About
A resource for action and consensus in clinical measurement
Psychometric methods in clinical outcome assessment are documented across scattered papers, guidance documents and institutional habit. Practitioners end up learning them by apprenticeship. The Handbook exists to write them down in plain language, in one place, with the disagreements left visible rather than smoothed over.
Volume 1 · 17 organizations · free to use, with attribution.
Why
Because the same questions come up on every programme, and the answers live in too many heads. A shared reference makes the arguments faster and the decisions more consistent.
Who it is for
Psychometricians, COA scientists, statisticians, clinical outcome leads, and anyone who has to defend a measurement decision to a regulator.
How it is written
One volume at a time. Each is drafted, opened for review across the contributor group, revised against what comes back, then published free.
Who runs it
A SeeingTheta community project
SeeingTheta is a clinical outcomes consultancy working with biotechs, CROs and pharmaceutical companies. It convenes and edits the Handbook, funds the work, and keeps it free. The content belongs to the contributors.
Get involved
Meaningful Change
Volume 2 takes on the question every trial eventually asks: how much change actually matters? Anchors, thresholds, responder definitions, and the evidence each one needs to stand up.
Tell me when I can contribute
We will email you when Volume 2 opens for contributors.