3.3,0.4 "PHB-CH1","PHB-CH1-128",128,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,2.3,3.3,-1 "PHB-CH1","PHB-CH1-128",128,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.2,3.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-128",128,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,2.4,3.3,-0.9 "PHB-CH1","PHB-CH1-128",128,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.4,3.3,0.1 "PHB-CH1","PHB-CH1-128",128,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.1,3.3,0.8 "PHB-CH1","PHB-CH1-128",128,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.1,3.3,0.8 "PHB-CH1","PHB-CH1-128",128,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.1,3.3,-0.2 "PHB-CH1","PHB-CH1-128",128,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.6,5.6,0 "PHB-CH1","PHB-CH1-128",128,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.8,5.6,0.2 "PHB-CH1","PHB-CH1-128",128,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.5,5.6,-1.1 "PHB-CH1","PHB-CH1-128",128,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.6,5.6,0 "PHB-CH1","PHB-CH1-128",128,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.9,5.6,-1.7 "PHB-CH1","PHB-CH1-128",128,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4,5.6,-1.6 "PHB-CH1","PHB-CH1-128",128,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.8,5.6,-1.8 "PHB-CH1","PHB-CH1-128",128,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.8,5.6,-2.8 "PHB-CH1","PHB-CH1-128",128,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.8,5.6,-1.8 "PHB-CH1","PHB-CH1-128",128,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.4,5.6,-2.2 "PHB-CH1","PHB-CH1-128",128,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.6,5.6,-2 "PHB-CH1","PHB-CH1-128",128,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.2,5.6,-1.4 "PHB-CH1","PHB-CH1-128",128,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.4,5.6,-0.199999999999999 "PHB-CH1","PHB-CH1-128",128,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.6,5.6,-1 "PHB-CH1","PHB-CH1-129",129,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,53,53,0 "PHB-CH1","PHB-CH1-129",129,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,60,53,7 "PHB-CH1","PHB-CH1-129",129,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,59,53,6 "PHB-CH1","PHB-CH1-129",129,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,53,, "PHB-CH1","PHB-CH1-129",129,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,57,, "PHB-CH1","PHB-CH1-129",129,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,33,, "PHB-CH1","PHB-CH1-129",129,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-129",129,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-129",129,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-129",129,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-129",129,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,18,, "PHB-CH1","PHB-CH1-129",129,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,348,, "PHB-CH1","PHB-CH1-129",129,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-129",129,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-129",129,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-129",129,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-129",129,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,52.1,52.1,0 "PHB-CH1","PHB-CH1-129",129,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,57.1,52.1,5 "PHB-CH1","PHB-CH1-129",129,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,37.1,52.1,-15 "PHB-CH1","PHB-CH1-129",129,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,42.2,52.1,-9.9 "PHB-CH1","PHB-CH1-129",129,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,55.9,55.9,0 "PHB-CH1","PHB-CH1-129",129,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,53.8,55.9,-2.1 "PHB-CH1","PHB-CH1-129",129,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,51.1,55.9,-4.8 "PHB-CH1","PHB-CH1-129",129,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,62.5,55.9,6.6 "PHB-CH1","PHB-CH1-129",129,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3,3,0 "PHB-CH1","PHB-CH1-129",129,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2,3,-1 "PHB-CH1","PHB-CH1-129",129,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.7,3,-0.3 "PHB-CH1","PHB-CH1-129",129,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.4,3,-0.6 "PHB-CH1","PHB-CH1-129",129,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,1.2,3,-1.8 "PHB-CH1","PHB-CH1-129",129,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2.5,3,-0.5 "PHB-CH1","PHB-CH1-129",129,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2.3,3,-0.7 "PHB-CH1","PHB-CH1-129",129,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.1,3,0.1 "PHB-CH1","PHB-CH1-129",129,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,2.9,3,-0.1 "PHB-CH1","PHB-CH1-129",129,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,2.3,3,-0.7 "PHB-CH1","PHB-CH1-129",129,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,1.9,3,-1.1 "PHB-CH1","PHB-CH1-129",129,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,2.9,3,-0.1 "PHB-CH1","PHB-CH1-129",129,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,1.6,3,-1.4 "PHB-CH1","PHB-CH1-129",129,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2.2,3,-0.8 "PHB-CH1","PHB-CH1-129",129,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.9,4.9,0 "PHB-CH1","PHB-CH1-129",129,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.5,4.9,0.6 "PHB-CH1","PHB-CH1-129",129,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.3,4.9,1.4 "PHB-CH1","PHB-CH1-129",129,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.4,4.9,0.5 "PHB-CH1","PHB-CH1-129",129,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.9,4.9,0 "PHB-CH1","PHB-CH1-129",129,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5,4.9,0.0999999999999996 "PHB-CH1","PHB-CH1-129",129,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.5,4.9,0.6 "PHB-CH1","PHB-CH1-129",129,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.6,4.9,0.699999999999999 "PHB-CH1","PHB-CH1-129",129,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.6,4.9,0.699999999999999 "PHB-CH1","PHB-CH1-129",129,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.8,4.9,0.9 "PHB-CH1","PHB-CH1-129",129,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.9,4.9,0 "PHB-CH1","PHB-CH1-129",129,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.6,4.9,0.699999999999999 "PHB-CH1","PHB-CH1-129",129,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.8,4.9,1.9 "PHB-CH1","PHB-CH1-129",129,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.3,4.9,1.4 "PHB-CH1","PHB-CH1-130",130,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,56,56,0 "PHB-CH1","PHB-CH1-130",130,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,62,56,6 "PHB-CH1","PHB-CH1-130",130,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,52,56,-4 "PHB-CH1","PHB-CH1-130",130,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,45,, "PHB-CH1","PHB-CH1-130",130,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,39,, "PHB-CH1","PHB-CH1-130",130,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,53,, "PHB-CH1","PHB-CH1-130",130,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-130",130,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-130",130,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-130",130,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-130",130,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,5,, "PHB-CH1","PHB-CH1-130",130,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,452,, "PHB-CH1","PHB-CH1-130",130,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-130",130,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-130",130,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-130",130,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-130",130,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,46.3,46.3,0 "PHB-CH1","PHB-CH1-130",130,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,49.6,46.3,3.3 "PHB-CH1","PHB-CH1-130",130,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,41.6,46.3,-4.7 "PHB-CH1","PHB-CH1-130",130,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,38.8,46.3,-7.5 "PHB-CH1","PHB-CH1-130",130,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,52.2,52.2,0 "PHB-CH1","PHB-CH1-130",130,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,48.3,52.2,-3.90000000000001 "PHB-CH1","PHB-CH1-130",130,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,45.8,52.2,-6.40000000000001 "PHB-CH1","PHB-CH1-130",130,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,41.9,52.2,-10.3 "PHB-CH1","PHB-CH1-130",130,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.5,5.5,0 "PHB-CH1","PHB-CH1-130",130,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.3,5.5,-1.2 "PHB-CH1","PHB-CH1-130",130,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.2,5.5,-3.3 "PHB-CH1","PHB-CH1-130",130,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.4,5.5,-3.1 "PHB-CH1","PHB-CH1-130",130,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.7,5.5,-1.8 "PHB-CH1","PHB-CH1-130",130,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.2,5.5,-1.3 "PHB-CH1","PHB-CH1-130",130,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.2,5.5,-0.3 "PHB-CH1","PHB-CH1-130",130,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.4,5.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-130",130,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.1,5.5,-1.4 "PHB-CH1","PHB-CH1-130",130,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.5,5.5,-1 "PHB-CH1","PHB-CH1-130",130,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.8,5.5,-0.7 "PHB-CH1","PHB-CH1-130",130,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.6,5.5,-1.9 "PHB-CH1","PHB-CH1-130",130,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.9,5.5,-2.6 "PHB-CH1","PHB-CH1-130",130,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.9,5.5,-1.6 "PHB-CH1","PHB-CH1-130",130,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.2,6.2,0 "PHB-CH1","PHB-CH1-130",130,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.8,6.2,0.6 "PHB-CH1","PHB-CH1-130",130,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.2,6.2,-2 "PHB-CH1","PHB-CH1-130",130,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.5,6.2,-2.7 "PHB-CH1","PHB-CH1-130",130,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.2,6.2,-2 "PHB-CH1","PHB-CH1-130",130,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.9,6.2,-0.3 "PHB-CH1","PHB-CH1-130",130,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7.1,6.2,0.9 "PHB-CH1","PHB-CH1-130",130,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.1,6.2,-0.100000000000001 "PHB-CH1","PHB-CH1-130",130,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.3,6.2,-1.9 "PHB-CH1","PHB-CH1-130",130,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.6,6.2,-0.6 "PHB-CH1","PHB-CH1-130",130,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.1,6.2,-0.100000000000001 "PHB-CH1","PHB-CH1-130",130,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.8,6.2,-0.4 "PHB-CH1","PHB-CH1-130",130,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.9,6.2,-1.3 "PHB-CH1","PHB-CH1-130",130,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.4,6.2,-0.8 "PHB-CH1","PHB-CH1-131",131,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,43,43,0 "PHB-CH1","PHB-CH1-131",131,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,38,43,-5 "PHB-CH1","PHB-CH1-131",131,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,50,43,7 "PHB-CH1","PHB-CH1-131",131,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,49,, "PHB-CH1","PHB-CH1-131",131,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,41,, "PHB-CH1","PHB-CH1-131",131,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,37,, "PHB-CH1","PHB-CH1-131",131,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-131",131,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-131",131,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-131",131,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-131",131,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,0,, "PHB-CH1","PHB-CH1-131",131,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,661,, "PHB-CH1","PHB-CH1-131",131,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-131",131,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-131",131,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-131",131,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-131",131,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,71.8,71.8,0 "PHB-CH1","PHB-CH1-131",131,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,47.5,71.8,-24.3 "PHB-CH1","PHB-CH1-131",131,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,63.7,71.8,-8.09999999999999 "PHB-CH1","PHB-CH1-131",131,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,58.8,71.8,-13 "PHB-CH1","PHB-CH1-131",131,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,58.1,58.1,0 "PHB-CH1","PHB-CH1-131",131,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,36.4,58.1,-21.7 "PHB-CH1","PHB-CH1-131",131,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,48.6,58.1,-9.5 "PHB-CH1","PHB-CH1-131",131,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,56.1,58.1,-2 "PHB-CH1","PHB-CH1-131",131,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.6,4.6,0 "PHB-CH1","PHB-CH1-131",131,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2.9,4.6,-1.7 "PHB-CH1","PHB-CH1-131",131,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.6,4.6,-2 "PHB-CH1","PHB-CH1-131",131,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.2,4.6,-1.4 "PHB-CH1","PHB-CH1-131",131,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.9,4.6,0.300000000000001 "PHB-CH1","PHB-CH1-131",131,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.4,4.6,-0.199999999999999 "PHB-CH1","PHB-CH1-131",131,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.8,4.6,0.2 "PHB-CH1","PHB-CH1-131",131,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.4,4.6,0.800000000000001 "PHB-CH1","PHB-CH1-131",131,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.5,4.6,-0.0999999999999996 "PHB-CH1","PHB-CH1-131",131,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.1,4.6,-0.5 "PHB-CH1","PHB-CH1-131",131,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.1,4.6,-1.5 "PHB-CH1","PHB-CH1-131",131,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.1,4.6,-0.5 "PHB-CH1","PHB-CH1-131",131,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.1,4.6,-2.5 "PHB-CH1","PHB-CH1-131",131,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.9,4.6,0.300000000000001 "PHB-CH1","PHB-CH1-131",131,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.3,6.3,0 "PHB-CH1","PHB-CH1-131",131,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.9,6.3,-1.4 "PHB-CH1","PHB-CH1-131",131,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.7,6.3,-0.6 "PHB-CH1","PHB-CH1-131",131,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.6,6.3,-1.7 "PHB-CH1","PHB-CH1-131",131,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.4,6.3,-0.9 "PHB-CH1","PHB-CH1-131",131,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.1,6.3,-1.2 "PHB-CH1","PHB-CH1-131",131,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.6,6.3,0.3 "PHB-CH1","PHB-CH1-131",131,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.3,6.3,-1 "PHB-CH1","PHB-CH1-131",131,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.6,6.3,0.3 "PHB-CH1","PHB-CH1-131",131,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6,6.3,-0.3 "PHB-CH1","PHB-CH1-131",131,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.4,6.3,-0.9 "PHB-CH1","PHB-CH1-131",131,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.7,6.3,-0.6 "PHB-CH1","PHB-CH1-131",131,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4,6.3,-2.3 "PHB-CH1","PHB-CH1-131",131,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.9,6.3,-0.399999999999999 "PHB-CH1","PHB-CH1-132",132,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,52,52,0 "PHB-CH1","PHB-CH1-132",132,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,63,52,11 "PHB-CH1","PHB-CH1-132",132,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,47,52,-5 "PHB-CH1","PHB-CH1-132",132,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,37,, "PHB-CH1","PHB-CH1-132",132,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,54,, "PHB-CH1","PHB-CH1-132",132,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,40,, "PHB-CH1","PHB-CH1-132",132,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-132",132,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-132",132,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-132",132,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-132",132,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,25,, "PHB-CH1","PHB-CH1-132",132,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,272,, "PHB-CH1","PHB-CH1-132",132,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-132",132,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-132",132,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-132",132,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-132",132,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,38.4,38.4,0 "PHB-CH1","PHB-CH1-132",132,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,39.3,38.4,0.899999999999999 "PHB-CH1","PHB-CH1-132",132,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,56,38.4,17.6 "PHB-CH1","PHB-CH1-132",132,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,44.5,38.4,6.1 "PHB-CH1","PHB-CH1-132",132,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,33,33,0 "PHB-CH1","PHB-CH1-132",132,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,46,33,13 "PHB-CH1","PHB-CH1-132",132,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,45.7,33,12.7 "PHB-CH1","PHB-CH1-132",132,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,51.3,33,18.3 "PHB-CH1","PHB-CH1-132",132,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.5,3.5,0 "PHB-CH1","PHB-CH1-132",132,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.6,3.5,0.1 "PHB-CH1","PHB-CH1-132",132,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3,3.5,-0.5 "PHB-CH1","PHB-CH1-132",132,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.8,3.5,1.3 "PHB-CH1","PHB-CH1-132",132,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.4,3.5,1.9 "PHB-CH1","PHB-CH1-132",132,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.7,3.5,1.2 "PHB-CH1","PHB-CH1-132",132,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.5,3.5,1 "PHB-CH1","PHB-CH1-132",132,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.7,3.5,0.2 "PHB-CH1","PHB-CH1-132",132,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.9,3.5,1.4 "PHB-CH1","PHB-CH1-132",132,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.1,3.5,-0.4 "PHB-CH1","PHB-CH1-132",132,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.5,3.5,1 "PHB-CH1","PHB-CH1-132",132,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.8,3.5,0.3 "PHB-CH1","PHB-CH1-132",132,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.3,3.5,0.8 "PHB-CH1","PHB-CH1-132",132,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.6,3.5,2.1 "PHB-CH1","PHB-CH1-132",132,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.6,5.6,0 "PHB-CH1","PHB-CH1-132",132,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6,5.6,0.4 "PHB-CH1","PHB-CH1-132",132,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.5,5.6,-0.0999999999999996 "PHB-CH1","PHB-CH1-132",132,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.6,5.6,1 "PHB-CH1","PHB-CH1-132",132,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.9,5.6,1.3 "PHB-CH1","PHB-CH1-132",132,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.6,5.6,1 "PHB-CH1","PHB-CH1-132",132,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.4,5.6,0.800000000000001 "PHB-CH1","PHB-CH1-132",132,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.5,5.6,-0.0999999999999996 "PHB-CH1","PHB-CH1-132",132,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.6,5.6,1 "PHB-CH1","PHB-CH1-132",132,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.6,5.6,-1 "PHB-CH1","PHB-CH1-132",132,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.1,5.6,0.5 "PHB-CH1","PHB-CH1-132",132,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.1,5.6,0.5 "PHB-CH1","PHB-CH1-132",132,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6,5.6,0.4 "PHB-CH1","PHB-CH1-132",132,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.4,5.6,0.800000000000001 "PHB-CH1","PHB-CH1-133",133,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,53,53,0 "PHB-CH1","PHB-CH1-133",133,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,63,53,10 "PHB-CH1","PHB-CH1-133",133,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,44,53,-9 "PHB-CH1","PHB-CH1-133",133,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,58,, "PHB-CH1","PHB-CH1-133",133,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,71,, "PHB-CH1","PHB-CH1-133",133,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,69,, "PHB-CH1","PHB-CH1-133",133,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-133",133,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-133",133,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-133",133,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-133",133,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,8,, "PHB-CH1","PHB-CH1-133",133,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,419,, "PHB-CH1","PHB-CH1-133",133,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-133",133,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-133",133,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-133",133,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-133",133,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,36.4,36.4,0 "PHB-CH1","PHB-CH1-133",133,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,39.7,36.4,3.3 "PHB-CH1","PHB-CH1-133",133,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,51.7,36.4,15.3 "PHB-CH1","PHB-CH1-133",133,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,62.5,36.4,26.1 "PHB-CH1","PHB-CH1-133",133,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,29.1,29.1,0 "PHB-CH1","PHB-CH1-133",133,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,39.4,29.1,10.3 "PHB-CH1","PHB-CH1-133",133,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,42.3,29.1,13.2 "PHB-CH1","PHB-CH1-133",133,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,42.5,29.1,13.4 "PHB-CH1","PHB-CH1-133",133,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.7,3.7,0 "PHB-CH1","PHB-CH1-133",133,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.9,3.7,0.2 "PHB-CH1","PHB-CH1-133",133,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4,3.7,0.3 "PHB-CH1","PHB-CH1-133",133,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.4,3.7,-0.3 "PHB-CH1","PHB-CH1-133",133,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.2,3.7,0.5 "PHB-CH1","PHB-CH1-133",133,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.8,3.7,1.1 "PHB-CH1","PHB-CH1-133",133,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.4,3.7,0.7 "PHB-CH1","PHB-CH1-133",133,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5,3.7,1.3 "PHB-CH1","PHB-CH1-133",133,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.6,3.7,0.9 "PHB-CH1","PHB-CH1-133",133,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.1,3.7,0.399999999999999 "PHB-CH1","PHB-CH1-133",133,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4,3.7,0.3 "PHB-CH1","PHB-CH1-133",133,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.2,3.7,-0.5 "PHB-CH1","PHB-CH1-133",133,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.8,3.7,-0.9 "PHB-CH1","PHB-CH1-133",133,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.9,3.7,0.2 "PHB-CH1","PHB-CH1-133",133,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3,3,0 "PHB-CH1","PHB-CH1-133",133,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.5,3,0.5 "PHB-CH1","PHB-CH1-133",133,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.6,3,0.6 "PHB-CH1","PHB-CH1-133",133,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,2.7,3,-0.3 "PHB-CH1","PHB-CH1-133",133,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.3,3,0.3 "PHB-CH1","PHB-CH1-133",133,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.1,3,0.1 "PHB-CH1","PHB-CH1-133",133,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.8,3,0.8 "PHB-CH1","PHB-CH1-133",133,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.3,3,0.3 "PHB-CH1","PHB-CH1-133",133,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.3,3,1.3 "PHB-CH1","PHB-CH1-133",133,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,2.7,3,-0.3 "PHB-CH1","PHB-CH1-133",133,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,2.7,3,-0.3 "PHB-CH1","PHB-CH1-133",133,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.7,3,0.7 "PHB-CH1","PHB-CH1-133",133,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2.9,3,-0.1 "PHB-CH1","PHB-CH1-133",133,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4,3,1 "PHB-CH1","PHB-CH1-134",134,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,51,51,0 "PHB-CH1","PHB-CH1-134",134,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,39,51,-12 "PHB-CH1","PHB-CH1-134",134,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,49,51,-2 "PHB-CH1","PHB-CH1-134",134,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,44,, "PHB-CH1","PHB-CH1-134",134,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,59,, "PHB-CH1","PHB-CH1-134",134,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,42,, "PHB-CH1","PHB-CH1-134",134,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-134",134,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-134",134,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-134",134,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-134",134,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,19,, "PHB-CH1","PHB-CH1-134",134,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,369,, "PHB-CH1","PHB-CH1-134",134,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-134",134,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-134",134,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-134",134,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-134",134,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,28.3,28.3,0 "PHB-CH1","PHB-CH1-134",134,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,33.3,28.3,5 "PHB-CH1","PHB-CH1-134",134,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,34.9,28.3,6.6 "PHB-CH1","PHB-CH1-134",134,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,30,28.3,1.7 "PHB-CH1","PHB-CH1-134",134,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,39.3,39.3,0 "PHB-CH1","PHB-CH1-134",134,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,53.6,39.3,14.3 "PHB-CH1","PHB-CH1-134",134,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,63.3,39.3,24 "PHB-CH1","PHB-CH1-134",134,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,56.3,39.3,17 "PHB-CH1","PHB-CH1-134",134,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5,5,0 "PHB-CH1","PHB-CH1-134",134,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.3,5,0.3 "PHB-CH1","PHB-CH1-134",134,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.1,5,0.0999999999999996 "PHB-CH1","PHB-CH1-134",134,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.6,5,-1.4 "PHB-CH1","PHB-CH1-134",134,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.4,5,0.4 "PHB-CH1","PHB-CH1-134",134,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.6,5,0.6 "PHB-CH1","PHB-CH1-134",134,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.6,5,0.6 "PHB-CH1","PHB-CH1-134",134,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.8,5,-0.2 "PHB-CH1","PHB-CH1-134",134,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.9,5,0.9 "PHB-CH1","PHB-CH1-134",134,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.1,5,0.0999999999999996 "PHB-CH1","PHB-CH1-134",134,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4,5,-1 "PHB-CH1","PHB-CH1-134",134,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.9,5,-0.0999999999999996 "PHB-CH1","PHB-CH1-134",134,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.1,5,1.1 "PHB-CH1","PHB-CH1-134",134,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.2,5,1.2 "PHB-CH1","PHB-CH1-134",134,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-134",134,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.6,5.4,0.199999999999999 "PHB-CH1","PHB-CH1-134",134,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.3,5.4,-0.100000000000001 "PHB-CH1","PHB-CH1-134",134,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.4,5.4,-1 "PHB-CH1","PHB-CH1-134",134,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.5,5.4,0.0999999999999996 "PHB-CH1","PHB-CH1-134",134,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.9,5.4,0.5 "PHB-CH1","PHB-CH1-134",134,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.4,5.4,0 "PHB-CH1","PHB-CH1-134",134,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.6,5.4,-0.800000000000001 "PHB-CH1","PHB-CH1-134",134,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.3,5.4,-1.1 "PHB-CH1","PHB-CH1-134",134,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.8,5.4,-1.6 "PHB-CH1","PHB-CH1-134",134,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.2,5.4,-0.2 "PHB-CH1","PHB-CH1-134",134,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.2,5.4,0.8 "PHB-CH1","PHB-CH1-134",134,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.7,5.4,1.3 "PHB-CH1","PHB-CH1-134",134,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.1,5.4,0.699999999999999 "PHB-CH1","PHB-CH1-135",135,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,52,52,0 "PHB-CH1","PHB-CH1-135",135,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,65,52,13 "PHB-CH1","PHB-CH1-135",135,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,46,52,-6 "PHB-CH1","PHB-CH1-135",135,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,53,, "PHB-CH1","PHB-CH1-135",135,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,53,, "PHB-CH1","PHB-CH1-135",135,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,57,, "PHB-CH1","PHB-CH1-135",135,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-135",135,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-135",135,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-135",135,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-135",135,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,16,, "PHB-CH1","PHB-CH1-135",135,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,353,, "PHB-CH1","PHB-CH1-135",135,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-135",135,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-135",135,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-135",135,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-135",135,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,43.6,43.6,0 "PHB-CH1","PHB-CH1-135",135,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,44,43.6,0.399999999999999 "PHB-CH1","PHB-CH1-135",135,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,47.5,43.6,3.9 "PHB-CH1","PHB-CH1-135",135,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,45.5,43.6,1.9 "PHB-CH1","PHB-CH1-135",135,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,57,57,0 "PHB-CH1","PHB-CH1-135",135,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,62,57,5 "PHB-CH1","PHB-CH1-135",135,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,67.5,57,10.5 "PHB-CH1","PHB-CH1-135",135,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,59.5,57,2.5 "PHB-CH1","PHB-CH1-135",135,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,7.3,7.3,0 "PHB-CH1","PHB-CH1-135",135,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.6,7.3,-0.7 "PHB-CH1","PHB-CH1-135",135,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.5,7.3,-0.8 "PHB-CH1","PHB-CH1-135",135,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.9,7.3,-1.4 "PHB-CH1","PHB-CH1-135",135,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.1,7.3,-2.2 "PHB-CH1","PHB-CH1-135",135,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.5,7.3,-2.8 "PHB-CH1","PHB-CH1-135",135,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.6,7.3,-1.7 "PHB-CH1","PHB-CH1-135",135,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6,7.3,-1.3 "PHB-CH1","PHB-CH1-135",135,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.8,7.3,-1.5 "PHB-CH1","PHB-CH1-135",135,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.7,7.3,-2.6 "PHB-CH1","PHB-CH1-135",135,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.1,7.3,-2.2 "PHB-CH1","PHB-CH1-135",135,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.4,7.3,-1.9 "PHB-CH1","PHB-CH1-135",135,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.1,7.3,-1.2 "PHB-CH1","PHB-CH1-135",135,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.6,7.3,-2.7 "PHB-CH1","PHB-CH1-135",135,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,10,10,0 "PHB-CH1","PHB-CH1-135",135,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,9.8,10,-0.199999999999999 "PHB-CH1","PHB-CH1-135",135,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,9.7,10,-0.300000000000001 "PHB-CH1","PHB-CH1-135",135,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,9.2,10,-0.800000000000001 "PHB-CH1","PHB-CH1-135",135,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,8.5,10,-1.5 "PHB-CH1","PHB-CH1-135",135,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,8.3,10,-1.7 "PHB-CH1","PHB-CH1-135",135,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,9.1,10,-0.9 "PHB-CH1","PHB-CH1-135",135,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,10,10,0 "PHB-CH1","PHB-CH1-135",135,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,9.6,10,-0.4 "PHB-CH1","PHB-CH1-135",135,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,8.5,10,-1.5 "PHB-CH1","PHB-CH1-135",135,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,8.4,10,-1.6 "PHB-CH1","PHB-CH1-135",135,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,8.6,10,-1.4 "PHB-CH1","PHB-CH1-135",135,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,9.1,10,-0.9 "PHB-CH1","PHB-CH1-135",135,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,8.2,10,-1.8 "PHB-CH1","PHB-CH1-136",136,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,56,56,0 "PHB-CH1","PHB-CH1-136",136,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,53,56,-3 "PHB-CH1","PHB-CH1-136",136,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,50,56,-6 "PHB-CH1","PHB-CH1-136",136,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,54,, "PHB-CH1","PHB-CH1-136",136,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,56,, "PHB-CH1","PHB-CH1-136",136,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,59,, "PHB-CH1","PHB-CH1-136",136,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-136",136,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-136",136,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,5,, "PHB-CH1","PHB-CH1-136",136,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-136",136,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,8,, "PHB-CH1","PHB-CH1-136",136,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,377,, "PHB-CH1","PHB-CH1-136",136,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-136",136,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-136",136,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-136",136,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-136",136,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,38.2,38.2,0 "PHB-CH1","PHB-CH1-136",136,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,50.1,38.2,11.9 "PHB-CH1","PHB-CH1-136",136,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,35.4,38.2,-2.8 "PHB-CH1","PHB-CH1-136",136,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,26.8,38.2,-11.4 "PHB-CH1","PHB-CH1-136",136,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,42.7,42.7,0 "PHB-CH1","PHB-CH1-136",136,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,48.4,42.7,5.7 "PHB-CH1","PHB-CH1-136",136,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,55.7,42.7,13 "PHB-CH1","PHB-CH1-136",136,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,47.6,42.7,4.9 "PHB-CH1","PHB-CH1-136",136,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.3,5.3,0 "PHB-CH1","PHB-CH1-136",136,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.9,5.3,-1.4 "PHB-CH1","PHB-CH1-136",136,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.3,5.3,-2 "PHB-CH1","PHB-CH1-136",136,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.1,5.3,-0.2 "PHB-CH1","PHB-CH1-136",136,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.4,5.3,-0.9 "PHB-CH1","PHB-CH1-136",136,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.1,5.3,-1.2 "PHB-CH1","PHB-CH1-136",136,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.9,5.3,-1.4 "PHB-CH1","PHB-CH1-136",136,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.5,5.3,-1.8 "PHB-CH1","PHB-CH1-136",136,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.1,5.3,0.8 "PHB-CH1","PHB-CH1-136",136,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.6,5.3,-0.7 "PHB-CH1","PHB-CH1-136",136,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.5,5.3,-0.8 "PHB-CH1","PHB-CH1-136",136,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.3,5.3,0 "PHB-CH1","PHB-CH1-136",136,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.7,5.3,-1.6 "PHB-CH1","PHB-CH1-136",136,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.1,5.3,-1.2 "PHB-CH1","PHB-CH1-136",136,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.5,2.5,0 "PHB-CH1","PHB-CH1-136",136,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,0.6,2.5,-1.9 "PHB-CH1","PHB-CH1-136",136,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,1.1,2.5,-1.4 "PHB-CH1","PHB-CH1-136",136,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,2.8,2.5,0.3 "PHB-CH1","PHB-CH1-136",136,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,1.8,2.5,-0.7 "PHB-CH1","PHB-CH1-136",136,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,0.9,2.5,-1.6 "PHB-CH1","PHB-CH1-136",136,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,0,2.5,-2.5 "PHB-CH1","PHB-CH1-136",136,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,0,2.5,-2.5 "PHB-CH1","PHB-CH1-136",136,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2,2.5,-0.5 "PHB-CH1","PHB-CH1-136",136,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3,2.5,0.5 "PHB-CH1","PHB-CH1-136",136,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,2.6,2.5,0.1 "PHB-CH1","PHB-CH1-136",136,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.5,2.5,1 "PHB-CH1","PHB-CH1-136",136,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,1.9,2.5,-0.6 "PHB-CH1","PHB-CH1-136",136,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,2.8,2.5,0.3 "PHB-CH1","PHB-CH1-137",137,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,15,15,0 "PHB-CH1","PHB-CH1-137",137,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,31,15,16 "PHB-CH1","PHB-CH1-137",137,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,0,15,-15 "PHB-CH1","PHB-CH1-137",137,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,12,, "PHB-CH1","PHB-CH1-137",137,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,25,, "PHB-CH1","PHB-CH1-137",137,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,46,, "PHB-CH1","PHB-CH1-137",137,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-137",137,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-137",137,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-137",137,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-137",137,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,18,, "PHB-CH1","PHB-CH1-137",137,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,327,, "PHB-CH1","PHB-CH1-137",137,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-137",137,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-137",137,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-137",137,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-137",137,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,57.4,57.4,0 "PHB-CH1","PHB-CH1-137",137,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,60.9,57.4,3.5 "PHB-CH1","PHB-CH1-137",137,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,61.3,57.4,3.9 "PHB-CH1","PHB-CH1-137",137,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,48.7,57.4,-8.7 "PHB-CH1","PHB-CH1-137",137,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,50.3,50.3,0 "PHB-CH1","PHB-CH1-137",137,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,28.6,50.3,-21.7 "PHB-CH1","PHB-CH1-137",137,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,50.9,50.3,0.600000000000001 "PHB-CH1","PHB-CH1-137",137,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,42.9,50.3,-7.4 "PHB-CH1","PHB-CH1-137",137,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.5,3.5,0 "PHB-CH1","PHB-CH1-137",137,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.4,3.5,0.9 "PHB-CH1","PHB-CH1-137",137,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.9,3.5,1.4 "PHB-CH1","PHB-CH1-137",137,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.9,3.5,0.4 "PHB-CH1","PHB-CH1-137",137,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4,3.5,0.5 "PHB-CH1","PHB-CH1-137",137,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.2,3.5,1.7 "PHB-CH1","PHB-CH1-137",137,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.6,3.5,1.1 "PHB-CH1","PHB-CH1-137",137,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.5,3.5,0 "PHB-CH1","PHB-CH1-137",137,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.1,3.5,1.6 "PHB-CH1","PHB-CH1-137",137,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.1,3.5,1.6 "PHB-CH1","PHB-CH1-137",137,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.3,3.5,2.8 "PHB-CH1","PHB-CH1-137",137,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.5,3.5,3 "PHB-CH1","PHB-CH1-137",137,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.9,3.5,2.4 "PHB-CH1","PHB-CH1-137",137,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.8,3.5,3.3 "PHB-CH1","PHB-CH1-137",137,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.6,3.6,0 "PHB-CH1","PHB-CH1-137",137,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.9,3.6,0.3 "PHB-CH1","PHB-CH1-137",137,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.4,3.6,-0.2 "PHB-CH1","PHB-CH1-137",137,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.5,3.6,-0.1 "PHB-CH1","PHB-CH1-137",137,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,2.7,3.6,-0.9 "PHB-CH1","PHB-CH1-137",137,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.7,3.6,0.1 "PHB-CH1","PHB-CH1-137",137,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.8,3.6,1.2 "PHB-CH1","PHB-CH1-137",137,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.6,3.6,0 "PHB-CH1","PHB-CH1-137",137,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.7,3.6,1.1 "PHB-CH1","PHB-CH1-137",137,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.7,3.6,0.1 "PHB-CH1","PHB-CH1-137",137,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.8,3.6,1.2 "PHB-CH1","PHB-CH1-137",137,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.2,3.6,0.6 "PHB-CH1","PHB-CH1-137",137,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.1,3.6,1.5 "PHB-CH1","PHB-CH1-137",137,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.6,3.6,2 "PHB-CH1","PHB-CH1-138",138,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,55,55,0 "PHB-CH1","PHB-CH1-138",138,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,40,55,-15 "PHB-CH1","PHB-CH1-138",138,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,47,55,-8 "PHB-CH1","PHB-CH1-138",138,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,54,, "PHB-CH1","PHB-CH1-138",138,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,54,, "PHB-CH1","PHB-CH1-138",138,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,71,, "PHB-CH1","PHB-CH1-138",138,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-138",138,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-138",138,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-138",138,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-138",138,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,1,, "PHB-CH1","PHB-CH1-138",138,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,523,, "PHB-CH1","PHB-CH1-138",138,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-138",138,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-138",138,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-138",138,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-138",138,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,42.3,42.3,0 "PHB-CH1","PHB-CH1-138",138,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,28.4,42.3,-13.9 "PHB-CH1","PHB-CH1-138",138,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,31.6,42.3,-10.7 "PHB-CH1","PHB-CH1-138",138,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,42.7,42.3,0.400000000000006 "PHB-CH1","PHB-CH1-138",138,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,56.7,56.7,0 "PHB-CH1","PHB-CH1-138",138,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,41,56.7,-15.7 "PHB-CH1","PHB-CH1-138",138,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,42.9,56.7,-13.8 "PHB-CH1","PHB-CH1-138",138,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,46,56.7,-10.7 "PHB-CH1","PHB-CH1-138",138,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,1.6,1.6,0 "PHB-CH1","PHB-CH1-138",138,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,1.6,1.6,0 "PHB-CH1","PHB-CH1-138",138,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.3,1.6,1.7 "PHB-CH1","PHB-CH1-138",138,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3,1.6,1.4 "PHB-CH1","PHB-CH1-138",138,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.7,1.6,3.1 "PHB-CH1","PHB-CH1-138",138,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.6,1.6,4 "PHB-CH1","PHB-CH1-138",138,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.3,1.6,2.7 "PHB-CH1","PHB-CH1-138",138,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.2,1.6,1.6 "PHB-CH1","PHB-CH1-138",138,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5,1.6,3.4 "PHB-CH1","PHB-CH1-138",138,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.2,1.6,2.6 "PHB-CH1","PHB-CH1-138",138,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.8,1.6,2.2 "PHB-CH1","PHB-CH1-138",138,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.4,1.6,1.8 "PHB-CH1","PHB-CH1-138",138,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.8,1.6,2.2 "PHB-CH1","PHB-CH1-138",138,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.8,1.6,2.2 "PHB-CH1","PHB-CH1-138",138,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.2,6.2,0 "PHB-CH1","PHB-CH1-138",138,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.7,6.2,-1.5 "PHB-CH1","PHB-CH1-138",138,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.3,6.2,-0.9 "PHB-CH1","PHB-CH1-138",138,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.6,6.2,-0.6 "PHB-CH1","PHB-CH1-138",138,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,8.2,6.2,2 "PHB-CH1","PHB-CH1-138",138,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,8.3,6.2,2.1 "PHB-CH1","PHB-CH1-138",138,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.6,6.2,0.399999999999999 "PHB-CH1","PHB-CH1-138",138,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.1,6.2,-1.1 "PHB-CH1","PHB-CH1-138",138,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.7,6.2,1.5 "PHB-CH1","PHB-CH1-138",138,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.5,6.2,0.3 "PHB-CH1","PHB-CH1-138",138,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.4,6.2,0.2 "PHB-CH1","PHB-CH1-138",138,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.9,6.2,-0.3 "PHB-CH1","PHB-CH1-138",138,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.1,6.2,0.9 "PHB-CH1","PHB-CH1-138",138,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.3,6.2,0.0999999999999996 "PHB-CH1","PHB-CH1-139",139,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,52,52,0 "PHB-CH1","PHB-CH1-139",139,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,52,52,0 "PHB-CH1","PHB-CH1-139",139,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,34,52,-18 "PHB-CH1","PHB-CH1-139",139,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,50,, "PHB-CH1","PHB-CH1-139",139,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,51,, "PHB-CH1","PHB-CH1-139",139,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,49,, "PHB-CH1","PHB-CH1-139",139,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-139",139,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-139",139,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-139",139,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-139",139,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,15,, "PHB-CH1","PHB-CH1-139",139,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,347,, "PHB-CH1","PHB-CH1-139",139,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-139",139,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-139",139,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-139",139,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-139",139,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,54,54,0 "PHB-CH1","PHB-CH1-139",139,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,41.3,54,-12.7 "PHB-CH1","PHB-CH1-139",139,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,46,54,-8 "PHB-CH1","PHB-CH1-139",139,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,41.1,54,-12.9 "PHB-CH1","PHB-CH1-139",139,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,57.4,57.4,0 "PHB-CH1","PHB-CH1-139",139,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,59.2,57.4,1.8 "PHB-CH1","PHB-CH1-139",139,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,46.3,57.4,-11.1 "PHB-CH1","PHB-CH1-139",139,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,50.6,57.4,-6.8 "PHB-CH1","PHB-CH1-139",139,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.5,4.5,0 "PHB-CH1","PHB-CH1-139",139,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.7,4.5,0.2 "PHB-CH1","PHB-CH1-139",139,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5,4.5,0.5 "PHB-CH1","PHB-CH1-139",139,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.2,4.5,1.7 "PHB-CH1","PHB-CH1-139",139,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5,4.5,0.5 "PHB-CH1","PHB-CH1-139",139,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.3,4.5,-0.2 "PHB-CH1","PHB-CH1-139",139,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.9,4.5,-0.6 "PHB-CH1","PHB-CH1-139",139,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.5,4.5,0 "PHB-CH1","PHB-CH1-139",139,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.5,4.5,0 "PHB-CH1","PHB-CH1-139",139,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.5,4.5,0 "PHB-CH1","PHB-CH1-139",139,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.8,4.5,-1.7 "PHB-CH1","PHB-CH1-139",139,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.1,4.5,-0.4 "PHB-CH1","PHB-CH1-139",139,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.2,4.5,-0.3 "PHB-CH1","PHB-CH1-139",139,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.7,4.5,-0.8 "PHB-CH1","PHB-CH1-139",139,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7.5,7.5,0 "PHB-CH1","PHB-CH1-139",139,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.8,7.5,-0.7 "PHB-CH1","PHB-CH1-139",139,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.3,7.5,-1.2 "PHB-CH1","PHB-CH1-139",139,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.8,7.5,-0.7 "PHB-CH1","PHB-CH1-139",139,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.7,7.5,-1.8 "PHB-CH1","PHB-CH1-139",139,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.1,7.5,-3.4 "PHB-CH1","PHB-CH1-139",139,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.7,7.5,-2.8 "PHB-CH1","PHB-CH1-139",139,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.2,7.5,-2.3 "PHB-CH1","PHB-CH1-139",139,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.1,7.5,-3.4 "PHB-CH1","PHB-CH1-139",139,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.2,7.5,-2.3 "PHB-CH1","PHB-CH1-139",139,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.9,7.5,-3.6 "PHB-CH1","PHB-CH1-139",139,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.6,7.5,-0.9 "PHB-CH1","PHB-CH1-139",139,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.6,7.5,-0.9 "PHB-CH1","PHB-CH1-139",139,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5,7.5,-2.5 "PHB-CH1","PHB-CH1-140",140,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,74,74,0 "PHB-CH1","PHB-CH1-140",140,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,72,74,-2 "PHB-CH1","PHB-CH1-140",140,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,66,74,-8 "PHB-CH1","PHB-CH1-140",140,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,84,, "PHB-CH1","PHB-CH1-140",140,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,62,, "PHB-CH1","PHB-CH1-140",140,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,69,, "PHB-CH1","PHB-CH1-140",140,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-140",140,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-140",140,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-140",140,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-140",140,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,28,, "PHB-CH1","PHB-CH1-140",140,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,247,, "PHB-CH1","PHB-CH1-140",140,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-140",140,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-140",140,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-140",140,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-140",140,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,63.9,63.9,0 "PHB-CH1","PHB-CH1-140",140,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,61.7,63.9,-2.2 "PHB-CH1","PHB-CH1-140",140,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,66.3,63.9,2.4 "PHB-CH1","PHB-CH1-140",140,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,64.3,63.9,0.399999999999999 "PHB-CH1","PHB-CH1-140",140,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,64.2,64.2,0 "PHB-CH1","PHB-CH1-140",140,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,71.2,64.2,7 "PHB-CH1","PHB-CH1-140",140,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,72.3,64.2,8.09999999999999 "PHB-CH1","PHB-CH1-140",140,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,79.6,64.2,15.4 "PHB-CH1","PHB-CH1-140",140,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.9,4.9,0 "PHB-CH1","PHB-CH1-140",140,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.7,4.9,-0.2 "PHB-CH1","PHB-CH1-140",140,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.4,4.9,0.5 "PHB-CH1","PHB-CH1-140",140,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.1,4.9,0.199999999999999 "PHB-CH1","PHB-CH1-140",140,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.3,4.9,-0.6 "PHB-CH1","PHB-CH1-140",140,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.8,4.9,-1.1 "PHB-CH1","PHB-CH1-140",140,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.2,4.9,0.3 "PHB-CH1","PHB-CH1-140",140,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.9,4.9,1 "PHB-CH1","PHB-CH1-140",140,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.3,4.9,1.4 "PHB-CH1","PHB-CH1-140",140,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.7,4.9,-0.2 "PHB-CH1","PHB-CH1-140",140,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.5,4.9,0.6 "PHB-CH1","PHB-CH1-140",140,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5,4.9,0.0999999999999996 "PHB-CH1","PHB-CH1-140",140,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.5,4.9,0.6 "PHB-CH1","PHB-CH1-140",140,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,7.6,4.9,2.7 "PHB-CH1","PHB-CH1-140",140,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.8,3.8,0 "PHB-CH1","PHB-CH1-140",140,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5,3.8,1.2 "PHB-CH1","PHB-CH1-140",140,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.8,3.8,2 "PHB-CH1","PHB-CH1-140",140,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.9,3.8,2.1 "PHB-CH1","PHB-CH1-140",140,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.6,3.8,0.8 "PHB-CH1","PHB-CH1-140",140,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.7,3.8,0.9 "PHB-CH1","PHB-CH1-140",140,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.8,3.8,1 "PHB-CH1","PHB-CH1-140",140,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.4,3.8,1.6 "PHB-CH1","PHB-CH1-140",140,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.2,3.8,2.4 "PHB-CH1","PHB-CH1-140",140,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.9,3.8,2.1 "PHB-CH1","PHB-CH1-140",140,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.1,3.8,2.3 "PHB-CH1","PHB-CH1-140",140,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6,3.8,2.2 "PHB-CH1","PHB-CH1-140",140,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.7,3.8,2.9 "PHB-CH1","PHB-CH1-140",140,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.3,3.8,3.5 "PHB-CH1","PHB-CH1-141",141,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,63,63,0 "PHB-CH1","PHB-CH1-141",141,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,58,63,-5 "PHB-CH1","PHB-CH1-141",141,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,66,63,3 "PHB-CH1","PHB-CH1-141",141,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,67,, "PHB-CH1","PHB-CH1-141",141,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,52,, "PHB-CH1","PHB-CH1-141",141,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,67,, "PHB-CH1","PHB-CH1-141",141,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-141",141,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-141",141,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-141",141,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-141",141,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,33,, "PHB-CH1","PHB-CH1-141",141,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,179,, "PHB-CH1","PHB-CH1-141",141,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-141",141,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-141",141,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-141",141,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-141",141,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,48.4,48.4,0 "PHB-CH1","PHB-CH1-141",141,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,40,48.4,-8.4 "PHB-CH1","PHB-CH1-141",141,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,36.8,48.4,-11.6 "PHB-CH1","PHB-CH1-141",141,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,38.6,48.4,-9.8 "PHB-CH1","PHB-CH1-141",141,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,49.5,49.5,0 "PHB-CH1","PHB-CH1-141",141,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,48.5,49.5,-1 "PHB-CH1","PHB-CH1-141",141,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,68.8,49.5,19.3 "PHB-CH1","PHB-CH1-141",141,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,57.7,49.5,8.2 "PHB-CH1","PHB-CH1-141",141,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-141",141,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.4,5.1,0.300000000000001 "PHB-CH1","PHB-CH1-141",141,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.3,5.1,-0.8 "PHB-CH1","PHB-CH1-141",141,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.2,5.1,-0.9 "PHB-CH1","PHB-CH1-141",141,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.1,5.1,0 "PHB-CH1","PHB-CH1-141",141,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6,5.1,0.9 "PHB-CH1","PHB-CH1-141",141,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.2,5.1,-0.9 "PHB-CH1","PHB-CH1-141",141,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.8,5.1,-1.3 "PHB-CH1","PHB-CH1-141",141,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.3,5.1,-0.8 "PHB-CH1","PHB-CH1-141",141,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.1,5.1,0 "PHB-CH1","PHB-CH1-141",141,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.7,5.1,-0.399999999999999 "PHB-CH1","PHB-CH1-141",141,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,2.7,5.1,-2.4 "PHB-CH1","PHB-CH1-141",141,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.1,5.1,0 "PHB-CH1","PHB-CH1-141",141,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.7,5.1,0.6 "PHB-CH1","PHB-CH1-141",141,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.5,2.5,0 "PHB-CH1","PHB-CH1-141",141,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.1,2.5,1.6 "PHB-CH1","PHB-CH1-141",141,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.3,2.5,1.8 "PHB-CH1","PHB-CH1-141",141,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.3,2.5,0.8 "PHB-CH1","PHB-CH1-141",141,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.8,2.5,1.3 "PHB-CH1","PHB-CH1-141",141,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.6,2.5,1.1 "PHB-CH1","PHB-CH1-141",141,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,2.9,2.5,0.4 "PHB-CH1","PHB-CH1-141",141,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.7,2.5,0.2 "PHB-CH1","PHB-CH1-141",141,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.3,2.5,-0.2 "PHB-CH1","PHB-CH1-141",141,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,2.6,2.5,0.1 "PHB-CH1","PHB-CH1-141",141,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,1.7,2.5,-0.8 "PHB-CH1","PHB-CH1-141",141,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,1.1,2.5,-1.4 "PHB-CH1","PHB-CH1-141",141,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,1.8,2.5,-0.7 "PHB-CH1","PHB-CH1-141",141,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3,2.5,0.5 "PHB-CH1","PHB-CH1-142",142,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,48,48,0 "PHB-CH1","PHB-CH1-142",142,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,52,48,4 "PHB-CH1","PHB-CH1-142",142,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,12,48,-36 "PHB-CH1","PHB-CH1-142",142,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,54,, "PHB-CH1","PHB-CH1-142",142,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,59,, "PHB-CH1","PHB-CH1-142",142,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,31,, "PHB-CH1","PHB-CH1-142",142,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-142",142,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-142",142,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-142",142,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-142",142,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,5,, "PHB-CH1","PHB-CH1-142",142,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,432,, "PHB-CH1","PHB-CH1-142",142,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-142",142,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-142",142,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-142",142,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-142",142,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,51.7,51.7,0 "PHB-CH1","PHB-CH1-142",142,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,60.7,51.7,9 "PHB-CH1","PHB-CH1-142",142,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,54.5,51.7,2.8 "PHB-CH1","PHB-CH1-142",142,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,55.9,51.7,4.2 "PHB-CH1","PHB-CH1-142",142,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,51,51,0 "PHB-CH1","PHB-CH1-142",142,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,55.2,51,4.2 "PHB-CH1","PHB-CH1-142",142,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,46,51,-5 "PHB-CH1","PHB-CH1-142",142,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,55,51,4 "PHB-CH1","PHB-CH1-142",142,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-142",142,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.8,4.7,1.1 "PHB-CH1","PHB-CH1-142",142,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.9,4.7,-1.8 "PHB-CH1","PHB-CH1-142",142,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.9,4.7,-0.8 "PHB-CH1","PHB-CH1-142",142,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.5,4.7,-1.2 "PHB-CH1","PHB-CH1-142",142,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.5,4.7,-1.2 "PHB-CH1","PHB-CH1-142",142,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.2,4.7,-1.5 "PHB-CH1","PHB-CH1-142",142,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.4,4.7,0.7 "PHB-CH1","PHB-CH1-142",142,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.3,4.7,0.6 "PHB-CH1","PHB-CH1-142",142,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.2,4.7,0.5 "PHB-CH1","PHB-CH1-142",142,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.7,4.7,1 "PHB-CH1","PHB-CH1-142",142,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.3,4.7,0.6 "PHB-CH1","PHB-CH1-142",142,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.4,4.7,-0.3 "PHB-CH1","PHB-CH1-142",142,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.3,4.7,-1.4 "PHB-CH1","PHB-CH1-142",142,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.2,4.2,0 "PHB-CH1","PHB-CH1-142",142,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5,4.2,0.8 "PHB-CH1","PHB-CH1-142",142,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3,4.2,-1.2 "PHB-CH1","PHB-CH1-142",142,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.1,4.2,-1.1 "PHB-CH1","PHB-CH1-142",142,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.2,4.2,-1 "PHB-CH1","PHB-CH1-142",142,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4,4.2,-0.2 "PHB-CH1","PHB-CH1-142",142,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-142",142,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.1,4.2,0.9 "PHB-CH1","PHB-CH1-142",142,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.6,4.2,1.4 "PHB-CH1","PHB-CH1-142",142,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.9,4.2,0.7 "PHB-CH1","PHB-CH1-142",142,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.5,4.2,-0.7 "PHB-CH1","PHB-CH1-142",142,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.1,4.2,-0.100000000000001 "PHB-CH1","PHB-CH1-142",142,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.8,4.2,0.6 "PHB-CH1","PHB-CH1-142",142,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4,4.2,-0.2 "PHB-CH1","PHB-CH1-143",143,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,63,63,0 "PHB-CH1","PHB-CH1-143",143,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,54,63,-9 "PHB-CH1","PHB-CH1-143",143,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,51,63,-12 "PHB-CH1","PHB-CH1-143",143,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,51,, "PHB-CH1","PHB-CH1-143",143,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,52,, "PHB-CH1","PHB-CH1-143",143,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,52,, "PHB-CH1","PHB-CH1-143",143,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-143",143,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-143",143,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-143",143,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-143",143,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,7,, "PHB-CH1","PHB-CH1-143",143,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,479,, "PHB-CH1","PHB-CH1-143",143,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-143",143,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-143",143,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-143",143,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-143",143,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,38,38,0 "PHB-CH1","PHB-CH1-143",143,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,50,38,12 "PHB-CH1","PHB-CH1-143",143,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,45.8,38,7.8 "PHB-CH1","PHB-CH1-143",143,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,49.5,38,11.5 "PHB-CH1","PHB-CH1-143",143,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,49,49,0 "PHB-CH1","PHB-CH1-143",143,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,48.4,49,-0.600000000000001 "PHB-CH1","PHB-CH1-143",143,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,66.2,49,17.2 "PHB-CH1","PHB-CH1-143",143,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,65.6,49,16.6 "PHB-CH1","PHB-CH1-143",143,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.3,5.3,0 "PHB-CH1","PHB-CH1-143",143,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.8,5.3,0.5 "PHB-CH1","PHB-CH1-143",143,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.3,5.3,0 "PHB-CH1","PHB-CH1-143",143,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5,5.3,-0.3 "PHB-CH1","PHB-CH1-143",143,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.3,5.3,0 "PHB-CH1","PHB-CH1-143",143,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.3,5.3,-1 "PHB-CH1","PHB-CH1-143",143,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.7,5.3,0.4 "PHB-CH1","PHB-CH1-143",143,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.1,5.3,-0.2 "PHB-CH1","PHB-CH1-143",143,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.8,5.3,1.5 "PHB-CH1","PHB-CH1-143",143,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5,5.3,-0.3 "PHB-CH1","PHB-CH1-143",143,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.6,5.3,-0.7 "PHB-CH1","PHB-CH1-143",143,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.4,5.3,0.100000000000001 "PHB-CH1","PHB-CH1-143",143,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.8,5.3,0.5 "PHB-CH1","PHB-CH1-143",143,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.2,5.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-143",143,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.9,4.9,0 "PHB-CH1","PHB-CH1-143",143,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.8,4.9,-0.100000000000001 "PHB-CH1","PHB-CH1-143",143,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.6,4.9,-0.300000000000001 "PHB-CH1","PHB-CH1-143",143,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.5,4.9,0.6 "PHB-CH1","PHB-CH1-143",143,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.9,4.9,1 "PHB-CH1","PHB-CH1-143",143,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.3,4.9,0.399999999999999 "PHB-CH1","PHB-CH1-143",143,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5,4.9,0.0999999999999996 "PHB-CH1","PHB-CH1-143",143,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.4,4.9,-0.5 "PHB-CH1","PHB-CH1-143",143,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5,4.9,0.0999999999999996 "PHB-CH1","PHB-CH1-143",143,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5,4.9,0.0999999999999996 "PHB-CH1","PHB-CH1-143",143,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.8,4.9,-1.1 "PHB-CH1","PHB-CH1-143",143,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.5,4.9,-0.4 "PHB-CH1","PHB-CH1-143",143,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.9,4.9,0 "PHB-CH1","PHB-CH1-143",143,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.3,4.9,0.399999999999999 "PHB-CH1","PHB-CH1-144",144,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,56,56,0 "PHB-CH1","PHB-CH1-144",144,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,53,56,-3 "PHB-CH1","PHB-CH1-144",144,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,48,56,-8 "PHB-CH1","PHB-CH1-144",144,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,53,, "PHB-CH1","PHB-CH1-144",144,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,52,, "PHB-CH1","PHB-CH1-144",144,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,58,, "PHB-CH1","PHB-CH1-144",144,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-144",144,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-144",144,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-144",144,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-144",144,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,24,, "PHB-CH1","PHB-CH1-144",144,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,277,, "PHB-CH1","PHB-CH1-144",144,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-144",144,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-144",144,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-144",144,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-144",144,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,41.9,41.9,0 "PHB-CH1","PHB-CH1-144",144,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,50.1,41.9,8.2 "PHB-CH1","PHB-CH1-144",144,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,46.9,41.9,5 "PHB-CH1","PHB-CH1-144",144,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,52,41.9,10.1 "PHB-CH1","PHB-CH1-144",144,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,44.7,44.7,0 "PHB-CH1","PHB-CH1-144",144,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,59.8,44.7,15.1 "PHB-CH1","PHB-CH1-144",144,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,58.4,44.7,13.7 "PHB-CH1","PHB-CH1-144",144,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,60.7,44.7,16 "PHB-CH1","PHB-CH1-144",144,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.3,4.3,0 "PHB-CH1","PHB-CH1-144",144,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.8,4.3,0.5 "PHB-CH1","PHB-CH1-144",144,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.7,4.3,-0.6 "PHB-CH1","PHB-CH1-144",144,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.5,4.3,0.2 "PHB-CH1","PHB-CH1-144",144,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.4,4.3,0.100000000000001 "PHB-CH1","PHB-CH1-144",144,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.6,4.3,0.3 "PHB-CH1","PHB-CH1-144",144,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.6,4.3,1.3 "PHB-CH1","PHB-CH1-144",144,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.8,4.3,0.5 "PHB-CH1","PHB-CH1-144",144,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.1,4.3,-1.2 "PHB-CH1","PHB-CH1-144",144,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.8,4.3,-0.5 "PHB-CH1","PHB-CH1-144",144,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.2,4.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-144",144,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.9,4.3,1.6 "PHB-CH1","PHB-CH1-144",144,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5,4.3,0.7 "PHB-CH1","PHB-CH1-144",144,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.6,4.3,1.3 "PHB-CH1","PHB-CH1-144",144,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.8,3.8,0 "PHB-CH1","PHB-CH1-144",144,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.3,3.8,1.5 "PHB-CH1","PHB-CH1-144",144,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.6,3.8,1.8 "PHB-CH1","PHB-CH1-144",144,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.8,3.8,2 "PHB-CH1","PHB-CH1-144",144,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.4,3.8,1.6 "PHB-CH1","PHB-CH1-144",144,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.7,3.8,1.9 "PHB-CH1","PHB-CH1-144",144,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.6,3.8,1.8 "PHB-CH1","PHB-CH1-144",144,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.1,3.8,0.3 "PHB-CH1","PHB-CH1-144",144,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.5,3.8,-0.3 "PHB-CH1","PHB-CH1-144",144,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.4,3.8,0.6 "PHB-CH1","PHB-CH1-144",144,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4,3.8,0.2 "PHB-CH1","PHB-CH1-144",144,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.2,3.8,1.4 "PHB-CH1","PHB-CH1-144",144,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.5,3.8,0.7 "PHB-CH1","PHB-CH1-144",144,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.8,3.8,1 "PHB-CH1","PHB-CH1-145",145,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,60,60,0 "PHB-CH1","PHB-CH1-145",145,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,50,60,-10 "PHB-CH1","PHB-CH1-145",145,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,44,60,-16 "PHB-CH1","PHB-CH1-145",145,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,63,, "PHB-CH1","PHB-CH1-145",145,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,72,, "PHB-CH1","PHB-CH1-145",145,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,62,, "PHB-CH1","PHB-CH1-145",145,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-145",145,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-145",145,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-145",145,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-145",145,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,5,, "PHB-CH1","PHB-CH1-145",145,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,470,, "PHB-CH1","PHB-CH1-145",145,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-145",145,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-145",145,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-145",145,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-145",145,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,53.3,53.3,0 "PHB-CH1","PHB-CH1-145",145,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,45.4,53.3,-7.9 "PHB-CH1","PHB-CH1-145",145,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,45.7,53.3,-7.59999999999999 "PHB-CH1","PHB-CH1-145",145,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,57.1,53.3,3.8 "PHB-CH1","PHB-CH1-145",145,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,50.4,50.4,0 "PHB-CH1","PHB-CH1-145",145,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,70.2,50.4,19.8 "PHB-CH1","PHB-CH1-145",145,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,65.2,50.4,14.8 "PHB-CH1","PHB-CH1-145",145,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,67.6,50.4,17.2 "PHB-CH1","PHB-CH1-145",145,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.8,5.8,0 "PHB-CH1","PHB-CH1-145",145,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.2,5.8,-1.6 "PHB-CH1","PHB-CH1-145",145,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.6,5.8,-1.2 "PHB-CH1","PHB-CH1-145",145,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6,5.8,0.2 "PHB-CH1","PHB-CH1-145",145,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,7.3,5.8,1.5 "PHB-CH1","PHB-CH1-145",145,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,7.8,5.8,2 "PHB-CH1","PHB-CH1-145",145,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,7.1,5.8,1.3 "PHB-CH1","PHB-CH1-145",145,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.6,5.8,-0.2 "PHB-CH1","PHB-CH1-145",145,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.3,5.8,-1.5 "PHB-CH1","PHB-CH1-145",145,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.6,5.8,-2.2 "PHB-CH1","PHB-CH1-145",145,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.7,5.8,-1.1 "PHB-CH1","PHB-CH1-145",145,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.5,5.8,-1.3 "PHB-CH1","PHB-CH1-145",145,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5,5.8,-0.8 "PHB-CH1","PHB-CH1-145",145,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.7,5.8,-1.1 "PHB-CH1","PHB-CH1-145",145,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5,5,0 "PHB-CH1","PHB-CH1-145",145,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.7,5,-1.3 "PHB-CH1","PHB-CH1-145",145,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.8,5,-0.2 "PHB-CH1","PHB-CH1-145",145,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.7,5,0.7 "PHB-CH1","PHB-CH1-145",145,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6,5,1 "PHB-CH1","PHB-CH1-145",145,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.4,5,1.4 "PHB-CH1","PHB-CH1-145",145,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.4,5,0.4 "PHB-CH1","PHB-CH1-145",145,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.3,5,1.3 "PHB-CH1","PHB-CH1-145",145,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.7,5,0.7 "PHB-CH1","PHB-CH1-145",145,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.6,5,-0.4 "PHB-CH1","PHB-CH1-145",145,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.3,5,-0.7 "PHB-CH1","PHB-CH1-145",145,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.6,5,-0.4 "PHB-CH1","PHB-CH1-145",145,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.8,5,0.8 "PHB-CH1","PHB-CH1-145",145,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.3,5,0.3 "PHB-CH1","PHB-CH1-146",146,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,46,46,0 "PHB-CH1","PHB-CH1-146",146,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,48,46,2 "PHB-CH1","PHB-CH1-146",146,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,29,46,-17 "PHB-CH1","PHB-CH1-146",146,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,38,, "PHB-CH1","PHB-CH1-146",146,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,33,, "PHB-CH1","PHB-CH1-146",146,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,62,, "PHB-CH1","PHB-CH1-146",146,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-146",146,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-146",146,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-146",146,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-146",146,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,16,, "PHB-CH1","PHB-CH1-146",146,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,339,, "PHB-CH1","PHB-CH1-146",146,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-146",146,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-146",146,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-146",146,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-146",146,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,54.2,54.2,0 "PHB-CH1","PHB-CH1-146",146,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,47.2,54.2,-7 "PHB-CH1","PHB-CH1-146",146,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,61.4,54.2,7.2 "PHB-CH1","PHB-CH1-146",146,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,46.5,54.2,-7.7 "PHB-CH1","PHB-CH1-146",146,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,52,52,0 "PHB-CH1","PHB-CH1-146",146,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,72,52,20 "PHB-CH1","PHB-CH1-146",146,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,69.2,52,17.2 "PHB-CH1","PHB-CH1-146",146,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,63.7,52,11.7 "PHB-CH1","PHB-CH1-146",146,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.9,3.9,0 "PHB-CH1","PHB-CH1-146",146,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2,3.9,-1.9 "PHB-CH1","PHB-CH1-146",146,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.3,3.9,-1.6 "PHB-CH1","PHB-CH1-146",146,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.3,3.9,-1.6 "PHB-CH1","PHB-CH1-146",146,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.2,3.9,-0.7 "PHB-CH1","PHB-CH1-146",146,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2,3.9,-1.9 "PHB-CH1","PHB-CH1-146",146,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.3,3.9,-0.6 "PHB-CH1","PHB-CH1-146",146,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4,3.9,0.1 "PHB-CH1","PHB-CH1-146",146,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.8,3.9,0.9 "PHB-CH1","PHB-CH1-146",146,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,2.8,3.9,-1.1 "PHB-CH1","PHB-CH1-146",146,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.5,3.9,0.6 "PHB-CH1","PHB-CH1-146",146,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.1,3.9,1.2 "PHB-CH1","PHB-CH1-146",146,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.1,3.9,0.2 "PHB-CH1","PHB-CH1-146",146,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.6,3.9,1.7 "PHB-CH1","PHB-CH1-146",146,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.9,6.9,0 "PHB-CH1","PHB-CH1-146",146,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.7,6.9,-2.2 "PHB-CH1","PHB-CH1-146",146,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.9,6.9,-2 "PHB-CH1","PHB-CH1-146",146,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.7,6.9,-2.2 "PHB-CH1","PHB-CH1-146",146,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.2,6.9,-1.7 "PHB-CH1","PHB-CH1-146",146,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.5,6.9,-2.4 "PHB-CH1","PHB-CH1-146",146,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.1,6.9,-0.800000000000001 "PHB-CH1","PHB-CH1-146",146,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.6,6.9,-1.3 "PHB-CH1","PHB-CH1-146",146,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.3,6.9,-0.6 "PHB-CH1","PHB-CH1-146",146,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.1,6.9,-1.8 "PHB-CH1","PHB-CH1-146",146,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.9,6.9,0 "PHB-CH1","PHB-CH1-146",146,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.5,6.9,0.6 "PHB-CH1","PHB-CH1-146",146,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.4,6.9,-1.5 "PHB-CH1","PHB-CH1-146",146,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.5,6.9,-0.4 "PHB-CH1","PHB-CH1-147",147,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,48,48,0 "PHB-CH1","PHB-CH1-147",147,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,47,48,-1 "PHB-CH1","PHB-CH1-147",147,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,58,48,10 "PHB-CH1","PHB-CH1-147",147,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,46,, "PHB-CH1","PHB-CH1-147",147,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,51,, "PHB-CH1","PHB-CH1-147",147,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,54,, "PHB-CH1","PHB-CH1-147",147,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-147",147,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-147",147,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-147",147,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-147",147,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,7,, "PHB-CH1","PHB-CH1-147",147,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,446,, "PHB-CH1","PHB-CH1-147",147,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-147",147,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-147",147,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-147",147,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-147",147,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,24.8,24.8,0 "PHB-CH1","PHB-CH1-147",147,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,34.8,24.8,10 "PHB-CH1","PHB-CH1-147",147,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,24.6,24.8,-0.199999999999999 "PHB-CH1","PHB-CH1-147",147,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,23,24.8,-1.8 "PHB-CH1","PHB-CH1-147",147,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,32.6,32.6,0 "PHB-CH1","PHB-CH1-147",147,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,40,32.6,7.4 "PHB-CH1","PHB-CH1-147",147,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,32.2,32.6,-0.399999999999999 "PHB-CH1","PHB-CH1-147",147,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,32.6,32.6,0 "PHB-CH1","PHB-CH1-147",147,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-147",147,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.5,4.7,-1.2 "PHB-CH1","PHB-CH1-147",147,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.2,4.7,-0.5 "PHB-CH1","PHB-CH1-147",147,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-147",147,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.1,4.7,1.4 "PHB-CH1","PHB-CH1-147",147,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.1,4.7,-0.6 "PHB-CH1","PHB-CH1-147",147,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4,4.7,-0.7 "PHB-CH1","PHB-CH1-147",147,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.5,4.7,-0.2 "PHB-CH1","PHB-CH1-147",147,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.3,4.7,0.6 "PHB-CH1","PHB-CH1-147",147,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.5,4.7,-0.2 "PHB-CH1","PHB-CH1-147",147,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.3,4.7,1.6 "PHB-CH1","PHB-CH1-147",147,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.5,4.7,0.8 "PHB-CH1","PHB-CH1-147",147,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5,4.7,0.3 "PHB-CH1","PHB-CH1-147",147,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.8,4.7,1.1 "PHB-CH1","PHB-CH1-147",147,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.1,6.1,0 "PHB-CH1","PHB-CH1-147",147,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.7,6.1,-1.4 "PHB-CH1","PHB-CH1-147",147,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.7,6.1,-0.399999999999999 "PHB-CH1","PHB-CH1-147",147,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.9,6.1,-0.199999999999999 "PHB-CH1","PHB-CH1-147",147,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.5,6.1,0.4 "PHB-CH1","PHB-CH1-147",147,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.6,6.1,0.5 "PHB-CH1","PHB-CH1-147",147,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.9,6.1,-1.2 "PHB-CH1","PHB-CH1-147",147,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.8,6.1,-2.3 "PHB-CH1","PHB-CH1-147",147,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5,6.1,-1.1 "PHB-CH1","PHB-CH1-147",147,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.3,6.1,-0.8 "PHB-CH1","PHB-CH1-147",147,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.4,6.1,-0.699999999999999 "PHB-CH1","PHB-CH1-147",147,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.8,6.1,-0.3 "PHB-CH1","PHB-CH1-147",147,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.3,6.1,-0.8 "PHB-CH1","PHB-CH1-147",147,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7,6.1,0.9 "PHB-CH1","PHB-CH1-148",148,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,32,32,0 "PHB-CH1","PHB-CH1-148",148,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,34,32,2 "PHB-CH1","PHB-CH1-148",148,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,32,32,0 "PHB-CH1","PHB-CH1-148",148,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,45,, "PHB-CH1","PHB-CH1-148",148,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,38,, "PHB-CH1","PHB-CH1-148",148,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,44,, "PHB-CH1","PHB-CH1-148",148,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-148",148,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-148",148,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-148",148,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-148",148,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,4,, "PHB-CH1","PHB-CH1-148",148,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,431,, "PHB-CH1","PHB-CH1-148",148,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-148",148,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-148",148,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-148",148,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-148",148,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,43.4,43.4,0 "PHB-CH1","PHB-CH1-148",148,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,49,43.4,5.6 "PHB-CH1","PHB-CH1-148",148,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,45.3,43.4,1.9 "PHB-CH1","PHB-CH1-148",148,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,32.3,43.4,-11.1 "PHB-CH1","PHB-CH1-148",148,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,73.3,73.3,0 "PHB-CH1","PHB-CH1-148",148,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,58.7,73.3,-14.6 "PHB-CH1","PHB-CH1-148",148,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,67.2,73.3,-6.09999999999999 "PHB-CH1","PHB-CH1-148",148,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,54,73.3,-19.3 "PHB-CH1","PHB-CH1-148",148,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.4,4.4,0 "PHB-CH1","PHB-CH1-148",148,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.6,4.4,1.2 "PHB-CH1","PHB-CH1-148",148,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.8,4.4,-0.6 "PHB-CH1","PHB-CH1-148",148,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.7,4.4,-0.7 "PHB-CH1","PHB-CH1-148",148,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,2.9,4.4,-1.5 "PHB-CH1","PHB-CH1-148",148,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.3,4.4,-1.1 "PHB-CH1","PHB-CH1-148",148,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.8,4.4,0.399999999999999 "PHB-CH1","PHB-CH1-148",148,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.8,4.4,1.4 "PHB-CH1","PHB-CH1-148",148,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6,4.4,1.6 "PHB-CH1","PHB-CH1-148",148,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,7.1,4.4,2.7 "PHB-CH1","PHB-CH1-148",148,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.1,4.4,0.699999999999999 "PHB-CH1","PHB-CH1-148",148,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.2,4.4,-0.2 "PHB-CH1","PHB-CH1-148",148,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.2,4.4,0.8 "PHB-CH1","PHB-CH1-148",148,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.2,4.4,0.8 "PHB-CH1","PHB-CH1-148",148,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.7,6.7,0 "PHB-CH1","PHB-CH1-148",148,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,7.2,6.7,0.5 "PHB-CH1","PHB-CH1-148",148,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.7,6.7,0 "PHB-CH1","PHB-CH1-148",148,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.9,6.7,0.2 "PHB-CH1","PHB-CH1-148",148,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.6,6.7,-0.100000000000001 "PHB-CH1","PHB-CH1-148",148,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,7.4,6.7,0.7 "PHB-CH1","PHB-CH1-148",148,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.9,6.7,0.2 "PHB-CH1","PHB-CH1-148",148,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,7.5,6.7,0.8 "PHB-CH1","PHB-CH1-148",148,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.9,6.7,0.2 "PHB-CH1","PHB-CH1-148",148,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.3,6.7,0.6 "PHB-CH1","PHB-CH1-148",148,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.2,6.7,0.5 "PHB-CH1","PHB-CH1-148",148,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.1,6.7,0.399999999999999 "PHB-CH1","PHB-CH1-148",148,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.1,6.7,0.399999999999999 "PHB-CH1","PHB-CH1-148",148,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.3,6.7,0.6 "PHB-CH1","PHB-CH1-149",149,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,77,77,0 "PHB-CH1","PHB-CH1-149",149,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,78,77,1 "PHB-CH1","PHB-CH1-149",149,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,62,77,-15 "PHB-CH1","PHB-CH1-149",149,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,69,, "PHB-CH1","PHB-CH1-149",149,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,58,, "PHB-CH1","PHB-CH1-149",149,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,51,, "PHB-CH1","PHB-CH1-149",149,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-149",149,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-149",149,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-149",149,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-149",149,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,10,, "PHB-CH1","PHB-CH1-149",149,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,394,, "PHB-CH1","PHB-CH1-149",149,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-149",149,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-149",149,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-149",149,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-149",149,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,40.7,40.7,0 "PHB-CH1","PHB-CH1-149",149,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,33.5,40.7,-7.2 "PHB-CH1","PHB-CH1-149",149,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,46.9,40.7,6.2 "PHB-CH1","PHB-CH1-149",149,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,42,40.7,1.3 "PHB-CH1","PHB-CH1-149",149,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,43.6,43.6,0 "PHB-CH1","PHB-CH1-149",149,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,52.8,43.6,9.2 "PHB-CH1","PHB-CH1-149",149,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,50.4,43.6,6.8 "PHB-CH1","PHB-CH1-149",149,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,56.1,43.6,12.5 "PHB-CH1","PHB-CH1-149",149,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.6,4.6,0 "PHB-CH1","PHB-CH1-149",149,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.2,4.6,-1.4 "PHB-CH1","PHB-CH1-149",149,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.3,4.6,-1.3 "PHB-CH1","PHB-CH1-149",149,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.7,4.6,0.100000000000001 "PHB-CH1","PHB-CH1-149",149,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.5,4.6,-0.0999999999999996 "PHB-CH1","PHB-CH1-149",149,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.9,4.6,0.300000000000001 "PHB-CH1","PHB-CH1-149",149,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.3,4.6,-0.3 "PHB-CH1","PHB-CH1-149",149,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.1,4.6,0.5 "PHB-CH1","PHB-CH1-149",149,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.5,4.6,-0.0999999999999996 "PHB-CH1","PHB-CH1-149",149,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.2,4.6,-0.399999999999999 "PHB-CH1","PHB-CH1-149",149,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.9,4.6,-0.7 "PHB-CH1","PHB-CH1-149",149,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,1.9,4.6,-2.7 "PHB-CH1","PHB-CH1-149",149,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.4,4.6,-0.199999999999999 "PHB-CH1","PHB-CH1-149",149,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.5,4.6,-0.0999999999999996 "PHB-CH1","PHB-CH1-149",149,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,8.1,8.1,0 "PHB-CH1","PHB-CH1-149",149,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.9,8.1,-1.2 "PHB-CH1","PHB-CH1-149",149,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7.7,8.1,-0.399999999999999 "PHB-CH1","PHB-CH1-149",149,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,7.2,8.1,-0.9 "PHB-CH1","PHB-CH1-149",149,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,7.8,8.1,-0.3 "PHB-CH1","PHB-CH1-149",149,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,7.6,8.1,-0.5 "PHB-CH1","PHB-CH1-149",149,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7.7,8.1,-0.399999999999999 "PHB-CH1","PHB-CH1-149",149,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,7.7,8.1,-0.399999999999999 "PHB-CH1","PHB-CH1-149",149,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.7,8.1,-0.399999999999999 "PHB-CH1","PHB-CH1-149",149,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.2,8.1,-0.9 "PHB-CH1","PHB-CH1-149",149,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.6,8.1,-0.5 "PHB-CH1","PHB-CH1-149",149,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.2,8.1,-2.9 "PHB-CH1","PHB-CH1-149",149,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.7,8.1,-0.399999999999999 "PHB-CH1","PHB-CH1-149",149,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.2,8.1,-0.9 "PHB-CH1","PHB-CH1-150",150,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,39,39,0 "PHB-CH1","PHB-CH1-150",150,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,37,39,-2 "PHB-CH1","PHB-CH1-150",150,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,35,39,-4 "PHB-CH1","PHB-CH1-150",150,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,39,, "PHB-CH1","PHB-CH1-150",150,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,33,, "PHB-CH1","PHB-CH1-150",150,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,48,, "PHB-CH1","PHB-CH1-150",150,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-150",150,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-150",150,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-150",150,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-150",150,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,8,, "PHB-CH1","PHB-CH1-150",150,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,399,, "PHB-CH1","PHB-CH1-150",150,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-150",150,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-150",150,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-150",150,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-150",150,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,37.7,37.7,0 "PHB-CH1","PHB-CH1-150",150,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,55.2,37.7,17.5 "PHB-CH1","PHB-CH1-150",150,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,50.9,37.7,13.2 "PHB-CH1","PHB-CH1-150",150,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,56.9,37.7,19.2 "PHB-CH1","PHB-CH1-150",150,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,55.5,55.5,0 "PHB-CH1","PHB-CH1-150",150,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,62.6,55.5,7.1 "PHB-CH1","PHB-CH1-150",150,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,54.4,55.5,-1.1 "PHB-CH1","PHB-CH1-150",150,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,73.4,55.5,17.9 "PHB-CH1","PHB-CH1-150",150,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.9,3.9,0 "PHB-CH1","PHB-CH1-150",150,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.4,3.9,0.5 "PHB-CH1","PHB-CH1-150",150,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.2,3.9,-0.7 "PHB-CH1","PHB-CH1-150",150,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.4,3.9,-0.5 "PHB-CH1","PHB-CH1-150",150,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.7,3.9,-0.2 "PHB-CH1","PHB-CH1-150",150,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.7,3.9,0.8 "PHB-CH1","PHB-CH1-150",150,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.9,3.9,1 "PHB-CH1","PHB-CH1-150",150,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.4,3.9,-0.5 "PHB-CH1","PHB-CH1-150",150,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.8,3.9,-0.1 "PHB-CH1","PHB-CH1-150",150,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.5,3.9,-0.4 "PHB-CH1","PHB-CH1-150",150,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.8,3.9,-0.1 "PHB-CH1","PHB-CH1-150",150,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.9,3.9,1 "PHB-CH1","PHB-CH1-150",150,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.3,3.9,-0.6 "PHB-CH1","PHB-CH1-150",150,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2.8,3.9,-1.1 "PHB-CH1","PHB-CH1-150",150,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.8,3.8,0 "PHB-CH1","PHB-CH1-150",150,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.7,3.8,0.9 "PHB-CH1","PHB-CH1-150",150,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.4,3.8,0.6 "PHB-CH1","PHB-CH1-150",150,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.1,3.8,0.3 "PHB-CH1","PHB-CH1-150",150,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.2,3.8,-0.6 "PHB-CH1","PHB-CH1-150",150,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.5,3.8,0.7 "PHB-CH1","PHB-CH1-150",150,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4,3.8,0.2 "PHB-CH1","PHB-CH1-150",150,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.8,3.8,0 "PHB-CH1","PHB-CH1-150",150,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.9,3.8,0.1 "PHB-CH1","PHB-CH1-150",150,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,2.8,3.8,-1 "PHB-CH1","PHB-CH1-150",150,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.7,3.8,0.9 "PHB-CH1","PHB-CH1-150",150,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.5,3.8,1.7 "PHB-CH1","PHB-CH1-150",150,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.3,3.8,0.5 "PHB-CH1","PHB-CH1-150",150,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.1,3.8,0.3 "PHB-CH1","PHB-CH1-151",151,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,42,42,0 "PHB-CH1","PHB-CH1-151",151,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,41,42,-1 "PHB-CH1","PHB-CH1-151",151,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,33,42,-9 "PHB-CH1","PHB-CH1-151",151,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,49,, "PHB-CH1","PHB-CH1-151",151,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,48,, "PHB-CH1","PHB-CH1-151",151,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,54,, "PHB-CH1","PHB-CH1-151",151,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-151",151,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-151",151,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-151",151,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-151",151,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,6,, "PHB-CH1","PHB-CH1-151",151,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,458,, "PHB-CH1","PHB-CH1-151",151,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-151",151,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-151",151,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-151",151,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-151",151,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,37.1,37.1,0 "PHB-CH1","PHB-CH1-151",151,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,56.1,37.1,19 "PHB-CH1","PHB-CH1-151",151,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,41.1,37.1,4 "PHB-CH1","PHB-CH1-151",151,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,41.5,37.1,4.4 "PHB-CH1","PHB-CH1-151",151,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,28.3,28.3,0 "PHB-CH1","PHB-CH1-151",151,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,41,28.3,12.7 "PHB-CH1","PHB-CH1-151",151,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,39.6,28.3,11.3 "PHB-CH1","PHB-CH1-151",151,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,45.2,28.3,16.9 "PHB-CH1","PHB-CH1-151",151,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.2,5.2,0 "PHB-CH1","PHB-CH1-151",151,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.2,5.2,0 "PHB-CH1","PHB-CH1-151",151,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.3,5.2,-0.9 "PHB-CH1","PHB-CH1-151",151,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3,5.2,-2.2 "PHB-CH1","PHB-CH1-151",151,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.7,5.2,-1.5 "PHB-CH1","PHB-CH1-151",151,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.2,5.2,-2 "PHB-CH1","PHB-CH1-151",151,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3,5.2,-2.2 "PHB-CH1","PHB-CH1-151",151,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.1,5.2,-2.1 "PHB-CH1","PHB-CH1-151",151,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.6,5.2,-1.6 "PHB-CH1","PHB-CH1-151",151,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.9,5.2,-1.3 "PHB-CH1","PHB-CH1-151",151,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.1,5.2,-3.1 "PHB-CH1","PHB-CH1-151",151,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.5,5.2,-1.7 "PHB-CH1","PHB-CH1-151",151,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.6,5.2,-1.6 "PHB-CH1","PHB-CH1-151",151,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.7,5.2,-0.5 "PHB-CH1","PHB-CH1-151",151,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.1,4.1,0 "PHB-CH1","PHB-CH1-151",151,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.6,4.1,0.5 "PHB-CH1","PHB-CH1-151",151,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.7,4.1,-0.399999999999999 "PHB-CH1","PHB-CH1-151",151,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,2,4.1,-2.1 "PHB-CH1","PHB-CH1-151",151,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,2.1,4.1,-2 "PHB-CH1","PHB-CH1-151",151,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,2.6,4.1,-1.5 "PHB-CH1","PHB-CH1-151",151,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,2.5,4.1,-1.6 "PHB-CH1","PHB-CH1-151",151,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3,4.1,-1.1 "PHB-CH1","PHB-CH1-151",151,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.6,4.1,-0.5 "PHB-CH1","PHB-CH1-151",151,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.4,4.1,-0.7 "PHB-CH1","PHB-CH1-151",151,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.6,4.1,-0.5 "PHB-CH1","PHB-CH1-151",151,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4,4.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-151",151,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.9,4.1,-0.2 "PHB-CH1","PHB-CH1-151",151,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.4,4.1,0.300000000000001 "PHB-CH1","PHB-CH1-152",152,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,56,56,0 "PHB-CH1","PHB-CH1-152",152,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,55,56,-1 "PHB-CH1","PHB-CH1-152",152,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,42,56,-14 "PHB-CH1","PHB-CH1-152",152,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,53,, "PHB-CH1","PHB-CH1-152",152,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,51,, "PHB-CH1","PHB-CH1-152",152,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,32,, "PHB-CH1","PHB-CH1-152",152,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-152",152,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-152",152,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-152",152,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-152",152,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,5,, "PHB-CH1","PHB-CH1-152",152,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,381,, "PHB-CH1","PHB-CH1-152",152,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-152",152,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-152",152,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-152",152,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-152",152,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,36.8,36.8,0 "PHB-CH1","PHB-CH1-152",152,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,44.8,36.8,8 "PHB-CH1","PHB-CH1-152",152,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,49.2,36.8,12.4 "PHB-CH1","PHB-CH1-152",152,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,54.9,36.8,18.1 "PHB-CH1","PHB-CH1-152",152,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,26.1,26.1,0 "PHB-CH1","PHB-CH1-152",152,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,33.6,26.1,7.5 "PHB-CH1","PHB-CH1-152",152,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,53.2,26.1,27.1 "PHB-CH1","PHB-CH1-152",152,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,38.5,26.1,12.4 "PHB-CH1","PHB-CH1-152",152,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.7,5.7,0 "PHB-CH1","PHB-CH1-152",152,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.3,5.7,-0.4 "PHB-CH1","PHB-CH1-152",152,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.6,5.7,-1.1 "PHB-CH1","PHB-CH1-152",152,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.4,5.7,-0.3 "PHB-CH1","PHB-CH1-152",152,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.2,5.7,0.5 "PHB-CH1","PHB-CH1-152",152,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.8,5.7,0.0999999999999996 "PHB-CH1","PHB-CH1-152",152,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.2,5.7,0.5 "PHB-CH1","PHB-CH1-152",152,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.8,5.7,-0.9 "PHB-CH1","PHB-CH1-152",152,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.1,5.7,-0.6 "PHB-CH1","PHB-CH1-152",152,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5,5.7,-0.7 "PHB-CH1","PHB-CH1-152",152,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.4,5.7,-1.3 "PHB-CH1","PHB-CH1-152",152,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.8,5.7,-1.9 "PHB-CH1","PHB-CH1-152",152,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.5,5.7,-0.2 "PHB-CH1","PHB-CH1-152",152,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6,5.7,0.3 "PHB-CH1","PHB-CH1-152",152,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7,7,0 "PHB-CH1","PHB-CH1-152",152,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,7,7,0 "PHB-CH1","PHB-CH1-152",152,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.6,7,-1.4 "PHB-CH1","PHB-CH1-152",152,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.9,7,-1.1 "PHB-CH1","PHB-CH1-152",152,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.1,7,-0.9 "PHB-CH1","PHB-CH1-152",152,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.1,7,-0.9 "PHB-CH1","PHB-CH1-152",152,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.4,7,-0.6 "PHB-CH1","PHB-CH1-152",152,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6,7,-1 "PHB-CH1","PHB-CH1-152",152,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.6,7,-0.4 "PHB-CH1","PHB-CH1-152",152,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.9,7,-0.0999999999999996 "PHB-CH1","PHB-CH1-152",152,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.6,7,-1.4 "PHB-CH1","PHB-CH1-152",152,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.1,7,0.0999999999999996 "PHB-CH1","PHB-CH1-152",152,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,8.1,7,1.1 "PHB-CH1","PHB-CH1-152",152,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.6,7,0.6 "PHB-CH1","PHB-CH1-153",153,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,54,54,0 "PHB-CH1","PHB-CH1-153",153,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,52,54,-2 "PHB-CH1","PHB-CH1-153",153,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,53,54,-1 "PHB-CH1","PHB-CH1-153",153,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,62,, "PHB-CH1","PHB-CH1-153",153,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,67,, "PHB-CH1","PHB-CH1-153",153,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,64,, "PHB-CH1","PHB-CH1-153",153,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-153",153,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-153",153,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-153",153,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-153",153,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,18,, "PHB-CH1","PHB-CH1-153",153,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,331,, "PHB-CH1","PHB-CH1-153",153,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-153",153,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-153",153,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-153",153,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-153",153,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,41.5,41.5,0 "PHB-CH1","PHB-CH1-153",153,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,43.8,41.5,2.3 "PHB-CH1","PHB-CH1-153",153,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,42.2,41.5,0.700000000000003 "PHB-CH1","PHB-CH1-153",153,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,30.3,41.5,-11.2 "PHB-CH1","PHB-CH1-153",153,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,52.6,52.6,0 "PHB-CH1","PHB-CH1-153",153,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,38.6,52.6,-14 "PHB-CH1","PHB-CH1-153",153,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,53,52.6,0.399999999999999 "PHB-CH1","PHB-CH1-153",153,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,37.4,52.6,-15.2 "PHB-CH1","PHB-CH1-153",153,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.3,5.3,0 "PHB-CH1","PHB-CH1-153",153,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.9,5.3,0.6 "PHB-CH1","PHB-CH1-153",153,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.2,5.3,0.9 "PHB-CH1","PHB-CH1-153",153,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.1,5.3,-0.2 "PHB-CH1","PHB-CH1-153",153,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.9,5.3,1.6 "PHB-CH1","PHB-CH1-153",153,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,7.1,5.3,1.8 "PHB-CH1","PHB-CH1-153",153,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.2,5.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-153",153,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.8,5.3,-0.5 "PHB-CH1","PHB-CH1-153",153,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.4,5.3,1.1 "PHB-CH1","PHB-CH1-153",153,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,7,5.3,1.7 "PHB-CH1","PHB-CH1-153",153,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,7.4,5.3,2.1 "PHB-CH1","PHB-CH1-153",153,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.9,5.3,0.6 "PHB-CH1","PHB-CH1-153",153,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.4,5.3,1.1 "PHB-CH1","PHB-CH1-153",153,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.1,5.3,0.8 "PHB-CH1","PHB-CH1-153",153,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.4,4.4,0 "PHB-CH1","PHB-CH1-153",153,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.6,4.4,0.199999999999999 "PHB-CH1","PHB-CH1-153",153,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.3,4.4,0.9 "PHB-CH1","PHB-CH1-153",153,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.1,4.4,-0.300000000000001 "PHB-CH1","PHB-CH1-153",153,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.6,4.4,1.2 "PHB-CH1","PHB-CH1-153",153,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.5,4.4,1.1 "PHB-CH1","PHB-CH1-153",153,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.4,4.4,1 "PHB-CH1","PHB-CH1-153",153,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.8,4.4,0.399999999999999 "PHB-CH1","PHB-CH1-153",153,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.8,4.4,0.399999999999999 "PHB-CH1","PHB-CH1-153",153,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.6,4.4,0.199999999999999 "PHB-CH1","PHB-CH1-153",153,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.2,4.4,-0.2 "PHB-CH1","PHB-CH1-153",153,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.5,4.4,-0.9 "PHB-CH1","PHB-CH1-153",153,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.6,4.4,-0.8 "PHB-CH1","PHB-CH1-153",153,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.4,4.4,0 "PHB-CH1","PHB-CH1-154",154,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,45,45,0 "PHB-CH1","PHB-CH1-154",154,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,52,45,7 "PHB-CH1","PHB-CH1-154",154,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,45,45,0 "PHB-CH1","PHB-CH1-154",154,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,52,, "PHB-CH1","PHB-CH1-154",154,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,49,, "PHB-CH1","PHB-CH1-154",154,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,46,, "PHB-CH1","PHB-CH1-154",154,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-154",154,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-154",154,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-154",154,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-154",154,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,37,, "PHB-CH1","PHB-CH1-154",154,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,198,, "PHB-CH1","PHB-CH1-154",154,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-154",154,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-154",154,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-154",154,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-154",154,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,25.1,25.1,0 "PHB-CH1","PHB-CH1-154",154,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,46.3,25.1,21.2 "PHB-CH1","PHB-CH1-154",154,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,35.2,25.1,10.1 "PHB-CH1","PHB-CH1-154",154,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,32,25.1,6.9 "PHB-CH1","PHB-CH1-154",154,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,38.4,38.4,0 "PHB-CH1","PHB-CH1-154",154,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,44,38.4,5.6 "PHB-CH1","PHB-CH1-154",154,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,36.5,38.4,-1.9 "PHB-CH1","PHB-CH1-154",154,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,30.9,38.4,-7.5 "PHB-CH1","PHB-CH1-154",154,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.7,5.7,0 "PHB-CH1","PHB-CH1-154",154,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.7,5.7,0 "PHB-CH1","PHB-CH1-154",154,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.1,5.7,-0.6 "PHB-CH1","PHB-CH1-154",154,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.2,5.7,0.5 "PHB-CH1","PHB-CH1-154",154,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.5,5.7,-0.2 "PHB-CH1","PHB-CH1-154",154,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,7.1,5.7,1.4 "PHB-CH1","PHB-CH1-154",154,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,7.3,5.7,1.6 "PHB-CH1","PHB-CH1-154",154,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.5,5.7,1.8 "PHB-CH1","PHB-CH1-154",154,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.9,5.7,1.2 "PHB-CH1","PHB-CH1-154",154,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.7,5.7,1 "PHB-CH1","PHB-CH1-154",154,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.9,5.7,1.2 "PHB-CH1","PHB-CH1-154",154,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.9,5.7,1.2 "PHB-CH1","PHB-CH1-154",154,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,7.7,5.7,2 "PHB-CH1","PHB-CH1-154",154,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,7.6,5.7,1.9 "PHB-CH1","PHB-CH1-154",154,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.1,4.1,0 "PHB-CH1","PHB-CH1-154",154,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.6,4.1,-0.5 "PHB-CH1","PHB-CH1-154",154,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.1,4.1,-1 "PHB-CH1","PHB-CH1-154",154,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.8,4.1,0.7 "PHB-CH1","PHB-CH1-154",154,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.2,4.1,0.100000000000001 "PHB-CH1","PHB-CH1-154",154,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5,4.1,0.9 "PHB-CH1","PHB-CH1-154",154,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.8,4.1,0.7 "PHB-CH1","PHB-CH1-154",154,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.3,4.1,1.2 "PHB-CH1","PHB-CH1-154",154,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6,4.1,1.9 "PHB-CH1","PHB-CH1-154",154,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.6,4.1,0.5 "PHB-CH1","PHB-CH1-154",154,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.8,4.1,-0.3 "PHB-CH1","PHB-CH1-154",154,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.5,4.1,0.4 "PHB-CH1","PHB-CH1-154",154,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.2,4.1,0.100000000000001 "PHB-CH1","PHB-CH1-154",154,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.7,4.1,0.6 "PHB-CH1","PHB-CH1-155",155,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,81,81,0 "PHB-CH1","PHB-CH1-155",155,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,84,81,3 "PHB-CH1","PHB-CH1-155",155,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,67,81,-14 "PHB-CH1","PHB-CH1-155",155,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,69,, "PHB-CH1","PHB-CH1-155",155,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,61,, "PHB-CH1","PHB-CH1-155",155,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,62,, "PHB-CH1","PHB-CH1-155",155,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-155",155,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-155",155,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-155",155,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-155",155,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,6,, "PHB-CH1","PHB-CH1-155",155,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,452,, "PHB-CH1","PHB-CH1-155",155,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-155",155,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-155",155,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-155",155,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-155",155,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,42.6,42.6,0 "PHB-CH1","PHB-CH1-155",155,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,27.1,42.6,-15.5 "PHB-CH1","PHB-CH1-155",155,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,37.5,42.6,-5.1 "PHB-CH1","PHB-CH1-155",155,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,46.7,42.6,4.1 "PHB-CH1","PHB-CH1-155",155,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,55.2,55.2,0 "PHB-CH1","PHB-CH1-155",155,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,54.3,55.2,-0.900000000000006 "PHB-CH1","PHB-CH1-155",155,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,50.7,55.2,-4.5 "PHB-CH1","PHB-CH1-155",155,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,47.3,55.2,-7.90000000000001 "PHB-CH1","PHB-CH1-155",155,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.9,4.9,0 "PHB-CH1","PHB-CH1-155",155,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.8,4.9,-0.100000000000001 "PHB-CH1","PHB-CH1-155",155,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.1,4.9,-0.800000000000001 "PHB-CH1","PHB-CH1-155",155,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.8,4.9,-0.100000000000001 "PHB-CH1","PHB-CH1-155",155,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5,4.9,0.0999999999999996 "PHB-CH1","PHB-CH1-155",155,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.1,4.9,0.199999999999999 "PHB-CH1","PHB-CH1-155",155,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4,4.9,-0.9 "PHB-CH1","PHB-CH1-155",155,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.1,4.9,0.199999999999999 "PHB-CH1","PHB-CH1-155",155,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.6,4.9,-1.3 "PHB-CH1","PHB-CH1-155",155,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.7,4.9,-1.2 "PHB-CH1","PHB-CH1-155",155,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.9,4.9,0 "PHB-CH1","PHB-CH1-155",155,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.3,4.9,-0.6 "PHB-CH1","PHB-CH1-155",155,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.4,4.9,-0.5 "PHB-CH1","PHB-CH1-155",155,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.6,4.9,1.7 "PHB-CH1","PHB-CH1-155",155,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.7,3.7,0 "PHB-CH1","PHB-CH1-155",155,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.7,3.7,0 "PHB-CH1","PHB-CH1-155",155,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.2,3.7,-0.5 "PHB-CH1","PHB-CH1-155",155,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4,3.7,0.3 "PHB-CH1","PHB-CH1-155",155,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.2,3.7,1.5 "PHB-CH1","PHB-CH1-155",155,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.4,3.7,0.7 "PHB-CH1","PHB-CH1-155",155,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.4,3.7,-0.3 "PHB-CH1","PHB-CH1-155",155,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.3,3.7,0.6 "PHB-CH1","PHB-CH1-155",155,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.6,3.7,-1.1 "PHB-CH1","PHB-CH1-155",155,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3,3.7,-0.7 "PHB-CH1","PHB-CH1-155",155,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.2,3.7,0.5 "PHB-CH1","PHB-CH1-155",155,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.3,3.7,-0.4 "PHB-CH1","PHB-CH1-155",155,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.4,3.7,0.7 "PHB-CH1","PHB-CH1-155",155,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.4,3.7,1.7 "PHB-CH1","PHB-CH1-156",156,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,51,51,0 "PHB-CH1","PHB-CH1-156",156,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,66,51,15 "PHB-CH1","PHB-CH1-156",156,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,64,51,13 "PHB-CH1","PHB-CH1-156",156,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,54,, "PHB-CH1","PHB-CH1-156",156,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,51,, "PHB-CH1","PHB-CH1-156",156,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,48,, "PHB-CH1","PHB-CH1-156",156,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-156",156,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-156",156,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,5,, "PHB-CH1","PHB-CH1-156",156,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-156",156,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,2,, "PHB-CH1","PHB-CH1-156",156,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,541,, "PHB-CH1","PHB-CH1-156",156,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-156",156,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-156",156,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-156",156,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-156",156,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,41.7,41.7,0 "PHB-CH1","PHB-CH1-156",156,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,28.1,41.7,-13.6 "PHB-CH1","PHB-CH1-156",156,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,40.8,41.7,-0.900000000000006 "PHB-CH1","PHB-CH1-156",156,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,47.2,41.7,5.5 "PHB-CH1","PHB-CH1-156",156,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,43.5,43.5,0 "PHB-CH1","PHB-CH1-156",156,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,50.2,43.5,6.7 "PHB-CH1","PHB-CH1-156",156,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,54.9,43.5,11.4 "PHB-CH1","PHB-CH1-156",156,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,47.3,43.5,3.8 "PHB-CH1","PHB-CH1-156",156,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-156",156,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.7,4.7,2 "PHB-CH1","PHB-CH1-156",156,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.3,4.7,1.6 "PHB-CH1","PHB-CH1-156",156,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.5,4.7,1.8 "PHB-CH1","PHB-CH1-156",156,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.6,4.7,0.9 "PHB-CH1","PHB-CH1-156",156,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.8,4.7,1.1 "PHB-CH1","PHB-CH1-156",156,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.8,4.7,2.1 "PHB-CH1","PHB-CH1-156",156,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.9,4.7,1.2 "PHB-CH1","PHB-CH1-156",156,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.2,4.7,0.5 "PHB-CH1","PHB-CH1-156",156,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-156",156,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.5,4.7,0.8 "PHB-CH1","PHB-CH1-156",156,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.4,4.7,-0.3 "PHB-CH1","PHB-CH1-156",156,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.7,4.7,1 "PHB-CH1","PHB-CH1-156",156,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6,4.7,1.3 "PHB-CH1","PHB-CH1-156",156,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.7,3.7,0 "PHB-CH1","PHB-CH1-156",156,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.3,3.7,1.6 "PHB-CH1","PHB-CH1-156",156,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.6,3.7,0.9 "PHB-CH1","PHB-CH1-156",156,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.6,3.7,1.9 "PHB-CH1","PHB-CH1-156",156,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4,3.7,0.3 "PHB-CH1","PHB-CH1-156",156,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.1,3.7,1.4 "PHB-CH1","PHB-CH1-156",156,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.4,3.7,1.7 "PHB-CH1","PHB-CH1-156",156,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.2,3.7,0.5 "PHB-CH1","PHB-CH1-156",156,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.6,3.7,-0.1 "PHB-CH1","PHB-CH1-156",156,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.8,3.7,1.1 "PHB-CH1","PHB-CH1-156",156,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.4,3.7,1.7 "PHB-CH1","PHB-CH1-156",156,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.8,3.7,0.0999999999999996 "PHB-CH1","PHB-CH1-156",156,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.8,3.7,1.1 "PHB-CH1","PHB-CH1-156",156,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.6,3.7,0.9 "PHB-CH1","PHB-CH1-157",157,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,43,43,0 "PHB-CH1","PHB-CH1-157",157,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,42,43,-1 "PHB-CH1","PHB-CH1-157",157,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,29,43,-14 "PHB-CH1","PHB-CH1-157",157,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,49,, "PHB-CH1","PHB-CH1-157",157,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,53,, "PHB-CH1","PHB-CH1-157",157,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,67,, "PHB-CH1","PHB-CH1-157",157,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,1,, "PHB-CH1","PHB-CH1-157",157,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-157",157,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-157",157,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-157",157,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,3,, "PHB-CH1","PHB-CH1-157",157,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,493,, "PHB-CH1","PHB-CH1-157",157,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-157",157,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-157",157,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-157",157,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-157",157,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,26.2,26.2,0 "PHB-CH1","PHB-CH1-157",157,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,21.3,26.2,-4.9 "PHB-CH1","PHB-CH1-157",157,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,31.3,26.2,5.1 "PHB-CH1","PHB-CH1-157",157,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,36.5,26.2,10.3 "PHB-CH1","PHB-CH1-157",157,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,41.2,41.2,0 "PHB-CH1","PHB-CH1-157",157,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,33.1,41.2,-8.1 "PHB-CH1","PHB-CH1-157",157,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,46.1,41.2,4.9 "PHB-CH1","PHB-CH1-157",157,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,40.1,41.2,-1.1 "PHB-CH1","PHB-CH1-157",157,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,2.3,2.3,0 "PHB-CH1","PHB-CH1-157",157,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,1.2,2.3,-1.1 "PHB-CH1","PHB-CH1-157",157,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.2,2.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-157",157,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4,2.3,1.7 "PHB-CH1","PHB-CH1-157",157,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.2,2.3,1.9 "PHB-CH1","PHB-CH1-157",157,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2.3,2.3,0 "PHB-CH1","PHB-CH1-157",157,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2.7,2.3,0.4 "PHB-CH1","PHB-CH1-157",157,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,2.5,2.3,0.2 "PHB-CH1","PHB-CH1-157",157,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,1.8,2.3,-0.5 "PHB-CH1","PHB-CH1-157",157,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,2.5,2.3,0.2 "PHB-CH1","PHB-CH1-157",157,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.5,2.3,0.2 "PHB-CH1","PHB-CH1-157",157,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,1.5,2.3,-0.8 "PHB-CH1","PHB-CH1-157",157,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.1,2.3,1.8 "PHB-CH1","PHB-CH1-157",157,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2.8,2.3,0.5 "PHB-CH1","PHB-CH1-157",157,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.8,4.8,0 "PHB-CH1","PHB-CH1-157",157,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.1,4.8,-0.7 "PHB-CH1","PHB-CH1-157",157,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.6,4.8,-1.2 "PHB-CH1","PHB-CH1-157",157,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.9,4.8,0.100000000000001 "PHB-CH1","PHB-CH1-157",157,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.5,4.8,0.7 "PHB-CH1","PHB-CH1-157",157,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.4,4.8,0.6 "PHB-CH1","PHB-CH1-157",157,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5,4.8,0.2 "PHB-CH1","PHB-CH1-157",157,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.4,4.8,-0.399999999999999 "PHB-CH1","PHB-CH1-157",157,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.8,4.8,-1 "PHB-CH1","PHB-CH1-157",157,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.3,4.8,-0.5 "PHB-CH1","PHB-CH1-157",157,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.9,4.8,0.100000000000001 "PHB-CH1","PHB-CH1-157",157,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5,4.8,0.2 "PHB-CH1","PHB-CH1-157",157,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.3,4.8,2.5 "PHB-CH1","PHB-CH1-157",157,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.7,4.8,0.9 "PHB-CH1","PHB-CH1-158",158,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,80,80,0 "PHB-CH1","PHB-CH1-158",158,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,89,80,9 "PHB-CH1","PHB-CH1-158",158,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,82,80,2 "PHB-CH1","PHB-CH1-158",158,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,56,, "PHB-CH1","PHB-CH1-158",158,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,58,, "PHB-CH1","PHB-CH1-158",158,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,72,, "PHB-CH1","PHB-CH1-158",158,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-158",158,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-158",158,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-158",158,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-158",158,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,12,, "PHB-CH1","PHB-CH1-158",158,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,339,, "PHB-CH1","PHB-CH1-158",158,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-158",158,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-158",158,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-158",158,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-158",158,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,63.3,63.3,0 "PHB-CH1","PHB-CH1-158",158,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,50,63.3,-13.3 "PHB-CH1","PHB-CH1-158",158,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,49.5,63.3,-13.8 "PHB-CH1","PHB-CH1-158",158,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,42.5,63.3,-20.8 "PHB-CH1","PHB-CH1-158",158,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,56.7,56.7,0 "PHB-CH1","PHB-CH1-158",158,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,72.4,56.7,15.7 "PHB-CH1","PHB-CH1-158",158,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,55.8,56.7,-0.900000000000006 "PHB-CH1","PHB-CH1-158",158,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,63,56.7,6.3 "PHB-CH1","PHB-CH1-158",158,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.9,4.9,0 "PHB-CH1","PHB-CH1-158",158,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3,4.9,-1.9 "PHB-CH1","PHB-CH1-158",158,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.9,4.9,-2 "PHB-CH1","PHB-CH1-158",158,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.9,4.9,-2 "PHB-CH1","PHB-CH1-158",158,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.7,4.9,-1.2 "PHB-CH1","PHB-CH1-158",158,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.7,4.9,-1.2 "PHB-CH1","PHB-CH1-158",158,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.3,4.9,-1.6 "PHB-CH1","PHB-CH1-158",158,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,2.9,4.9,-2 "PHB-CH1","PHB-CH1-158",158,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,2.4,4.9,-2.5 "PHB-CH1","PHB-CH1-158",158,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3,4.9,-1.9 "PHB-CH1","PHB-CH1-158",158,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.3,4.9,-1.6 "PHB-CH1","PHB-CH1-158",158,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.3,4.9,-1.6 "PHB-CH1","PHB-CH1-158",158,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.5,4.9,-2.4 "PHB-CH1","PHB-CH1-158",158,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.3,4.9,-1.6 "PHB-CH1","PHB-CH1-158",158,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-158",158,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4,5.1,-1.1 "PHB-CH1","PHB-CH1-158",158,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,2.2,5.1,-2.9 "PHB-CH1","PHB-CH1-158",158,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,2.2,5.1,-2.9 "PHB-CH1","PHB-CH1-158",158,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,2.2,5.1,-2.9 "PHB-CH1","PHB-CH1-158",158,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,2.4,5.1,-2.7 "PHB-CH1","PHB-CH1-158",158,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.6,5.1,-0.5 "PHB-CH1","PHB-CH1-158",158,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.8,5.1,-1.3 "PHB-CH1","PHB-CH1-158",158,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.9,5.1,-1.2 "PHB-CH1","PHB-CH1-158",158,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.4,5.1,-1.7 "PHB-CH1","PHB-CH1-158",158,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.7,5.1,-1.4 "PHB-CH1","PHB-CH1-158",158,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.7,5.1,-1.4 "PHB-CH1","PHB-CH1-158",158,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,1.2,5.1,-3.9 "PHB-CH1","PHB-CH1-158",158,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,1.9,5.1,-3.2 "PHB-CH1","PHB-CH1-159",159,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,55,55,0 "PHB-CH1","PHB-CH1-159",159,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,56,55,1 "PHB-CH1","PHB-CH1-159",159,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,50,55,-5 "PHB-CH1","PHB-CH1-159",159,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,51,, "PHB-CH1","PHB-CH1-159",159,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,67,, "PHB-CH1","PHB-CH1-159",159,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,43,, "PHB-CH1","PHB-CH1-159",159,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-159",159,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-159",159,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-159",159,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-159",159,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,10,, "PHB-CH1","PHB-CH1-159",159,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,347,, "PHB-CH1","PHB-CH1-159",159,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-159",159,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-159",159,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-159",159,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-159",159,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,51.9,51.9,0 "PHB-CH1","PHB-CH1-159",159,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,59.7,51.9,7.8 "PHB-CH1","PHB-CH1-159",159,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,56.8,51.9,4.9 "PHB-CH1","PHB-CH1-159",159,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,68,51.9,16.1 "PHB-CH1","PHB-CH1-159",159,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,54.2,54.2,0 "PHB-CH1","PHB-CH1-159",159,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,74.8,54.2,20.6 "PHB-CH1","PHB-CH1-159",159,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,58.8,54.2,4.59999999999999 "PHB-CH1","PHB-CH1-159",159,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,76.1,54.2,21.9 "PHB-CH1","PHB-CH1-159",159,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6,6,0 "PHB-CH1","PHB-CH1-159",159,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6,6,0 "PHB-CH1","PHB-CH1-159",159,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.8,6,-0.2 "PHB-CH1","PHB-CH1-159",159,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.5,6,-0.5 "PHB-CH1","PHB-CH1-159",159,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.6,6,0.6 "PHB-CH1","PHB-CH1-159",159,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.5,6,-0.5 "PHB-CH1","PHB-CH1-159",159,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.8,6,-1.2 "PHB-CH1","PHB-CH1-159",159,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6,6,0 "PHB-CH1","PHB-CH1-159",159,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.3,6,-0.7 "PHB-CH1","PHB-CH1-159",159,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.9,6,-0.0999999999999996 "PHB-CH1","PHB-CH1-159",159,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.3,6,0.3 "PHB-CH1","PHB-CH1-159",159,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.6,6,-0.4 "PHB-CH1","PHB-CH1-159",159,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.1,6,0.0999999999999996 "PHB-CH1","PHB-CH1-159",159,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.8,6,0.8 "PHB-CH1","PHB-CH1-159",159,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.6,6.6,0 "PHB-CH1","PHB-CH1-159",159,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,7.4,6.6,0.800000000000001 "PHB-CH1","PHB-CH1-159",159,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7.4,6.6,0.800000000000001 "PHB-CH1","PHB-CH1-159",159,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.8,6.6,0.2 "PHB-CH1","PHB-CH1-159",159,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,7.6,6.6,1 "PHB-CH1","PHB-CH1-159",159,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.9,6.6,-0.699999999999999 "PHB-CH1","PHB-CH1-159",159,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7.9,6.6,1.3 "PHB-CH1","PHB-CH1-159",159,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,8.6,6.6,2 "PHB-CH1","PHB-CH1-159",159,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.5,6.6,0.9 "PHB-CH1","PHB-CH1-159",159,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,8.5,6.6,1.9 "PHB-CH1","PHB-CH1-159",159,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,9.1,6.6,2.5 "PHB-CH1","PHB-CH1-159",159,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.6,6.6,1 "PHB-CH1","PHB-CH1-159",159,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.6,6.6,1 "PHB-CH1","PHB-CH1-159",159,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.5,6.6,0.9 "PHB-CH1","PHB-CH1-160",160,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,39,39,0 "PHB-CH1","PHB-CH1-160",160,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,25,39,-14 "PHB-CH1","PHB-CH1-160",160,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,30,39,-9 "PHB-CH1","PHB-CH1-160",160,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,53,, "PHB-CH1","PHB-CH1-160",160,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,39,, "PHB-CH1","PHB-CH1-160",160,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,39,, "PHB-CH1","PHB-CH1-160",160,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-160",160,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-160",160,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-160",160,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-160",160,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,2,, "PHB-CH1","PHB-CH1-160",160,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,519,, "PHB-CH1","PHB-CH1-160",160,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-160",160,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-160",160,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-160",160,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-160",160,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,47.5,47.5,0 "PHB-CH1","PHB-CH1-160",160,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,51.8,47.5,4.3 "PHB-CH1","PHB-CH1-160",160,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,38.3,47.5,-9.2 "PHB-CH1","PHB-CH1-160",160,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,45,47.5,-2.5 "PHB-CH1","PHB-CH1-160",160,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,51.6,51.6,0 "PHB-CH1","PHB-CH1-160",160,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,44.5,51.6,-7.1 "PHB-CH1","PHB-CH1-160",160,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,32.9,51.6,-18.7 "PHB-CH1","PHB-CH1-160",160,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,35.8,51.6,-15.8 "PHB-CH1","PHB-CH1-160",160,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.9,4.9,0 "PHB-CH1","PHB-CH1-160",160,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.8,4.9,0.9 "PHB-CH1","PHB-CH1-160",160,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.1,4.9,0.199999999999999 "PHB-CH1","PHB-CH1-160",160,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.4,4.9,-0.5 "PHB-CH1","PHB-CH1-160",160,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5,4.9,0.0999999999999996 "PHB-CH1","PHB-CH1-160",160,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.5,4.9,-1.4 "PHB-CH1","PHB-CH1-160",160,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.3,4.9,-0.6 "PHB-CH1","PHB-CH1-160",160,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.5,4.9,-1.4 "PHB-CH1","PHB-CH1-160",160,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.6,4.9,-1.3 "PHB-CH1","PHB-CH1-160",160,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.2,4.9,-0.7 "PHB-CH1","PHB-CH1-160",160,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.8,4.9,-0.100000000000001 "PHB-CH1","PHB-CH1-160",160,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5,4.9,0.0999999999999996 "PHB-CH1","PHB-CH1-160",160,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.4,4.9,-0.5 "PHB-CH1","PHB-CH1-160",160,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.3,4.9,-0.6 "PHB-CH1","PHB-CH1-160",160,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.7,5.7,0 "PHB-CH1","PHB-CH1-160",160,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.7,5.7,-1 "PHB-CH1","PHB-CH1-160",160,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.3,5.7,-0.4 "PHB-CH1","PHB-CH1-160",160,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.3,5.7,-1.4 "PHB-CH1","PHB-CH1-160",160,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.9,5.7,-0.8 "PHB-CH1","PHB-CH1-160",160,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.1,5.7,-2.6 "PHB-CH1","PHB-CH1-160",160,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,1.6,5.7,-4.1 "PHB-CH1","PHB-CH1-160",160,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.9,5.7,-2.8 "PHB-CH1","PHB-CH1-160",160,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.9,5.7,-2.8 "PHB-CH1","PHB-CH1-160",160,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.5,5.7,-1.2 "PHB-CH1","PHB-CH1-160",160,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.7,5.7,-1 "PHB-CH1","PHB-CH1-160",160,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.7,5.7,-2 "PHB-CH1","PHB-CH1-160",160,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.1,5.7,-2.6 "PHB-CH1","PHB-CH1-160",160,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.5,5.7,-2.2 "PHB-CH1","PHB-CH1-161",161,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,50,50,0 "PHB-CH1","PHB-CH1-161",161,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,38,50,-12 "PHB-CH1","PHB-CH1-161",161,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,44,50,-6 "PHB-CH1","PHB-CH1-161",161,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,52,, "PHB-CH1","PHB-CH1-161",161,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,48,, "PHB-CH1","PHB-CH1-161",161,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,37,, "PHB-CH1","PHB-CH1-161",161,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-161",161,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-161",161,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-161",161,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-161",161,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,12,, "PHB-CH1","PHB-CH1-161",161,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,375,, "PHB-CH1","PHB-CH1-161",161,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-161",161,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-161",161,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-161",161,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-161",161,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,42.3,42.3,0 "PHB-CH1","PHB-CH1-161",161,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,42.5,42.3,0.200000000000003 "PHB-CH1","PHB-CH1-161",161,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,31.6,42.3,-10.7 "PHB-CH1","PHB-CH1-161",161,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,24.9,42.3,-17.4 "PHB-CH1","PHB-CH1-161",161,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,35.5,35.5,0 "PHB-CH1","PHB-CH1-161",161,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,35.1,35.5,-0.399999999999999 "PHB-CH1","PHB-CH1-161",161,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,26.1,35.5,-9.4 "PHB-CH1","PHB-CH1-161",161,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,27.5,35.5,-8 "PHB-CH1","PHB-CH1-161",161,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,1.1,1.1,0 "PHB-CH1","PHB-CH1-161",161,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,0.6,1.1,-0.5 "PHB-CH1","PHB-CH1-161",161,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,1.9,1.1,0.8 "PHB-CH1","PHB-CH1-161",161,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.9,1.1,1.8 "PHB-CH1","PHB-CH1-161",161,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,2.8,1.1,1.7 "PHB-CH1","PHB-CH1-161",161,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.1,1.1,2 "PHB-CH1","PHB-CH1-161",161,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,2.7,1.1,1.6 "PHB-CH1","PHB-CH1-161",161,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,0.3,1.1,-0.8 "PHB-CH1","PHB-CH1-161",161,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,1.5,1.1,0.4 "PHB-CH1","PHB-CH1-161",161,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,1.3,1.1,0.2 "PHB-CH1","PHB-CH1-161",161,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2,1.1,0.9 "PHB-CH1","PHB-CH1-161",161,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,2.5,1.1,1.4 "PHB-CH1","PHB-CH1-161",161,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4,1.1,2.9 "PHB-CH1","PHB-CH1-161",161,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.3,1.1,2.2 "PHB-CH1","PHB-CH1-161",161,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-161",161,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.8,5.1,0.7 "PHB-CH1","PHB-CH1-161",161,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.4,5.1,0.300000000000001 "PHB-CH1","PHB-CH1-161",161,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.7,5.1,0.6 "PHB-CH1","PHB-CH1-161",161,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.7,5.1,-0.399999999999999 "PHB-CH1","PHB-CH1-161",161,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.4,5.1,-0.699999999999999 "PHB-CH1","PHB-CH1-161",161,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.2,5.1,1.1 "PHB-CH1","PHB-CH1-161",161,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.4,5.1,-0.699999999999999 "PHB-CH1","PHB-CH1-161",161,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6,5.1,0.9 "PHB-CH1","PHB-CH1-161",161,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.8,5.1,0.7 "PHB-CH1","PHB-CH1-161",161,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.9,5.1,0.800000000000001 "PHB-CH1","PHB-CH1-161",161,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.2,5.1,0.100000000000001 "PHB-CH1","PHB-CH1-161",161,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.3,5.1,1.2 "PHB-CH1","PHB-CH1-161",161,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.8,5.1,0.7 "PHB-CH1","PHB-CH1-162",162,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,55,55,0 "PHB-CH1","PHB-CH1-162",162,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,45,55,-10 "PHB-CH1","PHB-CH1-162",162,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,61,55,6 "PHB-CH1","PHB-CH1-162",162,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,43,, "PHB-CH1","PHB-CH1-162",162,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,53,, "PHB-CH1","PHB-CH1-162",162,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,37,, "PHB-CH1","PHB-CH1-162",162,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-162",162,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-162",162,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-162",162,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-162",162,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,8,, "PHB-CH1","PHB-CH1-162",162,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,373,, "PHB-CH1","PHB-CH1-162",162,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-162",162,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-162",162,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-162",162,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-162",162,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,36.3,36.3,0 "PHB-CH1","PHB-CH1-162",162,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,29.1,36.3,-7.2 "PHB-CH1","PHB-CH1-162",162,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,29,36.3,-7.3 "PHB-CH1","PHB-CH1-162",162,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,33.4,36.3,-2.9 "PHB-CH1","PHB-CH1-162",162,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,55.2,55.2,0 "PHB-CH1","PHB-CH1-162",162,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,59.8,55.2,4.59999999999999 "PHB-CH1","PHB-CH1-162",162,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,37.5,55.2,-17.7 "PHB-CH1","PHB-CH1-162",162,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,53.1,55.2,-2.1 "PHB-CH1","PHB-CH1-162",162,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.8,3.8,0 "PHB-CH1","PHB-CH1-162",162,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3,3.8,-0.8 "PHB-CH1","PHB-CH1-162",162,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.6,3.8,-0.2 "PHB-CH1","PHB-CH1-162",162,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.3,3.8,0.5 "PHB-CH1","PHB-CH1-162",162,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.4,3.8,0.6 "PHB-CH1","PHB-CH1-162",162,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.2,3.8,1.4 "PHB-CH1","PHB-CH1-162",162,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.3,3.8,1.5 "PHB-CH1","PHB-CH1-162",162,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5,3.8,1.2 "PHB-CH1","PHB-CH1-162",162,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.4,3.8,0.6 "PHB-CH1","PHB-CH1-162",162,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,2.4,3.8,-1.4 "PHB-CH1","PHB-CH1-162",162,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.2,3.8,-0.6 "PHB-CH1","PHB-CH1-162",162,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.4,3.8,-0.4 "PHB-CH1","PHB-CH1-162",162,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.4,3.8,0.6 "PHB-CH1","PHB-CH1-162",162,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.6,3.8,1.8 "PHB-CH1","PHB-CH1-162",162,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-162",162,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.1,5.1,0 "PHB-CH1","PHB-CH1-162",162,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.9,5.1,-0.199999999999999 "PHB-CH1","PHB-CH1-162",162,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.3,5.1,0.2 "PHB-CH1","PHB-CH1-162",162,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.8,5.1,-0.3 "PHB-CH1","PHB-CH1-162",162,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.1,5.1,0 "PHB-CH1","PHB-CH1-162",162,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.2,5.1,1.1 "PHB-CH1","PHB-CH1-162",162,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.8,5.1,0.7 "PHB-CH1","PHB-CH1-162",162,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.5,5.1,1.4 "PHB-CH1","PHB-CH1-162",162,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.3,5.1,0.2 "PHB-CH1","PHB-CH1-162",162,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.5,5.1,-0.6 "PHB-CH1","PHB-CH1-162",162,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.2,5.1,-0.9 "PHB-CH1","PHB-CH1-162",162,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.1,5.1,-1 "PHB-CH1","PHB-CH1-162",162,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5,5.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-163",163,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,51,51,0 "PHB-CH1","PHB-CH1-163",163,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,41,51,-10 "PHB-CH1","PHB-CH1-163",163,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,56,51,5 "PHB-CH1","PHB-CH1-163",163,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,59,, "PHB-CH1","PHB-CH1-163",163,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,64,, "PHB-CH1","PHB-CH1-163",163,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,39,, "PHB-CH1","PHB-CH1-163",163,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-163",163,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-163",163,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-163",163,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-163",163,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,13,, "PHB-CH1","PHB-CH1-163",163,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,317,, "PHB-CH1","PHB-CH1-163",163,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-163",163,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-163",163,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-163",163,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-163",163,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,58.6,58.6,0 "PHB-CH1","PHB-CH1-163",163,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,36.1,58.6,-22.5 "PHB-CH1","PHB-CH1-163",163,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,52.5,58.6,-6.1 "PHB-CH1","PHB-CH1-163",163,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,68,58.6,9.4 "PHB-CH1","PHB-CH1-163",163,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,40,40,0 "PHB-CH1","PHB-CH1-163",163,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,64.7,40,24.7 "PHB-CH1","PHB-CH1-163",163,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,52.2,40,12.2 "PHB-CH1","PHB-CH1-163",163,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,45.7,40,5.7 "PHB-CH1","PHB-CH1-163",163,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.5,3.5,0 "PHB-CH1","PHB-CH1-163",163,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2.8,3.5,-0.7 "PHB-CH1","PHB-CH1-163",163,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.1,3.5,-0.4 "PHB-CH1","PHB-CH1-163",163,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.9,3.5,0.4 "PHB-CH1","PHB-CH1-163",163,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4,3.5,0.5 "PHB-CH1","PHB-CH1-163",163,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.3,3.5,-0.2 "PHB-CH1","PHB-CH1-163",163,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4,3.5,0.5 "PHB-CH1","PHB-CH1-163",163,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.9,3.5,0.4 "PHB-CH1","PHB-CH1-163",163,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.3,3.5,-0.2 "PHB-CH1","PHB-CH1-163",163,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3,3.5,-0.5 "PHB-CH1","PHB-CH1-163",163,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,2.9,3.5,-0.6 "PHB-CH1","PHB-CH1-163",163,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.1,3.5,0.6 "PHB-CH1","PHB-CH1-163",163,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.6,3.5,0.1 "PHB-CH1","PHB-CH1-163",163,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2.6,3.5,-0.9 "PHB-CH1","PHB-CH1-163",163,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.5,5.5,0 "PHB-CH1","PHB-CH1-163",163,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.5,5.5,1 "PHB-CH1","PHB-CH1-163",163,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.4,5.5,0.9 "PHB-CH1","PHB-CH1-163",163,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.8,5.5,-0.7 "PHB-CH1","PHB-CH1-163",163,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.6,5.5,-0.9 "PHB-CH1","PHB-CH1-163",163,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.3,5.5,-1.2 "PHB-CH1","PHB-CH1-163",163,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.5,5.5,0 "PHB-CH1","PHB-CH1-163",163,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.6,5.5,0.0999999999999996 "PHB-CH1","PHB-CH1-163",163,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.7,5.5,-0.8 "PHB-CH1","PHB-CH1-163",163,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.5,5.5,0 "PHB-CH1","PHB-CH1-163",163,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.4,5.5,-1.1 "PHB-CH1","PHB-CH1-163",163,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.4,5.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-163",163,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.5,5.5,1 "PHB-CH1","PHB-CH1-163",163,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.8,5.5,-1.7 "PHB-CH1","PHB-CH1-164",164,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,44,44,0 "PHB-CH1","PHB-CH1-164",164,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,47,44,3 "PHB-CH1","PHB-CH1-164",164,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,39,44,-5 "PHB-CH1","PHB-CH1-164",164,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,32,, "PHB-CH1","PHB-CH1-164",164,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,24,, "PHB-CH1","PHB-CH1-164",164,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,53,, "PHB-CH1","PHB-CH1-164",164,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-164",164,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-164",164,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-164",164,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-164",164,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,8,, "PHB-CH1","PHB-CH1-164",164,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,424,, "PHB-CH1","PHB-CH1-164",164,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-164",164,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-164",164,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-164",164,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-164",164,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,51.4,51.4,0 "PHB-CH1","PHB-CH1-164",164,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,60.1,51.4,8.7 "PHB-CH1","PHB-CH1-164",164,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,49.3,51.4,-2.1 "PHB-CH1","PHB-CH1-164",164,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,30.9,51.4,-20.5 "PHB-CH1","PHB-CH1-164",164,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,44.1,44.1,0 "PHB-CH1","PHB-CH1-164",164,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,35,44.1,-9.1 "PHB-CH1","PHB-CH1-164",164,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,49.8,44.1,5.7 "PHB-CH1","PHB-CH1-164",164,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,32.7,44.1,-11.4 "PHB-CH1","PHB-CH1-164",164,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.7,5.7,0 "PHB-CH1","PHB-CH1-164",164,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.8,5.7,-0.9 "PHB-CH1","PHB-CH1-164",164,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.4,5.7,-0.3 "PHB-CH1","PHB-CH1-164",164,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.1,5.7,-0.6 "PHB-CH1","PHB-CH1-164",164,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4,5.7,-1.7 "PHB-CH1","PHB-CH1-164",164,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.3,5.7,-1.4 "PHB-CH1","PHB-CH1-164",164,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.5,5.7,-1.2 "PHB-CH1","PHB-CH1-164",164,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4,5.7,-1.7 "PHB-CH1","PHB-CH1-164",164,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.7,5.7,-2 "PHB-CH1","PHB-CH1-164",164,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.7,5.7,0 "PHB-CH1","PHB-CH1-164",164,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.5,5.7,-0.2 "PHB-CH1","PHB-CH1-164",164,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.4,5.7,-0.3 "PHB-CH1","PHB-CH1-164",164,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.4,5.7,-0.3 "PHB-CH1","PHB-CH1-164",164,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.7,5.7,0 "PHB-CH1","PHB-CH1-164",164,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5,5,0 "PHB-CH1","PHB-CH1-164",164,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.4,5,-1.6 "PHB-CH1","PHB-CH1-164",164,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.8,5,-1.2 "PHB-CH1","PHB-CH1-164",164,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.8,5,-0.2 "PHB-CH1","PHB-CH1-164",164,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.3,5,-0.7 "PHB-CH1","PHB-CH1-164",164,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.2,5,-1.8 "PHB-CH1","PHB-CH1-164",164,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3,5,-2 "PHB-CH1","PHB-CH1-164",164,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.3,5,-2.7 "PHB-CH1","PHB-CH1-164",164,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.2,5,-2.8 "PHB-CH1","PHB-CH1-164",164,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.2,5,-0.8 "PHB-CH1","PHB-CH1-164",164,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.3,5,-0.7 "PHB-CH1","PHB-CH1-164",164,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4,5,-1 "PHB-CH1","PHB-CH1-164",164,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3,5,-2 "PHB-CH1","PHB-CH1-164",164,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.3,5,-1.7 "PHB-CH1","PHB-CH1-165",165,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,45,45,0 "PHB-CH1","PHB-CH1-165",165,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,58,45,13 "PHB-CH1","PHB-CH1-165",165,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,47,45,2 "PHB-CH1","PHB-CH1-165",165,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,38,, "PHB-CH1","PHB-CH1-165",165,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,54,, "PHB-CH1","PHB-CH1-165",165,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,46,, "PHB-CH1","PHB-CH1-165",165,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-165",165,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-165",165,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-165",165,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-165",165,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,1,, "PHB-CH1","PHB-CH1-165",165,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,559,, "PHB-CH1","PHB-CH1-165",165,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-165",165,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-165",165,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-165",165,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-165",165,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,52.2,52.2,0 "PHB-CH1","PHB-CH1-165",165,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,53.1,52.2,0.899999999999999 "PHB-CH1","PHB-CH1-165",165,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,59.3,52.2,7.09999999999999 "PHB-CH1","PHB-CH1-165",165,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,59.8,52.2,7.59999999999999 "PHB-CH1","PHB-CH1-165",165,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,67.5,67.5,0 "PHB-CH1","PHB-CH1-165",165,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,49.4,67.5,-18.1 "PHB-CH1","PHB-CH1-165",165,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,76.6,67.5,9.09999999999999 "PHB-CH1","PHB-CH1-165",165,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,63.4,67.5,-4.1 "PHB-CH1","PHB-CH1-165",165,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.1,4.1,0 "PHB-CH1","PHB-CH1-165",165,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.2,4.1,-0.9 "PHB-CH1","PHB-CH1-165",165,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.4,4.1,-0.7 "PHB-CH1","PHB-CH1-165",165,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.5,4.1,-0.6 "PHB-CH1","PHB-CH1-165",165,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3,4.1,-1.1 "PHB-CH1","PHB-CH1-165",165,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2.9,4.1,-1.2 "PHB-CH1","PHB-CH1-165",165,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.6,4.1,-0.5 "PHB-CH1","PHB-CH1-165",165,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.6,4.1,-0.5 "PHB-CH1","PHB-CH1-165",165,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.7,4.1,-0.399999999999999 "PHB-CH1","PHB-CH1-165",165,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.7,4.1,0.6 "PHB-CH1","PHB-CH1-165",165,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.4,4.1,-0.7 "PHB-CH1","PHB-CH1-165",165,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.5,4.1,-0.6 "PHB-CH1","PHB-CH1-165",165,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.1,4.1,0 "PHB-CH1","PHB-CH1-165",165,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.7,4.1,-0.399999999999999 "PHB-CH1","PHB-CH1-165",165,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.8,2.8,0 "PHB-CH1","PHB-CH1-165",165,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,2.6,2.8,-0.2 "PHB-CH1","PHB-CH1-165",165,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.6,2.8,0.8 "PHB-CH1","PHB-CH1-165",165,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.7,2.8,0.9 "PHB-CH1","PHB-CH1-165",165,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.5,2.8,0.7 "PHB-CH1","PHB-CH1-165",165,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3,2.8,0.2 "PHB-CH1","PHB-CH1-165",165,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.2,2.8,0.4 "PHB-CH1","PHB-CH1-165",165,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.1,2.8,0.3 "PHB-CH1","PHB-CH1-165",165,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.5,2.8,-0.3 "PHB-CH1","PHB-CH1-165",165,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4,2.8,1.2 "PHB-CH1","PHB-CH1-165",165,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,2.9,2.8,0.1 "PHB-CH1","PHB-CH1-165",165,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.4,2.8,0.6 "PHB-CH1","PHB-CH1-165",165,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.3,2.8,0.5 "PHB-CH1","PHB-CH1-165",165,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.2,2.8,0.4 "PHB-CH1","PHB-CH1-166",166,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,33,33,0 "PHB-CH1","PHB-CH1-166",166,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,38,33,5 "PHB-CH1","PHB-CH1-166",166,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,27,33,-6 "PHB-CH1","PHB-CH1-166",166,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,29,, "PHB-CH1","PHB-CH1-166",166,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,31,, "PHB-CH1","PHB-CH1-166",166,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,45,, "PHB-CH1","PHB-CH1-166",166,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-166",166,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-166",166,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-166",166,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-166",166,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,30,, "PHB-CH1","PHB-CH1-166",166,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,217,, "PHB-CH1","PHB-CH1-166",166,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-166",166,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-166",166,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-166",166,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-166",166,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,43.1,43.1,0 "PHB-CH1","PHB-CH1-166",166,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,51.8,43.1,8.7 "PHB-CH1","PHB-CH1-166",166,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,46.3,43.1,3.2 "PHB-CH1","PHB-CH1-166",166,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,40.4,43.1,-2.7 "PHB-CH1","PHB-CH1-166",166,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,27.8,27.8,0 "PHB-CH1","PHB-CH1-166",166,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,45.5,27.8,17.7 "PHB-CH1","PHB-CH1-166",166,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,43.8,27.8,16 "PHB-CH1","PHB-CH1-166",166,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,44.4,27.8,16.6 "PHB-CH1","PHB-CH1-166",166,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.5,4.5,0 "PHB-CH1","PHB-CH1-166",166,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.5,4.5,0 "PHB-CH1","PHB-CH1-166",166,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.6,4.5,0.0999999999999996 "PHB-CH1","PHB-CH1-166",166,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.8,4.5,-0.7 "PHB-CH1","PHB-CH1-166",166,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.1,4.5,-0.4 "PHB-CH1","PHB-CH1-166",166,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.6,4.5,-0.9 "PHB-CH1","PHB-CH1-166",166,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.7,4.5,-0.8 "PHB-CH1","PHB-CH1-166",166,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.8,4.5,-0.7 "PHB-CH1","PHB-CH1-166",166,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.9,4.5,-0.6 "PHB-CH1","PHB-CH1-166",166,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.6,4.5,-0.9 "PHB-CH1","PHB-CH1-166",166,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.9,4.5,-0.6 "PHB-CH1","PHB-CH1-166",166,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.7,4.5,0.2 "PHB-CH1","PHB-CH1-166",166,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.5,4.5,0 "PHB-CH1","PHB-CH1-166",166,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.9,4.5,0.4 "PHB-CH1","PHB-CH1-166",166,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-166",166,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6,5.4,0.6 "PHB-CH1","PHB-CH1-166",166,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.8,5.4,0.399999999999999 "PHB-CH1","PHB-CH1-166",166,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.4,5.4,0 "PHB-CH1","PHB-CH1-166",166,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.9,5.4,0.5 "PHB-CH1","PHB-CH1-166",166,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.9,5.4,0.5 "PHB-CH1","PHB-CH1-166",166,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.5,5.4,1.1 "PHB-CH1","PHB-CH1-166",166,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.4,5.4,1 "PHB-CH1","PHB-CH1-166",166,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.6,5.4,1.2 "PHB-CH1","PHB-CH1-166",166,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.8,5.4,1.4 "PHB-CH1","PHB-CH1-166",166,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,8.2,5.4,2.8 "PHB-CH1","PHB-CH1-166",166,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.9,5.4,1.5 "PHB-CH1","PHB-CH1-166",166,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.4,5.4,1 "PHB-CH1","PHB-CH1-166",166,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.5,5.4,2.1 "PHB-CH1","PHB-CH1-167",167,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,47,47,0 "PHB-CH1","PHB-CH1-167",167,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,44,47,-3 "PHB-CH1","PHB-CH1-167",167,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,49,47,2 "PHB-CH1","PHB-CH1-167",167,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,65,, "PHB-CH1","PHB-CH1-167",167,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,55,, "PHB-CH1","PHB-CH1-167",167,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,34,, "PHB-CH1","PHB-CH1-167",167,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-167",167,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-167",167,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-167",167,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,5,, "PHB-CH1","PHB-CH1-167",167,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,30,, "PHB-CH1","PHB-CH1-167",167,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,244,, "PHB-CH1","PHB-CH1-167",167,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-167",167,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-167",167,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-167",167,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-167",167,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,42.9,42.9,0 "PHB-CH1","PHB-CH1-167",167,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,44.5,42.9,1.6 "PHB-CH1","PHB-CH1-167",167,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,53.4,42.9,10.5 "PHB-CH1","PHB-CH1-167",167,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,51.1,42.9,8.2 "PHB-CH1","PHB-CH1-167",167,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,45.4,45.4,0 "PHB-CH1","PHB-CH1-167",167,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,58.9,45.4,13.5 "PHB-CH1","PHB-CH1-167",167,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,45.1,45.4,-0.299999999999997 "PHB-CH1","PHB-CH1-167",167,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,44.1,45.4,-1.3 "PHB-CH1","PHB-CH1-167",167,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,0.6,0.6,0 "PHB-CH1","PHB-CH1-167",167,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,1.2,0.6,0.6 "PHB-CH1","PHB-CH1-167",167,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.7,0.6,2.1 "PHB-CH1","PHB-CH1-167",167,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,0.9,0.6,0.3 "PHB-CH1","PHB-CH1-167",167,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,0.6,0.6,0 "PHB-CH1","PHB-CH1-167",167,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,0.5,0.6,-0.1 "PHB-CH1","PHB-CH1-167",167,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,1.8,0.6,1.2 "PHB-CH1","PHB-CH1-167",167,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,0.8,0.6,0.2 "PHB-CH1","PHB-CH1-167",167,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,1.1,0.6,0.5 "PHB-CH1","PHB-CH1-167",167,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,0.9,0.6,0.3 "PHB-CH1","PHB-CH1-167",167,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,0.6,0.6,0 "PHB-CH1","PHB-CH1-167",167,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,0.1,0.6,-0.5 "PHB-CH1","PHB-CH1-167",167,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,0.7,0.6,0.1 "PHB-CH1","PHB-CH1-167",167,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,0.2,0.6,-0.4 "PHB-CH1","PHB-CH1-167",167,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7.4,7.4,0 "PHB-CH1","PHB-CH1-167",167,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.5,7.4,-0.9 "PHB-CH1","PHB-CH1-167",167,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,8.1,7.4,0.699999999999999 "PHB-CH1","PHB-CH1-167",167,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.8,7.4,-0.6 "PHB-CH1","PHB-CH1-167",167,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.7,7.4,-2.7 "PHB-CH1","PHB-CH1-167",167,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.9,7.4,-2.5 "PHB-CH1","PHB-CH1-167",167,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.4,7.4,-2 "PHB-CH1","PHB-CH1-167",167,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.3,7.4,-2.1 "PHB-CH1","PHB-CH1-167",167,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.2,7.4,-1.2 "PHB-CH1","PHB-CH1-167",167,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7,7.4,-0.4 "PHB-CH1","PHB-CH1-167",167,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.4,7.4,-2 "PHB-CH1","PHB-CH1-167",167,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.5,7.4,-2.9 "PHB-CH1","PHB-CH1-167",167,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6,7.4,-1.4 "PHB-CH1","PHB-CH1-167",167,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.8,7.4,-1.6 "PHB-CH1","PHB-CH1-168",168,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,70,70,0 "PHB-CH1","PHB-CH1-168",168,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,61,70,-9 "PHB-CH1","PHB-CH1-168",168,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,63,70,-7 "PHB-CH1","PHB-CH1-168",168,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,57,, "PHB-CH1","PHB-CH1-168",168,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,49,, "PHB-CH1","PHB-CH1-168",168,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,38,, "PHB-CH1","PHB-CH1-168",168,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-168",168,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-168",168,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-168",168,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-168",168,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,10,, "PHB-CH1","PHB-CH1-168",168,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,425,, "PHB-CH1","PHB-CH1-168",168,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-168",168,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-168",168,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-168",168,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-168",168,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,31.4,31.4,0 "PHB-CH1","PHB-CH1-168",168,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,16.5,31.4,-14.9 "PHB-CH1","PHB-CH1-168",168,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,28.4,31.4,-3 "PHB-CH1","PHB-CH1-168",168,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,19.7,31.4,-11.7 "PHB-CH1","PHB-CH1-168",168,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,45.9,45.9,0 "PHB-CH1","PHB-CH1-168",168,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,53.2,45.9,7.3 "PHB-CH1","PHB-CH1-168",168,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,29.3,45.9,-16.6 "PHB-CH1","PHB-CH1-168",168,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,50.2,45.9,4.3 "PHB-CH1","PHB-CH1-168",168,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,7.1,7.1,0 "PHB-CH1","PHB-CH1-168",168,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,8.9,7.1,1.8 "PHB-CH1","PHB-CH1-168",168,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.8,7.1,-0.3 "PHB-CH1","PHB-CH1-168",168,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.6,7.1,-1.5 "PHB-CH1","PHB-CH1-168",168,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6,7.1,-1.1 "PHB-CH1","PHB-CH1-168",168,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.3,7.1,-1.8 "PHB-CH1","PHB-CH1-168",168,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5,7.1,-2.1 "PHB-CH1","PHB-CH1-168",168,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6,7.1,-1.1 "PHB-CH1","PHB-CH1-168",168,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.2,7.1,-0.9 "PHB-CH1","PHB-CH1-168",168,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.7,7.1,-1.4 "PHB-CH1","PHB-CH1-168",168,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,7.4,7.1,0.300000000000001 "PHB-CH1","PHB-CH1-168",168,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.3,7.1,-0.8 "PHB-CH1","PHB-CH1-168",168,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.6,7.1,-1.5 "PHB-CH1","PHB-CH1-168",168,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.4,7.1,-2.7 "PHB-CH1","PHB-CH1-168",168,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7.5,7.5,0 "PHB-CH1","PHB-CH1-168",168,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,9.8,7.5,2.3 "PHB-CH1","PHB-CH1-168",168,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7.3,7.5,-0.2 "PHB-CH1","PHB-CH1-168",168,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.5,7.5,-1 "PHB-CH1","PHB-CH1-168",168,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,7,7.5,-0.5 "PHB-CH1","PHB-CH1-168",168,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.8,7.5,-0.7 "PHB-CH1","PHB-CH1-168",168,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7.2,7.5,-0.3 "PHB-CH1","PHB-CH1-168",168,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,7.7,7.5,0.2 "PHB-CH1","PHB-CH1-168",168,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.4,7.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-168",168,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.2,7.5,-2.3 "PHB-CH1","PHB-CH1-168",168,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.3,7.5,-0.2 "PHB-CH1","PHB-CH1-168",168,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7.9,7.5,0.4 "PHB-CH1","PHB-CH1-168",168,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.5,7.5,-1 "PHB-CH1","PHB-CH1-168",168,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.2,7.5,-1.3 "PHB-CH1","PHB-CH1-169",169,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,58,58,0 "PHB-CH1","PHB-CH1-169",169,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,69,58,11 "PHB-CH1","PHB-CH1-169",169,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,66,58,8 "PHB-CH1","PHB-CH1-169",169,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,61,, "PHB-CH1","PHB-CH1-169",169,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,52,, "PHB-CH1","PHB-CH1-169",169,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,65,, "PHB-CH1","PHB-CH1-169",169,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-169",169,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-169",169,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-169",169,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,5,, "PHB-CH1","PHB-CH1-169",169,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,33,, "PHB-CH1","PHB-CH1-169",169,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,211,, "PHB-CH1","PHB-CH1-169",169,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-169",169,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-169",169,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-169",169,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-169",169,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,70.4,70.4,0 "PHB-CH1","PHB-CH1-169",169,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,59.9,70.4,-10.5 "PHB-CH1","PHB-CH1-169",169,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,65.4,70.4,-5 "PHB-CH1","PHB-CH1-169",169,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,63.7,70.4,-6.7 "PHB-CH1","PHB-CH1-169",169,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,60.9,60.9,0 "PHB-CH1","PHB-CH1-169",169,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,60.4,60.9,-0.5 "PHB-CH1","PHB-CH1-169",169,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,65.5,60.9,4.6 "PHB-CH1","PHB-CH1-169",169,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,61.3,60.9,0.399999999999999 "PHB-CH1","PHB-CH1-169",169,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.5,6.5,0 "PHB-CH1","PHB-CH1-169",169,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.5,6.5,0 "PHB-CH1","PHB-CH1-169",169,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.2,6.5,-1.3 "PHB-CH1","PHB-CH1-169",169,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.2,6.5,-0.3 "PHB-CH1","PHB-CH1-169",169,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.4,6.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-169",169,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.9,6.5,0.4 "PHB-CH1","PHB-CH1-169",169,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.7,6.5,-0.8 "PHB-CH1","PHB-CH1-169",169,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.7,6.5,-0.8 "PHB-CH1","PHB-CH1-169",169,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.1,6.5,-0.4 "PHB-CH1","PHB-CH1-169",169,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5,6.5,-1.5 "PHB-CH1","PHB-CH1-169",169,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.1,6.5,-0.4 "PHB-CH1","PHB-CH1-169",169,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.8,6.5,-1.7 "PHB-CH1","PHB-CH1-169",169,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.7,6.5,-0.8 "PHB-CH1","PHB-CH1-169",169,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.6,6.5,-0.9 "PHB-CH1","PHB-CH1-169",169,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.1,6.1,0 "PHB-CH1","PHB-CH1-169",169,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.5,6.1,-0.6 "PHB-CH1","PHB-CH1-169",169,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.5,6.1,-0.6 "PHB-CH1","PHB-CH1-169",169,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.8,6.1,-0.3 "PHB-CH1","PHB-CH1-169",169,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.2,6.1,-0.9 "PHB-CH1","PHB-CH1-169",169,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.4,6.1,0.300000000000001 "PHB-CH1","PHB-CH1-169",169,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.5,6.1,-0.6 "PHB-CH1","PHB-CH1-169",169,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.6,6.1,0.5 "PHB-CH1","PHB-CH1-169",169,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.2,6.1,1.1 "PHB-CH1","PHB-CH1-169",169,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.2,6.1,-0.9 "PHB-CH1","PHB-CH1-169",169,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.6,6.1,-0.5 "PHB-CH1","PHB-CH1-169",169,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5,6.1,-1.1 "PHB-CH1","PHB-CH1-169",169,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.6,6.1,-0.5 "PHB-CH1","PHB-CH1-169",169,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.3,6.1,-0.8 "PHB-CH1","PHB-CH1-170",170,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,36,36,0 "PHB-CH1","PHB-CH1-170",170,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,34,36,-2 "PHB-CH1","PHB-CH1-170",170,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,16,36,-20 "PHB-CH1","PHB-CH1-170",170,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,44,, "PHB-CH1","PHB-CH1-170",170,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,44,, "PHB-CH1","PHB-CH1-170",170,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,68,, "PHB-CH1","PHB-CH1-170",170,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-170",170,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-170",170,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,5,, "PHB-CH1","PHB-CH1-170",170,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,5,, "PHB-CH1","PHB-CH1-170",170,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,22,, "PHB-CH1","PHB-CH1-170",170,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,394,, "PHB-CH1","PHB-CH1-170",170,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-170",170,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-170",170,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-170",170,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-170",170,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,41.6,41.6,0 "PHB-CH1","PHB-CH1-170",170,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,52.8,41.6,11.2 "PHB-CH1","PHB-CH1-170",170,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,62,41.6,20.4 "PHB-CH1","PHB-CH1-170",170,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,50.6,41.6,9 "PHB-CH1","PHB-CH1-170",170,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,57.8,57.8,0 "PHB-CH1","PHB-CH1-170",170,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,49.1,57.8,-8.7 "PHB-CH1","PHB-CH1-170",170,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,41.8,57.8,-16 "PHB-CH1","PHB-CH1-170",170,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,47,57.8,-10.8 "PHB-CH1","PHB-CH1-170",170,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.2,6.2,0 "PHB-CH1","PHB-CH1-170",170,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.3,6.2,0.0999999999999996 "PHB-CH1","PHB-CH1-170",170,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.5,6.2,-1.7 "PHB-CH1","PHB-CH1-170",170,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.9,6.2,-3.3 "PHB-CH1","PHB-CH1-170",170,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,2.9,6.2,-3.3 "PHB-CH1","PHB-CH1-170",170,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.6,6.2,-2.6 "PHB-CH1","PHB-CH1-170",170,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.2,6.2,-2 "PHB-CH1","PHB-CH1-170",170,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.9,6.2,-1.3 "PHB-CH1","PHB-CH1-170",170,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.8,6.2,-2.4 "PHB-CH1","PHB-CH1-170",170,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.8,6.2,-1.4 "PHB-CH1","PHB-CH1-170",170,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.6,6.2,-0.6 "PHB-CH1","PHB-CH1-170",170,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.1,6.2,-2.1 "PHB-CH1","PHB-CH1-170",170,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4,6.2,-2.2 "PHB-CH1","PHB-CH1-170",170,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.8,6.2,-1.4 "PHB-CH1","PHB-CH1-170",170,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.7,2.7,0 "PHB-CH1","PHB-CH1-170",170,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.5,2.7,0.8 "PHB-CH1","PHB-CH1-170",170,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,2.8,2.7,0.0999999999999996 "PHB-CH1","PHB-CH1-170",170,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,2.8,2.7,0.0999999999999996 "PHB-CH1","PHB-CH1-170",170,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,2.6,2.7,-0.1 "PHB-CH1","PHB-CH1-170",170,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,2.1,2.7,-0.6 "PHB-CH1","PHB-CH1-170",170,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,2.4,2.7,-0.3 "PHB-CH1","PHB-CH1-170",170,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.9,2.7,0.2 "PHB-CH1","PHB-CH1-170",170,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.8,2.7,1.1 "PHB-CH1","PHB-CH1-170",170,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.3,2.7,0.6 "PHB-CH1","PHB-CH1-170",170,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.9,2.7,1.2 "PHB-CH1","PHB-CH1-170",170,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,2.6,2.7,-0.1 "PHB-CH1","PHB-CH1-170",170,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.2,2.7,0.5 "PHB-CH1","PHB-CH1-170",170,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.1,2.7,0.4 "PHB-CH1","PHB-CH1-171",171,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,64,64,0 "PHB-CH1","PHB-CH1-171",171,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,69,64,5 "PHB-CH1","PHB-CH1-171",171,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,70,64,6 "PHB-CH1","PHB-CH1-171",171,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,54,, "PHB-CH1","PHB-CH1-171",171,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,59,, "PHB-CH1","PHB-CH1-171",171,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,91,, "PHB-CH1","PHB-CH1-171",171,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-171",171,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-171",171,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-171",171,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-171",171,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,2,, "PHB-CH1","PHB-CH1-171",171,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,475,, "PHB-CH1","PHB-CH1-171",171,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-171",171,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-171",171,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-171",171,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,5,, "PHB-CH1","PHB-CH1-171",171,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,57.4,57.4,0 "PHB-CH1","PHB-CH1-171",171,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,38.7,57.4,-18.7 "PHB-CH1","PHB-CH1-171",171,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,55,57.4,-2.4 "PHB-CH1","PHB-CH1-171",171,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,47.9,57.4,-9.5 "PHB-CH1","PHB-CH1-171",171,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,43.3,43.3,0 "PHB-CH1","PHB-CH1-171",171,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,40.5,43.3,-2.8 "PHB-CH1","PHB-CH1-171",171,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,51.8,43.3,8.5 "PHB-CH1","PHB-CH1-171",171,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,42.5,43.3,-0.799999999999997 "PHB-CH1","PHB-CH1-171",171,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.5,4.5,0 "PHB-CH1","PHB-CH1-171",171,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.9,4.5,0.4 "PHB-CH1","PHB-CH1-171",171,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.3,4.5,-0.2 "PHB-CH1","PHB-CH1-171",171,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.2,4.5,0.7 "PHB-CH1","PHB-CH1-171",171,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4,4.5,-0.5 "PHB-CH1","PHB-CH1-171",171,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.6,4.5,-0.9 "PHB-CH1","PHB-CH1-171",171,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.4,4.5,-1.1 "PHB-CH1","PHB-CH1-171",171,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5,4.5,0.5 "PHB-CH1","PHB-CH1-171",171,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5,4.5,0.5 "PHB-CH1","PHB-CH1-171",171,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5,4.5,0.5 "PHB-CH1","PHB-CH1-171",171,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.5,4.5,2 "PHB-CH1","PHB-CH1-171",171,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.5,4.5,1 "PHB-CH1","PHB-CH1-171",171,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.7,4.5,0.2 "PHB-CH1","PHB-CH1-171",171,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.9,4.5,1.4 "PHB-CH1","PHB-CH1-171",171,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-171",171,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.1,4.7,0.399999999999999 "PHB-CH1","PHB-CH1-171",171,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.2,4.7,-0.5 "PHB-CH1","PHB-CH1-171",171,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.1,4.7,-0.6 "PHB-CH1","PHB-CH1-171",171,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.2,4.7,-0.5 "PHB-CH1","PHB-CH1-171",171,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.8,4.7,-0.9 "PHB-CH1","PHB-CH1-171",171,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.7,4.7,-1 "PHB-CH1","PHB-CH1-171",171,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.2,4.7,-0.5 "PHB-CH1","PHB-CH1-171",171,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.2,4.7,0.5 "PHB-CH1","PHB-CH1-171",171,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.7,4.7,0 "PHB-CH1","PHB-CH1-171",171,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.1,4.7,0.399999999999999 "PHB-CH1","PHB-CH1-171",171,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-171",171,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.7,4.7,-1 "PHB-CH1","PHB-CH1-171",171,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.8,4.7,1.1 "PHB-CH1","PHB-CH1-172",172,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,56,56,0 "PHB-CH1","PHB-CH1-172",172,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,46,56,-10 "PHB-CH1","PHB-CH1-172",172,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,53,56,-3 "PHB-CH1","PHB-CH1-172",172,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,51,, "PHB-CH1","PHB-CH1-172",172,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,68,, "PHB-CH1","PHB-CH1-172",172,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,34,, "PHB-CH1","PHB-CH1-172",172,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-172",172,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-172",172,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-172",172,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-172",172,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,21,, "PHB-CH1","PHB-CH1-172",172,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,296,, "PHB-CH1","PHB-CH1-172",172,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-172",172,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-172",172,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-172",172,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-172",172,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,7.1,7.1,0 "PHB-CH1","PHB-CH1-172",172,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,18,7.1,10.9 "PHB-CH1","PHB-CH1-172",172,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,19.7,7.1,12.6 "PHB-CH1","PHB-CH1-172",172,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,19.9,7.1,12.8 "PHB-CH1","PHB-CH1-172",172,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,47.2,47.2,0 "PHB-CH1","PHB-CH1-172",172,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,47,47.2,-0.200000000000003 "PHB-CH1","PHB-CH1-172",172,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,25.5,47.2,-21.7 "PHB-CH1","PHB-CH1-172",172,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,48.5,47.2,1.3 "PHB-CH1","PHB-CH1-172",172,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.8,4.8,0 "PHB-CH1","PHB-CH1-172",172,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.6,4.8,-0.2 "PHB-CH1","PHB-CH1-172",172,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.9,4.8,1.1 "PHB-CH1","PHB-CH1-172",172,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.7,4.8,0.9 "PHB-CH1","PHB-CH1-172",172,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.7,4.8,1.9 "PHB-CH1","PHB-CH1-172",172,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.2,4.8,-0.6 "PHB-CH1","PHB-CH1-172",172,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.3,4.8,-0.5 "PHB-CH1","PHB-CH1-172",172,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.1,4.8,-0.7 "PHB-CH1","PHB-CH1-172",172,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.5,4.8,-0.3 "PHB-CH1","PHB-CH1-172",172,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.1,4.8,-0.7 "PHB-CH1","PHB-CH1-172",172,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.7,4.8,0.9 "PHB-CH1","PHB-CH1-172",172,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.7,4.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-172",172,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.6,4.8,0.8 "PHB-CH1","PHB-CH1-172",172,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.9,4.8,1.1 "PHB-CH1","PHB-CH1-172",172,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-172",172,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.9,4.7,1.2 "PHB-CH1","PHB-CH1-172",172,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.8,4.7,2.1 "PHB-CH1","PHB-CH1-172",172,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.2,4.7,1.5 "PHB-CH1","PHB-CH1-172",172,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.2,4.7,1.5 "PHB-CH1","PHB-CH1-172",172,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.6,4.7,-0.100000000000001 "PHB-CH1","PHB-CH1-172",172,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.8,4.7,1.1 "PHB-CH1","PHB-CH1-172",172,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5,4.7,0.3 "PHB-CH1","PHB-CH1-172",172,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.3,4.7,0.6 "PHB-CH1","PHB-CH1-172",172,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.3,4.7,-0.4 "PHB-CH1","PHB-CH1-172",172,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.1,4.7,1.4 "PHB-CH1","PHB-CH1-172",172,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-172",172,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.1,4.7,1.4 "PHB-CH1","PHB-CH1-172",172,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.5,4.7,0.8 "PHB-CH1","PHB-CH1-173",173,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,44,44,0 "PHB-CH1","PHB-CH1-173",173,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,40,44,-4 "PHB-CH1","PHB-CH1-173",173,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,48,44,4 "PHB-CH1","PHB-CH1-173",173,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,49,, "PHB-CH1","PHB-CH1-173",173,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,43,, "PHB-CH1","PHB-CH1-173",173,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,31,, "PHB-CH1","PHB-CH1-173",173,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-173",173,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-173",173,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-173",173,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-173",173,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,2,, "PHB-CH1","PHB-CH1-173",173,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,500,, "PHB-CH1","PHB-CH1-173",173,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-173",173,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-173",173,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-173",173,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-173",173,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,62.5,62.5,0 "PHB-CH1","PHB-CH1-173",173,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,63.9,62.5,1.4 "PHB-CH1","PHB-CH1-173",173,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,53,62.5,-9.5 "PHB-CH1","PHB-CH1-173",173,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,74.5,62.5,12 "PHB-CH1","PHB-CH1-173",173,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,53.4,53.4,0 "PHB-CH1","PHB-CH1-173",173,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,72,53.4,18.6 "PHB-CH1","PHB-CH1-173",173,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,53.2,53.4,-0.199999999999996 "PHB-CH1","PHB-CH1-173",173,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,66.3,53.4,12.9 "PHB-CH1","PHB-CH1-173",173,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3,3,0 "PHB-CH1","PHB-CH1-173",173,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.1,3,1.1 "PHB-CH1","PHB-CH1-173",173,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.9,3,0.9 "PHB-CH1","PHB-CH1-173",173,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.6,3,2.6 "PHB-CH1","PHB-CH1-173",173,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.9,3,2.9 "PHB-CH1","PHB-CH1-173",173,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.5,3,2.5 "PHB-CH1","PHB-CH1-173",173,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.9,3,3.9 "PHB-CH1","PHB-CH1-173",173,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.1,3,3.1 "PHB-CH1","PHB-CH1-173",173,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.2,3,3.2 "PHB-CH1","PHB-CH1-173",173,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.4,3,2.4 "PHB-CH1","PHB-CH1-173",173,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.6,3,2.6 "PHB-CH1","PHB-CH1-173",173,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.8,3,2.8 "PHB-CH1","PHB-CH1-173",173,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.5,3,3.5 "PHB-CH1","PHB-CH1-173",173,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.1,3,2.1 "PHB-CH1","PHB-CH1-173",173,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,0.1,0.1,0 "PHB-CH1","PHB-CH1-173",173,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,0,0.1,-0.1 "PHB-CH1","PHB-CH1-173",173,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,0.7,0.1,0.6 "PHB-CH1","PHB-CH1-173",173,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,1.1,0.1,1 "PHB-CH1","PHB-CH1-173",173,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,0.5,0.1,0.4 "PHB-CH1","PHB-CH1-173",173,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,0.5,0.1,0.4 "PHB-CH1","PHB-CH1-173",173,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.4,0.1,3.3 "PHB-CH1","PHB-CH1-173",173,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,1,0.1,0.9 "PHB-CH1","PHB-CH1-173",173,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,1.8,0.1,1.7 "PHB-CH1","PHB-CH1-173",173,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,1.8,0.1,1.7 "PHB-CH1","PHB-CH1-173",173,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,1.8,0.1,1.7 "PHB-CH1","PHB-CH1-173",173,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,2.5,0.1,2.4 "PHB-CH1","PHB-CH1-173",173,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3,0.1,2.9 "PHB-CH1","PHB-CH1-173",173,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,1.4,0.1,1.3 "PHB-CH1","PHB-CH1-174",174,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,72,72,0 "PHB-CH1","PHB-CH1-174",174,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,57,72,-15 "PHB-CH1","PHB-CH1-174",174,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,81,72,9 "PHB-CH1","PHB-CH1-174",174,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,57,, "PHB-CH1","PHB-CH1-174",174,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,81,, "PHB-CH1","PHB-CH1-174",174,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,52,, "PHB-CH1","PHB-CH1-174",174,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-174",174,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-174",174,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-174",174,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-174",174,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,6,, "PHB-CH1","PHB-CH1-174",174,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,415,, "PHB-CH1","PHB-CH1-174",174,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-174",174,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-174",174,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-174",174,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-174",174,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,35.6,35.6,0 "PHB-CH1","PHB-CH1-174",174,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,28.2,35.6,-7.4 "PHB-CH1","PHB-CH1-174",174,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,19.1,35.6,-16.5 "PHB-CH1","PHB-CH1-174",174,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,27.6,35.6,-8 "PHB-CH1","PHB-CH1-174",174,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,30.8,30.8,0 "PHB-CH1","PHB-CH1-174",174,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,24.2,30.8,-6.6 "PHB-CH1","PHB-CH1-174",174,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,36.8,30.8,6 "PHB-CH1","PHB-CH1-174",174,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,31.5,30.8,0.699999999999999 "PHB-CH1","PHB-CH1-174",174,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.9,3.9,0 "PHB-CH1","PHB-CH1-174",174,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.4,3.9,0.5 "PHB-CH1","PHB-CH1-174",174,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.2,3.9,-0.7 "PHB-CH1","PHB-CH1-174",174,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.5,3.9,0.6 "PHB-CH1","PHB-CH1-174",174,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.2,3.9,-0.7 "PHB-CH1","PHB-CH1-174",174,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2.9,3.9,-1 "PHB-CH1","PHB-CH1-174",174,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.4,3.9,0.5 "PHB-CH1","PHB-CH1-174",174,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.4,3.9,0.5 "PHB-CH1","PHB-CH1-174",174,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.4,3.9,1.5 "PHB-CH1","PHB-CH1-174",174,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.5,3.9,1.6 "PHB-CH1","PHB-CH1-174",174,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.9,3.9,0 "PHB-CH1","PHB-CH1-174",174,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.1,3.9,0.2 "PHB-CH1","PHB-CH1-174",174,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4,3.9,0.1 "PHB-CH1","PHB-CH1-174",174,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.3,3.9,0.4 "PHB-CH1","PHB-CH1-174",174,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.7,2.7,0 "PHB-CH1","PHB-CH1-174",174,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,2.9,2.7,0.2 "PHB-CH1","PHB-CH1-174",174,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.3,2.7,0.6 "PHB-CH1","PHB-CH1-174",174,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.3,2.7,1.6 "PHB-CH1","PHB-CH1-174",174,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.7,2.7,2 "PHB-CH1","PHB-CH1-174",174,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.1,2.7,2.4 "PHB-CH1","PHB-CH1-174",174,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.9,2.7,1.2 "PHB-CH1","PHB-CH1-174",174,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.2,2.7,0.5 "PHB-CH1","PHB-CH1-174",174,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.5,2.7,2.8 "PHB-CH1","PHB-CH1-174",174,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.7,2.7,2 "PHB-CH1","PHB-CH1-174",174,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.3,2.7,1.6 "PHB-CH1","PHB-CH1-174",174,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.8,2.7,1.1 "PHB-CH1","PHB-CH1-174",174,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.1,2.7,0.4 "PHB-CH1","PHB-CH1-174",174,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,2.6,2.7,-0.1 "PHB-CH1","PHB-CH1-175",175,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,55,55,0 "PHB-CH1","PHB-CH1-175",175,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,49,55,-6 "PHB-CH1","PHB-CH1-175",175,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,58,55,3 "PHB-CH1","PHB-CH1-175",175,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,48,, "PHB-CH1","PHB-CH1-175",175,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,61,, "PHB-CH1","PHB-CH1-175",175,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,43,, "PHB-CH1","PHB-CH1-175",175,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-175",175,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,1,, "PHB-CH1","PHB-CH1-175",175,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-175",175,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-175",175,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,15,, "PHB-CH1","PHB-CH1-175",175,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,360,, "PHB-CH1","PHB-CH1-175",175,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-175",175,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-175",175,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-175",175,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-175",175,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,74.3,74.3,0 "PHB-CH1","PHB-CH1-175",175,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,64.4,74.3,-9.89999999999999 "PHB-CH1","PHB-CH1-175",175,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,60.3,74.3,-14 "PHB-CH1","PHB-CH1-175",175,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,70.1,74.3,-4.2 "PHB-CH1","PHB-CH1-175",175,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,86.8,86.8,0 "PHB-CH1","PHB-CH1-175",175,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,75.3,86.8,-11.5 "PHB-CH1","PHB-CH1-175",175,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,77.6,86.8,-9.2 "PHB-CH1","PHB-CH1-175",175,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,98.3,86.8,11.5 "PHB-CH1","PHB-CH1-175",175,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-175",175,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.9,4.7,-0.8 "PHB-CH1","PHB-CH1-175",175,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.6,4.7,-1.1 "PHB-CH1","PHB-CH1-175",175,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4,4.7,-0.7 "PHB-CH1","PHB-CH1-175",175,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,2.7,4.7,-2 "PHB-CH1","PHB-CH1-175",175,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2.5,4.7,-2.2 "PHB-CH1","PHB-CH1-175",175,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.9,4.7,-0.8 "PHB-CH1","PHB-CH1-175",175,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.6,4.7,-1.1 "PHB-CH1","PHB-CH1-175",175,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,2.6,4.7,-2.1 "PHB-CH1","PHB-CH1-175",175,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.1,4.7,-1.6 "PHB-CH1","PHB-CH1-175",175,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.5,4.7,-1.2 "PHB-CH1","PHB-CH1-175",175,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.4,4.7,-1.3 "PHB-CH1","PHB-CH1-175",175,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.3,4.7,-0.4 "PHB-CH1","PHB-CH1-175",175,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2.6,4.7,-2.1 "PHB-CH1","PHB-CH1-175",175,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-175",175,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5,5.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-175",175,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.4,5.1,0.300000000000001 "PHB-CH1","PHB-CH1-175",175,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,7,5.1,1.9 "PHB-CH1","PHB-CH1-175",175,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.6,5.1,-0.5 "PHB-CH1","PHB-CH1-175",175,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.4,5.1,-1.7 "PHB-CH1","PHB-CH1-175",175,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.5,5.1,0.4 "PHB-CH1","PHB-CH1-175",175,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5,5.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-175",175,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.7,5.1,-0.399999999999999 "PHB-CH1","PHB-CH1-175",175,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.4,5.1,-0.699999999999999 "PHB-CH1","PHB-CH1-175",175,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5,5.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-175",175,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5,5.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-175",175,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.1,5.1,0 "PHB-CH1","PHB-CH1-175",175,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.5,5.1,-0.6 "PHB-CH1","PHB-CH1-176",176,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,59,59,0 "PHB-CH1","PHB-CH1-176",176,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,67,59,8 "PHB-CH1","PHB-CH1-176",176,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,71,59,12 "PHB-CH1","PHB-CH1-176",176,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,57,, "PHB-CH1","PHB-CH1-176",176,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,58,, "PHB-CH1","PHB-CH1-176",176,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,47,, "PHB-CH1","PHB-CH1-176",176,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-176",176,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,1,, "PHB-CH1","PHB-CH1-176",176,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-176",176,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-176",176,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,29,, "PHB-CH1","PHB-CH1-176",176,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,262,, "PHB-CH1","PHB-CH1-176",176,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-176",176,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-176",176,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-176",176,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-176",176,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,58.9,58.9,0 "PHB-CH1","PHB-CH1-176",176,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,45.7,58.9,-13.2 "PHB-CH1","PHB-CH1-176",176,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,56.4,58.9,-2.5 "PHB-CH1","PHB-CH1-176",176,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,60.2,58.9,1.3 "PHB-CH1","PHB-CH1-176",176,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,64.1,64.1,0 "PHB-CH1","PHB-CH1-176",176,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,53.7,64.1,-10.4 "PHB-CH1","PHB-CH1-176",176,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,51.2,64.1,-12.9 "PHB-CH1","PHB-CH1-176",176,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,51.6,64.1,-12.5 "PHB-CH1","PHB-CH1-176",176,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.8,3.8,0 "PHB-CH1","PHB-CH1-176",176,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.9,3.8,0.1 "PHB-CH1","PHB-CH1-176",176,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.9,3.8,1.1 "PHB-CH1","PHB-CH1-176",176,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,2.7,3.8,-1.1 "PHB-CH1","PHB-CH1-176",176,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.1,3.8,-0.7 "PHB-CH1","PHB-CH1-176",176,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2.1,3.8,-1.7 "PHB-CH1","PHB-CH1-176",176,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.8,3.8,1 "PHB-CH1","PHB-CH1-176",176,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.5,3.8,-0.3 "PHB-CH1","PHB-CH1-176",176,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.2,3.8,0.4 "PHB-CH1","PHB-CH1-176",176,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.5,3.8,0.7 "PHB-CH1","PHB-CH1-176",176,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.1,3.8,0.3 "PHB-CH1","PHB-CH1-176",176,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.5,3.8,1.7 "PHB-CH1","PHB-CH1-176",176,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.4,3.8,0.6 "PHB-CH1","PHB-CH1-176",176,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.9,3.8,0.1 "PHB-CH1","PHB-CH1-176",176,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.1,3.1,0 "PHB-CH1","PHB-CH1-176",176,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.3,3.1,1.2 "PHB-CH1","PHB-CH1-176",176,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.6,3.1,2.5 "PHB-CH1","PHB-CH1-176",176,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.5,3.1,0.4 "PHB-CH1","PHB-CH1-176",176,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4,3.1,0.9 "PHB-CH1","PHB-CH1-176",176,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.1,3.1,0 "PHB-CH1","PHB-CH1-176",176,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.9,3.1,1.8 "PHB-CH1","PHB-CH1-176",176,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.7,3.1,1.6 "PHB-CH1","PHB-CH1-176",176,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.6,3.1,1.5 "PHB-CH1","PHB-CH1-176",176,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.1,3.1,2 "PHB-CH1","PHB-CH1-176",176,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.2,3.1,2.1 "PHB-CH1","PHB-CH1-176",176,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.4,3.1,1.3 "PHB-CH1","PHB-CH1-176",176,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.3,3.1,0.2 "PHB-CH1","PHB-CH1-176",176,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.7,3.1,0.6 "PHB-CH1","PHB-CH1-177",177,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,66,66,0 "PHB-CH1","PHB-CH1-177",177,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,61,66,-5 "PHB-CH1","PHB-CH1-177",177,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,66,66,0 "PHB-CH1","PHB-CH1-177",177,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,56,, "PHB-CH1","PHB-CH1-177",177,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,72,, "PHB-CH1","PHB-CH1-177",177,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,51,, "PHB-CH1","PHB-CH1-177",177,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-177",177,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-177",177,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-177",177,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-177",177,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,4,, "PHB-CH1","PHB-CH1-177",177,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,510,, "PHB-CH1","PHB-CH1-177",177,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-177",177,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-177",177,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-177",177,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-177",177,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,42.7,42.7,0 "PHB-CH1","PHB-CH1-177",177,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,48.6,42.7,5.9 "PHB-CH1","PHB-CH1-177",177,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,35.3,42.7,-7.40000000000001 "PHB-CH1","PHB-CH1-177",177,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,49.2,42.7,6.5 "PHB-CH1","PHB-CH1-177",177,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,21.2,21.2,0 "PHB-CH1","PHB-CH1-177",177,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,34.4,21.2,13.2 "PHB-CH1","PHB-CH1-177",177,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,25.4,21.2,4.2 "PHB-CH1","PHB-CH1-177",177,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,36.6,21.2,15.4 "PHB-CH1","PHB-CH1-177",177,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.9,6.9,0 "PHB-CH1","PHB-CH1-177",177,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.2,6.9,-0.7 "PHB-CH1","PHB-CH1-177",177,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7.7,6.9,0.8 "PHB-CH1","PHB-CH1-177",177,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,7.9,6.9,1 "PHB-CH1","PHB-CH1-177",177,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.1,6.9,-1.8 "PHB-CH1","PHB-CH1-177",177,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.1,6.9,-0.800000000000001 "PHB-CH1","PHB-CH1-177",177,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.4,6.9,-0.5 "PHB-CH1","PHB-CH1-177",177,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.9,6.9,-1 "PHB-CH1","PHB-CH1-177",177,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.5,6.9,-1.4 "PHB-CH1","PHB-CH1-177",177,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.2,6.9,-0.7 "PHB-CH1","PHB-CH1-177",177,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,7.2,6.9,0.3 "PHB-CH1","PHB-CH1-177",177,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.7,6.9,-1.2 "PHB-CH1","PHB-CH1-177",177,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.8,6.9,-1.1 "PHB-CH1","PHB-CH1-177",177,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,7.2,6.9,0.3 "PHB-CH1","PHB-CH1-177",177,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.6,3.6,0 "PHB-CH1","PHB-CH1-177",177,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3,3.6,-0.6 "PHB-CH1","PHB-CH1-177",177,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5,3.6,1.4 "PHB-CH1","PHB-CH1-177",177,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.6,3.6,1 "PHB-CH1","PHB-CH1-177",177,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.3,3.6,-0.3 "PHB-CH1","PHB-CH1-177",177,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.4,3.6,-0.2 "PHB-CH1","PHB-CH1-177",177,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.3,3.6,-0.3 "PHB-CH1","PHB-CH1-177",177,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,2.8,3.6,-0.8 "PHB-CH1","PHB-CH1-177",177,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.1,3.6,-0.5 "PHB-CH1","PHB-CH1-177",177,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.3,3.6,0.7 "PHB-CH1","PHB-CH1-177",177,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.6,3.6,0 "PHB-CH1","PHB-CH1-177",177,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.9,3.6,1.3 "PHB-CH1","PHB-CH1-177",177,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.4,3.6,1.8 "PHB-CH1","PHB-CH1-177",177,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.6,3.6,1 "PHB-CH1","PHB-CH1-178",178,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,49,49,0 "PHB-CH1","PHB-CH1-178",178,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,54,49,5 "PHB-CH1","PHB-CH1-178",178,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,27,49,-22 "PHB-CH1","PHB-CH1-178",178,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,67,, "PHB-CH1","PHB-CH1-178",178,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,52,, "PHB-CH1","PHB-CH1-178",178,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,50,, "PHB-CH1","PHB-CH1-178",178,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-178",178,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-178",178,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-178",178,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-178",178,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,12,, "PHB-CH1","PHB-CH1-178",178,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,420,, "PHB-CH1","PHB-CH1-178",178,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-178",178,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-178",178,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-178",178,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-178",178,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,34.8,34.8,0 "PHB-CH1","PHB-CH1-178",178,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,32.8,34.8,-2 "PHB-CH1","PHB-CH1-178",178,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,32.3,34.8,-2.5 "PHB-CH1","PHB-CH1-178",178,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,32.9,34.8,-1.9 "PHB-CH1","PHB-CH1-178",178,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,41.7,41.7,0 "PHB-CH1","PHB-CH1-178",178,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,56.5,41.7,14.8 "PHB-CH1","PHB-CH1-178",178,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,44.6,41.7,2.9 "PHB-CH1","PHB-CH1-178",178,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,59.2,41.7,17.5 "PHB-CH1","PHB-CH1-178",178,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,7.2,7.2,0 "PHB-CH1","PHB-CH1-178",178,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.8,7.2,-1.4 "PHB-CH1","PHB-CH1-178",178,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.6,7.2,-1.6 "PHB-CH1","PHB-CH1-178",178,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.7,7.2,-1.5 "PHB-CH1","PHB-CH1-178",178,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.2,7.2,-2 "PHB-CH1","PHB-CH1-178",178,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.8,7.2,-1.4 "PHB-CH1","PHB-CH1-178",178,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5,7.2,-2.2 "PHB-CH1","PHB-CH1-178",178,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.9,7.2,-1.3 "PHB-CH1","PHB-CH1-178",178,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.8,7.2,-1.4 "PHB-CH1","PHB-CH1-178",178,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.6,7.2,-1.6 "PHB-CH1","PHB-CH1-178",178,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.3,7.2,-0.9 "PHB-CH1","PHB-CH1-178",178,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,7.9,7.2,0.7 "PHB-CH1","PHB-CH1-178",178,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.2,7.2,-1 "PHB-CH1","PHB-CH1-178",178,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.8,7.2,-2.4 "PHB-CH1","PHB-CH1-178",178,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-178",178,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.7,5.4,-0.7 "PHB-CH1","PHB-CH1-178",178,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.3,5.4,-1.1 "PHB-CH1","PHB-CH1-178",178,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.7,5.4,-0.7 "PHB-CH1","PHB-CH1-178",178,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.5,5.4,-0.9 "PHB-CH1","PHB-CH1-178",178,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.5,5.4,-0.9 "PHB-CH1","PHB-CH1-178",178,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.7,5.4,-0.7 "PHB-CH1","PHB-CH1-178",178,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.2,5.4,-0.2 "PHB-CH1","PHB-CH1-178",178,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.8,5.4,0.399999999999999 "PHB-CH1","PHB-CH1-178",178,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5,5.4,-0.4 "PHB-CH1","PHB-CH1-178",178,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.6,5.4,0.199999999999999 "PHB-CH1","PHB-CH1-178",178,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.5,5.4,0.0999999999999996 "PHB-CH1","PHB-CH1-178",178,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.3,5.4,-0.100000000000001 "PHB-CH1","PHB-CH1-178",178,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.4,5.4,-2 "PHB-CH1","PHB-CH1-179",179,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,53,53,0 "PHB-CH1","PHB-CH1-179",179,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,38,53,-15 "PHB-CH1","PHB-CH1-179",179,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,43,53,-10 "PHB-CH1","PHB-CH1-179",179,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,46,, "PHB-CH1","PHB-CH1-179",179,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,25,, "PHB-CH1","PHB-CH1-179",179,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,24,, "PHB-CH1","PHB-CH1-179",179,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,5,, "PHB-CH1","PHB-CH1-179",179,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,5,, "PHB-CH1","PHB-CH1-179",179,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-179",179,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,5,, "PHB-CH1","PHB-CH1-179",179,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,26,, "PHB-CH1","PHB-CH1-179",179,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,254,, "PHB-CH1","PHB-CH1-179",179,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-179",179,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-179",179,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-179",179,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-179",179,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,50.3,50.3,0 "PHB-CH1","PHB-CH1-179",179,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,44.4,50.3,-5.9 "PHB-CH1","PHB-CH1-179",179,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,39.4,50.3,-10.9 "PHB-CH1","PHB-CH1-179",179,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,40.8,50.3,-9.5 "PHB-CH1","PHB-CH1-179",179,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,45.9,45.9,0 "PHB-CH1","PHB-CH1-179",179,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,40.3,45.9,-5.6 "PHB-CH1","PHB-CH1-179",179,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,51.1,45.9,5.2 "PHB-CH1","PHB-CH1-179",179,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,51.2,45.9,5.3 "PHB-CH1","PHB-CH1-179",179,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.1,5.1,0 "PHB-CH1","PHB-CH1-179",179,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.1,5.1,0 "PHB-CH1","PHB-CH1-179",179,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5,5.1,-0.0999999999999996 "PHB-CH1","PHB-CH1-179",179,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.4,5.1,-0.699999999999999 "PHB-CH1","PHB-CH1-179",179,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.6,5.1,-1.5 "PHB-CH1","PHB-CH1-179",179,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.5,5.1,-0.6 "PHB-CH1","PHB-CH1-179",179,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.1,5.1,-1 "PHB-CH1","PHB-CH1-179",179,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.6,5.1,-1.5 "PHB-CH1","PHB-CH1-179",179,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.2,5.1,-0.9 "PHB-CH1","PHB-CH1-179",179,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.8,5.1,-0.3 "PHB-CH1","PHB-CH1-179",179,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.2,5.1,-0.9 "PHB-CH1","PHB-CH1-179",179,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.8,5.1,-1.3 "PHB-CH1","PHB-CH1-179",179,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3,5.1,-2.1 "PHB-CH1","PHB-CH1-179",179,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.8,5.1,-1.3 "PHB-CH1","PHB-CH1-179",179,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.8,3.8,0 "PHB-CH1","PHB-CH1-179",179,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.2,3.8,0.4 "PHB-CH1","PHB-CH1-179",179,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.6,3.8,-0.2 "PHB-CH1","PHB-CH1-179",179,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,2.9,3.8,-0.9 "PHB-CH1","PHB-CH1-179",179,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,2.8,3.8,-1 "PHB-CH1","PHB-CH1-179",179,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.7,3.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-179",179,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.1,3.8,-0.7 "PHB-CH1","PHB-CH1-179",179,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.7,3.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-179",179,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.7,3.8,0.9 "PHB-CH1","PHB-CH1-179",179,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.1,3.8,0.3 "PHB-CH1","PHB-CH1-179",179,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4,3.8,0.2 "PHB-CH1","PHB-CH1-179",179,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.4,3.8,-0.4 "PHB-CH1","PHB-CH1-179",179,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2.5,3.8,-1.3 "PHB-CH1","PHB-CH1-179",179,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.1,3.8,0.3 "PHB-CH1","PHB-CH1-180",180,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,30,30,0 "PHB-CH1","PHB-CH1-180",180,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,30,30,0 "PHB-CH1","PHB-CH1-180",180,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,33,30,3 "PHB-CH1","PHB-CH1-180",180,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,37,, "PHB-CH1","PHB-CH1-180",180,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,33,, "PHB-CH1","PHB-CH1-180",180,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,64,, "PHB-CH1","PHB-CH1-180",180,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-180",180,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-180",180,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-180",180,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-180",180,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,10,, "PHB-CH1","PHB-CH1-180",180,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,431,, "PHB-CH1","PHB-CH1-180",180,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-180",180,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-180",180,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-180",180,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-180",180,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,34.8,34.8,0 "PHB-CH1","PHB-CH1-180",180,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,39.1,34.8,4.3 "PHB-CH1","PHB-CH1-180",180,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,46.4,34.8,11.6 "PHB-CH1","PHB-CH1-180",180,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,44.4,34.8,9.6 "PHB-CH1","PHB-CH1-180",180,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,56.2,56.2,0 "PHB-CH1","PHB-CH1-180",180,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,46,56.2,-10.2 "PHB-CH1","PHB-CH1-180",180,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,52.8,56.2,-3.40000000000001 "PHB-CH1","PHB-CH1-180",180,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,50.2,56.2,-6 "PHB-CH1","PHB-CH1-180",180,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.8,4.8,0 "PHB-CH1","PHB-CH1-180",180,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.9,4.8,2.1 "PHB-CH1","PHB-CH1-180",180,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.9,4.8,1.1 "PHB-CH1","PHB-CH1-180",180,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.1,4.8,0.3 "PHB-CH1","PHB-CH1-180",180,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.8,4.8,1 "PHB-CH1","PHB-CH1-180",180,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.2,4.8,1.4 "PHB-CH1","PHB-CH1-180",180,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.3,4.8,0.5 "PHB-CH1","PHB-CH1-180",180,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5,4.8,0.2 "PHB-CH1","PHB-CH1-180",180,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.3,4.8,-0.5 "PHB-CH1","PHB-CH1-180",180,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.3,4.8,-0.5 "PHB-CH1","PHB-CH1-180",180,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.8,4.8,1 "PHB-CH1","PHB-CH1-180",180,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.1,4.8,1.3 "PHB-CH1","PHB-CH1-180",180,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.1,4.8,0.3 "PHB-CH1","PHB-CH1-180",180,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.2,4.8,1.4 "PHB-CH1","PHB-CH1-180",180,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.6,2.6,0 "PHB-CH1","PHB-CH1-180",180,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.7,2.6,2.1 "PHB-CH1","PHB-CH1-180",180,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6,2.6,3.4 "PHB-CH1","PHB-CH1-180",180,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.3,2.6,1.7 "PHB-CH1","PHB-CH1-180",180,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.8,2.6,1.2 "PHB-CH1","PHB-CH1-180",180,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4,2.6,1.4 "PHB-CH1","PHB-CH1-180",180,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.4,2.6,0.8 "PHB-CH1","PHB-CH1-180",180,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.9,2.6,1.3 "PHB-CH1","PHB-CH1-180",180,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,2.5,2.6,-0.1 "PHB-CH1","PHB-CH1-180",180,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.4,2.6,0.8 "PHB-CH1","PHB-CH1-180",180,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.1,2.6,2.5 "PHB-CH1","PHB-CH1-180",180,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4,2.6,1.4 "PHB-CH1","PHB-CH1-180",180,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2,2.6,-0.6 "PHB-CH1","PHB-CH1-180",180,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.1,2.6,1.5 "PHB-CH1","PHB-CH1-181",181,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,55,55,0 "PHB-CH1","PHB-CH1-181",181,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,54,55,-1 "PHB-CH1","PHB-CH1-181",181,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,45,55,-10 "PHB-CH1","PHB-CH1-181",181,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,56,, "PHB-CH1","PHB-CH1-181",181,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,49,, "PHB-CH1","PHB-CH1-181",181,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,63,, "PHB-CH1","PHB-CH1-181",181,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-181",181,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-181",181,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-181",181,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-181",181,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,1,, "PHB-CH1","PHB-CH1-181",181,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,545,, "PHB-CH1","PHB-CH1-181",181,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-181",181,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-181",181,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-181",181,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-181",181,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,44.1,44.1,0 "PHB-CH1","PHB-CH1-181",181,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,35.1,44.1,-9 "PHB-CH1","PHB-CH1-181",181,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,40.2,44.1,-3.9 "PHB-CH1","PHB-CH1-181",181,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,54.5,44.1,10.4 "PHB-CH1","PHB-CH1-181",181,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,42.9,42.9,0 "PHB-CH1","PHB-CH1-181",181,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,58.8,42.9,15.9 "PHB-CH1","PHB-CH1-181",181,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,46.1,42.9,3.2 "PHB-CH1","PHB-CH1-181",181,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,57,42.9,14.1 "PHB-CH1","PHB-CH1-181",181,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.2,3.2,0 "PHB-CH1","PHB-CH1-181",181,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5,3.2,1.8 "PHB-CH1","PHB-CH1-181",181,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5,3.2,1.8 "PHB-CH1","PHB-CH1-181",181,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.8,3.2,1.6 "PHB-CH1","PHB-CH1-181",181,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.2,3.2,2 "PHB-CH1","PHB-CH1-181",181,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.1,3.2,0.9 "PHB-CH1","PHB-CH1-181",181,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.7,3.2,2.5 "PHB-CH1","PHB-CH1-181",181,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.2,3.2,3 "PHB-CH1","PHB-CH1-181",181,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.7,3.2,1.5 "PHB-CH1","PHB-CH1-181",181,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.1,3.2,-0.1 "PHB-CH1","PHB-CH1-181",181,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.6,3.2,1.4 "PHB-CH1","PHB-CH1-181",181,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.6,3.2,0.4 "PHB-CH1","PHB-CH1-181",181,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.6,3.2,2.4 "PHB-CH1","PHB-CH1-181",181,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.7,3.2,0.5 "PHB-CH1","PHB-CH1-181",181,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.8,6.8,0 "PHB-CH1","PHB-CH1-181",181,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,7.1,6.8,0.3 "PHB-CH1","PHB-CH1-181",181,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7.5,6.8,0.7 "PHB-CH1","PHB-CH1-181",181,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,7.4,6.8,0.6 "PHB-CH1","PHB-CH1-181",181,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,8.1,6.8,1.3 "PHB-CH1","PHB-CH1-181",181,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.5,6.8,-0.3 "PHB-CH1","PHB-CH1-181",181,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,7.3,6.8,0.5 "PHB-CH1","PHB-CH1-181",181,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,9,6.8,2.2 "PHB-CH1","PHB-CH1-181",181,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.8,6.8,0 "PHB-CH1","PHB-CH1-181",181,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.9,6.8,-0.9 "PHB-CH1","PHB-CH1-181",181,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.9,6.8,-0.9 "PHB-CH1","PHB-CH1-181",181,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.5,6.8,-0.3 "PHB-CH1","PHB-CH1-181",181,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,8.6,6.8,1.8 "PHB-CH1","PHB-CH1-181",181,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.8,6.8,1 "PHB-CH1","PHB-CH1-182",182,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,65,65,0 "PHB-CH1","PHB-CH1-182",182,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,57,65,-8 "PHB-CH1","PHB-CH1-182",182,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,63,65,-2 "PHB-CH1","PHB-CH1-182",182,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,53,, "PHB-CH1","PHB-CH1-182",182,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,58,, "PHB-CH1","PHB-CH1-182",182,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,59,, "PHB-CH1","PHB-CH1-182",182,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-182",182,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,4,, "PHB-CH1","PHB-CH1-182",182,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-182",182,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-182",182,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,22,, "PHB-CH1","PHB-CH1-182",182,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,263,, "PHB-CH1","PHB-CH1-182",182,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-182",182,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-182",182,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-182",182,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-182",182,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,25.1,25.1,0 "PHB-CH1","PHB-CH1-182",182,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,46.2,25.1,21.1 "PHB-CH1","PHB-CH1-182",182,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,49.3,25.1,24.2 "PHB-CH1","PHB-CH1-182",182,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,42.7,25.1,17.6 "PHB-CH1","PHB-CH1-182",182,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,50.5,50.5,0 "PHB-CH1","PHB-CH1-182",182,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,65.5,50.5,15 "PHB-CH1","PHB-CH1-182",182,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,52.9,50.5,2.4 "PHB-CH1","PHB-CH1-182",182,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,54.6,50.5,4.1 "PHB-CH1","PHB-CH1-182",182,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.6,4.6,0 "PHB-CH1","PHB-CH1-182",182,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.4,4.6,-0.199999999999999 "PHB-CH1","PHB-CH1-182",182,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.7,4.6,1.1 "PHB-CH1","PHB-CH1-182",182,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.8,4.6,1.2 "PHB-CH1","PHB-CH1-182",182,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.5,4.6,1.9 "PHB-CH1","PHB-CH1-182",182,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.2,4.6,1.6 "PHB-CH1","PHB-CH1-182",182,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.8,4.6,1.2 "PHB-CH1","PHB-CH1-182",182,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.5,4.6,0.9 "PHB-CH1","PHB-CH1-182",182,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.1,4.6,0.5 "PHB-CH1","PHB-CH1-182",182,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4.3,4.6,-0.3 "PHB-CH1","PHB-CH1-182",182,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.9,4.6,0.300000000000001 "PHB-CH1","PHB-CH1-182",182,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.3,4.6,0.7 "PHB-CH1","PHB-CH1-182",182,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.3,4.6,-0.3 "PHB-CH1","PHB-CH1-182",182,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4,4.6,-0.6 "PHB-CH1","PHB-CH1-182",182,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.1,4.1,0 "PHB-CH1","PHB-CH1-182",182,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.1,4.1,0 "PHB-CH1","PHB-CH1-182",182,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.9,4.1,-0.2 "PHB-CH1","PHB-CH1-182",182,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.9,4.1,-0.2 "PHB-CH1","PHB-CH1-182",182,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.3,4.1,1.2 "PHB-CH1","PHB-CH1-182",182,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.3,4.1,1.2 "PHB-CH1","PHB-CH1-182",182,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5,4.1,0.9 "PHB-CH1","PHB-CH1-182",182,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.1,4.1,1 "PHB-CH1","PHB-CH1-182",182,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.8,4.1,0.7 "PHB-CH1","PHB-CH1-182",182,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.3,4.1,0.2 "PHB-CH1","PHB-CH1-182",182,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.7,4.1,0.6 "PHB-CH1","PHB-CH1-182",182,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5,4.1,0.9 "PHB-CH1","PHB-CH1-182",182,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5,4.1,0.9 "PHB-CH1","PHB-CH1-182",182,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.4,4.1,0.300000000000001 "PHB-CH1","PHB-CH1-183",183,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,37,37,0 "PHB-CH1","PHB-CH1-183",183,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,44,37,7 "PHB-CH1","PHB-CH1-183",183,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,28,37,-9 "PHB-CH1","PHB-CH1-183",183,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,43,, "PHB-CH1","PHB-CH1-183",183,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,41,, "PHB-CH1","PHB-CH1-183",183,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,45,, "PHB-CH1","PHB-CH1-183",183,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-183",183,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,1,, "PHB-CH1","PHB-CH1-183",183,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-183",183,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-183",183,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,17,, "PHB-CH1","PHB-CH1-183",183,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,343,, "PHB-CH1","PHB-CH1-183",183,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-183",183,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-183",183,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-183",183,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-183",183,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,31.9,31.9,0 "PHB-CH1","PHB-CH1-183",183,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,39.8,31.9,7.9 "PHB-CH1","PHB-CH1-183",183,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,34.8,31.9,2.9 "PHB-CH1","PHB-CH1-183",183,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,43.4,31.9,11.5 "PHB-CH1","PHB-CH1-183",183,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,53,53,0 "PHB-CH1","PHB-CH1-183",183,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,54.1,53,1.1 "PHB-CH1","PHB-CH1-183",183,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,50.8,53,-2.2 "PHB-CH1","PHB-CH1-183",183,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,56.5,53,3.5 "PHB-CH1","PHB-CH1-183",183,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.2,3.2,0 "PHB-CH1","PHB-CH1-183",183,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.5,3.2,0.3 "PHB-CH1","PHB-CH1-183",183,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.5,3.2,0.3 "PHB-CH1","PHB-CH1-183",183,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.2,3.2,0 "PHB-CH1","PHB-CH1-183",183,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.6,3.2,0.4 "PHB-CH1","PHB-CH1-183",183,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.2,3.2,0 "PHB-CH1","PHB-CH1-183",183,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.2,3.2,1 "PHB-CH1","PHB-CH1-183",183,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.3,3.2,1.1 "PHB-CH1","PHB-CH1-183",183,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,2.6,3.2,-0.6 "PHB-CH1","PHB-CH1-183",183,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.9,3.2,0.7 "PHB-CH1","PHB-CH1-183",183,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.2,3.2,0 "PHB-CH1","PHB-CH1-183",183,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.4,3.2,1.2 "PHB-CH1","PHB-CH1-183",183,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.9,3.2,0.7 "PHB-CH1","PHB-CH1-183",183,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,1.7,3.2,-1.5 "PHB-CH1","PHB-CH1-183",183,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,8.2,8.2,0 "PHB-CH1","PHB-CH1-183",183,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,8.8,8.2,0.600000000000001 "PHB-CH1","PHB-CH1-183",183,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,8.5,8.2,0.300000000000001 "PHB-CH1","PHB-CH1-183",183,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,7.4,8.2,-0.799999999999999 "PHB-CH1","PHB-CH1-183",183,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,7.8,8.2,-0.399999999999999 "PHB-CH1","PHB-CH1-183",183,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.6,8.2,-1.6 "PHB-CH1","PHB-CH1-183",183,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,8.3,8.2,0.100000000000001 "PHB-CH1","PHB-CH1-183",183,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,7.3,8.2,-0.9 "PHB-CH1","PHB-CH1-183",183,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.6,8.2,-0.6 "PHB-CH1","PHB-CH1-183",183,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.5,8.2,-0.699999999999999 "PHB-CH1","PHB-CH1-183",183,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.9,8.2,-1.3 "PHB-CH1","PHB-CH1-183",183,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,8.1,8.2,-0.0999999999999996 "PHB-CH1","PHB-CH1-183",183,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.7,8.2,-0.499999999999999 "PHB-CH1","PHB-CH1-183",183,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,8.3,8.2,0.100000000000001 "PHB-CH1","PHB-CH1-184",184,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,47,47,0 "PHB-CH1","PHB-CH1-184",184,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,39,47,-8 "PHB-CH1","PHB-CH1-184",184,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,46,47,-1 "PHB-CH1","PHB-CH1-184",184,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,45,, "PHB-CH1","PHB-CH1-184",184,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,61,, "PHB-CH1","PHB-CH1-184",184,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,51,, "PHB-CH1","PHB-CH1-184",184,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-184",184,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-184",184,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-184",184,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-184",184,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,22,, "PHB-CH1","PHB-CH1-184",184,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,296,, "PHB-CH1","PHB-CH1-184",184,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-184",184,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-184",184,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-184",184,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-184",184,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,47.3,47.3,0 "PHB-CH1","PHB-CH1-184",184,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,31.1,47.3,-16.2 "PHB-CH1","PHB-CH1-184",184,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,55.4,47.3,8.1 "PHB-CH1","PHB-CH1-184",184,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,33,47.3,-14.3 "PHB-CH1","PHB-CH1-184",184,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,71.8,71.8,0 "PHB-CH1","PHB-CH1-184",184,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,62.4,71.8,-9.4 "PHB-CH1","PHB-CH1-184",184,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,67.4,71.8,-4.39999999999999 "PHB-CH1","PHB-CH1-184",184,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,54.5,71.8,-17.3 "PHB-CH1","PHB-CH1-184",184,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.6,3.6,0 "PHB-CH1","PHB-CH1-184",184,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.2,3.6,0.6 "PHB-CH1","PHB-CH1-184",184,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.9,3.6,1.3 "PHB-CH1","PHB-CH1-184",184,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3.7,3.6,0.1 "PHB-CH1","PHB-CH1-184",184,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.9,3.6,1.3 "PHB-CH1","PHB-CH1-184",184,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.7,3.6,0.1 "PHB-CH1","PHB-CH1-184",184,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.7,3.6,0.1 "PHB-CH1","PHB-CH1-184",184,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,2.8,3.6,-0.8 "PHB-CH1","PHB-CH1-184",184,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.1,3.6,0.5 "PHB-CH1","PHB-CH1-184",184,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.7,3.6,0.1 "PHB-CH1","PHB-CH1-184",184,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.6,3.6,0 "PHB-CH1","PHB-CH1-184",184,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.1,3.6,0.5 "PHB-CH1","PHB-CH1-184",184,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.9,3.6,1.3 "PHB-CH1","PHB-CH1-184",184,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5,3.6,1.4 "PHB-CH1","PHB-CH1-184",184,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-184",184,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.4,5.4,1 "PHB-CH1","PHB-CH1-184",184,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5,5.4,-0.4 "PHB-CH1","PHB-CH1-184",184,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.1,5.4,-1.3 "PHB-CH1","PHB-CH1-184",184,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.8,5.4,-0.6 "PHB-CH1","PHB-CH1-184",184,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.9,5.4,-0.5 "PHB-CH1","PHB-CH1-184",184,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.9,5.4,-1.5 "PHB-CH1","PHB-CH1-184",184,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.7,5.4,-1.7 "PHB-CH1","PHB-CH1-184",184,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.6,5.4,-0.800000000000001 "PHB-CH1","PHB-CH1-184",184,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.1,5.4,-0.300000000000001 "PHB-CH1","PHB-CH1-184",184,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.2,5.4,-1.2 "PHB-CH1","PHB-CH1-184",184,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.4,5.4,-1 "PHB-CH1","PHB-CH1-184",184,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.3,5.4,0.9 "PHB-CH1","PHB-CH1-184",184,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6.1,5.4,0.699999999999999 "PHB-CH1","PHB-CH1-185",185,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,53,53,0 "PHB-CH1","PHB-CH1-185",185,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,55,53,2 "PHB-CH1","PHB-CH1-185",185,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,48,53,-5 "PHB-CH1","PHB-CH1-185",185,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,44,, "PHB-CH1","PHB-CH1-185",185,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,45,, "PHB-CH1","PHB-CH1-185",185,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,37,, "PHB-CH1","PHB-CH1-185",185,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-185",185,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-185",185,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-185",185,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-185",185,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,9,, "PHB-CH1","PHB-CH1-185",185,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,357,, "PHB-CH1","PHB-CH1-185",185,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-185",185,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-185",185,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-185",185,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-185",185,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,48.1,48.1,0 "PHB-CH1","PHB-CH1-185",185,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,53.9,48.1,5.8 "PHB-CH1","PHB-CH1-185",185,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,53,48.1,4.9 "PHB-CH1","PHB-CH1-185",185,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,64.1,48.1,16 "PHB-CH1","PHB-CH1-185",185,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,57.1,57.1,0 "PHB-CH1","PHB-CH1-185",185,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,56,57.1,-1.1 "PHB-CH1","PHB-CH1-185",185,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,47.3,57.1,-9.8 "PHB-CH1","PHB-CH1-185",185,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,47.7,57.1,-9.4 "PHB-CH1","PHB-CH1-185",185,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.7,5.7,0 "PHB-CH1","PHB-CH1-185",185,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.4,5.7,0.7 "PHB-CH1","PHB-CH1-185",185,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.1,5.7,0.399999999999999 "PHB-CH1","PHB-CH1-185",185,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.8,5.7,0.0999999999999996 "PHB-CH1","PHB-CH1-185",185,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.5,5.7,-0.2 "PHB-CH1","PHB-CH1-185",185,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.8,5.7,1.1 "PHB-CH1","PHB-CH1-185",185,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.8,5.7,0.0999999999999996 "PHB-CH1","PHB-CH1-185",185,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.1,5.7,1.4 "PHB-CH1","PHB-CH1-185",185,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.6,5.7,0.9 "PHB-CH1","PHB-CH1-185",185,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.6,5.7,-0.100000000000001 "PHB-CH1","PHB-CH1-185",185,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.1,5.7,-0.6 "PHB-CH1","PHB-CH1-185",185,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.7,5.7,1 "PHB-CH1","PHB-CH1-185",185,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,5.2,5.7,-0.5 "PHB-CH1","PHB-CH1-185",185,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,7.7,5.7,2 "PHB-CH1","PHB-CH1-185",185,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,7.2,7.2,0 "PHB-CH1","PHB-CH1-185",185,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,8.2,7.2,0.999999999999999 "PHB-CH1","PHB-CH1-185",185,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7.5,7.2,0.3 "PHB-CH1","PHB-CH1-185",185,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,8.7,7.2,1.5 "PHB-CH1","PHB-CH1-185",185,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,8.3,7.2,1.1 "PHB-CH1","PHB-CH1-185",185,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,7.9,7.2,0.7 "PHB-CH1","PHB-CH1-185",185,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,8.4,7.2,1.2 "PHB-CH1","PHB-CH1-185",185,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,8.4,7.2,1.2 "PHB-CH1","PHB-CH1-185",185,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,7.6,7.2,0.399999999999999 "PHB-CH1","PHB-CH1-185",185,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,8.9,7.2,1.7 "PHB-CH1","PHB-CH1-185",185,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.8,7.2,0.6 "PHB-CH1","PHB-CH1-185",185,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,8.8,7.2,1.6 "PHB-CH1","PHB-CH1-185",185,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,7.9,7.2,0.7 "PHB-CH1","PHB-CH1-185",185,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,8,7.2,0.8 "PHB-CH1","PHB-CH1-186",186,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,43,43,0 "PHB-CH1","PHB-CH1-186",186,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,46,43,3 "PHB-CH1","PHB-CH1-186",186,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,38,43,-5 "PHB-CH1","PHB-CH1-186",186,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,50,, "PHB-CH1","PHB-CH1-186",186,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,45,, "PHB-CH1","PHB-CH1-186",186,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,53,, "PHB-CH1","PHB-CH1-186",186,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-186",186,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-186",186,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-186",186,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-186",186,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,27,, "PHB-CH1","PHB-CH1-186",186,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,268,, "PHB-CH1","PHB-CH1-186",186,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-186",186,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-186",186,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-186",186,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-186",186,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,43.4,43.4,0 "PHB-CH1","PHB-CH1-186",186,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,29.6,43.4,-13.8 "PHB-CH1","PHB-CH1-186",186,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,20.3,43.4,-23.1 "PHB-CH1","PHB-CH1-186",186,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,36.9,43.4,-6.5 "PHB-CH1","PHB-CH1-186",186,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,46.3,46.3,0 "PHB-CH1","PHB-CH1-186",186,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,42.9,46.3,-3.4 "PHB-CH1","PHB-CH1-186",186,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,37.9,46.3,-8.4 "PHB-CH1","PHB-CH1-186",186,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,64.1,46.3,17.8 "PHB-CH1","PHB-CH1-186",186,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.2,4.2,0 "PHB-CH1","PHB-CH1-186",186,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.4,4.2,-0.8 "PHB-CH1","PHB-CH1-186",186,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.9,4.2,-0.3 "PHB-CH1","PHB-CH1-186",186,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-186",186,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.2,4.2,0 "PHB-CH1","PHB-CH1-186",186,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2.8,4.2,-1.4 "PHB-CH1","PHB-CH1-186",186,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5,4.2,0.8 "PHB-CH1","PHB-CH1-186",186,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.8,4.2,-0.4 "PHB-CH1","PHB-CH1-186",186,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.5,4.2,0.3 "PHB-CH1","PHB-CH1-186",186,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.3,4.2,1.1 "PHB-CH1","PHB-CH1-186",186,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-186",186,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.2,4.2,0 "PHB-CH1","PHB-CH1-186",186,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.4,4.2,0.2 "PHB-CH1","PHB-CH1-186",186,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.9,4.2,0.7 "PHB-CH1","PHB-CH1-186",186,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-186",186,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.8,5.4,-0.6 "PHB-CH1","PHB-CH1-186",186,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.6,5.4,-0.800000000000001 "PHB-CH1","PHB-CH1-186",186,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5,5.4,-0.4 "PHB-CH1","PHB-CH1-186",186,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.6,5.4,0.199999999999999 "PHB-CH1","PHB-CH1-186",186,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.3,5.4,-1.1 "PHB-CH1","PHB-CH1-186",186,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.9,5.4,-0.5 "PHB-CH1","PHB-CH1-186",186,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.1,5.4,-0.300000000000001 "PHB-CH1","PHB-CH1-186",186,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.8,5.4,0.399999999999999 "PHB-CH1","PHB-CH1-186",186,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.1,5.4,0.699999999999999 "PHB-CH1","PHB-CH1-186",186,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.3,5.4,-0.100000000000001 "PHB-CH1","PHB-CH1-186",186,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.9,5.4,-0.5 "PHB-CH1","PHB-CH1-186",186,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5,5.4,-0.4 "PHB-CH1","PHB-CH1-186",186,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,5.1,5.4,-0.300000000000001 "PHB-CH1","PHB-CH1-187",187,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,48,48,0 "PHB-CH1","PHB-CH1-187",187,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,54,48,6 "PHB-CH1","PHB-CH1-187",187,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,48,48,0 "PHB-CH1","PHB-CH1-187",187,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,52,, "PHB-CH1","PHB-CH1-187",187,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,23,, "PHB-CH1","PHB-CH1-187",187,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,37,, "PHB-CH1","PHB-CH1-187",187,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-187",187,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-187",187,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-187",187,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-187",187,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,11,, "PHB-CH1","PHB-CH1-187",187,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,362,, "PHB-CH1","PHB-CH1-187",187,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-187",187,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-187",187,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-187",187,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-187",187,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,43.5,43.5,0 "PHB-CH1","PHB-CH1-187",187,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,32.1,43.5,-11.4 "PHB-CH1","PHB-CH1-187",187,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,37.4,43.5,-6.1 "PHB-CH1","PHB-CH1-187",187,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,41.8,43.5,-1.7 "PHB-CH1","PHB-CH1-187",187,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,55.1,55.1,0 "PHB-CH1","PHB-CH1-187",187,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,55.8,55.1,0.699999999999996 "PHB-CH1","PHB-CH1-187",187,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,56.2,55.1,1.1 "PHB-CH1","PHB-CH1-187",187,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,54.5,55.1,-0.600000000000001 "PHB-CH1","PHB-CH1-187",187,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,3.6,3.6,0 "PHB-CH1","PHB-CH1-187",187,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.4,3.6,-0.2 "PHB-CH1","PHB-CH1-187",187,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,3.1,3.6,-0.5 "PHB-CH1","PHB-CH1-187",187,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.2,3.6,0.6 "PHB-CH1","PHB-CH1-187",187,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4,3.6,0.4 "PHB-CH1","PHB-CH1-187",187,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.4,3.6,1.8 "PHB-CH1","PHB-CH1-187",187,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.4,3.6,0.8 "PHB-CH1","PHB-CH1-187",187,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,3.9,3.6,0.3 "PHB-CH1","PHB-CH1-187",187,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,3.9,3.6,0.3 "PHB-CH1","PHB-CH1-187",187,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5,3.6,1.4 "PHB-CH1","PHB-CH1-187",187,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,3.2,3.6,-0.4 "PHB-CH1","PHB-CH1-187",187,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.9,3.6,0.3 "PHB-CH1","PHB-CH1-187",187,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.5,3.6,-0.1 "PHB-CH1","PHB-CH1-187",187,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.4,3.6,-0.2 "PHB-CH1","PHB-CH1-187",187,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.4,3.4,0 "PHB-CH1","PHB-CH1-187",187,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.3,3.4,-0.1 "PHB-CH1","PHB-CH1-187",187,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.3,3.4,-0.1 "PHB-CH1","PHB-CH1-187",187,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.6,3.4,0.2 "PHB-CH1","PHB-CH1-187",187,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,2.8,3.4,-0.6 "PHB-CH1","PHB-CH1-187",187,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.9,3.4,1.5 "PHB-CH1","PHB-CH1-187",187,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.1,3.4,-0.3 "PHB-CH1","PHB-CH1-187",187,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.7,3.4,0.3 "PHB-CH1","PHB-CH1-187",187,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.4,3.4,0 "PHB-CH1","PHB-CH1-187",187,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.6,3.4,0.2 "PHB-CH1","PHB-CH1-187",187,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,2,3.4,-1.4 "PHB-CH1","PHB-CH1-187",187,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.6,3.4,0.2 "PHB-CH1","PHB-CH1-187",187,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.3,3.4,-0.1 "PHB-CH1","PHB-CH1-187",187,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,2.6,3.4,-0.8 "PHB-CH1","PHB-CH1-188",188,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,32,32,0 "PHB-CH1","PHB-CH1-188",188,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,43,32,11 "PHB-CH1","PHB-CH1-188",188,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,39,32,7 "PHB-CH1","PHB-CH1-188",188,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,58,, "PHB-CH1","PHB-CH1-188",188,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,47,, "PHB-CH1","PHB-CH1-188",188,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,49,, "PHB-CH1","PHB-CH1-188",188,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-188",188,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-188",188,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-188",188,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-188",188,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,10,, "PHB-CH1","PHB-CH1-188",188,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,372,, "PHB-CH1","PHB-CH1-188",188,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-188",188,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-188",188,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-188",188,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,4,, "PHB-CH1","PHB-CH1-188",188,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,36.5,36.5,0 "PHB-CH1","PHB-CH1-188",188,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,60.4,36.5,23.9 "PHB-CH1","PHB-CH1-188",188,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,44.9,36.5,8.4 "PHB-CH1","PHB-CH1-188",188,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,45.9,36.5,9.4 "PHB-CH1","PHB-CH1-188",188,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,47.5,47.5,0 "PHB-CH1","PHB-CH1-188",188,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,48.4,47.5,0.899999999999999 "PHB-CH1","PHB-CH1-188",188,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,49,47.5,1.5 "PHB-CH1","PHB-CH1-188",188,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,58.6,47.5,11.1 "PHB-CH1","PHB-CH1-188",188,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.3,6.3,0 "PHB-CH1","PHB-CH1-188",188,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.7,6.3,0.4 "PHB-CH1","PHB-CH1-188",188,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.1,6.3,-0.2 "PHB-CH1","PHB-CH1-188",188,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.4,6.3,0.100000000000001 "PHB-CH1","PHB-CH1-188",188,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,7.2,6.3,0.9 "PHB-CH1","PHB-CH1-188",188,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.4,6.3,0.100000000000001 "PHB-CH1","PHB-CH1-188",188,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.7,6.3,0.4 "PHB-CH1","PHB-CH1-188",188,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.5,6.3,0.2 "PHB-CH1","PHB-CH1-188",188,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.4,6.3,-0.9 "PHB-CH1","PHB-CH1-188",188,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.2,6.3,-0.0999999999999996 "PHB-CH1","PHB-CH1-188",188,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.9,6.3,0.6 "PHB-CH1","PHB-CH1-188",188,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,7.2,6.3,0.9 "PHB-CH1","PHB-CH1-188",188,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.6,6.3,0.3 "PHB-CH1","PHB-CH1-188",188,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6,6.3,-0.3 "PHB-CH1","PHB-CH1-188",188,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-188",188,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.3,5.4,-0.100000000000001 "PHB-CH1","PHB-CH1-188",188,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.1,5.4,-0.300000000000001 "PHB-CH1","PHB-CH1-188",188,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.3,5.4,-0.100000000000001 "PHB-CH1","PHB-CH1-188",188,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6,5.4,0.6 "PHB-CH1","PHB-CH1-188",188,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.9,5.4,0.5 "PHB-CH1","PHB-CH1-188",188,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.7,5.4,0.3 "PHB-CH1","PHB-CH1-188",188,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.4,5.4,1 "PHB-CH1","PHB-CH1-188",188,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.5,5.4,-0.9 "PHB-CH1","PHB-CH1-188",188,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.2,5.4,-0.2 "PHB-CH1","PHB-CH1-188",188,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.4,5.4,1 "PHB-CH1","PHB-CH1-188",188,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.3,5.4,0.9 "PHB-CH1","PHB-CH1-188",188,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.7,5.4,0.3 "PHB-CH1","PHB-CH1-188",188,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.7,5.4,-0.7 "PHB-CH1","PHB-CH1-189",189,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,64,64,0 "PHB-CH1","PHB-CH1-189",189,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,69,64,5 "PHB-CH1","PHB-CH1-189",189,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,55,64,-9 "PHB-CH1","PHB-CH1-189",189,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,62,, "PHB-CH1","PHB-CH1-189",189,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,63,, "PHB-CH1","PHB-CH1-189",189,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,38,, "PHB-CH1","PHB-CH1-189",189,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-189",189,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-189",189,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-189",189,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-189",189,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,9,, "PHB-CH1","PHB-CH1-189",189,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,364,, "PHB-CH1","PHB-CH1-189",189,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-189",189,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-189",189,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-189",189,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-189",189,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,40.9,40.9,0 "PHB-CH1","PHB-CH1-189",189,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,47.2,40.9,6.3 "PHB-CH1","PHB-CH1-189",189,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,31.8,40.9,-9.1 "PHB-CH1","PHB-CH1-189",189,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,56.8,40.9,15.9 "PHB-CH1","PHB-CH1-189",189,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,32.9,32.9,0 "PHB-CH1","PHB-CH1-189",189,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,53.4,32.9,20.5 "PHB-CH1","PHB-CH1-189",189,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,36.1,32.9,3.2 "PHB-CH1","PHB-CH1-189",189,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,61.1,32.9,28.2 "PHB-CH1","PHB-CH1-189",189,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.6,5.6,0 "PHB-CH1","PHB-CH1-189",189,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4.8,5.6,-0.8 "PHB-CH1","PHB-CH1-189",189,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.9,5.6,-2.7 "PHB-CH1","PHB-CH1-189",189,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.3,5.6,-1.3 "PHB-CH1","PHB-CH1-189",189,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.7,5.6,-0.9 "PHB-CH1","PHB-CH1-189",189,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.5,5.6,-1.1 "PHB-CH1","PHB-CH1-189",189,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.3,5.6,-0.3 "PHB-CH1","PHB-CH1-189",189,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.8,5.6,-0.8 "PHB-CH1","PHB-CH1-189",189,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,2.7,5.6,-2.9 "PHB-CH1","PHB-CH1-189",189,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,4,5.6,-1.6 "PHB-CH1","PHB-CH1-189",189,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.9,5.6,-0.699999999999999 "PHB-CH1","PHB-CH1-189",189,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.6,5.6,0 "PHB-CH1","PHB-CH1-189",189,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.9,5.6,-1.7 "PHB-CH1","PHB-CH1-189",189,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2.2,5.6,-3.4 "PHB-CH1","PHB-CH1-189",189,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.3,6.3,0 "PHB-CH1","PHB-CH1-189",189,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.3,6.3,-1 "PHB-CH1","PHB-CH1-189",189,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5,6.3,-1.3 "PHB-CH1","PHB-CH1-189",189,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.2,6.3,-1.1 "PHB-CH1","PHB-CH1-189",189,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.6,6.3,-1.7 "PHB-CH1","PHB-CH1-189",189,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.6,6.3,-1.7 "PHB-CH1","PHB-CH1-189",189,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,5.4,6.3,-0.9 "PHB-CH1","PHB-CH1-189",189,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6,6.3,-0.3 "PHB-CH1","PHB-CH1-189",189,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.1,6.3,-1.2 "PHB-CH1","PHB-CH1-189",189,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.4,6.3,-0.9 "PHB-CH1","PHB-CH1-189",189,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.3,6.3,0 "PHB-CH1","PHB-CH1-189",189,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,7,6.3,0.7 "PHB-CH1","PHB-CH1-189",189,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.6,6.3,-1.7 "PHB-CH1","PHB-CH1-189",189,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.6,6.3,-1.7 "PHB-CH1","PHB-CH1-190",190,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,43,43,0 "PHB-CH1","PHB-CH1-190",190,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,54,43,11 "PHB-CH1","PHB-CH1-190",190,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,28,43,-15 "PHB-CH1","PHB-CH1-190",190,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,46,, "PHB-CH1","PHB-CH1-190",190,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,53,, "PHB-CH1","PHB-CH1-190",190,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,53,, "PHB-CH1","PHB-CH1-190",190,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-190",190,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-190",190,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-190",190,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-190",190,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,48,, "PHB-CH1","PHB-CH1-190",190,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,168,, "PHB-CH1","PHB-CH1-190",190,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-190",190,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-190",190,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-190",190,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-190",190,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,27.3,27.3,0 "PHB-CH1","PHB-CH1-190",190,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,27.4,27.3,0.0999999999999979 "PHB-CH1","PHB-CH1-190",190,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,36.5,27.3,9.2 "PHB-CH1","PHB-CH1-190",190,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,36.6,27.3,9.3 "PHB-CH1","PHB-CH1-190",190,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,60.6,60.6,0 "PHB-CH1","PHB-CH1-190",190,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,27.3,60.6,-33.3 "PHB-CH1","PHB-CH1-190",190,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,55.8,60.6,-4.8 "PHB-CH1","PHB-CH1-190",190,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,62.8,60.6,2.2 "PHB-CH1","PHB-CH1-190",190,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.8,4.8,0 "PHB-CH1","PHB-CH1-190",190,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,3.3,4.8,-1.5 "PHB-CH1","PHB-CH1-190",190,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,4.7,4.8,-0.0999999999999996 "PHB-CH1","PHB-CH1-190",190,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,4.6,4.8,-0.2 "PHB-CH1","PHB-CH1-190",190,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,2.9,4.8,-1.9 "PHB-CH1","PHB-CH1-190",190,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.4,4.8,0.6 "PHB-CH1","PHB-CH1-190",190,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,4.4,4.8,-0.399999999999999 "PHB-CH1","PHB-CH1-190",190,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5.2,4.8,0.4 "PHB-CH1","PHB-CH1-190",190,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.2,4.8,1.4 "PHB-CH1","PHB-CH1-190",190,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.5,4.8,1.7 "PHB-CH1","PHB-CH1-190",190,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.9,4.8,0.100000000000001 "PHB-CH1","PHB-CH1-190",190,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,4.1,4.8,-0.7 "PHB-CH1","PHB-CH1-190",190,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.5,4.8,-0.3 "PHB-CH1","PHB-CH1-190",190,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.9,4.8,1.1 "PHB-CH1","PHB-CH1-190",190,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.2,5.2,0 "PHB-CH1","PHB-CH1-190",190,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.3,5.2,-0.9 "PHB-CH1","PHB-CH1-190",190,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,5.9,5.2,0.7 "PHB-CH1","PHB-CH1-190",190,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.6,5.2,1.4 "PHB-CH1","PHB-CH1-190",190,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.9,5.2,-0.3 "PHB-CH1","PHB-CH1-190",190,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.8,5.2,-0.4 "PHB-CH1","PHB-CH1-190",190,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.3,5.2,-0.9 "PHB-CH1","PHB-CH1-190",190,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.6,5.2,-0.6 "PHB-CH1","PHB-CH1-190",190,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.8,5.2,0.6 "PHB-CH1","PHB-CH1-190",190,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.9,5.2,0.7 "PHB-CH1","PHB-CH1-190",190,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6,5.2,0.8 "PHB-CH1","PHB-CH1-190",190,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.4,5.2,0.2 "PHB-CH1","PHB-CH1-190",190,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.1,5.2,0.9 "PHB-CH1","PHB-CH1-190",190,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.7,5.2,2.5 "PHB-CH1","PHB-CH1-191",191,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,63,63,0 "PHB-CH1","PHB-CH1-191",191,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,63,63,0 "PHB-CH1","PHB-CH1-191",191,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,67,63,4 "PHB-CH1","PHB-CH1-191",191,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,55,, "PHB-CH1","PHB-CH1-191",191,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,54,, "PHB-CH1","PHB-CH1-191",191,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,39,, "PHB-CH1","PHB-CH1-191",191,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-191",191,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-191",191,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-191",191,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-191",191,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,20,, "PHB-CH1","PHB-CH1-191",191,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,309,, "PHB-CH1","PHB-CH1-191",191,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-191",191,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-191",191,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-191",191,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-191",191,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,47.8,47.8,0 "PHB-CH1","PHB-CH1-191",191,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,69.6,47.8,21.8 "PHB-CH1","PHB-CH1-191",191,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,54.2,47.8,6.40000000000001 "PHB-CH1","PHB-CH1-191",191,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,47.9,47.8,0.100000000000001 "PHB-CH1","PHB-CH1-191",191,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,65.3,65.3,0 "PHB-CH1","PHB-CH1-191",191,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,65.9,65.3,0.600000000000009 "PHB-CH1","PHB-CH1-191",191,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,58.1,65.3,-7.2 "PHB-CH1","PHB-CH1-191",191,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,55.1,65.3,-10.2 "PHB-CH1","PHB-CH1-191",191,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,2.8,2.8,0 "PHB-CH1","PHB-CH1-191",191,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2,2.8,-0.8 "PHB-CH1","PHB-CH1-191",191,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,2.6,2.8,-0.2 "PHB-CH1","PHB-CH1-191",191,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,3,2.8,0.2 "PHB-CH1","PHB-CH1-191",191,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.1,2.8,0.3 "PHB-CH1","PHB-CH1-191",191,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,2.6,2.8,-0.2 "PHB-CH1","PHB-CH1-191",191,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,1.5,2.8,-1.3 "PHB-CH1","PHB-CH1-191",191,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,0.5,2.8,-2.3 "PHB-CH1","PHB-CH1-191",191,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,1.2,2.8,-1.6 "PHB-CH1","PHB-CH1-191",191,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,1.2,2.8,-1.6 "PHB-CH1","PHB-CH1-191",191,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,0.4,2.8,-2.4 "PHB-CH1","PHB-CH1-191",191,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,1.7,2.8,-1.1 "PHB-CH1","PHB-CH1-191",191,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,0.7,2.8,-2.1 "PHB-CH1","PHB-CH1-191",191,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,1.3,2.8,-1.5 "PHB-CH1","PHB-CH1-191",191,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.7,4.7,0 "PHB-CH1","PHB-CH1-191",191,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4.2,4.7,-0.5 "PHB-CH1","PHB-CH1-191",191,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.2,4.7,-0.5 "PHB-CH1","PHB-CH1-191",191,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-191",191,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.6,4.7,1.9 "PHB-CH1","PHB-CH1-191",191,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6,4.7,1.3 "PHB-CH1","PHB-CH1-191",191,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.8,4.7,0.0999999999999996 "PHB-CH1","PHB-CH1-191",191,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.6,4.7,-0.100000000000001 "PHB-CH1","PHB-CH1-191",191,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.3,4.7,-0.4 "PHB-CH1","PHB-CH1-191",191,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.1,4.7,0.399999999999999 "PHB-CH1","PHB-CH1-191",191,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4.9,4.7,0.2 "PHB-CH1","PHB-CH1-191",191,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.2,4.7,0.5 "PHB-CH1","PHB-CH1-191",191,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.9,4.7,-0.8 "PHB-CH1","PHB-CH1-191",191,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.8,4.7,-0.9 "PHB-CH1","PHB-CH1-192",192,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,37,37,0 "PHB-CH1","PHB-CH1-192",192,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,30,37,-7 "PHB-CH1","PHB-CH1-192",192,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,20,37,-17 "PHB-CH1","PHB-CH1-192",192,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,40,, "PHB-CH1","PHB-CH1-192",192,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,46,, "PHB-CH1","PHB-CH1-192",192,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,40,, "PHB-CH1","PHB-CH1-192",192,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-192",192,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-192",192,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,1,, "PHB-CH1","PHB-CH1-192",192,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-192",192,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,0,, "PHB-CH1","PHB-CH1-192",192,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,670,, "PHB-CH1","PHB-CH1-192",192,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-192",192,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-192",192,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,1,, "PHB-CH1","PHB-CH1-192",192,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-192",192,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,30.7,30.7,0 "PHB-CH1","PHB-CH1-192",192,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,50.7,30.7,20 "PHB-CH1","PHB-CH1-192",192,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,35.2,30.7,4.5 "PHB-CH1","PHB-CH1-192",192,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,44.3,30.7,13.6 "PHB-CH1","PHB-CH1-192",192,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,56.7,56.7,0 "PHB-CH1","PHB-CH1-192",192,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,58,56.7,1.3 "PHB-CH1","PHB-CH1-192",192,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,46.7,56.7,-10 "PHB-CH1","PHB-CH1-192",192,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,65.2,56.7,8.5 "PHB-CH1","PHB-CH1-192",192,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.4,6.4,0 "PHB-CH1","PHB-CH1-192",192,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,7.1,6.4,0.699999999999999 "PHB-CH1","PHB-CH1-192",192,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7.2,6.4,0.8 "PHB-CH1","PHB-CH1-192",192,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.8,6.4,0.399999999999999 "PHB-CH1","PHB-CH1-192",192,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,7.2,6.4,0.8 "PHB-CH1","PHB-CH1-192",192,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,7.5,6.4,1.1 "PHB-CH1","PHB-CH1-192",192,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.8,6.4,0.399999999999999 "PHB-CH1","PHB-CH1-192",192,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.7,6.4,0.3 "PHB-CH1","PHB-CH1-192",192,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,7.4,6.4,1 "PHB-CH1","PHB-CH1-192",192,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.2,6.4,-0.2 "PHB-CH1","PHB-CH1-192",192,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.1,6.4,-0.300000000000001 "PHB-CH1","PHB-CH1-192",192,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.5,6.4,0.0999999999999996 "PHB-CH1","PHB-CH1-192",192,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,7.4,6.4,1 "PHB-CH1","PHB-CH1-192",192,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,7.3,6.4,0.9 "PHB-CH1","PHB-CH1-192",192,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,3.9,3.9,0 "PHB-CH1","PHB-CH1-192",192,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4,3.9,0.1 "PHB-CH1","PHB-CH1-192",192,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.9,3.9,0 "PHB-CH1","PHB-CH1-192",192,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.9,3.9,0 "PHB-CH1","PHB-CH1-192",192,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.8,3.9,-0.1 "PHB-CH1","PHB-CH1-192",192,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,3.9,3.9,0 "PHB-CH1","PHB-CH1-192",192,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,2.8,3.9,-1.1 "PHB-CH1","PHB-CH1-192",192,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,3.6,3.9,-0.3 "PHB-CH1","PHB-CH1-192",192,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,4.9,3.9,1 "PHB-CH1","PHB-CH1-192",192,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.1,3.9,-0.8 "PHB-CH1","PHB-CH1-192",192,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.7,3.9,-0.2 "PHB-CH1","PHB-CH1-192",192,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,2.7,3.9,-1.2 "PHB-CH1","PHB-CH1-192",192,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.2,3.9,1.3 "PHB-CH1","PHB-CH1-192",192,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.3,3.9,-0.6 "PHB-CH1","PHB-CH1-193",193,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,64,64,0 "PHB-CH1","PHB-CH1-193",193,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,70,64,6 "PHB-CH1","PHB-CH1-193",193,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,61,64,-3 "PHB-CH1","PHB-CH1-193",193,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,58,, "PHB-CH1","PHB-CH1-193",193,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,60,, "PHB-CH1","PHB-CH1-193",193,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,63,, "PHB-CH1","PHB-CH1-193",193,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-193",193,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,2,, "PHB-CH1","PHB-CH1-193",193,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-193",193,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-193",193,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,5,, "PHB-CH1","PHB-CH1-193",193,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,493,, "PHB-CH1","PHB-CH1-193",193,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-193",193,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-193",193,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-193",193,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,6,, "PHB-CH1","PHB-CH1-193",193,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,52.9,52.9,0 "PHB-CH1","PHB-CH1-193",193,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,60.8,52.9,7.9 "PHB-CH1","PHB-CH1-193",193,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,60.6,52.9,7.7 "PHB-CH1","PHB-CH1-193",193,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,63.1,52.9,10.2 "PHB-CH1","PHB-CH1-193",193,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,44.7,44.7,0 "PHB-CH1","PHB-CH1-193",193,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,46.1,44.7,1.4 "PHB-CH1","PHB-CH1-193",193,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,52.5,44.7,7.8 "PHB-CH1","PHB-CH1-193",193,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,49.2,44.7,4.5 "PHB-CH1","PHB-CH1-193",193,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-193",193,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.3,5.4,-0.100000000000001 "PHB-CH1","PHB-CH1-193",193,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.7,5.4,1.3 "PHB-CH1","PHB-CH1-193",193,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.4,5.4,1 "PHB-CH1","PHB-CH1-193",193,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,4.6,5.4,-0.800000000000001 "PHB-CH1","PHB-CH1-193",193,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,4.6,5.4,-0.800000000000001 "PHB-CH1","PHB-CH1-193",193,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.9,5.4,-1.5 "PHB-CH1","PHB-CH1-193",193,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.1,5.4,0.699999999999999 "PHB-CH1","PHB-CH1-193",193,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.5,5.4,0.0999999999999996 "PHB-CH1","PHB-CH1-193",193,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.5,5.4,0.0999999999999996 "PHB-CH1","PHB-CH1-193",193,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5,5.4,-0.4 "PHB-CH1","PHB-CH1-193",193,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.5,5.4,-1.9 "PHB-CH1","PHB-CH1-193",193,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.1,5.4,-2.3 "PHB-CH1","PHB-CH1-193",193,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2.6,5.4,-2.8 "PHB-CH1","PHB-CH1-193",193,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.5,4.5,0 "PHB-CH1","PHB-CH1-193",193,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.5,4.5,1 "PHB-CH1","PHB-CH1-193",193,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,7.2,4.5,2.7 "PHB-CH1","PHB-CH1-193",193,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,6.1,4.5,1.6 "PHB-CH1","PHB-CH1-193",193,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.2,4.5,1.7 "PHB-CH1","PHB-CH1-193",193,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.3,4.5,1.8 "PHB-CH1","PHB-CH1-193",193,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.4,4.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-193",193,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.4,4.5,0.9 "PHB-CH1","PHB-CH1-193",193,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.2,4.5,0.7 "PHB-CH1","PHB-CH1-193",193,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,4.6,4.5,0.0999999999999996 "PHB-CH1","PHB-CH1-193",193,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,4,4.5,-0.5 "PHB-CH1","PHB-CH1-193",193,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.4,4.5,-0.0999999999999996 "PHB-CH1","PHB-CH1-193",193,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.7,4.5,-0.8 "PHB-CH1","PHB-CH1-193",193,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,3.7,4.5,-0.8 "PHB-CH1","PHB-CH1-194",194,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,67,67,0 "PHB-CH1","PHB-CH1-194",194,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,78,67,11 "PHB-CH1","PHB-CH1-194",194,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,68,67,1 "PHB-CH1","PHB-CH1-194",194,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,46,, "PHB-CH1","PHB-CH1-194",194,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,57,, "PHB-CH1","PHB-CH1-194",194,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,62,, "PHB-CH1","PHB-CH1-194",194,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-194",194,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-194",194,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-194",194,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-194",194,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,19,, "PHB-CH1","PHB-CH1-194",194,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,392,, "PHB-CH1","PHB-CH1-194",194,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,1,, "PHB-CH1","PHB-CH1-194",194,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-194",194,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-194",194,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,3,, "PHB-CH1","PHB-CH1-194",194,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,38.2,38.2,0 "PHB-CH1","PHB-CH1-194",194,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,39,38.2,0.799999999999997 "PHB-CH1","PHB-CH1-194",194,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,45.4,38.2,7.2 "PHB-CH1","PHB-CH1-194",194,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,37.5,38.2,-0.700000000000003 "PHB-CH1","PHB-CH1-194",194,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,64.8,64.8,0 "PHB-CH1","PHB-CH1-194",194,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,58,64.8,-6.8 "PHB-CH1","PHB-CH1-194",194,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,70.7,64.8,5.90000000000001 "PHB-CH1","PHB-CH1-194",194,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,72.3,64.8,7.5 "PHB-CH1","PHB-CH1-194",194,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,0,0,0 "PHB-CH1","PHB-CH1-194",194,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,0,0,0 "PHB-CH1","PHB-CH1-194",194,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,0.2,0,0.2 "PHB-CH1","PHB-CH1-194",194,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,0.1,0,0.1 "PHB-CH1","PHB-CH1-194",194,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,0.7,0,0.7 "PHB-CH1","PHB-CH1-194",194,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,0,0,0 "PHB-CH1","PHB-CH1-194",194,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,0,0,0 "PHB-CH1","PHB-CH1-194",194,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,0,0,0 "PHB-CH1","PHB-CH1-194",194,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,0,0,0 "PHB-CH1","PHB-CH1-194",194,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,0.2,0,0.2 "PHB-CH1","PHB-CH1-194",194,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,0.3,0,0.3 "PHB-CH1","PHB-CH1-194",194,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,0,0,0 "PHB-CH1","PHB-CH1-194",194,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,0,0,0 "PHB-CH1","PHB-CH1-194",194,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,1.3,0,1.3 "PHB-CH1","PHB-CH1-194",194,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,2.3,2.3,0 "PHB-CH1","PHB-CH1-194",194,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,2.4,2.3,0.1 "PHB-CH1","PHB-CH1-194",194,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,3.4,2.3,1.1 "PHB-CH1","PHB-CH1-194",194,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,3.5,2.3,1.2 "PHB-CH1","PHB-CH1-194",194,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,3.8,2.3,1.5 "PHB-CH1","PHB-CH1-194",194,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,2.3,2.3,0 "PHB-CH1","PHB-CH1-194",194,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,1.8,2.3,-0.5 "PHB-CH1","PHB-CH1-194",194,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,1.9,2.3,-0.4 "PHB-CH1","PHB-CH1-194",194,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.1,2.3,0.8 "PHB-CH1","PHB-CH1-194",194,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.8,2.3,1.5 "PHB-CH1","PHB-CH1-194",194,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.3,2.3,1 "PHB-CH1","PHB-CH1-194",194,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3,2.3,0.7 "PHB-CH1","PHB-CH1-194",194,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,2.9,2.3,0.6 "PHB-CH1","PHB-CH1-194",194,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.4,2.3,2.1 "PHB-CH1","PHB-CH1-195",195,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,47,47,0 "PHB-CH1","PHB-CH1-195",195,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,50,47,3 "PHB-CH1","PHB-CH1-195",195,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,43,47,-4 "PHB-CH1","PHB-CH1-195",195,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,51,, "PHB-CH1","PHB-CH1-195",195,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,32,, "PHB-CH1","PHB-CH1-195",195,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,47,, "PHB-CH1","PHB-CH1-195",195,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-195",195,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-195",195,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-195",195,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-195",195,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,4,, "PHB-CH1","PHB-CH1-195",195,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,491,, "PHB-CH1","PHB-CH1-195",195,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-195",195,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-195",195,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,5,, "PHB-CH1","PHB-CH1-195",195,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-195",195,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,63.3,63.3,0 "PHB-CH1","PHB-CH1-195",195,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,53.4,63.3,-9.9 "PHB-CH1","PHB-CH1-195",195,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,57.3,63.3,-6 "PHB-CH1","PHB-CH1-195",195,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,62.2,63.3,-1.09999999999999 "PHB-CH1","PHB-CH1-195",195,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,78.6,78.6,0 "PHB-CH1","PHB-CH1-195",195,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,64.7,78.6,-13.9 "PHB-CH1","PHB-CH1-195",195,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,59.8,78.6,-18.8 "PHB-CH1","PHB-CH1-195",195,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,69.3,78.6,-9.3 "PHB-CH1","PHB-CH1-195",195,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,6.9,6.9,0 "PHB-CH1","PHB-CH1-195",195,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.5,6.9,-0.4 "PHB-CH1","PHB-CH1-195",195,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6.6,6.9,-0.300000000000001 "PHB-CH1","PHB-CH1-195",195,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.6,6.9,-0.300000000000001 "PHB-CH1","PHB-CH1-195",195,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6,6.9,-0.9 "PHB-CH1","PHB-CH1-195",195,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6.8,6.9,-0.100000000000001 "PHB-CH1","PHB-CH1-195",195,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6,6.9,-0.9 "PHB-CH1","PHB-CH1-195",195,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7,6.9,0.0999999999999996 "PHB-CH1","PHB-CH1-195",195,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,5.6,6.9,-1.3 "PHB-CH1","PHB-CH1-195",195,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.3,6.9,-1.6 "PHB-CH1","PHB-CH1-195",195,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.4,6.9,-1.5 "PHB-CH1","PHB-CH1-195",195,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.6,6.9,-1.3 "PHB-CH1","PHB-CH1-195",195,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.4,6.9,-2.5 "PHB-CH1","PHB-CH1-195",195,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.7,6.9,-1.2 "PHB-CH1","PHB-CH1-195",195,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.3,5.3,0 "PHB-CH1","PHB-CH1-195",195,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,5.1,5.3,-0.2 "PHB-CH1","PHB-CH1-195",195,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.3,5.3,-1 "PHB-CH1","PHB-CH1-195",195,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.1,5.3,-0.2 "PHB-CH1","PHB-CH1-195",195,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,4.8,5.3,-0.5 "PHB-CH1","PHB-CH1-195",195,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.3,5.3,-1 "PHB-CH1","PHB-CH1-195",195,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.6,5.3,-1.7 "PHB-CH1","PHB-CH1-195",195,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,5.7,5.3,0.4 "PHB-CH1","PHB-CH1-195",195,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,3.3,5.3,-2 "PHB-CH1","PHB-CH1-195",195,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,3.7,5.3,-1.6 "PHB-CH1","PHB-CH1-195",195,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,3.5,5.3,-1.8 "PHB-CH1","PHB-CH1-195",195,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,3.8,5.3,-1.5 "PHB-CH1","PHB-CH1-195",195,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,3.2,5.3,-2.1 "PHB-CH1","PHB-CH1-195",195,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.9,5.3,-0.399999999999999 "PHB-CH1","PHB-CH1-196",196,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,62,62,0 "PHB-CH1","PHB-CH1-196",196,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,55,62,-7 "PHB-CH1","PHB-CH1-196",196,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,72,62,10 "PHB-CH1","PHB-CH1-196",196,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,68,, "PHB-CH1","PHB-CH1-196",196,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,50,, "PHB-CH1","PHB-CH1-196",196,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,55,, "PHB-CH1","PHB-CH1-196",196,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,2,, "PHB-CH1","PHB-CH1-196",196,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-196",196,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-196",196,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-196",196,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,3,, "PHB-CH1","PHB-CH1-196",196,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,485,, "PHB-CH1","PHB-CH1-196",196,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-196",196,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-196",196,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,3,, "PHB-CH1","PHB-CH1-196",196,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-196",196,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,42.7,42.7,0 "PHB-CH1","PHB-CH1-196",196,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,40.8,42.7,-1.90000000000001 "PHB-CH1","PHB-CH1-196",196,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,55.9,42.7,13.2 "PHB-CH1","PHB-CH1-196",196,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,43.7,42.7,1 "PHB-CH1","PHB-CH1-196",196,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,55.7,55.7,0 "PHB-CH1","PHB-CH1-196",196,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,69.6,55.7,13.9 "PHB-CH1","PHB-CH1-196",196,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,70.1,55.7,14.4 "PHB-CH1","PHB-CH1-196",196,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,60.8,55.7,5.09999999999999 "PHB-CH1","PHB-CH1-196",196,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.4,5.4,0 "PHB-CH1","PHB-CH1-196",196,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.2,5.4,0.8 "PHB-CH1","PHB-CH1-196",196,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5.8,5.4,0.399999999999999 "PHB-CH1","PHB-CH1-196",196,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.3,5.4,0.9 "PHB-CH1","PHB-CH1-196",196,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,5.7,5.4,0.3 "PHB-CH1","PHB-CH1-196",196,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,6,5.4,0.6 "PHB-CH1","PHB-CH1-196",196,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.3,5.4,-0.100000000000001 "PHB-CH1","PHB-CH1-196",196,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,6.9,5.4,1.5 "PHB-CH1","PHB-CH1-196",196,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.8,5.4,-0.6 "PHB-CH1","PHB-CH1-196",196,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,7.6,5.4,2.2 "PHB-CH1","PHB-CH1-196",196,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.2,5.4,-0.2 "PHB-CH1","PHB-CH1-196",196,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6,5.4,0.6 "PHB-CH1","PHB-CH1-196",196,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,4.9,5.4,-0.5 "PHB-CH1","PHB-CH1-196",196,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,5.9,5.4,0.5 "PHB-CH1","PHB-CH1-196",196,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,5.7,5.7,0 "PHB-CH1","PHB-CH1-196",196,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,6.8,5.7,1.1 "PHB-CH1","PHB-CH1-196",196,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,8.2,5.7,2.5 "PHB-CH1","PHB-CH1-196",196,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,8,5.7,2.3 "PHB-CH1","PHB-CH1-196",196,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,7.3,5.7,1.6 "PHB-CH1","PHB-CH1-196",196,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,7.3,5.7,1.6 "PHB-CH1","PHB-CH1-196",196,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.9,5.7,1.2 "PHB-CH1","PHB-CH1-196",196,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,7.4,5.7,1.7 "PHB-CH1","PHB-CH1-196",196,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.2,5.7,-0.5 "PHB-CH1","PHB-CH1-196",196,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.5,5.7,1.8 "PHB-CH1","PHB-CH1-196",196,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,6.1,5.7,0.399999999999999 "PHB-CH1","PHB-CH1-196",196,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,6.5,5.7,0.8 "PHB-CH1","PHB-CH1-196",196,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,6.9,5.7,1.2 "PHB-CH1","PHB-CH1-196",196,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,7.1,5.7,1.4 "PHB-CH1","PHB-CH1-197",197,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,41,41,0 "PHB-CH1","PHB-CH1-197",197,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,45,41,4 "PHB-CH1","PHB-CH1-197",197,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,35,41,-6 "PHB-CH1","PHB-CH1-197",197,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,39,, "PHB-CH1","PHB-CH1-197",197,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,53,, "PHB-CH1","PHB-CH1-197",197,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,62,, "PHB-CH1","PHB-CH1-197",197,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-197",197,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-197",197,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,3,, "PHB-CH1","PHB-CH1-197",197,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,3,, "PHB-CH1","PHB-CH1-197",197,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,3,, "PHB-CH1","PHB-CH1-197",197,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,504,, "PHB-CH1","PHB-CH1-197",197,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-197",197,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,1,, "PHB-CH1","PHB-CH1-197",197,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-197",197,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,1,, "PHB-CH1","PHB-CH1-197",197,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,28.8,28.8,0 "PHB-CH1","PHB-CH1-197",197,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,28.2,28.8,-0.600000000000001 "PHB-CH1","PHB-CH1-197",197,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,34.5,28.8,5.7 "PHB-CH1","PHB-CH1-197",197,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,27.6,28.8,-1.2 "PHB-CH1","PHB-CH1-197",197,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,43.4,43.4,0 "PHB-CH1","PHB-CH1-197",197,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,27.9,43.4,-15.5 "PHB-CH1","PHB-CH1-197",197,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,29,43.4,-14.4 "PHB-CH1","PHB-CH1-197",197,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,39.3,43.4,-4.1 "PHB-CH1","PHB-CH1-197",197,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,4.4,4.4,0 "PHB-CH1","PHB-CH1-197",197,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,4,4.4,-0.4 "PHB-CH1","PHB-CH1-197",197,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,5,4.4,0.6 "PHB-CH1","PHB-CH1-197",197,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,5.4,4.4,1 "PHB-CH1","PHB-CH1-197",197,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,3.8,4.4,-0.6 "PHB-CH1","PHB-CH1-197",197,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,3.5,4.4,-0.9 "PHB-CH1","PHB-CH1-197",197,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.5,4.4,-0.9 "PHB-CH1","PHB-CH1-197",197,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,4.3,4.4,-0.100000000000001 "PHB-CH1","PHB-CH1-197",197,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.6,4.4,0.199999999999999 "PHB-CH1","PHB-CH1-197",197,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,6.7,4.4,2.3 "PHB-CH1","PHB-CH1-197",197,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5,4.4,0.6 "PHB-CH1","PHB-CH1-197",197,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.2,4.4,-1.2 "PHB-CH1","PHB-CH1-197",197,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,3.8,4.4,-0.6 "PHB-CH1","PHB-CH1-197",197,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,3.3,4.4,-1.1 "PHB-CH1","PHB-CH1-197",197,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4,4,0 "PHB-CH1","PHB-CH1-197",197,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,4,4,0 "PHB-CH1","PHB-CH1-197",197,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.7,4,0.7 "PHB-CH1","PHB-CH1-197",197,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,4.4,4,0.4 "PHB-CH1","PHB-CH1-197",197,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,5.3,4,1.3 "PHB-CH1","PHB-CH1-197",197,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,4.3,4,0.3 "PHB-CH1","PHB-CH1-197",197,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,3.8,4,-0.2 "PHB-CH1","PHB-CH1-197",197,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.8,4,0.8 "PHB-CH1","PHB-CH1-197",197,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,5.4,4,1.4 "PHB-CH1","PHB-CH1-197",197,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,7.7,4,3.7 "PHB-CH1","PHB-CH1-197",197,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.8,4,1.8 "PHB-CH1","PHB-CH1-197",197,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.7,4,0.7 "PHB-CH1","PHB-CH1-197",197,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.5,4,0.5 "PHB-CH1","PHB-CH1-197",197,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.4,4,0.4 "PHB-CH1","PHB-CH1-198",198,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,41,41,0 "PHB-CH1","PHB-CH1-198",198,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,39,41,-2 "PHB-CH1","PHB-CH1-198",198,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,46,41,5 "PHB-CH1","PHB-CH1-198",198,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,47,, "PHB-CH1","PHB-CH1-198",198,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,50,, "PHB-CH1","PHB-CH1-198",198,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,48,, "PHB-CH1","PHB-CH1-198",198,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-198",198,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-198",198,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-198",198,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,1,, "PHB-CH1","PHB-CH1-198",198,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,14,, "PHB-CH1","PHB-CH1-198",198,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,364,, "PHB-CH1","PHB-CH1-198",198,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-198",198,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-198",198,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,4,, "PHB-CH1","PHB-CH1-198",198,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-198",198,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,30,30,0 "PHB-CH1","PHB-CH1-198",198,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,28.6,30,-1.4 "PHB-CH1","PHB-CH1-198",198,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,17.6,30,-12.4 "PHB-CH1","PHB-CH1-198",198,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,22,30,-8 "PHB-CH1","PHB-CH1-198",198,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,33,33,0 "PHB-CH1","PHB-CH1-198",198,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,39.3,33,6.3 "PHB-CH1","PHB-CH1-198",198,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,43,33,10 "PHB-CH1","PHB-CH1-198",198,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,42.6,33,9.6 "PHB-CH1","PHB-CH1-198",198,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.6,5.6,0 "PHB-CH1","PHB-CH1-198",198,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,5.3,5.6,-0.3 "PHB-CH1","PHB-CH1-198",198,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,6,5.6,0.4 "PHB-CH1","PHB-CH1-198",198,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,7.2,5.6,1.6 "PHB-CH1","PHB-CH1-198",198,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.5,5.6,0.9 "PHB-CH1","PHB-CH1-198",198,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,8.1,5.6,2.5 "PHB-CH1","PHB-CH1-198",198,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,5.4,5.6,-0.199999999999999 "PHB-CH1","PHB-CH1-198",198,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,5,5.6,-0.6 "PHB-CH1","PHB-CH1-198",198,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.8,5.6,1.2 "PHB-CH1","PHB-CH1-198",198,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,7.2,5.6,1.6 "PHB-CH1","PHB-CH1-198",198,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,6.8,5.6,1.2 "PHB-CH1","PHB-CH1-198",198,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,6.1,5.6,0.5 "PHB-CH1","PHB-CH1-198",198,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6,5.6,0.4 "PHB-CH1","PHB-CH1-198",198,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,6.5,5.6,0.9 "PHB-CH1","PHB-CH1-198",198,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,4.3,4.3,0 "PHB-CH1","PHB-CH1-198",198,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,3.6,4.3,-0.7 "PHB-CH1","PHB-CH1-198",198,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,4.5,4.3,0.2 "PHB-CH1","PHB-CH1-198",198,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.6,4.3,1.3 "PHB-CH1","PHB-CH1-198",198,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.3,4.3,2 "PHB-CH1","PHB-CH1-198",198,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,5.6,4.3,1.3 "PHB-CH1","PHB-CH1-198",198,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,4.7,4.3,0.4 "PHB-CH1","PHB-CH1-198",198,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,4.6,4.3,0.3 "PHB-CH1","PHB-CH1-198",198,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.1,4.3,1.8 "PHB-CH1","PHB-CH1-198",198,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,5.2,4.3,0.9 "PHB-CH1","PHB-CH1-198",198,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,5.4,4.3,1.1 "PHB-CH1","PHB-CH1-198",198,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,5.4,4.3,1.1 "PHB-CH1","PHB-CH1-198",198,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,5.2,4.3,0.9 "PHB-CH1","PHB-CH1-198",198,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,4.7,4.3,0.4 "PHB-CH1","PHB-CH1-199",199,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,46,46,0 "PHB-CH1","PHB-CH1-199",199,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,48,46,2 "PHB-CH1","PHB-CH1-199",199,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,53,46,7 "PHB-CH1","PHB-CH1-199",199,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,66,, "PHB-CH1","PHB-CH1-199",199,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,61,, "PHB-CH1","PHB-CH1-199",199,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,38,, "PHB-CH1","PHB-CH1-199",199,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,4,, "PHB-CH1","PHB-CH1-199",199,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-199",199,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,4,, "PHB-CH1","PHB-CH1-199",199,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,4,, "PHB-CH1","PHB-CH1-199",199,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,5,, "PHB-CH1","PHB-CH1-199",199,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,450,, "PHB-CH1","PHB-CH1-199",199,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-199",199,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-199",199,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-199",199,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,7,, "PHB-CH1","PHB-CH1-199",199,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,62.8,62.8,0 "PHB-CH1","PHB-CH1-199",199,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,61,62.8,-1.8 "PHB-CH1","PHB-CH1-199",199,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,45.6,62.8,-17.2 "PHB-CH1","PHB-CH1-199",199,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,51.2,62.8,-11.6 "PHB-CH1","PHB-CH1-199",199,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,50.7,50.7,0 "PHB-CH1","PHB-CH1-199",199,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,43,50.7,-7.7 "PHB-CH1","PHB-CH1-199",199,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,51.7,50.7,1 "PHB-CH1","PHB-CH1-199",199,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,47.9,50.7,-2.8 "PHB-CH1","PHB-CH1-199",199,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,0,0,0 "PHB-CH1","PHB-CH1-199",199,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,2.2,0,2.2 "PHB-CH1","PHB-CH1-199",199,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,1.7,0,1.7 "PHB-CH1","PHB-CH1-199",199,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,0.9,0,0.9 "PHB-CH1","PHB-CH1-199",199,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,1.7,0,1.7 "PHB-CH1","PHB-CH1-199",199,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,1.4,0,1.4 "PHB-CH1","PHB-CH1-199",199,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,3.1,0,3.1 "PHB-CH1","PHB-CH1-199",199,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,2.5,0,2.5 "PHB-CH1","PHB-CH1-199",199,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,4.1,0,4.1 "PHB-CH1","PHB-CH1-199",199,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,3.9,0,3.9 "PHB-CH1","PHB-CH1-199",199,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,4.1,0,4.1 "PHB-CH1","PHB-CH1-199",199,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,3.1,0,3.1 "PHB-CH1","PHB-CH1-199",199,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,2.6,0,2.6 "PHB-CH1","PHB-CH1-199",199,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,2.3,0,2.3 "PHB-CH1","PHB-CH1-199",199,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,6.8,6.8,0 "PHB-CH1","PHB-CH1-199",199,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,7.2,6.8,0.4 "PHB-CH1","PHB-CH1-199",199,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,6.8,6.8,0 "PHB-CH1","PHB-CH1-199",199,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,5.8,6.8,-1 "PHB-CH1","PHB-CH1-199",199,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,6.3,6.8,-0.5 "PHB-CH1","PHB-CH1-199",199,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,6.2,6.8,-0.6 "PHB-CH1","PHB-CH1-199",199,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,6.5,6.8,-0.3 "PHB-CH1","PHB-CH1-199",199,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,6.5,6.8,-0.3 "PHB-CH1","PHB-CH1-199",199,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,6.3,6.8,-0.5 "PHB-CH1","PHB-CH1-199",199,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,6.8,6.8,0 "PHB-CH1","PHB-CH1-199",199,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,7.2,6.8,0.4 "PHB-CH1","PHB-CH1-199",199,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,4.5,6.8,-2.3 "PHB-CH1","PHB-CH1-199",199,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,4.6,6.8,-2.2 "PHB-CH1","PHB-CH1-199",199,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,6,6.8,-0.8 "PHB-CH1","PHB-CH1-200",200,"TARGTOT","Target PRO - total score (continuous)",1,"Baseline",0,45,45,0 "PHB-CH1","PHB-CH1-200",200,"TARGTOT","Target PRO - total score (continuous)",1,"Retest",1,48,45,3 "PHB-CH1","PHB-CH1-200",200,"TARGTOT","Target PRO - total score (continuous)",1,"Week 12",12,39,45,-6 "PHB-CH1","PHB-CH1-200",200,"RELATEDA","Related measure A - total score (convergent, continuous)",2,"Baseline",0,36,, "PHB-CH1","PHB-CH1-200",200,"RELATEDB","Related measure B - total score (convergent, continuous)",3,"Baseline",0,45,, "PHB-CH1","PHB-CH1-200",200,"UNRELATD","Unrelated measure - total score (divergent, continuous)",4,"Baseline",0,43,, "PHB-CH1","PHB-CH1-200",200,"ITEM01","Symptom item 1 - ordinal 5-point Likert",5,"Baseline",0,3,, "PHB-CH1","PHB-CH1-200",200,"ITEM02","Symptom item 2 - ordinal 5-point Likert",6,"Baseline",0,3,, "PHB-CH1","PHB-CH1-200",200,"ITEM03","Symptom item 3 - ordinal 5-point Likert",7,"Baseline",0,2,, "PHB-CH1","PHB-CH1-200",200,"ITEM04","Symptom item 4 - ordinal 5-point Likert",8,"Baseline",0,2,, "PHB-CH1","PHB-CH1-200",200,"FATVAS","Fatigue VAS - right-skewed continuous (0-100)",9,"Baseline",0,9,, "PHB-CH1","PHB-CH1-200",200,"WALK6MIN","Six-minute walk distance - approximately normal continuous (m)",10,"Baseline",0,367,, "PHB-CH1","PHB-CH1-200",200,"SEVGRP","Clinical status - genuine dichotomy (0=absent, 1=present)",11,"Baseline",0,0,, "PHB-CH1","PHB-CH1-200",200,"DICHOTOM","Disease present by score cutoff - dichotomised continuum",12,"Baseline",0,0,, "PHB-CH1","PHB-CH1-200",200,"PGIS","Patient Global Impression of Severity - ordinal anchor (5-point)",13,"Baseline",0,2,, "PHB-CH1","PHB-CH1-200",200,"PGIC","Patient Global Impression of Change - ordinal anchor (7-point)",14,"Week 12",12,2,, "PHB-CH1","PHB-CH1-200",200,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 1",1,45.8,45.8,0 "PHB-CH1","PHB-CH1-200",200,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 2",2,58.9,45.8,13.1 "PHB-CH1","PHB-CH1-200",200,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 3",3,46.7,45.8,0.900000000000006 "PHB-CH1","PHB-CH1-200",200,"FINTOX","Financial toxicity - repeated continuous (monthly)",15,"Month 4",4,55.4,45.8,9.6 "PHB-CH1","PHB-CH1-200",200,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 1",1,52.1,52.1,0 "PHB-CH1","PHB-CH1-200",200,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 2",2,66.9,52.1,14.8 "PHB-CH1","PHB-CH1-200",200,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 3",3,73.7,52.1,21.6 "PHB-CH1","PHB-CH1-200",200,"SYMBUR","Symptom burden - repeated continuous (monthly)",16,"Month 4",4,62.1,52.1,10 "PHB-CH1","PHB-CH1-200",200,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 1",1,5.6,5.6,0 "PHB-CH1","PHB-CH1-200",200,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 2",2,6.5,5.6,0.9 "PHB-CH1","PHB-CH1-200",200,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 3",3,7,5.6,1.4 "PHB-CH1","PHB-CH1-200",200,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 4",4,6.9,5.6,1.3 "PHB-CH1","PHB-CH1-200",200,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 5",5,6.9,5.6,1.3 "PHB-CH1","PHB-CH1-200",200,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 6",6,5.7,5.6,0.100000000000001 "PHB-CH1","PHB-CH1-200",200,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 7",7,6.8,5.6,1.2 "PHB-CH1","PHB-CH1-200",200,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 8",8,7.4,5.6,1.8 "PHB-CH1","PHB-CH1-200",200,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 9",9,6.8,5.6,1.2 "PHB-CH1","PHB-CH1-200",200,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 10",10,5.4,5.6,-0.199999999999999 "PHB-CH1","PHB-CH1-200",200,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 11",11,5.1,5.6,-0.5 "PHB-CH1","PHB-CH1-200",200,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 12",12,5.1,5.6,-0.5 "PHB-CH1","PHB-CH1-200",200,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 13",13,6.1,5.6,0.5 "PHB-CH1","PHB-CH1-200",200,"DIARY1","Daily symptom diary assessment 1 - repeated continuous (daily)",17,"Day 14",14,4.9,5.6,-0.699999999999999 "PHB-CH1","PHB-CH1-200",200,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 1",1,8.2,8.2,0 "PHB-CH1","PHB-CH1-200",200,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 2",2,8.4,8.2,0.200000000000001 "PHB-CH1","PHB-CH1-200",200,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 3",3,9.8,8.2,1.6 "PHB-CH1","PHB-CH1-200",200,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 4",4,10,8.2,1.8 "PHB-CH1","PHB-CH1-200",200,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 5",5,9,8.2,0.800000000000001 "PHB-CH1","PHB-CH1-200",200,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 6",6,9.5,8.2,1.3 "PHB-CH1","PHB-CH1-200",200,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 7",7,9.3,8.2,1.1 "PHB-CH1","PHB-CH1-200",200,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 8",8,9.7,8.2,1.5 "PHB-CH1","PHB-CH1-200",200,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 9",9,9,8.2,0.800000000000001 "PHB-CH1","PHB-CH1-200",200,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 10",10,8.8,8.2,0.600000000000001 "PHB-CH1","PHB-CH1-200",200,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 11",11,10,8.2,1.8 "PHB-CH1","PHB-CH1-200",200,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 12",12,9.5,8.2,1.3 "PHB-CH1","PHB-CH1-200",200,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 13",13,9.9,8.2,1.7 "PHB-CH1","PHB-CH1-200",200,"DIARY2","Daily symptom diary assessment 2 - repeated continuous (daily)",18,"Day 14",14,9,8.2,0.800000000000001